iloprost and Hepatitis-C

We report the case of a 43-year-old male with liver cirrhosis based on a chronically active hepatitis C.. Before liver transplantation right-ventricular pressure values of 36 mmHg (+ central venous pressure) were measured whereas, after transplantation, he developed severe pulmonary hypertension with pressure values up to 90 mmHg. These elevated pressure values correlated inversely with graft function. Given the diagnosis of portopulmonary hypertension, we initiated treatment with intravenous epoprostenol and inhalative iloprost but both treatments were not tolerated because of systemic side effects. A combined heart-lung transplantation was considered but the patient died from insufficient cardiac function.. The case report discusses the present diagnostic and therapeutic state of the art in portopulmonary hypertension and reveals basic problems of the present screening strategy.

Topics: Adult; Antihypertensive Agents; Drug Combinations; Epoprostenol; Fatal Outcome; Hepatitis C; Humans; Hypertension, Pulmonary; Iloprost; Liver Cirrhosis; Liver Transplantation; Male; Treatment Failure; Vasodilator Agents

Topics: Adult; Antihypertensive Agents; Drug Combinations; Epoprostenol; Hepatitis C; Humans; Hypertension, Pulmonary; Iloprost; Liver Cirrhosis; Liver Transplantation; Male; Treatment Failure; Vasodilator Agents