ifosfamide has been researched along with Medulloblastoma in 19 studies
Medulloblastoma: A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study is to evaluate the stem cell mobilization capacity, anti-tumor effect, and feasibility of ifosfamide/carboplatin/etoposide (ICE) for transplant-eligible patients with medulloblastoma." | 9.12 | Pilot study of ifosfamide/carboplatin/etoposide (ICE) for peripheral blood stem cell mobilization in patients with high-risk or relapsed medulloblastoma. ( Hongo, T; Nishizawa, S; Ohzeki, T; Okada, S; Sakaguchi, K; Suzuki, K, 2007) |
| "Ten children with newly diagnosed medulloblastoma/primitive neuroectodermal tumor of the posterior fossa were treated with total surgical resection, radiation therapy, and ICE chemotherapy regimen with ifosfamide (900 mg/m2, days 1-5), cisplatin (20 mg/m2, days 1-5), and etoposide (60 mg/m2, days 1-5) every 4 weeks for eight cycles." | 7.69 | Combined irradiation and chemotherapy using ifosfamide, cisplatin, and etoposide for children with medulloblastoma/posterior fossa primitive neuroectodermal tumor--results of a pilot study. ( Abe, H; Ikeda, J; Ishii, N; Kato, T; Sawamura, Y; Shirato, H; Tada, M, 1996) |
| "The purpose of this study is to evaluate the stem cell mobilization capacity, anti-tumor effect, and feasibility of ifosfamide/carboplatin/etoposide (ICE) for transplant-eligible patients with medulloblastoma." | 5.12 | Pilot study of ifosfamide/carboplatin/etoposide (ICE) for peripheral blood stem cell mobilization in patients with high-risk or relapsed medulloblastoma. ( Hongo, T; Nishizawa, S; Ohzeki, T; Okada, S; Sakaguchi, K; Suzuki, K, 2007) |
| "Ten children with newly diagnosed medulloblastoma/primitive neuroectodermal tumor of the posterior fossa were treated with total surgical resection, radiation therapy, and ICE chemotherapy regimen with ifosfamide (900 mg/m2, days 1-5), cisplatin (20 mg/m2, days 1-5), and etoposide (60 mg/m2, days 1-5) every 4 weeks for eight cycles." | 3.69 | Combined irradiation and chemotherapy using ifosfamide, cisplatin, and etoposide for children with medulloblastoma/posterior fossa primitive neuroectodermal tumor--results of a pilot study. ( Abe, H; Ikeda, J; Ishii, N; Kato, T; Sawamura, Y; Shirato, H; Tada, M, 1996) |
| "The present case, a CNS PNET, is suspected as a secondary brain tumor induced by radiation therapy previously used to treat a medulloblastoma, and it represents a rare late-onset complication of radiation therapy." | 2.50 | [CNS primitive neuroectodermal tumor suspected as a secondary recurrence after radiation therapy for medulloblastoma:a case report]. ( Endo, S; Kato, S; Koizumi, T; Sato, H; Shibuya, K, 2014) |
| "Medulloblastomas are among the most frequently diagnosed pediatric solid tumors, and drug resistance remains as the principal cause of treatment failure." | 1.51 | Hypoxia increases chemoresistance in human medulloblastoma DAOY cells via hypoxia‑inducible factor 1α‑mediated downregulation of the CYP2B6, CYP3A4 and CYP3A5 enzymes and inhibition of cell proliferation. ( Aquino-Jarquín, G; Arias-Montaño, JA; Dávila-Borja, VM; Huerta-Yepez, S; Martínez-Fong, D; Rodríguez-Enríquez, S; Valencia-Cervantes, J, 2019) |
| "The adverse effects of combination chemotherapy of ifosfamide, cisplatin, and etoposide (ICE) were evaluated in the treatment of various intracranial brain tumors." | 1.36 | [The safety of combination chemotherapy with ifosfamide, cisplatin, and etoposide (ICE): single-institution retrospective review of 108 cases]. ( Kanamori, M; Kumabe, T; Saito, R; Sonoda, Y; Tominaga, T; Yamashita, Y, 2010) |
| "Medulloblastoma is a common paediatric brain tumor." | 1.35 | [Frontal relapse of medulloblastoma. Causes and consequences (a case report)]. ( Besbes, M; Chaari, N; Ghorbel, I; Kochbati, L; Maalej, M, 2008) |
| "Medulloblastomas are highly lethal tumors when they recur." | 1.33 | Stereotactic radiation therapy with chemotherapy in the management of recurrent medulloblastomas. ( Abe, M; Imamura, J; Kida, Y; Tabuchi, K; Takagi, M; Tokumaru, S, 2006) |
