iloprost and Foot-Injuries

Non-freezing cold injury (NFCI) remains largely under-reported, and is of particular importance in the armed forces where its prevalence is greatest. Iloprost, a synthetic prostaglandin I. An Iloprost infusion was used to treat the long-term sequelae of an ex-soldier suffering with ongoing pedal pain and loss of function 20 years after the initial NFCI insult sustained on military exercise. Following 5 days of iloprost infusion, he reported 4 weeks of markedly reduced pain and increased mobility before symptom relapse. A second infusion was thus given 3 months later, which resulted in increased pain and analgesic requirements.. The use of iloprost in the treatment of NFCI is discussed and its use in a condition which physicians consistently struggle to treat effectively is considered. Careful counselling is recommended as symptoms may be worsened.

Topics: Adult; Cold Injury; Foot Injuries; Humans; Iloprost; Infusions, Intravenous; Male; Military Personnel; Pain; United Kingdom; Vasodilator Agents

Topics: Adult; Canada; Facial Injuries; Foot Injuries; Frostbite; Hand Injuries; Humans; Iloprost; Male; Middle Aged; Nose; Severity of Illness Index; Vasodilator Agents