Page last updated: 2024-10-29

ifosfamide and Kidney Diseases

ifosfamide has been researched along with Kidney Diseases in 95 studies

Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.

Research Excerpts

ExcerptRelevanceReference
" ifosfamide and etoposide) and to improve overall survival of previously untreated patients with metastatic rhabdomyosarcoma."9.09Ifosfamide and etoposide are superior to vincristine and melphalan for pediatric metastatic rhabdomyosarcoma when administered with irradiation and combination chemotherapy: a report from the Intergroup Rhabdomyosarcoma Study Group. ( Breitfeld, PP; Crist, WM; Donaldson, SS; Lobe, T; Lyden, E; Maurer, HM; Raney, RB; Ruymann, FB; Teot, LA; Wharam, M, 2001)
" The aim of the present study was to assess long-term renal function in children and adolescents who received at-risk chemotherapy, including cisplatin, ifosfamide, and methotrexate, to treat an osteosarcoma."9.08Long-term nephrotoxicity of cisplatin, ifosfamide, and methotrexate in osteosarcoma. ( Brunat-Mentigny, M; Cochat, P; Dubourg, L; Hadj-Aïssa, A; Koch Nogueira, PC; Schell, M, 1998)
"Forty three patients with histologically confirmed malignant mesothelioma were entered onto an Eastern Cooperative Oncology Group phase II study of ifosfamide given with mesna."9.07An extended phase II trial of ifosfamide plus mesna in malignant mesothelioma. ( Borden, EC; Falkson, CI; Falkson, G; Hayes, JA; Hunt, M; Smith, TJ, 1992)
"Three patients with stage 4 neuroblastoma were treated with a schedule comprising alternating modules of myelosuppressive (ifosfamide, etoposide, doxorubicin) and less myelosuppressive (vincristine, cisplatin) drugs given every 10 days regardless of the neutrophil count."9.07Prohibitive toxicity of a dose-intense regime for metastatic neuroblastoma containing ifosfamide, doxorubicin and cisplatin. ( Craft, AW; Lowis, SP; Pearson, AD; Reid, MM, 1993)
"Ifosfamide is an alkylating agent, frequently used in the treatment of sarcoma."7.77Ifosfamide nephropathy in patients with sarcoma. ( Keikhaei, M; Mashhadi, MA; Sanadgol, H, 2011)
"Sixteen pediatric osteosarcoma patients, previously treated with conventional chemotherapy (including ifosfamide (IFX), 9 g/m(2)) were retreated with high-dose ifosfamide (HD-IFX, 14 g/m(2) per course), following relapse or development of a new bone tumor."7.73High-dose ifosfamide in relapsed pediatric osteosarcoma: therapeutic effects and renal toxicity. ( Berberoğlu, S; Berrak, SG; Ilhan, IE; Jaffe, N; Pearson, M, 2005)
"Early results with ifosfamide plus mesna in soft tissue sarcoma showed an initial response rate of 38% in 42 patients."7.67Ifosfamide plus mesna with and without adriamycin in soft tissue sarcoma. ( Fisher, C; Harmer, C; McKinna, A; Westbury, G; Wiltshaw, E, 1986)
" The authors evaluated the impact of factors such as age and prior nephrotoxic agents on MTX pharmacokinetics in children and young adults with osteosarcoma and examined whether MTX pharmacokinetic parameters were associated with outcome."6.71High-dose methotrexate pharmacokinetics and outcome of children and young adults with osteosarcoma. ( Crews, KR; Daw, NC; Link, MP; Liu, T; Meyer, WH; Panetta, JC; Rodriguez-Galindo, C; Tan, M, 2004)
" The male patient was enrolled into the research programme for the evaluation of the association between deletion of the genes encoding a number of classes of glutathione S-transferases (GST) and adverse reactions to alkylating agents."5.31Growth retardation and osteomalacia as a result of ifosfamide nephrotoxicity in a 3-year-old boy whose genotype reveals the genes encoding glutathione S-transferases GSTM1 and GSTT1. ( Bodalski, J; Zielińska, E, 2001)
", hypotension (which requires catecholamine support) results in unique nephrotoxicity in combination with select chemotherapeutic agents."5.30Whole-body hyperthermia combined with ifosfamide and carboplatin causes hypotension and nephrotoxicity. ( Brauer, LP; Kriz, W; Pagel, H; Prieshof, B; Robins, HI; Schramm, U; Weiss, C; Wiedemann, GJ, 1998)
" The patients were treated between 1/1/1998 and 6/30/1999 according to the sarcoma protocols COSS-96, CWS-96, and EICESS-92, the median cumulative doses of the focussed drugs were for cisplatin: 360 mg/m(2), for doxorubicin: 270 mg/m(2), and for ifosfamide: 24 g/m(2)."5.11Late effects surveillance system for sarcoma patients. ( Beck, JD; Bielack, S; Langer, T; Paulussen, M; Stöhr, W; Treuner, J, 2004)
" ifosfamide and etoposide) and to improve overall survival of previously untreated patients with metastatic rhabdomyosarcoma."5.09Ifosfamide and etoposide are superior to vincristine and melphalan for pediatric metastatic rhabdomyosarcoma when administered with irradiation and combination chemotherapy: a report from the Intergroup Rhabdomyosarcoma Study Group. ( Breitfeld, PP; Crist, WM; Donaldson, SS; Lobe, T; Lyden, E; Maurer, HM; Raney, RB; Ruymann, FB; Teot, LA; Wharam, M, 2001)
" The aim of the present study was to assess long-term renal function in children and adolescents who received at-risk chemotherapy, including cisplatin, ifosfamide, and methotrexate, to treat an osteosarcoma."5.08Long-term nephrotoxicity of cisplatin, ifosfamide, and methotrexate in osteosarcoma. ( Brunat-Mentigny, M; Cochat, P; Dubourg, L; Hadj-Aïssa, A; Koch Nogueira, PC; Schell, M, 1998)
"Ifosfamide is one of the most efficient antimitotic in soft tissue sarcoma."5.08[High dose ifosfamide at 15 g/m2/cycle: a feasibility study in 10 patients]. ( Baranzelli, MC; Deligny, N; Demaille, MC; Gourmel, B; N'Guyen, M; Pichon, F, 1997)
"Forty three patients with histologically confirmed malignant mesothelioma were entered onto an Eastern Cooperative Oncology Group phase II study of ifosfamide given with mesna."5.07An extended phase II trial of ifosfamide plus mesna in malignant mesothelioma. ( Borden, EC; Falkson, CI; Falkson, G; Hayes, JA; Hunt, M; Smith, TJ, 1992)
