Page last updated: 2024-10-29

ifosfamide and Ewing Sarcoma

ifosfamide has been researched along with Ewing Sarcoma in 188 studies

Research Excerpts

ExcerptRelevanceReference
"Cyclophosphamide may be able to replace ifosfamide in consolidation treatment of standard-risk Ewing sarcoma."9.19Cyclophosphamide compared with ifosfamide in consolidation treatment of standard-risk Ewing sarcoma: results of the randomized noninferiority Euro-EWING99-R1 trial. ( Brennan, B; Craft, A; Dirksen, U; Hjorth, L; Judson, I; Juergens, H; Ladenstein, R; Le Deley, MC; Le Teuff, G; Lewis, I; Marec-Bérard, P; Michon, J; Oberlin, O; Paulussen, M; Ranft, A; van den Berg, H; Wheatley, K; Whelan, J, 2014)
"The EICESS-92 Trial compared the efficacy of cyclophosphamide and ifosfamide in patients with Ewing sarcoma."9.14Chemotherapy: The role of ifosfamide and etoposide in Ewing sarcoma. ( DuBois, SG; Grier, HE, 2009)
"In the prospective high-risk sarcoma (HIRISA) Phase II trial HIRISA1, pediatric patients with high-risk sarcomas received 3 cycles of intensive vincristine, ifosfamide, etoposide, cyclophosphamide, and doxorubicin (VACIE) before radiotherapy and/or surgery began at Week 9 with concurrent vincristine, cyclophosphamide, and doxorubicin (Week 9) and vincristine and ifosfamide (Week 12)."9.12Concomitant administration of vincristine, doxorubicin, cyclophosphamide, ifosfamide, and etoposide for high-risk sarcomas: the St. Jude Children's Research Hospital experience. ( Billups, CA; Cain, AM; Furman, WL; Hale, GA; Merchant, TE; Navid, F; Pappo, AS; Rao, BN; Santana, VM; Spunt, SL, 2006)
"The addition of ifosfamide and etoposide to a standard regimen does not affect the outcome for patients with metastatic disease, but it significantly improves the outcome for patients with nonmetastatic Ewing's sarcoma, primitive neuroectodermal tumor of bone, or primitive sarcoma of bone."9.10Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone. ( Dickman, PS; Donaldson, SS; Fryer, CJ; Gebhardt, MC; Grier, HE; Krailo, MD; Link, MP; Meyers, PA; Miser, JS; Moore, S; Perlman, EJ; Pritchard, DJ; Rausen, AR; Tarbell, NJ; Vietti, TJ, 2003)
"This Phase II study evaluated doxorubicin, dacarbazine, ifosfamide, and mesna (MAID) in adults with inoperable or metastatic Ewing's sarcoma, rhabdomyosarcoma, or osteosarcoma."9.08A Southwest Oncology Group and Cancer and Leukemia Group B phase II study of doxorubicin, dacarbazine, ifosfamide, and mesna in adults with advanced osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma. ( Antman, K; Baker, LH; Balcerzak, SP; Clamon, GH; Crowley, J; Kempf, RA; Weiss, RB, 1998)
"The current study was performed to evaluate the toxicity profile of therapeutic doses of ifosfamide (IFX) given concurrently with full-dose external beam radiotherapy (EBRT) in patients with soft tissue and bone sarcomas."8.81Concurrent ifosfamide-based chemotherapy and irradiation. Analysis of treatment-related toxicity in 43 patients with sarcoma. ( Ballo, MT; Benjamin, RS; Burgess, MA; Cormier, JN; Feig, BW; Herzog, CE; Hunt, KK; Patel, SR; Pisters, PW; Raney, RB; Zagars, GK, 2001)
"Ifosfamide is an analogue of cyclophosphamide that has been extensively investigated in sarcomas."8.78The role of ifosfamide in the treatment of adult soft tissue sarcomas, Ewing's sarcoma, and osteosarcoma: a review. ( Dirix, LY; Van Oosterom, AT, 1990)
"The alkylating agent ifosfamide has demonstrated significant activity against advanced sarcomas."8.77The role of ifosfamide in the treatment of sarcomas. ( Dirix, LY; Van Oosterom, AT, 1989)
