ifosfamide has been researched along with Neurofibromatosis 1 in 4 studies
Neurofibromatosis 1: An autosomal dominant inherited disorder (with a high frequency of spontaneous mutations) that features developmental changes in the nervous system, muscles, bones, and skin, most notably in tissue derived from the embryonic NEURAL CREST. Multiple hyperpigmented skin lesions and subcutaneous tumors are the hallmark of this disease. Peripheral and central nervous system neoplasms occur frequently, especially OPTIC NERVE GLIOMA and NEUROFIBROSARCOMA. NF1 is caused by mutations which inactivate the NF1 gene (GENES, NEUROFIBROMATOSIS 1) on chromosome 17q. The incidence of learning disabilities is also elevated in this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1014-18) There is overlap of clinical features with NOONAN SYNDROME in a syndrome called neurofibromatosis-Noonan syndrome. Both the PTPN11 and NF1 gene products are involved in the SIGNAL TRANSDUCTION pathway of Ras (RAS PROTEINS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prognosis of metastatic malignant peripheral nerve sheath tumor (MPNST) is poor and the role of chemotherapy is controversial." | 1.56 | Metastatic Malignant Peripheral Nerve Sheath Tumor With NF1 Successfully Treated With 'Gradual Subtraction' ICE Chemotherapy. ( Kakuda, Y; Katagiri, H; Miyagi, M; Murata, H; Takahashi, M; Wang, Y; Wasa, J, 2020) |
| "Malignant peripheral nerve sheath tumors (MPNST) are rare soft-tissue sarcomas with a tendency for recurrence and metastasis." | 1.37 | Early outcomes for malignant peripheral nerve sheath tumor treated with chemotherapy. ( Crawford, EA; Lackman, RD; Moretti, VM; Ogilvie, CM; Staddon, AP, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Y | 1 |
| Katagiri, H | 1 |
| Murata, H | 1 |
| Wasa, J | 1 |
| Miyagi, M | 1 |
| Kakuda, Y | 1 |
| Takahashi, M | 1 |
| Pannu, AK | 1 |
| Sharma, N | 1 |
| Raffaella, B | 1 |
| Antonio, P | 1 |
| Philippe, C | 1 |
| Appenzeller, O | 1 |
| Moretti, VM | 1 |
| Crawford, EA | 1 |
| Staddon, AP | 1 |
| Lackman, RD | 1 |
| Ogilvie, CM | 1 |
4 other studies available for ifosfamide and Neurofibromatosis 1
| Article | Year |
|---|---|
Metastatic Malignant Peripheral Nerve Sheath Tumor With NF1 Successfully Treated With 'Gradual Subtraction' ICE Chemotherapy.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Etoposide; Humans; Ifosfamide; M | 2020 |
Neurofibromatosis type 1 and disseminated malignant peripheral nerve sheath tumor.
Topics: Antineoplastic Agents; Cafe-au-Lait Spots; Disease Management; Doxorubicin; Humans; Ifosfamide; Lung | 2017 |
The maid of the Bridal Room by Andrea Mantegna (1431-1506) shows evidence of hypopituitary dwarfism and neurofibromatosis type-1.
Topics: Dacarbazine; Dwarfism; Humans; Ifosfamide; Neurofibromatosis 1 | 2017 |
Early outcomes for malignant peripheral nerve sheath tumor treated with chemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Doxorubicin; | 2011 |