"Three patients with stage 4 neuroblastoma were treated with a schedule comprising alternating modules of myelosuppressive (ifosfamide, etoposide, doxorubicin) and less myelosuppressive (vincristine, cisplatin) drugs given every 10 days regardless of the neutrophil count."5.07Prohibitive toxicity of a dose-intense regime for metastatic neuroblastoma containing ifosfamide, doxorubicin and cisplatin. ( Craft, AW; Lowis, SP; Pearson, AD; Reid, MM, 1993)
"We report on two children with rhabdomyosarcoma who received ifosfamide as part of their chemotherapy schedule."4.79Ifosfamide nephrotoxicity in children: histopathological features in two cases. ( Mann, JR; Milford, DV; Morland, BJ; Raafat, F; Stevens, MC, 1996)
"Ifosfamide is an alkylating agent, frequently used in the treatment of sarcoma."3.77Ifosfamide nephropathy in patients with sarcoma. ( Keikhaei, M; Mashhadi, MA; Sanadgol, H, 2011)
" The adverse effects of ifosfamide include proximal tubular damage, and renal wasting of electrolytes, glucose and amino acids, Fanconi syndrome, rickets and osteomalacia have also been reported with ifosfamide treatment."3.75Children's toxicology from bench to bed--Drug-induced renal injury (2): Nephrotoxicity induced by cisplatin and ifosfamide in children. ( Chayama, K; Fujieda, M; Hayashi, A; Matsunaga, A; Sekine, T; Tauchi, H, 2009)
"Sixteen pediatric osteosarcoma patients, previously treated with conventional chemotherapy (including ifosfamide (IFX), 9 g/m(2)) were retreated with high-dose ifosfamide (HD-IFX, 14 g/m(2) per course), following relapse or development of a new bone tumor."3.73High-dose ifosfamide in relapsed pediatric osteosarcoma: therapeutic effects and renal toxicity. ( Berberoğlu, S; Berrak, SG; Ilhan, IE; Jaffe, N; Pearson, M, 2005)
" In addition, the chemotherapeutic agent ifosfamide caused a decrease in plasma GPx activity in pediatric osteosarcoma patients."3.70Plasma glutathione peroxidase and its relationship to renal proximal tubule function. ( Avissar, N; Bhamre, S; Cohen, HJ; Ornt, DB; Salvatierra, O; Scandling, JD; Tham, DM; Tune, BM; Whitin, JC, 1998)
"The renal function of newly diagnosed children and young adults with high risk sarcomas was followed during therapy with a high dose ifosfamide-containing regimen."3.69A prospective evaluation of ifosfamide-related nephrotoxicity in children and young adults. ( Balis, FM; Blaney, S; Ho, PT; Izraeli, S; Jarosinski, P; Weaver-McClure, L; Wexler, LH; Zimmerman, K, 1995)
"Early results with ifosfamide plus mesna in soft tissue sarcoma showed an initial response rate of 38% in 42 patients."3.67Ifosfamide plus mesna with and without adriamycin in soft tissue sarcoma. ( Fisher, C; Harmer, C; McKinna, A; Westbury, G; Wiltshaw, E, 1986)
" The authors evaluated the impact of factors such as age and prior nephrotoxic agents on MTX pharmacokinetics in children and young adults with osteosarcoma and examined whether MTX pharmacokinetic parameters were associated with outcome."2.71High-dose methotrexate pharmacokinetics and outcome of children and young adults with osteosarcoma. ( Crews, KR; Daw, NC; Link, MP; Liu, T; Meyer, WH; Panetta, JC; Rodriguez-Galindo, C; Tan, M, 2004)
"Thirty-one patients with solid tumors stratified according to pretreatment were randomized to receive cisplatin/ifosfamide-based chemotherapy with or without amifostine (1000 mg absolute) given as a short infusion prior to cisplatin."2.69The use of reduced doses of amifostine to ameliorate nephrotoxicity of cisplatin/ifosfamide-based chemotherapy in patients with solid tumors. ( Bokemeyer, C; Fels, LM; Hartmann, JT; Kanz, L; Knop, S; Stolte, H; van Vangerow, A, 2000)
"We report seven patients with germ cell tumors which either recurred following a minimum of two regimens of platinum-based chemotherapy or were refractory to cisplatin."2.67High dose carboplatin/VP-16 plus ifosfamide with autologous bone marrow support in the treatment of refractory germ cell tumors. ( Broun, ER; Einhorn, LH; Loehrer, PJ; Nichols, CR; Tricot, G; Williams, SD, 1991)
"Overall, childhood cancer survivors have a ninefold higher risk of developing renal failure compared with their siblings."2.58Late renal toxicity of treatment for childhood malignancy: risk factors, long-term outcomes, and surveillance. ( Skinner, R, 2018)
" The toxic metabolite of IFO thought to be responsible for IFO-induced kidney damage is chloroacetaldehyde (CAA)."2.45Ifosfamide nephrotoxicity in children: a mechanistic base for pharmacological prevention. ( Chen, N; Hanly, L; Koren, G; Rieder, M, 2009)
" However, this in vitro concentration of NAC needed to be compared to those used in human pharmacokinetic studies since the in vitro pharmacological effect of a compound is achieved at concentrations exceeding those used in clinical."2.44Prevention of ifosfamide nephrotoxicity by N-acetylcysteine: clinical pharmacokinetic considerations. ( Aleksa, K; Chen, N; Koren, G; Rieder, M; Woodland, C, 2007)
" Its main adverse effects are various forms of renal tubular and glomerular damage."2.40Ifosfamide-induced nephrotoxicity in children: critical review of predictive risk factors. ( Koren, G; Loebstein, R, 1998)
"Nephrotoxicity is a relatively common and potentially serious adverse effect of treatment with certain cytotoxic drugs (especially ifosfamide)."2.39Strategies to prevent nephrotoxicity of anticancer drugs. ( Skinner, R, 1995)
"Renal dysfunction and urinary disorders are the most troublesome adverse reaction to anticancer agents such as cisplatin (CDDP) and ifosfamide (IFM)."2.38[New treatments for urogenital toxicity of anti-neoplastic chemotherapy]. ( Hirosawa, A; Niitani, H; Shibuya, M, 1990)
"With the increasing use of ifosfamide in pediatric malignancies, nephrotoxicity has emerged as a potentially serious adverse effect, which may be dose-limiting or may cause severe chronic morbidity, including glomerular impairment and/or Fanconi's syndrome."2.38Ifosfamide, mesna, and nephrotoxicity in children. ( Craft, AW; Pearson, AD; Sharkey, IM; Skinner, R, 1993)
"Ifosfamide is an alkylating agent, a synthetic analogue of cyclophosphamide, used to treat various solid cancers."1.62Investigation of Ifosfamide Toxicity Induces Common Upstream Regulator in Liver and Kidney. ( Choi, MS; Han, HY; Kim, SK; Kim, TW; Ko, JW; Yoon, S, 2021)