"To assess feasibility and safety of outpatient administration of ifosfamide and etoposide (IE) for pediatric Ewing sarcoma (EWS) patients in a resource-limited setting amid the COVID-19 pandemic."8.12Feasibility and safety of outpatient administration of ifosfamide and etoposide for pediatric patients with Ewing sarcoma in a resource-limited setting amid the COVID-19 pandemic. ( Saeed, H; Sarfraz, S, 2022)
"The combination of topotecan and cyclophosphamide is active in relapsed Ewing sarcoma family of tumors (ESFT)."7.83Pilot Study of Adding Vincristine, Topotecan, and Cyclophosphamide to Interval-Compressed Chemotherapy in Newly Diagnosed Patients With Localized Ewing Sarcoma: A Report From the Children's Oncology Group. ( Bond, MC; Felgenhauer, JL; Femino, JD; Gorlick, R; Krailo, MD; Laack, NN; Marina, N; Mascarenhas, L; Meyer, J; Ranganathan, S; Villaluna, D; Womer, RB, 2016)
"To determine activity and toxicity of high-dose ifosfamide (HDIFO) in recurrent or advanced Ewing sarcoma family tumors (EFT)."7.75Response to high-dose ifosfamide in patients with advanced/recurrent Ewing sarcoma. ( Bacci, G; Balladelli, A; Berta, M; del Prever, AB; Fagioli, F; Ferrari, S; Palmerini, E; Picci, P; Staals, E; Vanel, D, 2009)
"We report a patient with primary lung adenocarcinoma who had Ewing's sarcoma and was successfully treated with ifosfamide."7.74[A case of primary lung adenocarcinoma accompanied by Ewing's sarcoma successfully treated with ifosfamide]. ( Arai, H; Fukumura, H; Kudo, M; Masuda, M; Nakajima, K; Oshiro, H; Rino, Y; Wada, N; Watanuki, Y; Yamanaka, S; Yukawa, N, 2008)
" The authors describe 2 postpubertal women aged 16 and 25 suffering from Ewing sarcoma who were treated with the very aggressive Sloan-Kettering protocol, which includes high-dose cyclophosphamide and ifosfamide in addition to other drugs."7.71Successful pregnancy after high-dose cyclophosphamide and ifosfamide treatment in two postpubertal women. ( Kenet, G; Neumann, Y; Rechavi, G; Schachter, J; Sharon, N; Toren, A, 2001)
"From January 1990 to December 1995 we treated 35 patients (pts) with bone and soft tissue sarcoma with ifosfamide (IFM)."7.69[The effects of high-dose ifosfamide in the treatment of bone and soft tissue sarcomas]. ( Ishii, T; Kitoh, M; Satoh, T; Tatezaki, S; Umeda, T; Yonemoto, T, 1997)
"A total of 64 courses of ifosfamide (IFM) treatments for sarcoma patients were evaluated for toxic effects."7.68[Toxic effects of ifosfamide in the treatment of bone and soft tissue sarcomas]. ( Ishii, T; Kitoh, M; Satoh, T; Tatezaki, S; Umeda, T, 1993)
"" The regimen included an intensification of ifosfamide dosing from 1,800 mg/m(2) /day × 5 days per cycle to 2,800 mg/m(2) /day × 5 days per cycle."6.80Ifosfamide dose-intensification for patients with metastatic Ewing sarcoma. ( Chou, AJ; Goodbody, CM; Magnan, H; Pratilas, CA; Riedel, E; Wexler, LH, 2015)
"Patients <30 years old with Ewing sarcoma were eligible."6.80Carboplatin in the treatment of Ewing sarcoma: Results of the first Brazilian collaborative study group for Ewing sarcoma family tumors-EWING1. ( Abujamra, AL; Almeida, MT; Benites, E; Boldrini, E; Brunetto, AL; Castillo, LA; Costa, C; Gadelha, A; Gregianin, LJ; Kirst, D; Macedo, CD; Morais, V; Nakasato, A; Pereira, WV; Petrilli, AS; Pizza, M; Rodriguez-Galindo, C; Watanabe, FM, 2015)
