Page last updated: 2024-10-29

ifosfamide and Leucocythaemia

ifosfamide has been researched along with Leucocythaemia in 26 studies

Research Excerpts

ExcerptRelevanceReference
"This article gives highlights of ongoing pediatric solid tumor and leukemia trials in the United States that use ifosfamide in combination with mesna."4.79Ongoing clinical studies of ifosfamide for pediatric cancer in the United States. ( Pratt, CB, 1996)
" 4-Hydroperoxyifosfamide appeared to be less cytotoxic against the leukemia cells than 4-hydroperoxycyclophosphamide."3.85Comparison of ( Blicharski, K; Fedoročko, P; Mazur, L; Mikeš, J; Niemeyer, U; Opydo-Chanek, M; Śladowska, K, 2017)
"Poor-risk solid tumors were treated with four courses of cyclophosphamide (4,200 mg/m2)/ doxorubicin (75 mg/m2), and three courses of ifosfamide (9,000 mg/m2)/etoposide (500 mg/m2)."2.69High risk of leukemia after short-term dose-intensive chemotherapy in young patients with solid tumors. ( Bajorin, D; Cheung, NK; Heller, G; Kramer, K; Kushner, BH; Meyers, PA; Polyak, T; Wollner, N, 1998)
"Seven of the 15 patients with malignant lymphoma responded."2.64Isophosphamide therapy for hematologic malignancies in patients refractory to prior treatment. ( Bodey, GP; Freireich, EJ; Keating, MJ; McCredie, KB; Rodriguez, V; Valdivieso, M, 1978)
"Etoposide has also been tested in a wide range of combination regimens, but for many of these combinations, relatively few patients are included, and some combinations have only been tested in patients who have undergone autologous transplants."2.48High-dose etoposide in allogeneic stem cell transplantation. ( Ahmed, AB; Bruserud, O; Hatfield, KJ; Kittang, AO; Reikvam, H; Sjo, M; Tvedt, TH, 2012)
" The authors' multidimensional analysis model revealed that besides the total ifosfamide dose and co-administration of other toxic drugs, polymorphic locus of GSTP1 gene may be one of the factors determining a higher toxicity of the cytostatic agent."1.33Role of GSTM1, GSTP1, and GSTT1 gene polymorphism in ifosfamide metabolism affecting neurotoxicity and nephrotoxicity in children. ( Misiura, K; Zielińska, E; Zubowska, M, 2005)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19907 (26.92)18.7374
1990's7 (26.92)18.2507
2000's4 (15.38)29.6817
2010's7 (26.92)24.3611
2020's1 (3.85)2.80

