Page last updated: 2024-10-29

ifosfamide and Innate Inflammatory Response

ifosfamide has been researched along with Innate Inflammatory Response in 12 studies

Research Excerpts

ExcerptRelevanceReference
"Acrolein is the main toxic metabolite of ifosfamide (IFO) that causes urothelial damage by oxidative stress and inflammation."8.31[8] and [10]-Gingerol reduces urothelial damage in ifosfamide-induced hemorrhagic cystitis via JAK/STAT/FOXO signaling pathway via IL-10. ( Clementino, M; da Silva, JA; de Freitas, TM; Ferreira, FCS; Havt, A; Lima, AAM; Lima, MA; Martins, DS; Mota, MRL; Queiroga, ML; Ribeiro, SA; Rodrigues, FAP; Silva, DO; Veras, HN, 2023)
"Ifosfamide (IFS) is often involved in the occurrence of hemorrhagic cystitis due to direct contact of its metabolite acrolein with uroepithelium."7.77Cyclooxygenase-2 contributes to functional changes seen on experimental hemorrhagic cystitis induced by ifosfamide in rat urinary bladder. ( Brito, GA; Jucá, DM; Lima, RC; Macedo, FY; Magalhães, PJ; Mourão, LT; Neto, Jde S; Palheta, RC; Ribeiro, RA; Santos, AA; Souza, MH, 2011)
"Acrolein is the main toxic metabolite of ifosfamide (IFO) that causes urothelial damage by oxidative stress and inflammation."4.31[8] and [10]-Gingerol reduces urothelial damage in ifosfamide-induced hemorrhagic cystitis via JAK/STAT/FOXO signaling pathway via IL-10. ( Clementino, M; da Silva, JA; de Freitas, TM; Ferreira, FCS; Havt, A; Lima, AAM; Lima, MA; Martins, DS; Mota, MRL; Queiroga, ML; Ribeiro, SA; Rodrigues, FAP; Silva, DO; Veras, HN, 2023)
"Ifosfamide (IFS) is often involved in the occurrence of hemorrhagic cystitis due to direct contact of its metabolite acrolein with uroepithelium."3.77Cyclooxygenase-2 contributes to functional changes seen on experimental hemorrhagic cystitis induced by ifosfamide in rat urinary bladder. ( Brito, GA; Jucá, DM; Lima, RC; Macedo, FY; Magalhães, PJ; Mourão, LT; Neto, Jde S; Palheta, RC; Ribeiro, RA; Santos, AA; Souza, MH, 2011)
" Groups (N = 6-8) were submitted to right or left paw edema (PE) with carrageenan (100 microg) or Dextran (200 microg), hemorrhagic cystitis with ifosfamide (200 mg/kg, ip) or gastric injury (GI) with indomethacin (20 mg/kg, vo)."3.75Hind limb ischemic preconditioning induces an anti-inflammatory response by remote organs in rats. ( Gomes, AS; Loiola, RT; Ribeiro, RA; Rocha, EL; Simão, AF; Souza Filho, MV; Souza, MH, 2009)
"Morin is a flavonoid and broadly found in white berry and cranberry branch."1.72The protective effect of Morin against ifosfamide-induced acute liver injury in rats associated with the inhibition of DNA damage and apoptosis. ( Çomaklı, S; Kandemir, FM; Kucukler, S; Özdemir, S, 2022)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19901 (8.33)18.7374
1990's0 (0.00)18.2507
2000's3 (25.00)29.6817
2010's6 (50.00)24.3611
2020's2 (16.67)2.80

