igmesine and Neoplasms

igmesine has been researched along with Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for igmesine and Neoplasms

Article	Year
SP600125 inhibits Kv channels through a JNK-independent pathway in cancer cells. Biochemical and biophysical research communications, 2008, Feb-22, Volume: 366, Issue:4 Kv channels represent new important targets for the control of cancer growth and a better understanding of their regulating pathways in cancer cells is necessary to develop therapeutic strategies. In this study, we have addressed the putative modulation of Kv by MAP kinases through a pharmacological approach. We have found that the commonly used JNK inhibitor SP600125 strongly inhibits Kv channels through a JNK-independent pathway, likely interacting directly with the channels at the external side of the membrane. Our results indicate that the use of this compound may produce misleading conclusions for the role of JNK in cell cycle. Topics: Anthracenes; Cell Line, Tumor; Cinnamates; Cyclopropanes; Extracellular Signal-Regulated MAP Kinases; Humans; Ion Channel Gating; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Neoplasms; p38 Mitogen-Activated Protein Kinases; Potassium Channels, Voltage-Gated	2008

Article

Year

SP600125 inhibits Kv channels through a JNK-independent pathway in cancer cells.

Biochemical and biophysical research communications, 2008, Feb-22, Volume: 366, Issue:4

Kv channels represent new important targets for the control of cancer growth and a better understanding of their regulating pathways in cancer cells is necessary to develop therapeutic strategies. In this study, we have addressed the putative modulation of Kv by MAP kinases through a pharmacological approach. We have found that the commonly used JNK inhibitor SP600125 strongly inhibits Kv channels through a JNK-independent pathway, likely interacting directly with the channels at the external side of the membrane. Our results indicate that the use of this compound may produce misleading conclusions for the role of JNK in cell cycle.

Topics: Anthracenes; Cell Line, Tumor; Cinnamates; Cyclopropanes; Extracellular Signal-Regulated MAP Kinases; Humans; Ion Channel Gating; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Neoplasms; p38 Mitogen-Activated Protein Kinases; Potassium Channels, Voltage-Gated

2008