| "In large-scale pediatric chemo- and radiotherapy trials a proportion of patients as high as 10-15% is usually reported as having severe treatment related toxicity occasionally resulting in toxic death." | 1.32 | Fatal toxicity following radio- and chemotherapy of medulloblastoma in a child with unrecognized Nijmegen breakage syndrome. ( Distel, L; Grabenbauer, G; Holter, W; Neubauer, S; Varon, R, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (26.32) | 18.2507 |
| 2000's | 8 (42.11) | 29.6817 |
| 2010's | 5 (26.32) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Nobre, L | 1 |
| Zapotocky, M | 1 |
| Khan, S | 1 |
| Fukuoka, K | 1 |
| Fonseca, A | 1 |
| McKeown, T | 1 |
| Sumerauer, D | 1 |
| Vicha, A | 1 |
| Grajkowska, WA | 1 |
| Trubicka, J | 1 |
| Li, KKW | 1 |
| Ng, HK | 1 |
| Massimi, L | 1 |
| Lee, JY | 1 |
| Kim, SK | 1 |
| Zelcer, S | 1 |
| Vasiljevic, A | 1 |
| Faure-Conter, C | 1 |
| Hauser, P | 1 |
| Lach, B | 1 |
| van Veelen-Vincent, ML | 1 |
| French, PJ | 1 |
| Van Meir, EG | 1 |
| Weiss, WA | 1 |
| Gupta, N | 1 |
| Pollack, IF | 1 |
| Hamilton, RL | 1 |
| Nageswara Rao, AA | 1 |
| Giannini, C | 1 |
| Rubin, JB | 1 |
| Moore, AS | 1 |
| Chambless, LB | 1 |
| Vibhakar, R | 1 |
| Ra, YS | 1 |
| Massimino, M | 1 |
| McLendon, RE | 1 |
| Wheeler, H | 1 |
| Zollo, M | 1 |
| Ferruci, V | 1 |
| Kumabe, T | 3 |
| Faria, CC | 1 |
| Sterba, J | 1 |
| Jung, S | 1 |
| López-Aguilar, E | 1 |
| Mora, J | 1 |
| Carlotti, CG | 1 |
| Olson, JM | 1 |
| Leary, S | 1 |
| Cain, J | 1 |
| Krskova, L | 1 |
| Zamecnik, J | 1 |
| Hawkins, CE | 1 |
| Tabori, U | 1 |
| Huang, A | 1 |
| Bartels, U | 1 |
| Northcott, PA | 1 |
| Taylor, MD | 1 |
| Yip, S | 1 |
| Hansford, JR | 1 |
| Bouffet, E | 1 |
| Ramaswamy, V | 1 |
| Valencia-Cervantes, J | 1 |
| Huerta-Yepez, S | 1 |
| Aquino-Jarquín, G | 1 |
| Rodríguez-Enríquez, S | 1 |
| Martínez-Fong, D | 1 |
| Arias-Montaño, JA | 1 |
| Dávila-Borja, VM | 1 |
| Clement, J | 1 |
| Varlotto, J | 1 |
| Rybka, W | 1 |
| Frauenhoffer, E | 1 |
| Drabick, JJ | 1 |
| Sato, H | 1 |
| Shibuya, K | 1 |
| Koizumi, T | 1 |
| Kato, S | 1 |
| Endo, S | 1 |
| Kochbati, L | 1 |
| Ghorbel, I | 1 |
| Chaari, N | 1 |
| Besbes, M | 1 |
| Maalej, M | 1 |
| Yasuda, K | 1 |
| Taguchi, H | 1 |
| Sawamura, Y | 2 |
| Ikeda, J | 2 |
| Aoyama, H | 1 |
| Fujieda, K | 1 |
| Ishii, N | 2 |
| Kashiwamura, M | 1 |
| Iwasaki, Y | 1 |
| Shirato, H | 2 |
| Kanamori, M | 2 |
| Saito, R | 2 |
| Yamashita, Y | 2 |
| Sonoda, Y | 2 |
| Tominaga, T | 2 |
| Watanabe, M | 1 |
| Distel, L | 1 |
| Neubauer, S | 1 |
| Varon, R | 1 |
| Holter, W | 1 |
| Grabenbauer, G | 1 |
| Razak, AR | 1 |
| Nasser, Q | 1 |
| Morris, P | 1 |
| Alcutt, D | 1 |
| Grogan, L | 1 |
| Geyer, JR | 1 |
| Sposto, R | 1 |
| Jennings, M | 1 |
| Boyett, JM | 1 |
| Axtell, RA | 1 |
| Breiger, D | 1 |
| Broxson, E | 1 |
| Donahue, B | 1 |
| Finlay, JL | 1 |
| Goldwein, JW | 1 |
| Heier, LA | 1 |
| Johnson, D | 1 |
| Mazewski, C | 1 |
| Miller, DC | 1 |
| Packer, R | 1 |
| Puccetti, D | 1 |
| Radcliffe, J | 1 |
| Tao, ML | 1 |
| Shiminski-Maher, T | 1 |
| Abe, M | 1 |
| Tokumaru, S | 1 |
| Tabuchi, K | 1 |
| Kida, Y | 1 |
| Takagi, M | 1 |
| Imamura, J | 1 |
| Okada, S | 1 |
| Hongo, T | 1 |
| Sakaguchi, K | 1 |
| Suzuki, K | 1 |
| Nishizawa, S | 1 |
| Ohzeki, T | 1 |
| Grabenbauer, GG | 1 |
| Löhnert, C | 1 |
| Erhardt, J | 1 |
| Buchfelder, M | 1 |
| Neubauer, U | 1 |
| Beck, JD | 1 |
| Reitz, S | 1 |
| Seyer, H | 1 |
| Thierauf, P | 1 |
| Fietkau, R | 1 |
| Kato, T | 1 |
| Tada, M | 1 |
| Abe, H | 1 |
| Leo, E | 1 |
| Schlegel, PG | 1 |
| Lindemann, A | 1 |
| Kaijser, GP | 1 |
| Ter Riet, PG | 1 |
| de Kraker, J | 1 |
| Bult, A | 1 |
| Beijnen, JH | 1 |
| Underberg, WJ | 1 |
| Urban, C | 1 |
| Benesch, M | 1 |
| Pakisch, B | 1 |
| Lackner, H | 1 |
| Kerbl, R | 1 |
| Schwinger, W | 1 |
| Oberbauer, R | 1 |
| Noël, G | 1 |
| Mazeron, JJ | 1 |
1 review available for ifosfamide and Medulloblastoma
| Article | Year |
|---|---|
[CNS primitive neuroectodermal tumor suspected as a secondary recurrence after radiation therapy for medulloblastoma:a case report].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherapy; Cisplatin | 2014 |
4 trials available for ifosfamide and Medulloblastoma