"Ifosfamide is a cytotoxic drug usually used in malignant sarcomas."1.48[Ifosphamide nephrotoxicity]. ( Ensergueix, G; Karras, A, 2018)
"Ifosfamide is an anticancer agent used largely in treatment of solid tumors."1.43Antioxidant activity of simvastatin prevents ifosfamide-induced nephrotoxicity. ( Ali, RM; Alkaraki, AK; Mhaidat, NM; Shotar, AM, 2016)
"Nephrotoxicity is a serious side effect associated with ifosfamide use."1.39N-acetylcysteine rescue protocol for nephrotoxicity in children caused by ifosfamide. ( Hanly, L; Huang, SH; Koren, G; Regueira, O; Rieder, MJ; Shah, RK; Vasylyeva, TL, 2013)
"Data from 763 adult childhood cancer survivors (414 men) were obtained during regular visits at the late-effects clinic between 2003 and 2009."1.39Long-term nephrotoxicity in adult survivors of childhood cancer. ( Blijdorp, K; Cransberg, K; Dekkers, IA; Neggers, SJ; Pieters, R; Pluijm, SM; van den Heuvel-Eibrink, MM, 2013)
"Ifosfamide nephrotoxicity is a serious adverse effect for children undergoing cancer chemotherapy."1.35N-Acetylcysteine prevents ifosfamide-induced nephrotoxicity in rats. ( Aleksa, K; Chen, N; Koren, G; Rieder, M; Woodland, C, 2008)
"Patients with tubulopathy also had stunted growth in comparison with a control group of cancer patients without renal disease (mean difference at last examination: 7."1.34Growth impairment after ifosfamide-induced nephrotoxicity in children. ( Beck, JD; Kremers, A; Langer, T; Patzer, L; Paulides, M; Rossi, R; Stöhr, W, 2007)
"Chloroacetaldehyde (CAA) is a metabolite of the alkylating agent ifosfamide (IFO) and putatively responsible for renal damage following anti-tumor therapy with IFO."1.33Chloroacetaldehyde as a sulfhydryl reagent: the role of critical thiol groups in ifosfamide nephropathy. ( Benesic, A; Freudinger, R; Gekle, M; Groezinger, F; Kirchhoff, A; Mildenberger, S; Schwerdt, G; Wollny, B, 2006)
"Ifosfamide treatment significantly inhibited oxidative phosphorylation with only C-I substrates."1.33Ifosfamide-induced nephrotoxicity: mechanism and prevention. ( Daikhin, Y; Horyn, O; Luhovyy, B; Nissim, I; Phillips, PC; Yudkoff, M, 2006)
" The authors' multidimensional analysis model revealed that besides the total ifosfamide dose and co-administration of other toxic drugs, polymorphic locus of GSTP1 gene may be one of the factors determining a higher toxicity of the cytostatic agent."1.33Role of GSTM1, GSTP1, and GSTT1 gene polymorphism in ifosfamide metabolism affecting neurotoxicity and nephrotoxicity in children. ( Misiura, K; Zielińska, E; Zubowska, M, 2005)
" The male patient was enrolled into the research programme for the evaluation of the association between deletion of the genes encoding a number of classes of glutathione S-transferases (GST) and adverse reactions to alkylating agents."1.31Growth retardation and osteomalacia as a result of ifosfamide nephrotoxicity in a 3-year-old boy whose genotype reveals the genes encoding glutathione S-transferases GSTM1 and GSTT1. ( Bodalski, J; Zielińska, E, 2001)
"The renal functions in pediatric cancer patients who received ifosfamide (IFO) treatment were evaluated and the risk factors related to IFO nephrotoxicity were determined."1.31Ifosfamide nephrotoxicity in pediatric cancer patients. ( Ahn, HS; Cheong, HI; Choi, Y; Ha, IS; Hahn, H; Kang, HG; Lee, BS; Lee, JH; Shin, HY, 2001)
"Ifosfamide is an oxazophosphorine widely used in the treatment of cancer in children and adults."1.30Urinary proton magnetic resonance studies of early ifosfamide-induced nephrotoxicity and encephalopathy. ( Foxall, PJ; Hartley, JM; Lapsley, M; Neild, GH; Nicholson, JK; Singer, JM; Souhami, RL, 1997)
", hypotension (which requires catecholamine support) results in unique nephrotoxicity in combination with select chemotherapeutic agents."1.30Whole-body hyperthermia combined with ifosfamide and carboplatin causes hypotension and nephrotoxicity. ( Brauer, LP; Kriz, W; Pagel, H; Prieshof, B; Robins, HI; Schramm, U; Weiss, C; Wiedemann, GJ, 1998)
" Its main adverse effects are various forms of renal tubular and glomerular damage."1.30Risk factors for long-term outcome of ifosfamide-induced nephrotoxicity in children. ( Atanackovic, G; Baruchel, S; Bishai, R; Gobrial, M; Hashemi, G; Ito, S; Khattak, S; Koren, G; Loebstein, R; Wolpin, J, 1999)
"The patients with prostatic cancer were treated with VIP (vincristine, ifosfamide, peplomycin) chemotherapy and the patients with urothelial cancer were treated with MP (methotrexate, cisplatinum) or MEP (methotrexate, Etoposide, cisplatinum) combination chemotherapy."1.29[Comparative study on urinary parameters reflecting renal damage during chemotherapy for urological cancer]. ( Kitamura, Y; Komatsubara, S; Sakata, Y; Watanabe, M, 1993)
" Dose-response curves for cisplatin (3-30 000 nmol) combined with non-toxic silibinin doses (7."1.29Silibinin protects against cisplatin-induced nephrotoxicity without compromising cisplatin or ifosfamide anti-tumour activity. ( Bokemeyer, C; Dunn, T; Fels, LM; Gaedeke, J; Lentzen, H; Schmoll, HJ; Stolte, H; Voigt, W, 1996)
"We describe 2 cases of proximal tubular defects induced by the administration of ifosfamide at a dosage of 6 g/m2/course over 2 days in children with a diagnosis of malignant mesenchymal tumors."1.29Ifosfamide-induced renal tubular defect. ( López Pérez, J; Melero, C; Muley, R; Torres Valdivieso, MJ; Vara, J; Vivanco, JL, 1994)
" We observed this acute toxic effect despite the administration of sufficient mesna to prevent hemorrhagic cystitis."1.27Ifosfamide-induced subclinical tubular nephrotoxicity despite mesna. ( Goren, MP; Horowitz, ME; Pratt, CB; Wright, RK, 1987)
"Thirty-two patients with advanced cancer were treated in a phase I-II trial with ifosfamide plus mesnum."1.26Mesnum as a protector against kidney and bladder toxicity with high-dose ifosfamide treatment. ( Falkson, G; Falkson, HC; Stapelberg, R; Van Dyk, JJ, 1982)