"CWS/RMS-96 was an international multicenter trial with randomization between two therapy arms of the standard four-drug therapy (vincristine, ifosfamide, adriamycin, dactinomycin [VAIA]) versus an intensified six-drug regimen (carboplatin, epirubicin, vincristine, dactinomycin, ifosfamide, and etoposide [CEVAIE]) for high-risk rhabdomyosarcoma (RMS), extraskeletal Ewing sarcoma (EES), and undifferentiated sarcoma (UDS) in children, adolescents, and young adults aiming to improve their survival."5.51Long-term results from the multicentric European randomized phase 3 trial CWS/RMS-96 for localized high-risk soft tissue sarcoma in children, adolescents, and young adults. ( Alaggio, R; Bisogno, G; Casanova, M; Cecchetto, G; Ferrari, A; Kazanowska, B; Klingebiel, T; Koscielniak, E; Kosztyla, D; Ladenstein, R; Ljungman, G; Milano, GM; Niggli, F; Scarzello, G; Sparber-Sauer, M; Vokuhl, C; Zin, A, 2022)
"Dose-intensive chemotherapy with vincristine, doxorubicin, cyclophosphamide, ifosfamide, and etoposide is more effective, less toxic, and shorter in duration for all stages of newly diagnosed Ewing sarcoma than vincristine, ifosfamide, doxorubicin, and etoposide induction and should now be the standard of care for Ewing sarcoma."5.51Comparison of two chemotherapy regimens in patients with newly diagnosed Ewing sarcoma (EE2012): an open-label, randomised, phase 3 trial. ( Brennan, B; Fenwick, N; Gaspar, N; Gelderblom, H; Kirton, L; Laurence, V; Marec-Bérard, P; Martín-Broto, J; Moroz, V; Owens, C; Sastre, A; Strauss, S; Wheatley, K; Whelan, J, 2022)
"Ewing sarcoma has recently been reported to be sensitive to poly(ADP)-ribose polymerase (PARP) inhibitors."5.42PARP Inhibitors Sensitize Ewing Sarcoma Cells to Temozolomide-Induced Apoptosis via the Mitochondrial Pathway. ( Engert, F; Fulda, S; Probst, M; Schneider, C; Weiβ, LM, 2015)
"Here we report a patient treated for Ewing sarcoma with multiple pulmonary and osseous metastases who repeatedly developed a supraventricular tachyarrhythmia following administration of ifosfamide as part of a polychemotherapy regimen."5.32Recurrent atrial ectopic tachycardia following chemotherapy with ifosfamide. ( Kramm, CM; Lawrenz, W; Müller, L; Schmidt, KG; Wessalowski, R, 2004)
"Despite the fact that Ewing sarcoma family of tumors (ET) is chemosensitive, long-term survival is extremely rare for patients with primary refractory or recurrent disease."5.32VIP (etoposide, ifosfamide, cisplatin) in adult patients with recurrent or refractory Ewing sarcoma family of tumors. ( Allam, A; Bazarbashi, S; El Foudeh, M; El Hassan, I; El Weshi, A; Ezzat, A; Memon, M; Pai, C; Rahal, M; Raja, M, 2004)
"Based on the randomised Euro-EWING99-R1 trial, vincristine, adriamycin, cyclophosphamide (VAC) may be able to replace vincristine, adriamycin, ifosfamide (VAI) in the treatment of standard-risk Ewing sarcoma."5.20Impact of gender on efficacy and acute toxicity of alkylating agent -based chemotherapy in Ewing sarcoma: secondary analysis of the Euro-Ewing99-R1 trial. ( Brennan, B; Brichard, B; Craft, A; Dirksen, U; Gaspar, N; Gelderblom, H; Hjorth, L; Judson, I; Juergens, H; Kruseova, J; Kühne, T; Ladenstein, RL; Le Deley, MC; Le Teuff, G; Marec-Berard, P; Paulussen, M; van den Berg, H; Wheatley, K; Whelan, J, 2015)
"Cyclophosphamide may be able to replace ifosfamide in consolidation treatment of standard-risk Ewing sarcoma."5.19Cyclophosphamide compared with ifosfamide in consolidation treatment of standard-risk Ewing sarcoma: results of the randomized noninferiority Euro-EWING99-R1 trial. ( Brennan, B; Craft, A; Dirksen, U; Hjorth, L; Judson, I; Juergens, H; Ladenstein, R; Le Deley, MC; Le Teuff, G; Lewis, I; Marec-Bérard, P; Michon, J; Oberlin, O; Paulussen, M; Ranft, A; van den Berg, H; Wheatley, K; Whelan, J, 2014)
