Page last updated: 2024-10-29

ifosfamide and Extranodal NK-T-Cell Lymphoma

ifosfamide has been researched along with Extranodal NK-T-Cell Lymphoma in 41 studies

Research Excerpts

ExcerptRelevanceReference
"Patients having rheumatoid arthritis (RA) treated with methotrexate (MTX) are at an increased risk of developing lymphoproliferative disorder (LPD)."3.81Methotrexate-associated lymphoproliferative disorder presenting as extranodal NK/T-cell lymphoma arising in the lungs. ( Fukayama, M; Koda, K; Tajima, S; Takanashi, Y, 2015)
"The aim of this study was to compare asparaginase-related toxicities in two asparaginase preparations, namely native Escherichia coli L-asparaginase (L-ASP) and pegylated asparaginase (PEG-ASP) in combination with ifosfamide, methotrexate, etoposide, and prednisolone (IMEP) in natural killer (NK)/T-cell lymphoma (NTCL)."1.48Comparison of Native Escherichia coli L-Asparaginase versus Pegylated Asparaginase, in Combination with Ifosfamide, Methotrexate, Etoposide, and Prednisolone, in Extranodal NK/T-Cell Lymphoma, Nasal Type. ( Cho, YS; Heo, DS; Jung, SH; Keam, B; Kim, DW; Kim, HJ; Kim, IH; Kim, M; Kim, TM; Lee, JY; Lee, SH; Ock, CY, 2018)
"However, some patients experience early disease progression."1.48Early disease progression in patients with localized natural killer/T-cell lymphoma treated with concurrent chemoradiotherapy. ( Amaki, J; Asano, N; Choi, I; Ejima, Y; Fukuhara, N; Katayama, N; Kim, SJ; Kim, WS; Ko, YH; Kobayashi, Y; Kubota, N; Maeda, T; Miyazaki, K; Oguchi, M; Saito, B; Shimada, K; Shimoda, E; Soejima, T; Suzuki, R; Terui, Y; Tsukamoto, N; Utsumi, T; Yamaguchi, M, 2018)

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (17.07)29.6817
2010's29 (70.73)24.3611
2020's5 (12.20)2.80