Research

Studies (95)

TimeframeStudies, this research(%)All Research%
pre-199015 (15.79)18.7374
1990's44 (46.32)18.2507
2000's24 (25.26)29.6817
2010's11 (11.58)24.3611
2020's1 (1.05)2.80

Authors

AuthorsStudies
Han, HY1
Choi, MS1
Yoon, S1
Ko, JW1
Kim, SK1
Kim, TW1
Skinner, R10
Ruggiero, A1
Ferrara, P1
Attinà, G1
Rizzo, D1
Riccardi, R1
Ensergueix, G1
Karras, A1
Schiavetti, A1
Pedetti, V1
Varrasso, G1
Marrucci, O1
Celani, C1
Andreoli, G1
Bonci, E1
Dekkers, IA1
Blijdorp, K1
Cransberg, K1
Pluijm, SM1
Pieters, R1
Neggers, SJ1
van den Heuvel-Eibrink, MM1
Hanly, L2
Rieder, MJ1
Huang, SH1
Vasylyeva, TL1
Shah, RK1
Regueira, O1
Koren, G9
Shkalim-Zemer, V1
Ash, S1
Toledano, H1
Kollender, Y1
Issakov, J1
Yaniv, I1
Cohen, IJ1
Mhaidat, NM1
Ali, RM1
Shotar, AM1
Alkaraki, AK1
Chen, N4
Rieder, M3
Fujieda, M1
Matsunaga, A1
Hayashi, A1
Tauchi, H1
Chayama, K1
Sekine, T1
Oberlin, O1
Fawaz, O1
Rey, A1
Niaudet, P2
Ridola, V1
Orbach, D1
Bergeron, C1
Defachelles, AS1
Gentet, JC1
Schmitt, C1
Rubie, H1
Munzer, M1
Plantaz, D1
Deville, A1
Minard, V1
Corradini, N1
Leverger, G1
de Vathaire, F1
Janeway, KA1
Grier, HE1
Parry, A1
Price, L5
Cole, M2
Craft, AW8
Pearson, AD8
Mashhadi, MA1
Sanadgol, H1
Keikhaei, M1
Caglar, K1
Kinalp, C1
Arpaci, F1
Turan, M1
Saglam, K1
Ozturk, B1
Komurcu, S1
Yavuz, I1
Yenicesu, M1
Ozet, A1
Vural, A1
Kremens, B1
Gruhn, B1
Klingebiel, T1
Hasan, C1
Laws, HJ1
Koscielniak, E1
Hero, B1
Selle, B1
Niemeyer, C1
Finckenstein, FG1
Schulz, A1
Wawer, A1
Zintl, F1
Graf, N1
Langer, T3
Stöhr, W3
Bielack, S2
Paulussen, M1
Treuner, J2
Beck, JD3
Crews, KR1
Liu, T1
Rodriguez-Galindo, C1
Tan, M1
Meyer, WH2
Panetta, JC1
Link, MP1
Daw, NC1
Berrak, SG1
Pearson, M1
Berberoğlu, S1
Ilhan, IE1
Jaffe, N1
Aleksa, K4
Halachmi, N1
Ito, S2
Benesic, A2
Schwerdt, G2
Mildenberger, S2
Freudinger, R2
Gordjani, N1
Gekle, M2
Zielińska, E2
Zubowska, M1
Misiura, K1
Paulides, M2
Jürgens, H2
Rossi, R3
Patzer, L1
Kremers, A1
Nissim, I2
Horyn, O1
Daikhin, Y1
Luhovyy, B1
Phillips, PC1
Yudkoff, M1
Groezinger, F1
Wollny, B1
Kirchhoff, A1
Woodland, C2
Hilgard, P1
Burkert, H1
Brock, N1
Stekar, J1
Kreusser, W1
Herrmann, R1
Tschöpe, W1
Ritz, E1
Falkson, G3
Van Dyk, JJ1
Stapelberg, R1
Falkson, HC1
Holoye, PY1
Duelge, J1
Hansen, RM1
Ritch, PS1
Anderson, T1
Torres Valdivieso, MJ1
López Pérez, J1
Melero, C1
Vivanco, JL1
Muley, R1
Vara, J1
Toma, S1
Palumbo, R1
Comandone, A1
Oliva, C1
Vincenti, M1
Bumma, C1
Rosso, R1
Kitamura, Y1
Watanabe, M1
Komatsubara, S1
Sakata, Y1
Jones, DP1
Chesney, RW1
Anninga, JK1
Valdés Olmos, RA1
de Kraker, J2
van Tinteren, H1
Hoefnagel, CA1
van Royen, EA1
Hanquinet, S1
Wouters, M1
Devalck, C1
Perlmutter, N1
Sariban, E1
Keir, MJ1
Wyllie, RA2
Coulthard, MG4
Gödde, A1
Kleinebrand, A1
Riepenhausen, M1
Boos, J1
Ritter, J1
Brandis, M2
von der Hardt, K1
Zimmerhackl, RB1
Mohrmann, M1
Leititis, J1
De Schepper, J1
Hachimi-Idrissi, S1
Verboven, M1
Piepsz, A1
Otten, J1
Stevens, MC2
Sharkey, IM1
Lowis, SP1
Reid, MM1
Morland, BJ1
Mann, JR1
Milford, DV1
Raafat, F1
Ho, PT1
Zimmerman, K1
Wexler, LH1
Blaney, S1
Jarosinski, P1
Weaver-McClure, L1
Izraeli, S1
Balis, FM1
English, MW1
Bokemeyer, C2
Fels, LM2
Dunn, T1
Voigt, W1
Gaedeke, J1
Schmoll, HJ1
Stolte, H2
Lentzen, H1
Cachat, F1
Guignard, JP1
Baranzelli, MC1
Pichon, F1
Gourmel, B1
N'Guyen, M1
Deligny, N1
Demaille, MC1
Springate, JE1
Tokuc, G1
Yalçiner, A1
Kebudi, R1
Dogan, S1
Görgün, O1
Ayan, I1
Suzuki, T1
Nosaka, K1
Morrison, SC1
O'Donnell, JK1
Loebstein, R2
Koch Nogueira, PC1
Hadj-Aïssa, A1
Schell, M1
Dubourg, L1
Brunat-Mentigny, M1
Cochat, P1
Foxall, PJ1
Singer, JM1
Hartley, JM1
Neild, GH1
Lapsley, M1
Nicholson, JK1
Souhami, RL1
Brauer, LP1
Prieshof, B1
Wiedemann, GJ1
Weiss, C1
Kriz, W1
Schramm, U1
Robins, HI1
Pagel, H1
Whitin, JC1
Tham, DM1
Bhamre, S1
Ornt, DB1
Scandling, JD1
Tune, BM1
Salvatierra, O1
Avissar, N1
Cohen, HJ1
Ferrari, S1
Zolezzi, C1
Cesari, M1
Fasano, MC1
Lamanna, G1
Bacci, G1
Atanackovic, G1
Bishai, R1
Wolpin, J1
Khattak, S1
Hashemi, G1
Gobrial, M1
Baruchel, S1
Hartmann, JT1
Knop, S1
van Vangerow, A1
Kanz, L1
Bodalski, J1
Lee, BS1
Lee, JH2
Kang, HG1
Hahn, H1
Shin, HY1
Ha, IS1
Cheong, HI1
Ahn, HS1
Choi, Y1
De Giorgi, U1
Rosti, G1
Papiani, G1
Marangolo, M1
Breitfeld, PP1
Lyden, E1
Raney, RB1
Teot, LA1
Wharam, M1
Lobe, T1
Crist, WM1
Maurer, HM1
Donaldson, SS1
Ruymann, FB1
Lewis, LD1
Burton, LC1
Harper, PG1
Rogers, HJ1
Hunt, M2
Borden, EC1
Hayes, JA1
Falkson, CI1
Smith, TJ1
Shore, R1
Greenberg, M1
Geary, D1
Broun, ER1
Nichols, CR1
Tricot, G1
Loehrer, PJ2
Williams, SD2
Einhorn, LH3
Heney, D1
Wheeldon, J1
Rushworth, P1
Chapman, C1
Lewis, IJ1
Bailey, CC1
Suarez, A1
McDowell, H1
Comoy, E1
Flamant, F1
Caron, HN1
Abeling, N1
van Gennip, A1
Voûte, PA1
Vogelzang, NJ1
Elias, AD1
Ayash, LJ1
Eder, JP1
Wheeler, C1
Deary, J1
Weissman, L1
Schryber, S1
Critchlow, J1
Schnipper, L1
Antman, KH1
Elias, A1
Ryan, L1
Shibuya, M1
Hirosawa, A1
Niitani, H1
Goren, MP3
Pratt, CB3
Wright, RK3
Dodge, RK1
Viar, MJ1
Lauer, R1
Roth, BJ1
Kalasinski, LA1
Horowitz, ME2
Patterson, WP1
Khojasteh, A1
Wiltshaw, E1
Westbury, G1
Harmer, C1
McKinna, A1
Fisher, C1
Alberts, AS1
Van Zyl, L1
Ghosn, M1
Droz, JP1
Theodore, C1
Pico, JL1
Baume, D1
Spielmann, M1
Ostronoff, M1
Moran, A1
Salloum, E1
Kramar, A1