"Chemotherapy with alternating vincristine-doxorubicin-cyclophosphamide and ifosfamide-etoposide cycles and primary tumor treatment with surgery and/or radiation therapy constitute the usual approach to localized Ewing sarcoma in North America."5.16Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group. ( Dickman, PS; Dormans, JP; Grier, HE; Healey, JH; Krailo, MD; Marcus, K; Pawel, BR; Sailer, S; Weiss, AR; West, DC; Womer, RB, 2012)
"Patients aged ≤40 years with nonmetastatic Ewing sarcoma (ES) received vincristine (V), doxorubicin (A), cyclofosfamide (C), actinomycin (Ac), ifosfamide (I) and etoposide (E) (VACAc-IE regimen) as induction chemotherapy."5.15Nonmetastatic Ewing family tumors: high-dose chemotherapy with stem cell rescue in poor responder patients. Results of the Italian Sarcoma Group/Scandinavian Sarcoma Group III protocol. ( Alberghini, M; Alvegard, TA; Bacci, G; Barbieri, E; Brach Del Prever, A; Capanna, R; Carli, M; Fagioli, F; Ferrari, S; Gandola, L; Luksch, R; Mapelli, S; Mercuri, M; Picci, P; Prete, A; Smeland, S; Sundby Hall, K; Tamburini, A; Tienghi, A; Wiebe, T, 2011)
"The EICESS-92 Trial compared the efficacy of cyclophosphamide and ifosfamide in patients with Ewing sarcoma."5.14Chemotherapy: The role of ifosfamide and etoposide in Ewing sarcoma. ( DuBois, SG; Grier, HE, 2009)
"In the prospective high-risk sarcoma (HIRISA) Phase II trial HIRISA1, pediatric patients with high-risk sarcomas received 3 cycles of intensive vincristine, ifosfamide, etoposide, cyclophosphamide, and doxorubicin (VACIE) before radiotherapy and/or surgery began at Week 9 with concurrent vincristine, cyclophosphamide, and doxorubicin (Week 9) and vincristine and ifosfamide (Week 12)."5.12Concomitant administration of vincristine, doxorubicin, cyclophosphamide, ifosfamide, and etoposide for high-risk sarcomas: the St. Jude Children's Research Hospital experience. ( Billups, CA; Cain, AM; Furman, WL; Hale, GA; Merchant, TE; Navid, F; Pappo, AS; Rao, BN; Santana, VM; Spunt, SL, 2006)
"Patients < or = 30 years with Ewing sarcoma, primitive neuroectodermal tumor or primitive sarcoma of bone were randomly assigned to receive chemotherapy with doxorubicin, vincristine, cyclophosphamide, and dactinomycin, (VACA) or with these four drugs alternating with ifosfamide and etoposide (VACA-IE)."5.12Local control in pelvic Ewing sarcoma: analysis from INT-0091--a report from the Children's Oncology Group. ( Bernstein, M; Chen, Z; Donaldson, SS; Fryer, CJ; Gebhardt, MC; Grier, HE; Krailo, M; Laurie, F; Miser, JS; Tarbell, NJ; Yock, TI, 2006)
"Adding ifosfamide and etoposide to standard therapy does not improve outcomes of patients with Ewing's sarcoma or PNET of bone with metastases at diagnosis."5.11Treatment of metastatic Ewing's sarcoma or primitive neuroectodermal tumor of bone: evaluation of combination ifosfamide and etoposide--a Children's Cancer Group and Pediatric Oncology Group study. ( Dickman, PS; Donaldson, SS; Fryer, CJ; Gebhardt, MC; Grier, HE; Krailo, MD; Link, MP; Meyers, PA; Miser, JS; Moore, S; Perlman, EJ; Pritchard, DJ; Rausen, AR; Tarbell, NJ; Vietti, TJ, 2004)
"The addition of ifosfamide and etoposide to a standard regimen does not affect the outcome for patients with metastatic disease, but it significantly improves the outcome for patients with nonmetastatic Ewing's sarcoma, primitive neuroectodermal tumor of bone, or primitive sarcoma of bone."5.10Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone. ( Dickman, PS; Donaldson, SS; Fryer, CJ; Gebhardt, MC; Grier, HE; Krailo, MD; Link, MP; Meyers, PA; Miser, JS; Moore, S; Perlman, EJ; Pritchard, DJ; Rausen, AR; Tarbell, NJ; Vietti, TJ, 2003)