Authors

AuthorsStudies
Saunders, MJ1
Edwards, BS1
Zhu, J1
Sklar, LA1
Graves, SW1
Ferreira, FCS1
Clementino, M1
Rodrigues, FAP1
Veras, HN1
Martins, DS1
Queiroga, ML1
Lima, MA1
Silva, DO1
de Freitas, TM1
Ribeiro, SA1
Mota, MRL1
da Silva, JA1
Lima, AAM1
Havt, A1
Özdemir, S1
Kucukler, S1
Çomaklı, S1
Kandemir, FM1
Souza Filho, MV1
Loiola, RT1
Rocha, EL1
Simão, AF1
Gomes, AS1
Souza, MH2
Ribeiro, RA4
Macedo, FY1
Mourão, LT2
Palheta, RC1
Jucá, DM1
Lima, RC1
Neto, Jde S1
Magalhães, PJ2
Santos, AA1
Brito, GA2
Helming, L1
de Siqueira, RJ1
Freire, WB1
Vasconcelos-Silva, AA1
Fonseca-Magalhães, PA1
Lima, FJ1
Brito, TS1
Lahlou, S1
Choucha Snouber, L1
Jacques, S1
Monge, M1
Legallais, C1
Leclerc, E1
Pereira, LM1
Lima-Júnior, RC1
Bem, AX1
Teixeira, CG1
Grassi, LS1
Medeiros, RP1
Marques-Neto, RD1
Callado, RB1
Aragão, KS1
Wong, DV1
Vale, ML1
Schlondorff, JS1
Mendez, GP1
Rennke, HG1
Magee, CC1
Cabanillas, F1
Hagemeister, FB1
Bodey, GP1
Freireich, EJ1
Maubec, E1
Oberlin, O1
Belhadj, K1
Roujeau, JC1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Remote Ischemic Preconditioning on Restenosis Post Lower Limb Revascularization Angioplasty: A Pilot Randomized Control Trial[NCT02406131]40 participants (Anticipated)Interventional2018-04-30Suspended (stopped due to logistic issues - no available scans for participants at the moment need to postponed starting dates)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

12 other studies available for ifosfamide and Innate Inflammatory Response

ArticleYear
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
    Current protocols in cytometry, 2010, Volume: Chapter 13

    Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr

2010
[8] and [10]-Gingerol reduces urothelial damage in ifosfamide-induced hemorrhagic cystitis via JAK/STAT/FOXO signaling pathway via IL-10.
    Naunyn-Schmiedeberg's archives of pharmacology, 2023, Volume: 396, Issue:8

    Topics: Animals; Cystitis; Female; Hemorrhage; Ifosfamide; Inflammation; Interleukin-10; Mesna; Mice; Signal

2023
The protective effect of Morin against ifosfamide-induced acute liver injury in rats associated with the inhibition of DNA damage and apoptosis.
    Drug and chemical toxicology, 2022, Volume: 45, Issue:3

    Topics: Animals; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; DNA Damage; Flavonoids; Gl

2022
Hind limb ischemic preconditioning induces an anti-inflammatory response by remote organs in rats.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2009, Volume: 42, Issue:10

    Topics: Acute Disease; Animals; Carrageenan; Cystitis; Edema; Hindlimb; Ifosfamide; Indomethacin; Inflammati

2009
Cyclooxygenase-2 contributes to functional changes seen on experimental hemorrhagic cystitis induced by ifosfamide in rat urinary bladder.
    Cancer chemotherapy and pharmacology, 2011, Volume: 67, Issue:4

    Topics: Animals; Antineoplastic Agents, Alkylating; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cystitis;

2011
Inflammation: cell recruitment versus local proliferation.
    Current biology : CB, 2011, Jul-26, Volume: 21, Issue:14

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blood; Cell Proliferation; Cisplatin; Filar

2011
In-vitro characterization of the pharmacological effects induced by (-)-α-bisabolol in rat smooth muscle preparations.
    Canadian journal of physiology and pharmacology, 2012, Volume: 90, Issue:1

    Topics: Animals; Carbachol; Cystitis; Disease Models, Animal; Duodenum; Ifosfamide; In Vitro Techniques; Inf

2012
Transcriptomic analysis of the effect of ifosfamide on MDCK cells cultivated in microfluidic biochips.
    Genomics, 2012, Volume: 100, Issue:1

    Topics: Animals; Antineoplastic Agents, Alkylating; Cell Culture Techniques; Dogs; Drug Evaluation, Preclini

2012
Blockade of TRPA1 with HC-030031 attenuates visceral nociception by a mechanism independent of inflammatory resident cells, nitric oxide and the opioid system.
    European journal of pain (London, England), 2013, Volume: 17, Issue:2

    Topics: Abdomen; Acetanilides; Animals; Antineoplastic Agents, Alkylating; Cell Count; Colitis; Cystitis; Di

2013
Electrolyte abnormalities and progressive renal failure in a cancer patient.
    Kidney international, 2007, Volume: 71, Issue:11

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Biopsy; C

2007
IMVP-16: an effective regimen for patients with lymphoma who have relapsed after initial combination chemotherapy.
    Blood, 1982, Volume: 60, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bacterial Infections; Cyclophosphamide; Drug

1982
[Subcutaneous inflammatory edema induced by MINE chemotherapy].
    Annales de dermatologie et de venereologie, 2001, Volume: 128, Issue:4

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Capillary Leak Syndrome; Creatin

2001