Reviews

19 reviews available for ifosfamide and Kidney Diseases

ArticleYear
Late renal toxicity of treatment for childhood malignancy: risk factors, long-term outcomes, and surveillance.
    Pediatric nephrology (Berlin, Germany), 2018, Volume: 33, Issue:2

    Topics: Antineoplastic Agents; Carboplatin; Child; Cisplatin; Humans; Ifosfamide; Kidney; Kidney Diseases; N

2018
Renal toxicity and chemotherapy in children with cancer.
    British journal of clinical pharmacology, 2017, Volume: 83, Issue:12

    Topics: Age of Onset; Antineoplastic Agents; Child; Child, Preschool; Cisplatin; Humans; Ifosfamide; Inciden

2017
Ifosfamide nephrotoxicity in children: a mechanistic base for pharmacological prevention.
    Expert opinion on drug safety, 2009, Volume: 8, Issue:2

    Topics: Acetaldehyde; Acetylcysteine; Age Factors; Antineoplastic Agents, Alkylating; Antioxidants; Child; H

2009
Sequelae of osteosarcoma medical therapy: a review of rare acute toxicities and late effects.
    The Lancet. Oncology, 2010, Volume: 11, Issue:7

    Topics: Antidotes; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; H

2010
Chronic ifosfamide nephrotoxicity in children.
    Medical and pediatric oncology, 2003, Volume: 41, Issue:3

    Topics: Antineoplastic Agents, Alkylating; Child; Chronic Disease; Humans; Ifosfamide; Kidney Diseases; Neop

2003
Prevention of ifosfamide nephrotoxicity by N-acetylcysteine: clinical pharmacokinetic considerations.
    The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique, 2007,Summer, Volume: 14, Issue:2

    Topics: Acetylcysteine; Humans; Ifosfamide; Kidney Diseases

2007
Nephrological complications of cancer therapy.
    Contributions to nephrology, 1982, Volume: 33

    Topics: Acute Kidney Injury; Antineoplastic Agents; Cisplatin; Cyclophosphamide; Humans; Ifosfamide; Kidney;

1982
Strategies to prevent nephrotoxicity of anticancer drugs.
    Current opinion in oncology, 1995, Volume: 7, Issue:4

    Topics: Adult; Antineoplastic Agents; Cell Line; Chelating Agents; Child; Child, Preschool; Cisplatin; Human

1995
Renal toxicity of cancer chemotherapeutic agents in children: ifosfamide and cisplatin.
    Current opinion in pediatrics, 1995, Volume: 7, Issue:2

    Topics: Child; Cisplatin; Glomerular Filtration Rate; Humans; Ifosfamide; Kidney; Kidney Diseases; Kidney Tu

1995
Cytostatics--induced tubular toxicity.
    The Clinical investigator, 1993, Volume: 71, Issue:10

    Topics: Antineoplastic Agents; Cisplatin; Humans; Ifosfamide; Kidney Diseases; Kidney Tubules; Methotrexate;

1993
Ifosfamide, mesna, and nephrotoxicity in children.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1993, Volume: 11, Issue:1

    Topics: Child; Humans; Ifosfamide; Kidney Diseases; Mesna; Risk Factors

1993
Ifosfamide nephrotoxicity in children: histopathological features in two cases.
    Medical and pediatric oncology, 1996, Volume: 27, Issue:1

    Topics: Adult; Antineoplastic Agents, Alkylating; Biopsy; Child; Child, Preschool; Female; Humans; Ifosfamid

1996
[The kidney in children under chemotherapy].
    Revue medicale de la Suisse romande, 1996, Volume: 116, Issue:12

    Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Carboplatin; Child; Cisplatin; Glomerular

1996
Toxic nephropathies.
    Current opinion in pediatrics, 1997, Volume: 9, Issue:2

    Topics: Analgesics; Analgesics, Non-Narcotic; Anti-Infective Agents; Antineoplastic Agents, Alkylating; Huma

1997
[Nephrotoxicity of antineoplastic drugs].
    Ryoikibetsu shokogun shirizu, 1997, Issue:16 Pt 1

    Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic

1997
Ifosfamide-induced nephrotoxicity in children: critical review of predictive risk factors.
    Pediatrics, 1998, Volume: 101, Issue:6

    Topics: Adolescent; Adult; Age Factors; Antineoplastic Agents, Alkylating; Child; Child, Preschool; Dose-Res

1998
The status of high-dose chemotherapy with hematopoietic stem cell transplantation in germ cell tumor patients.
    Haematologica, 2002, Volume: 87, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carboplatin; Cisplatin; Clinical T

2002
Nephrotoxicity from chemotherapy: prevention and management.
    Oncology (Williston Park, N.Y.), 1991, Volume: 5, Issue:10

    Topics: Antineoplastic Agents; Carboplatin; Cisplatin; Gallium; Humans; Ifosfamide; Kidney Diseases; Methotr

1991
[New treatments for urogenital toxicity of anti-neoplastic chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:4 Pt 2

    Topics: Antidotes; Antineoplastic Agents; Cisplatin; Humans; Ifosfamide; Kidney Diseases; Mesna; Thiosulfate

1990

Trials

14 trials available for ifosfamide and Kidney Diseases

ArticleYear
Long-term renal function and hypertension in adult survivors of childhood sarcoma: Single center experience.
    Pediatric hematology and oncology, 2018, Volume: 35, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Body Mass Index; Child; Child, Preschool; Cros