"This Phase II study evaluated doxorubicin, dacarbazine, ifosfamide, and mesna (MAID) in adults with inoperable or metastatic Ewing's sarcoma, rhabdomyosarcoma, or osteosarcoma."5.08A Southwest Oncology Group and Cancer and Leukemia Group B phase II study of doxorubicin, dacarbazine, ifosfamide, and mesna in adults with advanced osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma. ( Antman, K; Baker, LH; Balcerzak, SP; Clamon, GH; Crowley, J; Kempf, RA; Weiss, RB, 1998)
" In this case report, we treated a 20-year-old male patient with cyclophosphamide, doxorubicin, vincristine, dexamethasone, and methotrexate and cytarabine chemotherapy following a diagnosis of Stage IV Burkitt lymphoma."4.89Unusual presentation of Ewing sarcoma in the adrenal gland: a secondary malignancy from a survivor of Burkitt lymphoma. ( Choi, KH; Hyun, JY; Kim, JH; Kim, SJ; Kim, WS; Ko, YH; Lee, J; Lee, JY; Lim, SH, 2013)
"Phase II studies conducted in Europe and the USA on pediatric solid tumors have shown that ifosfamide, as a single agent, is an active drug against a variety of neoplasms - rhabdomyosarcoma (RMS), some non-RMS soft tissue sarcomas, Wilms' tumor, bone sarcomas and neuroblastoma."4.82Ifosfamide in pediatric solid tumors. ( Bisogno, G; Carli, M; Passone, E; Perilongo, G, 2003)
"The current study was performed to evaluate the toxicity profile of therapeutic doses of ifosfamide (IFX) given concurrently with full-dose external beam radiotherapy (EBRT) in patients with soft tissue and bone sarcomas."4.81Concurrent ifosfamide-based chemotherapy and irradiation. Analysis of treatment-related toxicity in 43 patients with sarcoma. ( Ballo, MT; Benjamin, RS; Burgess, MA; Cormier, JN; Feig, BW; Herzog, CE; Hunt, KK; Patel, SR; Pisters, PW; Raney, RB; Zagars, GK, 2001)
" The most active single agents against osteosarcoma are doxorubicin (overall response rate, 21%), methotrexate (30% to 40%), cisplatin (25%), and ifosfamide (28%)."4.78Chemotherapy of advanced sarcomas of bone and soft tissue. ( Antman, KH, 1992)
"Ifosfamide is an analogue of cyclophosphamide that has been extensively investigated in sarcomas."4.78The role of ifosfamide in the treatment of adult soft tissue sarcomas, Ewing's sarcoma, and osteosarcoma: a review. ( Dirix, LY; Van Oosterom, AT, 1990)
"The alkylating agent ifosfamide has demonstrated significant activity against advanced sarcomas."4.77The role of ifosfamide in the treatment of sarcomas. ( Dirix, LY; Van Oosterom, AT, 1989)
"Interval compression (IC), a regimen of alternating vincristine/doxorubicin/cyclophosphamide and ifosfamide/etoposide every 2 weeks, improves survival for localized Ewing sarcoma (ES), with uncertain effect on metastatic disease."4.31Outcomes of Pediatric Patients With Metastatic Ewing Sarcoma Treated With Interval Compression. ( Ghandour, K; Halalsheh, H; Ibrahimi, AKH; Ismael, T; Sarhan, N; Shehadeh, A; Sultan, I; Zandaki, D, 2023)
"To assess feasibility and safety of outpatient administration of ifosfamide and etoposide (IE) for pediatric Ewing sarcoma (EWS) patients in a resource-limited setting amid the COVID-19 pandemic."4.12Feasibility and safety of outpatient administration of ifosfamide and etoposide for pediatric patients with Ewing sarcoma in a resource-limited setting amid the COVID-19 pandemic. ( Saeed, H; Sarfraz, S, 2022)