Authors

AuthorsStudies
Miyazaki, K4
Suzuki, R8
Oguchi, M5
Taguchi, S1
Amaki, J4
Maeda, T4
Kubota, N4
Maruyama, D2
Terui, Y2
Sekiguchi, N3
Takizawa, J4
Tsukamoto, H1
Murayama, T2
Ando, T3
Matsuoka, H2
Hasegawa, M2
Wada, H3
Sakai, R2
Kameoka, Y2
Tsukamoto, N2
Choi, I2
Masaki, Y2
Shimada, K2
Fukuhara, N2
Utsumi, T2
Uoshima, N1
Kagami, Y2
Asano, N4
Ejima, Y3
Katayama, N4
Yamaguchi, M9
Fujii, T1
Ohno, N1
Kitahara, S1
Kobayashi, S1
Sahara, N1
Sakamoto, N1
Arahira, S1
Matsunaga, T1
Sánchez-Romero, C1
Paes de Almeida, O1
Díaz Molina, JP1
Carlos, R1
Wei, L1
Wang, L1
Cong, J1
Yang, L1
Ye, J1
Li, X2
Yao, N1
Yang, J2
Wang, J2
Ghione, P1
Qi, S1
Imber, BS1
Seshan, V1
Moskowitz, A1
Galasso, N1
Lunning, M1
Straus, D1
Sauter, C1
Dahi, P1
Dogan, A1
Yahalom, J1
Horwitz, S1
Kim, HJ1
Ock, CY1
Kim, TM2
Lee, SH2
Lee, JY1
Jung, SH1
Cho, YS1
Kim, M2
Keam, B2
Kim, DW3
Kim, IH1
Heo, DS3
Kim, SJ7
Ko, YH5
Kobayashi, Y4
Soejima, T1
Saito, B3
Shimoda, E1
Kim, WS8
Watanabe, J1
Makita, S1
Ito, Y2
Hatta, S1
Suzuki, T2
Yuda, S1
Maeshima, AM1
Fukuhara, S1
Munakata, W1
Kim, SW1
Izutsu, K3
Kinoshita, S1
Tomita, N2
Niitsu, N1
Hildyard, C1
Sheikh, S1
Eyre, T1
Collins, G1
So, JC1
Chan, KH1
Pang, AW1
Chan, JK1
Kwong, YL3
Saburi, M1
Itani, K1
Nagamatsu, K1
Miyazaki, Y1
Otsuka, E1
Urabe, S1
Saburi, Y1
Ji, J1
Liu, T1
Xiang, B1
Liu, W1
He, C1
Chen, X1
Li, J1
Chang, H1
Dai, Y1
Dong, T1
Park, S2
Kang, ES2
Choi, JY1
Lim, DH1
Kim, KH1
Lee, JS1
Jeon, YK1
Kim, CW2
Shi, Y1
He, X1
Dong, M1
Zhang, C1
Liu, P1
Zhou, S1
Qin, Y1
Gui, L1
Yang, S1
Sun, Y1
Tajima, S1
Takanashi, Y1
Koda, K1
Fukayama, M1
Oh, D1
Ahn, YC2
Dong, LH1
Zhang, LJ1
Wang, WJ1
Lei, W1
Sun, X1
Du, JW1
Gao, X1
Li, GP1
Li, YF1
McEachron, TA1
Kirov, I1
Wungwattana, M1
Cortes, D1
Zabokrtsky, KB1
Sassoon, A1
Craig, D1
Carpten, JD1
Sender, LS1
Cui, Y1
Sun, Z1
Zhang, L1
Li, L1
Wang, X1
Wu, J1
Fu, X1
Ma, W1
Zhang, X1
Chang, Y1
Nan, F1
Li, W1
Su, L1
Xue, H1
Zhang, M1
Jung, KS1
Cho, SH1
Yoon, DH1
Jeong, SH1
Shin, DY1
Bae, SH1
Hong, J1
Park, SK1
Yhim, HY1
Yang, DH1
Lee, H1
Kang, HJ1
Lee, MH1
Eom, HS2
Kwak, JY1
Lee, JH1
Suh, C2
Al Shawabkeh, MA1
Al Sulaiti, M1
Al Sa'ey, H1
Ganesan, S1
Akiba, T1
Itasaka, S1
Saito, Y1
Itami, J1
Ueda, K1
Ii, N1
Hyo, R2
Celentano, A1
Mascolo, M1
Cirillo, N1
De Rosa, G1
Mignogna, MD1
Mizuno, H1
Koya, J1
Fujioka, Y1
Ibaraki, T1
Nakamura, F2
Hayashi, A1
Shinozaki-Ushiku, A1
Akamatsu, N1
Hasegawa, K1
Kokudo, N1
Fukuyama, M1
Kurokawa, M2
Kim, BS2
Im, SA1
Kim, TY1
Yoon, SS1
Bang, YJ1
Kim, BK1
Kim, NK1
Kato, T1
Tanabe, J1
Kanemoto, M1
Kobayashi, C1
Morita, S1
Karahashi, T1
Tobinai, K1
Ishizuka, N1
Isobe, Y2
Ishizawa, K1
Maseki, N1
Itoh, K1
Usui, N1
Wasada, I1
Kinoshita, T1
Ohshima, K1
Matsuno, Y1
Terauchi, T1
Nawano, S1
Ishikura, S1
Hotta, T1
Oshimi, K3
Kim, K1
Kim, CY1
Huh, J1
Lee, SW1
Kim, JS1
Cho, J1
Lee, GW1
Kang, KM1
Pyo, HR1
Inoue, D1
Nagai, Y1
Takiuchi, Y1
Nagano, S1
Arima, H1
Kimura, T1
Shimoji, S1
Mori, M1
Togami, K1
Tabata, S1
Yanagita, S1
Matsushita, A1
Nagai, K1
Maruoka, H1
Imai, Y2
Takahashi, T1
Farid, M1
Yau, YW1
Tay, K1
Quek, R1
Tao, M1
Koo, GC1
Loong, S1
Lim, ST2
Kimura, H1
Maeda, Y1
Hashimoto, C1
Ishida, F1
Fukushima, N1
Hasegawa, Y2
Kobayashi, H2
Okamura, S1
Suzumiya, J2
Nakamura, S2
Kawa, K2
Tang, T1
Tse, E1
Leung, AY1
Chim, CS1
Kobayashi, T1
Hangaishi, A1
Yamamoto, G1
Shinohara, A1
Morikawa, T1
Takazawa, Y1
Ota, S1
Okamura, T1
Wills, AJ1
O'Connor, S1
McMillan, A1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized Controlled Multi-center Clinical Trial on Treatment of Stage Ⅲ/Ⅳ NK/T Cell Lymphoma With DDGP Regiment (Gemcitabine,Pegaspargase,Cisplatin,Dexamethasone)[NCT01501149]Phase 480 participants (Anticipated)Interventional2011-01-31Recruiting
Efficacy and Safety of Brentuximab Vedotin in Combination With Tislelizumab for the Treatment of CD30-positive Relapsed/Refractory NK/T-cell Lymphoma[NCT05316246]Phase 240 participants (Anticipated)Interventional2022-06-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for ifosfamide and Extranodal NK-T-Cell Lymphoma