2018
Late effects surveillance system for sarcoma patients.
    Pediatric blood & cancer, 2004, Volume: 42, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Agents; Child; Child, Preschool; Cisplatin; Doxorubicin; Feasibili

2004
High-dose methotrexate pharmacokinetics and outcome of children and young adults with osteosarcoma.
    Cancer, 2004, Apr-15, Volume: 100, Issue:8

    Topics: Adolescent; Adult; Age Factors; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Child, Presc

2004
Ambulatory 4-day continuous-infusion schedule of high-dose ifosfamide with mesna uroprotection and granulocyte colony-stimulating factor in advanced solid tumours: a phase I study.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1995, Volume: 6, Issue:2

    Topics: Adult; Aged; Ambulatory Care; Female; Granulocyte Colony-Stimulating Factor; Humans; Ifosfamide; Imm

1995
Prohibitive toxicity of a dose-intense regime for metastatic neuroblastoma containing ifosfamide, doxorubicin and cisplatin.
    Cancer chemotherapy and pharmacology, 1993, Volume: 31, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Child, Preschool; C

1993
[High dose ifosfamide at 15 g/m2/cycle: a feasibility study in 10 patients].
    Bulletin du cancer, 1997, Volume: 84, Issue:2

    Topics: Adult; Aged; Anticonvulsants; Antineoplastic Agents, Alkylating; Clonazepam; Dose-Response Relations

1997
Long-term nephrotoxicity of cisplatin, ifosfamide, and methotrexate in osteosarcoma.
    Pediatric nephrology (Berlin, Germany), 1998, Volume: 12, Issue:7

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin;

1998
Prospective evaluation of high-dose ifosfamide-related nephrotoxicity in young adult patients with recurrent osteosarcoma previously treated with cisplatin, methotrexate and standard-dose ifosfamide.
    Anti-cancer drugs, 1999, Volume: 10, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols

1999
The use of reduced doses of amifostine to ameliorate nephrotoxicity of cisplatin/ifosfamide-based chemotherapy in patients with solid tumors.
    Anti-cancer drugs, 2000, Volume: 11, Issue:1

    Topics: Adult; Amifostine; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Humans; Ifosfa

2000
Ifosfamide and etoposide are superior to vincristine and melphalan for pediatric metastatic rhabdomyosarcoma when administered with irradiation and combination chemotherapy: a report from the Intergroup Rhabdomyosarcoma Study Group.
    Journal of pediatric hematology/oncology, 2001, Volume: 23, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Bronchiolit

2001
An extended phase II trial of ifosfamide plus mesna in malignant mesothelioma.
    Investigational new drugs, 1992, Volume: 10, Issue:4

    Topics: Drug Administration Schedule; Female; Humans; Ifosfamide; Infusions, Intravenous; Kidney Diseases; M

1992
High dose carboplatin/VP-16 plus ifosfamide with autologous bone marrow support in the treatment of refractory germ cell tumors.
    Bone marrow transplantation, 1991, Volume: 7, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carb

1991
A phase I study of high-dose ifosfamide and escalating doses of carboplatin with autologous bone marrow support.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1991, Volume: 9, Issue:2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carboplatin; Com

1991
Ifosfamide and mesna: response and toxicity at standard- and high-dose schedules.
    Seminars in oncology, 1990, Volume: 17, Issue:2 Suppl 4

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Child; Chil

1990

Other Studies

62 other studies available for ifosfamide and Kidney Diseases

ArticleYear
Investigation of Ifosfamide Toxicity Induces Common Upstream Regulator in Liver and Kidney.
    International journal of molecular sciences, 2021, Nov-11, Volume: 22, Issue:22

    Topics: Animals; Chemical and Drug Induced Liver Injury; Gene Expression Regulation; Ifosfamide; Kidney; Kid

2021
[Ifosphamide nephrotoxicity].
    Nephrologie & therapeutique, 2018, Volume: 14 Suppl 1

    Topics: Adult; Antineoplastic Agents, Alkylating; Glomerular Filtration Rate; Humans; Ifosfamide; Kidney; Ki

2018
Long-term nephrotoxicity in adult survivors of childhood cancer.
    Clinical journal of the American Society of Nephrology : CJASN, 2013, Volume: 8, Issue:6

    Topics: Adolescent; Adult; Albuminuria; Antineoplastic Agents; beta 2-Microglobulin; Biomarkers; Chemotherap

2013
N-acetylcysteine rescue protocol for nephrotoxicity in children caused by ifosfamide.
    Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique, 2013, Volume: 20, Issue:2

    Topics: Acetylcysteine; Animals; Antidotes; Antineoplastic Agents, Alkylating; Antioxidants; Child; Drug Adm

2013
Highly effective reduced toxicity dose-intensive pilot protocol for non-metastatic limb osteogenic sarcoma (SCOS 89).
    Cancer chemotherapy and pharmacology, 2015, Volume: 76, Issue:5

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Combin

2015
Antioxidant activity of simvastatin prevents ifosfamide-induced nephrotoxicity.
    Pakistan journal of pharmaceutical sciences, 2016, Volume: 29, Issue:2

    Topics: Animals; Antioxidants; Biomarkers; Creatinine; Cytoprotection; Disease Models, Animal; Ifosfamide; K

2016
Children's toxicology from bench to bed--Drug-induced renal injury (2): Nephrotoxicity induced by cisplatin and ifosfamide in children.
    The Journal of toxicological sciences, 2009, Volume: 34 Suppl 2

    Topics: Adolescent; Antineoplastic Agents; Cell Death; Child; Child, Preschool; Cisplatin; Dose-Response Rel

2009
Long-term evaluation of Ifosfamide-related nephrotoxicity in children.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Nov-10, Volume: 27, Issue:32

    Topics: Antineoplastic Agents, Alkylating; Child; Follow-Up Studies; Humans; Ifosfamide; Kidney; Kidney Dise

2009
Glomerular toxicity persists 10 years after ifosfamide treatment in childhood and is not predictable by age or dose.
    Pediatric blood & cancer, 2010, Jul-01, Volume: 54, Issue:7

    Topics: Adolescent; Antineoplastic Agents; Child; Child, Preschool; Dose-Response Relationship, Drug; Female

2010
Ifosfamide nephropathy in patients with sarcoma.
    Iranian journal of kidney diseases, 2011, Volume: 5, Issue:4

    Topics: Adolescent; Adult; Age Distribution; Antineoplastic Agents, Alkylating; Child; Child, Preschool; Coh

2011
Cumulative prior dose of cisplatin as a cause of the nephrotoxicity of high-dose chemotherapy followed by autologous stem-cell transplantation.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2002, Volume: 17, Issue:11

    Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Antineoplastic Agents; Antineoplastic Agents, Alkyla

2002
High-dose chemotherapy with autologous stem cell rescue in children with nephroblastoma.
    Bone marrow transplantation, 2002, Volume: 30, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Child, Preschool; Combined Modal

2002
High-dose ifosfamide in relapsed pediatric osteosarcoma: therapeutic effects and renal toxicity.
    Pediatric blood & cancer, 2005, Volume: 44, Issue:3