Authors

AuthorsStudies
Gökçe, F1
Kaestli, A1
Lohasz, C1
de Geus, M1
Kaltenbach, HM1
Renggli, K1
Bornhauser, B1
Hierlemann, A1
Modena, M1
Teepen, JC1
van Leeuwen, FE1
Tissing, WJ1
van Dulmen-den Broeder, E1
van den Heuvel-Eibrink, MM1
van der Pal, HJ1
Loonen, JJ1
Bresters, D1
Versluys, B1
Neggers, SJCMM1
Jaspers, MWM1
Hauptmann, M1
van der Heiden-van der Loo, M1
Visser, O1
Kremer, LCM1
Ronckers, CM1
Opydo-Chanek, M1
Śladowska, K1
Blicharski, K1
Mikeš, J1
Fedoročko, P1
Niemeyer, U1
Mazur, L1
Rigaud, C1
Auperin, A1
Jourdain, A1
Haouy, S1
Couec, ML1
Aladjidi, N1
Gandemer, V1
Lambliotte, A1
Plat, G1
Landman-Parker, J1
Michon, J1
Leblanc, T1
Patte, C1
Minard-Colin, V1
Say, R1
Uzun, L1
Yazar, S1
Denizli, A1
Hür, D1
Yılmaz, F1
Ersöz, A1
Hoelzer, D1
Walewski, J1
Döhner, H1
Viardot, A1
Hiddemann, W2
Spiekermann, K1
Serve, H1
Dührsen, U1
Hüttmann, A1
Thiel, E1
Dengler, J1
Kneba, M1
Schaich, M1
Schmidt-Wolf, IG1
Beck, J1
Hertenstein, B1
Reichle, A1
Domanska-Czyz, K1
Fietkau, R1
Horst, HA1
Rieder, H1
Schwartz, S1
Burmeister, T1
Gökbuget, N1
Ramirez, MD1
Mertens, AC1
Esiashvili, N1
Meacham, LR1
Wasilewski-Masker, K1
Bruserud, O1
Reikvam, H1
Kittang, AO1
Ahmed, AB1
Tvedt, TH1
Sjo, M1
Hatfield, KJ1
Misiura, K2
Szymanowicz, D1
Kuśnierczyk, H1
Wietrzyk, J1
Opolski, A1
Oriol, A1
Ribera, JM1
Brunet, S1
del Potro, E1
Abella, E1
Esteve, J1
Zielińska, E1
Zubowska, M1
Moleti, ML1
Testi, AM1
Giona, F1
Malandruccolo, L1
Pescarmona, E1
Martino, P1
Paoloni, F1
Barberi, W1
Palumbo, G1
Mandelli, F1
Foa, R1
Gahrton, G1
Carter, SK1
Norberg, B1
Holm, J1
Winqvist, E1
Wahlin, A1
Hattori, M1
Tanaka, M1
Yamazaki, Y1
Nakahara, Y1
Tsushita, K1
Utumi, M1
Fields, KK1
Elfenbein, GJ1
Lazarus, HM1
Cooper, BW1
Perkins, JB1
Creger, RJ1
Ballester, OF1
Hiemenz, JH1
Janssen, WE1
Zorsky, PE1
Pratt, CB3
Kushner, BH1
Heller, G1
Cheung, NK1
Wollner, N1
Kramer, K1
Bajorin, D1
Polyak, T1
Meyers, PA1
Rodriguez, V1
McCredie, KB1
Keating, MJ1
Valdivieso, M1
Bodey, GP2
Freireich, EJ1
Büchner, T1
Urbanitz, D1
Kamanabroo, D1
Meister, R1
Balleisen, L1
Delvos, U1
Lagrèze, EM1
Schmitz-Huebner, U1
Schulte, H1
van de Loo, J1
Rentschler, RE1
Barlogie, B1
Johnston, DA1
Iwasaku-Fujimoto, M1
Fujiwara, F1
Todo, S1
Morioka, Y1
Imashuku, S1
Brade, WP1
Herdrich, K1
Varini, M1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Multicenter Study to Optimise Therapy of B-ALL, Burkitt's NHL and High-Grade Non-Hodgkin's Lymphoma in Adults (Amend 7)[NCT00199082]Phase 4650 participants (Anticipated)Interventional2002-07-31Completed
Intensive Conditioning Regimen With Thiotepa Combined With Busulfan, Fludarabine and Cytarabine for Allogeneic Hematopoietic Stem Cell Transplantation in the Treatment of Myeloid Malignancies With Extramedullary Involvement[NCT06111612]50 participants (Anticipated)Observational2024-01-01Not yet recruiting
LINFOTARGAM: First-line Treatment With Dose-dense Chemotherapy Plus Rituximab (R-CHOP/14) and Highly Active Antiretroviral Therapy (HAART) in Patients With Diffuse Large B Cell Lymphoma (DLBCL) and Infection With the Human Immunodeficiency Virus (HIV)[NCT00466258]Phase 450 participants (Anticipated)Interventional2006-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for ifosfamide and Leucocythaemia

ArticleYear
High-dose etoposide in allogeneic stem cell transplantation.
    Cancer chemotherapy and pharmacology, 2012, Volume: 70, Issue:6

    Topics: Adenine Nucleotides; Anthracyclines; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chem

2012
Treatment of acute leukemia--advances in chemotherapy, immunotherapy, and bone marrow transplantation.
    Advances in cancer research, 1983, Volume: 40

    Topics: Aclarubicin; Acute Disease; Adolescent; Adult; Age Factors; Aminoacridines; Amsacrine; Anthraquinone

1983
New cytotoxic drugs for breast cancer and their clinical evaluation.
    European journal of cancer, 1980, Volume: Suppl 1

    Topics: Altretamine; Aminoacridines; Amsacrine; Antineoplastic Agents; Breast Neoplasms; Clinical Trials as

1980
Ongoing clinical studies of ifosfamide for pediatric cancer in the United States.
    Seminars in oncology, 1996, Volume: 23, Issue:3 Suppl 6

    Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Proto

1996
Current studies of ifosfamide for pediatric solid tumors and leukemia in the United States.
    Seminars in oncology, 1992, Volume: 19, Issue:6 Suppl 12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Child; Chil

1992
Ifosfamide studies for primary or recurrent pediatric malignant solid tumors and leukemia.
    Seminars in oncology, 1990, Volume: 17, Issue:2 Suppl 4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Humans; Ifosfamide; Leukemia; Lymphoma; Neopl

1990
Ifosfamide--pharmacology, safety and therapeutic potential.
    Cancer treatment reviews, 1985, Volume: 12, Issue:1

    Topics: Animals; Biotransformation; Breast Neoplasms; Clinical Trials as Topic; Cyclophosphamide; Drug Evalu

1985

Trials

9 trials available for ifosfamide and Leucocythaemia

ArticleYear
Outcome of relapse in children and adolescents with B-cell non-Hodgkin lymphoma and mature acute leukemia: A report from the French LMB study.
    Pediatric blood & cancer, 2019, Volume: 66, Issue:9

    Topics: Acute Disease; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Carbopl

2019
Improved outcome of adult Burkitt lymphoma/leukemia with rituximab and chemotherapy: report of a large prospective multicenter trial.
    Blood, 2014, Dec-18, Volume: 124, Issue:26

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Murine-

2014
Yield of Urinalysis Screening in Pediatric Cancer Survivors.
    Pediatric blood & cancer, 2016, Volume: 63, Issue:5

    Topics: Adolescent; Adult; Child; Child, Preschool; Databases, Factual; Female; Follow-Up Studies; Glycosuri