ArticleYear
[Treatment of localized nasal NK/T-cell lymphoma].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2008, Volume: 49, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Clinical Trials as Topic; Combined Moda

2008
Treatment of advanced extranodal NK/T cell lymphoma, nasal-type and aggressive NK-cell leukemia.
    International journal of hematology, 2010, Volume: 92, Issue:5

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Dexamethasone;

2010
Current and future management of NK/T-cell lymphoma based on clinical trials.
    International journal of hematology, 2012, Volume: 96, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Carboplatin; Chemoradiotherapy; Clinic

2012

Trials

8 trials available for ifosfamide and Extranodal NK-T-Cell Lymphoma

ArticleYear
Improved prognosis of extranodal NK/T cell lymphoma, nasal type of nasal origin but not extranasal origin.
    Annals of hematology, 2019, Volume: 98, Issue:7

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Asparagi

2019
DDGP versus SMILE in Newly Diagnosed Advanced Natural Killer/T-Cell Lymphoma: A Randomized Controlled, Multicenter, Open-label Study in China.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2016, Nov-01, Volume: 22, Issue:21

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; China; Cisplatin; D

2016
Phase II trial of concurrent chemoradiotherapy with L-asparaginase and MIDLE chemotherapy for newly diagnosed stage I/II extranodal NK/T-cell lymphoma, nasal type (CISL-1008).
    Oncotarget, 2016, Dec-20, Volume: 7, Issue:51

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Chemoradiotherapy; Cispla

2016
Effective second-line chemotherapy for extranodal NK/T-cell lymphoma consisting of etoposide, ifosfamide, methotrexate, and prednisolone.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2009, Volume: 20, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Disease-Free Su

2009
Phase I/II study of concurrent chemoradiotherapy for localized nasal natural killer/T-cell lymphoma: Japan Clinical Oncology Group Study JCOG0211.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Nov-20, Volume: 27, Issue:33

    Topics: Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Biopsy, Needle; Carboplati

2009
Phase II trial of concurrent radiation and weekly cisplatin followed by VIPD chemotherapy in newly diagnosed, stage IE to IIE, nasal, extranodal NK/T-Cell Lymphoma: Consortium for Improving Survival of Lymphoma study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Dec-10, Volume: 27, Issue:35

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Dexa

2009
Pretreatment EBV-DNA copy number is predictive of response and toxicities to SMILE chemotherapy for extranodal NK/T-cell lymphoma, nasal type.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, Aug-01, Volume: 18, Issue:15

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; DNA, Viral; E

2012
Phase I study of dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide (SMILE) chemotherapy for advanced-stage, relapsed or refractory extranodal natural killer (NK)/T-cell lymphoma and leukemia.
    Cancer science, 2008, Volume: 99, Issue:5