    Topics: Adolescent; Adult; Bone Neoplasms; Child; Child, Preschool; Drug Administration Schedule; Female; Hu

2005
Renal ontogeny of ifosfamide nephrotoxicity.
    The Journal of laboratory and clinical medicine, 2004, Volume: 144, Issue:6

    Topics: Acetaldehyde; Age Factors; Animals; Antineoplastic Agents, Alkylating; Aryl Hydrocarbon Hydroxylases

2004
Disturbed Ca2+-signaling by chloroacetaldehyde: a possible cause for chronic ifosfamide nephrotoxicity.
    Kidney international, 2005, Volume: 68, Issue:5

    Topics: Acetaldehyde; Antineoplastic Agents, Alkylating; Calcium; Calcium Signaling; Calcium-Transporting AT

2005
Role of GSTM1, GSTP1, and GSTT1 gene polymorphism in ifosfamide metabolism affecting neurotoxicity and nephrotoxicity in children.
    Journal of pediatric hematology/oncology, 2005, Volume: 27, Issue:11

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Brain Neoplasms; Child; Child, Preschool; Cyclophosph

2005
Ifosfamide-induced nephrotoxicity in 593 sarcoma patients: a report from the Late Effects Surveillance System.
    Pediatric blood & cancer, 2007, Volume: 48, Issue:4

    Topics: Abdomen; Adolescent; Age Factors; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemoth

2007
Growth impairment after ifosfamide-induced nephrotoxicity in children.
    Pediatric blood & cancer, 2007, Volume: 48, Issue:5

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Body Height; Child; Child, Preschool; Female; Glomeru

2007
Ifosfamide-induced nephrotoxicity: mechanism and prevention.
    Cancer research, 2006, Aug-01, Volume: 66, Issue:15

    Topics: Acetaldehyde; Agmatine; Animals; Antineoplastic Agents, Alkylating; Drug Interactions; Electron Tran

2006
Chloroacetaldehyde as a sulfhydryl reagent: the role of critical thiol groups in ifosfamide nephropathy.
    Kidney & blood pressure research, 2006, Volume: 29, Issue:5

    Topics: Acetaldehyde; Antineoplastic Agents, Alkylating; Biomarkers; Caspase 3; Caspase 8; Cathepsin B; Cell

2006
Drug-induced nephrotoxicity in children: pharmacologically based prevention of long-term impairment.
    Paediatric drugs, 2007, Volume: 9, Issue:3

    Topics: Amphotericin B; Child; Cyclosporine; Humans; Ifosfamide; Kidney Diseases; Kidney Function Tests; Tim

2007
N-Acetylcysteine prevents ifosfamide-induced nephrotoxicity in rats.
    British journal of pharmacology, 2008, Volume: 153, Issue:7

    Topics: Acetylcysteine; Animals; Antineoplastic Agents, Alkylating; beta 2-Microglobulin; Creatinine; Diseas

2008
Sodium-2-mercaptoethanesulfonate (MESNA) and ifosfamide nephrotoxicity.
    European journal of cancer & clinical oncology, 1984, Volume: 20, Issue:11

    Topics: Cyclophosphamide; Humans; Ifosfamide; Infusions, Parenteral; Kidney Diseases; Mercaptoethanol; Mesna

1984
[Prevention of urotoxic actions of cyclophosphamide and ifosfamide by dimesna (preliminary communication) (author's transl)].
    Arzneimittel-Forschung, 1982, Volume: 32, Issue:5

    Topics: Animals; Cyclophosphamide; Ifosfamide; Kidney Diseases; Mercaptoethanol; Mesna; Oxidation-Reduction;

1982
Mesnum as a protector against kidney and bladder toxicity with high-dose ifosfamide treatment.
    Cancer chemotherapy and pharmacology, 1982, Volume: 9, Issue:2

    Topics: Adult; Aged; Cyclophosphamide; Female; Humans; Ifosfamide; Kidney Diseases; Leukopenia; Male; Mercap

1982
Prophylaxis of ifosfamide toxicity with oral acetylcysteine.
    Seminars in oncology, 1983, Volume: 10, Issue:1 Suppl 1

    Topics: Acetylcysteine; Adenocarcinoma; Aged; Carcinoma, Squamous Cell; Cyclophosphamide; Dose-Response Rela

1983
Ifosfamide-induced renal tubular defect.
    Medical and pediatric oncology, 1994, Volume: 22, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dactinomycin; Doxorubicin; Humans;

1994
[Comparative study on urinary parameters reflecting renal damage during chemotherapy for urological cancer].
    Hinyokika kiyo. Acta urologica Japonica, 1993, Volume: 39, Issue:2

    Topics: Acetylglucosaminidase; Adolescent; Adult; Aged; Aminopeptidases; Antineoplastic Combined Chemotherap

1993
Technetium-99m dimercaptosuccinic acid and ifosfamide tubular dysfunction in children with cancer.
    European journal of nuclear medicine, 1994, Volume: 21, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dose-Response Relationship,

1994
Increased renal parenchymal echogenicity in ifosfamide-induced renal Fanconi syndrome.
    Medical and pediatric oncology, 1995, Volume: 24, Issue:2

    Topics: Child; Child, Preschool; Fanconi Syndrome; Female; Humans; Ifosfamide; Infant; Kidney Diseases; Ultr

1995
Inaccuracy of glomerular filtration rate estimation from height/plasma creatinine ratio.
    Archives of disease in childhood, 1994, Volume: 70, Issue:5

    Topics: Adolescent; Body Height; Child; Child, Preschool; Cisplatin; Creatinine; Female; Glomerular Filtrati

1994
Ifosfamide nephrotoxicity in children.
    Medical and pediatric oncology, 1994, Volume: 22, Issue:2

    Topics: Glomerular Filtration Rate; Humans; Ifosfamide; Infant; Kidney Diseases

1994
Unilateral nephrectomy and cisplatin as risk factors of ifosfamide-induced nephrotoxicity: analysis of 120 patients.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1994, Volume: 12, Issue:1

    Topics: Adolescent; Adult; Child; Child, Preschool; Cisplatin; Fanconi Syndrome; Humans; Ifosfamide; Infant;

1994
Renal function abnormalities after ifosfamide treatment in children.
    Acta paediatrica (Oslo, Norway : 1992), 1993, Volume: 82, Issue:4

    Topics: Adolescent; Child; Child, Preschool; Cross-Sectional Studies; Female; Humans; Ifosfamide; Kidney Dis

1993
Incidence and etiology of ifosfamide nephrotoxicity: report of a meeting held in Rhodes, Greece, October 3, 1991, sponsored by Asta Medica, Frankfurt, Germany.
    Medical and pediatric oncology, 1993, Volume: 21, Issue:9

    Topics: Child; Child, Preschool; Cisplatin; Dose-Response Relationship, Drug; Humans; Ifosfamide; Incidence;

1993
A prospective evaluation of ifosfamide-related nephrotoxicity in children and young adults.
    Cancer, 1995, Dec-15, Volume: 76, Issue:12

    Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; beta 2-Microglobulin; Child; Child, Preschool;