2016
New cytotoxic drugs for breast cancer and their clinical evaluation.
    European journal of cancer, 1980, Volume: Suppl 1

    Topics: Altretamine; Aminoacridines; Amsacrine; Antineoplastic Agents; Breast Neoplasms; Clinical Trials as

1980
Maximum-tolerated doses of ifosfamide, carboplatin, and etoposide given over 6 days followed by autologous stem-cell rescue: toxicity profile.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:2

    Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neopl

1995
High risk of leukemia after short-term dose-intensive chemotherapy in young patients with solid tumors.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:9

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Cyclophosphamide; Dose-Res

1998
Isophosphamide therapy for hematologic malignancies in patients refractory to prior treatment.
    Cancer treatment reports, 1978, Volume: 62, Issue:4

    Topics: Acute Disease; Adolescent; Adult; Clinical Trials as Topic; Cyclophosphamide; Drug Resistance; Femal

1978
Intensification of remission induction therapy for acute nonlymphocytic leukemia (ANLL). I. Response and toxicity in four different regimens.
    Blut, 1979, Volume: 39, Issue:2

    Topics: Acute Disease; Age Factors; Cytarabine; Daunorubicin; Drug Therapy, Combination; Humans; Ifosfamide;

1979
Ifosfamide--pharmacology, safety and therapeutic potential.
    Cancer treatment reviews, 1985, Volume: 12, Issue:1

    Topics: Animals; Biotransformation; Breast Neoplasms; Clinical Trials as Topic; Cyclophosphamide; Drug Evalu

1985

Other Studies

12 other studies available for ifosfamide and Leucocythaemia

ArticleYear
Microphysiological Drug-Testing Platform for Identifying Responses to Prodrug Treatment in Primary Leukemia.
    Advanced healthcare materials, 2023, Volume: 12, Issue:6

    Topics: Child; Coculture Techniques; Humans; Ifosfamide; Leukemia; Liver; Prodrugs

2023
Long-Term Risk of Subsequent Malignant Neoplasms After Treatment of Childhood Cancer in the DCOG LATER Study Cohort: Role of Chemotherapy.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017, Jul-10, Volume: 35, Issue:20

    Topics: Adolescent; Adult; Adult Survivors of Child Adverse Events; Aged; Antineoplastic Agents; Bone Neopla

2017
Comparison of
    Anticancer research, 2017, Volume: 37, Issue:11

    Topics: Antineoplastic Agents; Apoptosis; Caspases; Cell Line, Tumor; Cell Membrane; Cell Survival; Cyclopho

2017
Bitargeting and ambushing nanotheranostics.
    Artificial cells, nanomedicine, and biotechnology, 2014, Volume: 42, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Drug Delivery Systems; HL-60 Cells; Humans; Ifosfamide; Leukemia;

2014
Isophosphoramide mustard analogues as prodrugs for anticancer gene-directed enzyme-prodrug therapy (GDEPT).
    Acta biochimica Polonica, 2002, Volume: 49, Issue:1

    Topics: Animals; Antineoplastic Agents; Carcinoma; Chromatography, High Pressure Liquid; Cytochrome P-450 En

2002
Highly active antiretroviral therapy and outcome of AIDS-related Burkitt's lymphoma or leukemia. Results of the PETHEMA-LAL3/97 study.
    Haematologica, 2005, Volume: 90, Issue:7

    Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Ant

2005
Role of GSTM1, GSTP1, and GSTT1 gene polymorphism in ifosfamide metabolism affecting neurotoxicity and nephrotoxicity in children.
    Journal of pediatric hematology/oncology, 2005, Volume: 27, Issue:11

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Brain Neoplasms; Child; Child, Preschool; Cyclophosph

2005
CODOX-M/IVAC (NCI 89-C-41) in children and adolescents with Burkitt's leukemia/lymphoma and large B-cell lymphomas: a 15-year monocentric experience.
    Leukemia & lymphoma, 2007, Volume: 48, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child; Child, P

2007
Treatment of advanced bone marrow neoplasms with ifosfamide combinations.
    Scandinavian journal of haematology, 1984, Volume: 32, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cyclophosphami

1984
Detection of major and minor bcr/abl fusion gene transcripts in a patient with acute undifferentiated leukemia secondary to treatment with an alkylating agent.
    Leukemia research, 1995, Volume: 19, Issue:6

    Topics: Acute Disease; Alkylating Agents; Anemia, Sideroblastic; Base Sequence; Cell Transformation, Neoplas

1995
In vivo perturbation of human marrow cell cycle progression by ifosfamide.
    Cancer research, 1978, Volume: 38, Issue:8

    Topics: Bone Marrow; Cell Cycle; Cyclophosphamide; DNA, Neoplasm; Erythroblasts; Humans; Ifosfamide; Kinetic

1978
[Effects of mesna (2-mercaptoethane sodium sulfonate) in children with malignant disease receiving oxazaphosphorine chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:3 Pt 1

    Topics: Bone Neoplasms; Child; Cyclophosphamide; Cystitis; Female; Hematuria; Humans; Ifosfamide; Leukemia;

1990