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Dexamethasone

2008

Other Studies

30 other studies available for ifosfamide and Extranodal NK-T-Cell Lymphoma

ArticleYear
Long-term outcomes and central nervous system relapse in extranodal natural killer/T-cell lymphoma.
    Hematological oncology, 2022, Volume: 40, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Carboplatin; Central Nervous System; D

2022
[Extranodal NK/T cell lymphoma, nasal type with local recurrence in the contralateral nasal cavity 15 years after initial sequential chemoradiotherapy].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2022, Volume: 63, Issue:3

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Chemoradiotherapy; Female; Human

2022
Pediatric nasal NK/T-cell lymphoma microscopically mimicking carcinoma.
    International journal of dermatology, 2020, Volume: 59, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Carboplatin; Carcinoma; Chemorad

2020
SVILE regimen, a combination of dexamethasone, vindesine, ifosfamide, pegaspargase, and etoposide, for treating relapsed/refractory extranodal natural killer/T-cell lymphoma, nasal type.
    Leukemia research, 2020, Volume: 96

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Dexamethasone

2020
Modified SMILE (mSMILE) and intensity-modulated radiotherapy (IMRT) for extranodal NK-T lymphoma nasal type in a single-center population.
    Leukemia & lymphoma, 2020, Volume: 61, Issue:14

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Dexamethasone; Humans; Ifosfamide; Lym

2020
Comparison of Native Escherichia coli L-Asparaginase versus Pegylated Asparaginase, in Combination with Ifosfamide, Methotrexate, Etoposide, and Prednisolone, in Extranodal NK/T-Cell Lymphoma, Nasal Type.
    Cancer research and treatment, 2018, Volume: 50, Issue:3

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Escherichia coli; Etoposide; Fem

2018
Early disease progression in patients with localized natural killer/T-cell lymphoma treated with concurrent chemoradiotherapy.
    Cancer science, 2018, Volume: 109, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carbopla

2018
Successful full-dose DeVIC therapy in a patient with advanced-stage extranodal natural killer/T-cell lymphoma refractory to L-asparaginase.
    Annals of hematology, 2018, Volume: 97, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Carboplatin; Dexamethasone; Drug Resis

2018
Extranodal NK/T cell lymphoma, nasal type, presenting with meningeal infiltration in a Caucasian female.
    British journal of haematology, 2013, Volume: 163, Issue:5

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Carboplatin; Cerebrospinal Fluid

2013
Diagnosis of brainstem involvement in NK/T cell lymphoma.
    Annals of hematology, 2014, Volume: 93, Issue:8

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Brain Stem; Cerebrospinal Fluid;

2014
[Successful treatment with high-dose methotrexate/cytarabine regimen in a patient in SMILE regimen-resistant extranodal natural killer/T-cell lymphoma].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2014, Volume: 55, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cytarabine; Dexamethasone; Drug

2014
A study of gemcitabine, l-asparaginase, ifosfamide, dexamethasone and etoposide chemotherapy for newly diagnosed stage IV, relapsed or refractory extranodal natural killer/T-cell lymphoma, nasal type.
    Leukemia & lymphoma, 2014, Volume: 55, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Deoxycytidine; Dexamethasone; Etoposid

2014
Induction treatment with SMILE and consolidation with autologous stem cell transplantation for newly diagnosed stage IV extranodal natural killer/T-cell lymphoma patients.
    Annals of hematology, 2015, Volume: 94, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cohort Studie

2015
Ifosfamide, methotrexate, etoposide, and prednisolone (IMEP) plus L-asparaginase as a first-line therapy improves outcomes in stage III/IV NK/T cell-lymphoma, nasal type (NTCL).
    Annals of hematology, 2015, Volume: 94, Issue:3

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Etoposide; Fe

2015
A pilot study of the safety and efficacy of dexamethasone, ifosfamide, methotrexate and gemcitabine chemotherapy for natural killer/T-cell lymphoma.
    Leukemia & lymphoma, 2015, Volume: 56, Issue:7