1995
Risk factors for ifosfamide nephrotoxicity in children.
    Lancet (London, England), 1996, Aug-31, Volume: 348, Issue:9027

    Topics: Adolescent; Child; Child, Preschool; Cohort Studies; Female; Glomerular Filtration Rate; Humans; Ifo

1996
Silibinin protects against cisplatin-induced nephrotoxicity without compromising cisplatin or ifosfamide anti-tumour activity.
    British journal of cancer, 1996, Volume: 74, Issue:12

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Cisplatin; Disease Models, A

1996
Renal dysfunctions secondary to ifosfamide treatment in children.
    Journal of experimental & clinical cancer research : CR, 1997, Volume: 16, Issue:2

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Child; Child, Preschool; Dose-Response Relationship,

1997
Ifosfamide-induced alteration of technetium-99m-DMSA renal parenchymal imaging.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1997, Volume: 38, Issue:11

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; I

1997
Urinary proton magnetic resonance studies of early ifosfamide-induced nephrotoxicity and encephalopathy.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1997, Volume: 3, Issue:9

    Topics: Adult; Amino Acids; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocol

1997
Whole-body hyperthermia combined with ifosfamide and carboplatin causes hypotension and nephrotoxicity.
    Journal of cancer research and clinical oncology, 1998, Volume: 124, Issue:10

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemother

1998
Plasma glutathione peroxidase and its relationship to renal proximal tubule function.
    Molecular genetics and metabolism, 1998, Volume: 65, Issue:3

    Topics: Adult; Animals; Antibodies; Cephaloglycin; Child; Creatinine; Fanconi Syndrome; Glutathione Peroxida

1998
Risk factors for long-term outcome of ifosfamide-induced nephrotoxicity in children.
    Journal of clinical pharmacology, 1999, Volume: 39, Issue:5

    Topics: Adolescent; Adult; Age Factors; Antineoplastic Agents, Alkylating; Child; Child, Preschool; Drug Adm

1999
Growth retardation and osteomalacia as a result of ifosfamide nephrotoxicity in a 3-year-old boy whose genotype reveals the genes encoding glutathione S-transferases GSTM1 and GSTT1.
    Cytobios, 2001, Volume: 106, Issue:413

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Child, Preschool;

2001
Ifosfamide nephrotoxicity in pediatric cancer patients.
    Pediatric nephrology (Berlin, Germany), 2001, Volume: 16, Issue:10

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Child; Child, Preschool; Cisplatin; Female; Humans; I

2001
Uroepithelial and nephrotubular toxicity in patients receiving ifosfamide/mesna: measurement of urinary N-acetyl-beta-D-glucosaminidase and beta-2-microglobulin.
    European journal of cancer (Oxford, England : 1990), 1992, Volume: 28A, Issue:12

    Topics: Acetylglucosaminidase; Adult; Aged; beta 2-Microglobulin; Creatinine; Female; Humans; Ifosfamide; Ki

1992
Iphosphamide-induced nephrotoxicity in children.
    Pediatric nephrology (Berlin, Germany), 1992, Volume: 6, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Humans; Ifosfamide; Infant;

1992
Progressive renal toxicity due to ifosfamide.
    Archives of disease in childhood, 1991, Volume: 66, Issue:8

    Topics: Acetylglucosaminidase; Albuminuria; Alpha-Globulins; Child; Child, Preschool; Female; Follow-Up Stud

1991
Long-term follow-up of ifosfamide renal toxicity in children treated for malignant mesenchymal tumors: an International Society of Pediatric Oncology report.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1991, Volume: 9, Issue:12

    Topics: Acute Kidney Injury; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Presc

1991
Hyperaminoaciduria identifies patients at risk of developing renal tubular toxicity associated with ifosfamide and platinate containing regimens.
    Medical and pediatric oncology, 1992, Volume: 20, Issue:1

    Topics: Alanine Transaminase; Amino Acids; Aspartate Aminotransferases; Carboplatin; Child; Child, Preschool

1992
Nephrotoxicity after ifosfamide.
    Archives of disease in childhood, 1990, Volume: 65, Issue:7

    Topics: Adolescent; Albuminuria; Bone and Bones; Child; Child, Preschool; Cross-Sectional Studies; Female; G

1990
Mesna excretion and ifosfamide nephrotoxicity in children.
    Cancer research, 1989, Dec-15, Volume: 49, Issue:24 Pt 1

    Topics: Adolescent; Adult; Child; Child, Preschool; Creatinine; Female; Humans; Ifosfamide; Kidney Diseases;

1989
Nephrotoxicity of ifosfamide in children.
    Lancet (London, England), 1989, Jul-15, Volume: 2, Issue:8655

    Topics: Adolescent; Child; Humans; Ifosfamide; Kidney Diseases

1989
Salvage therapy in recurrent germ cell cancer: ifosfamide and cisplatin plus either vinblastine or etoposide.
    Annals of internal medicine, 1988, Oct-01, Volume: 109, Issue:7

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Evaluation; Etopo

1988
Cancer chemotherapy-induced tubular nephrotoxicity evaluated by immunochemical determination of urinary adenosine deaminase binding protein.
    American journal of clinical pathology, 1986, Volume: 86, Issue:6

    Topics: Antineoplastic Agents; Carrier Proteins; Child; Child, Preschool; Dipeptidyl Peptidase 4; Humans; If

1986
Ifosfamide-induced subclinical tubular nephrotoxicity despite mesna.
    Cancer treatment reports, 1987, Volume: 71, Issue:2

    Topics: Acetylglucosaminidase; Adolescent; Adult; Aminopeptidases; CD13 Antigens; Child; Child, Preschool; C

1987
Ifosfamide-induced renal tubular defects.
    Cancer, 1989, Feb-15, Volume: 63, Issue:4

    Topics: Hematuria; Humans; Hydrogen-Ion Concentration; Ifosfamide; Kidney Diseases; Kidney Tubules; Lymphoma

1989
Ifosfamide plus mesna with and without adriamycin in soft tissue sarcoma.
    Cancer chemotherapy and pharmacology, 1986, Volume: 18 Suppl 2

    Topics: Adolescent; Adult; Aged; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Pre

1986
Malignant pleural mesothelioma: phase II pilot study of ifosfamide and mesna.
    Journal of the National Cancer Institute, 1988, Jul-06, Volume: 80, Issue:9

    Topics: Adolescent; Adult; Aged; Drug Evaluation; Female; Humans; Ifosfamide; Kidney Diseases; Male; Mercapt

1988
Salvage chemotherapy in refractory germ cell tumors with etoposide (VP-16) plus ifosfamide plus high-dose cisplatin. A VIhP regimen.
    Cancer, 1988, Jul-01, Volume: 62, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Choriocarcinoma; Cisplatin; Etopo

1988
VP 16 plus ifosfamide plus cisplatin as salvage therapy in refractory testicular cancer.
    Cancer chemotherapy and pharmacology, 1986, Volume: 18 Suppl 2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Evaluation; Humans; Ifosfamide; Kidn

1986