iloprost and Cyanosis

A retrospective study of drug abuse patients who developed arterial and venous complications in the upper extremity during 2002-2006 was performed. Twenty-two patients were admitted to hospital on 24 occasions over this period for treatment by our hand clinic. The drug most frequently causing complications was midazolam. The predominant clinical findings were increasing pain and loss of sensitivity in the hand, followed by oedema, cyanosis and marbling of the skin. Treatments included brachial block anaesthesia, low molecular weight heparin, embolectomy and fasciotomies. Despite these measures, amputations, mainly of the fingertips, were necessary in 15 patients. Complications in the upper extremity after self-injection by drug addicts are increasing; information and preventive procedures to minimize these complications are important and demanding tasks for health care bodies.

Topics: Adult; Amputation, Surgical; Angiography; Anti-Bacterial Agents; Anticoagulants; Compartment Syndromes; Cyanosis; Dermatologic Surgical Procedures; Edema; Embolectomy; Fasciotomy; Female; Fibrinolytic Agents; Heparin; Hospitalization; Humans; Iloprost; Male; Necrosis; Nerve Block; Retrospective Studies; Sensation Disorders; Skin; Skin Diseases; Substance Abuse, Intravenous; Surgical Flaps; Tissue Plasminogen Activator; Upper Extremity; Vasodilation; Vasodilator Agents