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Dexamethason

2015
Methotrexate-associated lymphoproliferative disorder presenting as extranodal NK/T-cell lymphoma arising in the lungs.
    Pathology international, 2015, Volume: 65, Issue:12

    Topics: Antineoplastic Agents; Arthritis, Rheumatoid; Asparaginase; Diagnosis, Differential; Epstein-Barr Vi

2015
Concurrent Chemoradiation Therapy Followed by Consolidation Chemotherapy for Localized Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type.
    International journal of radiation oncology, biology, physics, 2015, Nov-01, Volume: 93, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparagine; Chemoradiotherapy; Cisplati

2015
Sequential DICE combined with l-asparaginase chemotherapy followed by involved field radiation in newly diagnosed, stage IE to IIE, nasal and extranodal NK/T-cell lymphoma.
    Leukemia & lymphoma, 2016, Volume: 57, Issue:7

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Chemoradiothe

2016
Successful Treatment of Genetically Profiled Pediatric Extranodal NK/T-Cell Lymphoma Targeting Oncogenic STAT3 Mutation.
    Pediatric blood & cancer, 2016, Volume: 63, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Chemoradiotherapy; Child; Cytarabine;

2016
L-asparaginase-based regimens followed by allogeneic hematopoietic stem cell transplantation improve outcomes in aggressive natural killer cell leukemia.
    Journal of hematology & oncology, 2016, Apr-18, Volume: 9

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Combined Moda

2016
Nasal Type Extranodal Natural Killer/T (NK/T) Cell Lymphoma Presenting as Periorbital Cellulitis: A Case Report.
    The American journal of case reports, 2016, Dec-09, Volume: 17

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Dexamethasone; Diagnosis, Differential; Etopo

2016
Treatments and Outcomes of Patients With Extranodal Natural Killer/T-Cell Lymphoma Diagnosed Between 2000 and 2013: A Cooperative Study in Japan.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017, Volume: 35, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Asparagi

2017
Delayed Diagnosis of a Nasal Type Lymphoma Misdiagnosed as Persistent Sinusitis.
    Journal of adolescent and young adult oncology, 2017, Volume: 6, Issue:2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Chronic Disease; Delayed Diagno

2017
Extranodal NK/T cell lymphoma in a living donor liver transplant recipient.
    Annals of hematology, 2017, Volume: 96, Issue:6

    Topics: Allografts; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Dexamethasone; Drug Substi

2017
A case of extranodal NK/T-cell lymphoma, nasal type mimicking typical manifestations of adult-onset Still's disease (AOSD) with hemophagocytic syndrome: diagnostic consideration between malignant lymphoma without lymphadenopathy and AOSD.
    Modern rheumatology, 2009, Volume: 19, Issue:6

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Carboplatin; Dexamethasone

2009
Successful treatment of extranodal natural killer/T-cell lymphoma, nasal type, complicated by severe hemophagocytic syndrome, with dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide chemotherapy followed by autologous stem cell transpl
    Leukemia & lymphoma, 2010, Volume: 51, Issue:4

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Chemotherapy, Adjuvant; Combine

2010
A promising new regimen for the treatment of advanced extranodal NK/T cell lymphoma.
    Acta oncologica (Stockholm, Sweden), 2011, Volume: 50, Issue:4

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Deoxycytidine; Fem

2011
SMILE for natural killer/T-cell lymphoma: analysis of safety and efficacy from the Asia Lymphoma Study Group.
    Blood, 2012, Oct-11, Volume: 120, Issue:15

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Clinic

2012
Successful treatment of secondary NK/T-cell lymphoma of the testis.
    Annals of hematology, 2013, Volume: 92, Issue:7

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Combined Modality Therapy; Dexame

2013
Sub-acute demyelinating neuropathy associated with an NK/T cell lymphoma.
    Journal of neurology, neurosurgery, and psychiatry, 2008, Volume: 79, Issue:4

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Cyclophosphamide; Cytarabine; Demyeli

2008