| Article | Year |
|---|---|
Low-dose craniospinal irradiation and ifosfamide, cisplatin and etoposide for non-metastatic embryonal tumors in the central nervous system.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Pr | 2008 |
Multiagent chemotherapy and deferred radiotherapy in infants with malignant brain tumors: a report from the Children's Cancer Group.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child, Preschool; Cisplatin; Combin | 2005 |
Pilot study of ifosfamide/carboplatin/etoposide (ICE) for peripheral blood stem cell mobilization in patients with high-risk or relapsed medulloblastoma.
Topics: Adolescent; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Chil | 2007 |
Synchronous radiochemotherapy in unfavorable brain tumors of children and young adults.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Che | 1998 |
14 other studies available for ifosfamide and Medulloblastoma
| Article | Year |
|---|---|
Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Cerebellar Neoplasms; | 2020 |
Hypoxia increases chemoresistance in human medulloblastoma DAOY cells via hypoxia‑inducible factor 1α‑mediated downregulation of the CYP2B6, CYP3A4 and CYP3A5 enzymes and inhibition of cell proliferation.
Topics: Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cerebellar Neoplasms; Cyclophosphamide; Cytochro | 2019 |
Unusual case of recurrent extraneural metastatic medulloblastoma in a young adult: durable complete remission with Ewing sarcoma chemotherapy regimen and consolidation with autologous bone marrow transplantation and local radiation.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Axilla; Biopsy; Cerebellar Neoplasms; Cycloph | 2013 |
[Frontal relapse of medulloblastoma. Causes and consequences (a case report)].
Topics: Brain Neoplasms; Cerebellar Neoplasms; Child; Combined Modality Therapy; Humans; Ifosfamide; Male; M | 2008 |
[The safety of combination chemotherapy with ifosfamide, cisplatin, and etoposide (ICE): single-institution retrospective review of 108 cases].
Topics: Adolescent; Adult; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, | 2010 |
Combination chemotherapy with ifosfamide, cisplatin, and etoposide for medulloblastoma: single-institute experience and differences in efficacy for subgroups of medulloblastoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Pr | 2011 |
Fatal toxicity following radio- and chemotherapy of medulloblastoma in a child with unrecognized Nijmegen breakage syndrome.
Topics: Abnormalities, Multiple; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Cyc | 2003 |
Medulloblastoma in two successive pregnancies.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cerebellar Neoplasms; Chemotherapy, Adjuvant; | 2005 |
Stereotactic radiation therapy with chemotherapy in the management of recurrent medulloblastomas.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Cerebellar Neoplasms; Chemotherap | 2006 |
[Medulloblastomas--the results after postoperative radiotherapy with and without adjuvant chemotherapy].
Topics: Actuarial Analysis; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Cerebellar Ne | 1993 |
Combined irradiation and chemotherapy using ifosfamide, cisplatin, and etoposide for children with medulloblastoma/posterior fossa primitive neuroectodermal tumor--results of a pilot study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Carboplatin; Cerebellar Neopla | 1996 |
Chemotherapeutic induction of long-term remission in metastatic medulloblastoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cerebellar Neoplasms; Cisplat | 1997 |
Determination of 4-hydroxyifosfamide in biological matrices by high-performance liquid chromatography.
Topics: Cerebellar Neoplasms; Child; Chromatography, High Pressure Liquid; Drug Stability; Humans; Ifosfamid | 1997 |
[Post-operative neoadjuvant chemotherapy before radiotherapy as compared to immediate radiotherapy followed by maintenance chemotherapy in the treatment of medulloblastoma in childhood: results of German prospective randomised trial HIT'91].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; | 2001 |