"The combination of topotecan and cyclophosphamide is active in relapsed Ewing sarcoma family of tumors (ESFT)."3.83Pilot Study of Adding Vincristine, Topotecan, and Cyclophosphamide to Interval-Compressed Chemotherapy in Newly Diagnosed Patients With Localized Ewing Sarcoma: A Report From the Children's Oncology Group. ( Bond, MC; Felgenhauer, JL; Femino, JD; Gorlick, R; Krailo, MD; Laack, NN; Marina, N; Mascarenhas, L; Meyer, J; Ranganathan, S; Villaluna, D; Womer, RB, 2016)
"To determine activity and toxicity of high-dose ifosfamide (HDIFO) in recurrent or advanced Ewing sarcoma family tumors (EFT)."3.75Response to high-dose ifosfamide in patients with advanced/recurrent Ewing sarcoma. ( Bacci, G; Balladelli, A; Berta, M; del Prever, AB; Fagioli, F; Ferrari, S; Palmerini, E; Picci, P; Staals, E; Vanel, D, 2009)
"We report a patient with primary lung adenocarcinoma who had Ewing's sarcoma and was successfully treated with ifosfamide."3.74[A case of primary lung adenocarcinoma accompanied by Ewing's sarcoma successfully treated with ifosfamide]. ( Arai, H; Fukumura, H; Kudo, M; Masuda, M; Nakajima, K; Oshiro, H; Rino, Y; Wada, N; Watanuki, Y; Yamanaka, S; Yukawa, N, 2008)
" During the initial therapy, an ifosfamide-induced encephalopathy occurred as status epilepticus."3.72Prophylactic treatment of known ifosfamide-induced encephalopathy for chemotherapy with high-dose ifosfamide? ( Bellos, F; Egerer, G; Harter, C; Ho, AD; Kasper, B; Krasniqi, F; Meissner, J, 2004)
"Twenty-three children and adolescents with metastatic sarcomas received vincristine, doxorubicin, cyclophosphamide, ifosfamide, sodium mercaptoethanesulfonate (mensa), and etoposide (VACIME) chemotherapy, consisting of 8 courses of vincristine 2 mg/m(2) on Day 0, doxorubicin 37."3.71Peripheral blood stem cell support reduces the toxicity of intensive chemotherapy for children and adolescents with metastatic sarcomas. ( Douglas, J; Felgenhauer, J; Gooley, T; Hawkins, DS; Kreissman, S; Park, J; Pendergrass, TW; Rowley, SD; Sanders, JE; Thomson, B, 2002)
" The authors describe 2 postpubertal women aged 16 and 25 suffering from Ewing sarcoma who were treated with the very aggressive Sloan-Kettering protocol, which includes high-dose cyclophosphamide and ifosfamide in addition to other drugs."3.71Successful pregnancy after high-dose cyclophosphamide and ifosfamide treatment in two postpubertal women. ( Kenet, G; Neumann, Y; Rechavi, G; Schachter, J; Sharon, N; Toren, A, 2001)
"Neuroblastomas, nephroblastomas, malignant mesenchymal tumors, including rhabdomyosarcomas, Ewing's sarcomas, osteosarcomas, brain tumors, and non-Hodgkin's lymphomas respond to ifosfamide monotherapy."3.69Ifosfamide in the treatment of pediatric malignancies. ( Behrendt, H; de Kraker, J; Michiels, E; van den Berg, H; Voûte, PA, 1996)
"From January 1990 to December 1995 we treated 35 patients (pts) with bone and soft tissue sarcoma with ifosfamide (IFM)."3.69[The effects of high-dose ifosfamide in the treatment of bone and soft tissue sarcomas]. ( Ishii, T; Kitoh, M; Satoh, T; Tatezaki, S; Umeda, T; Yonemoto, T, 1997)
"A total of 64 courses of ifosfamide (IFM) treatments for sarcoma patients were evaluated for toxic effects."3.68[Toxic effects of ifosfamide in the treatment of bone and soft tissue sarcomas]. ( Ishii, T; Kitoh, M; Satoh, T; Tatezaki, S; Umeda, T, 1993)
"Patients with cutaneous/subcutaneous Ewing sarcoma may have better prognosis than those with Ewing sarcoma at other anatomical sites."3.01Clinical characteristics of primary cutaneous and subcutaneous Ewing sarcoma. ( Aiba, H; Arakawa, A; Imai, T; Iwata, S; Kawai, A; Kimura, H; Kobayashi, E; Kojima, Y; Ogawa, C; Shimoi, T; Sudo, K; Yazaki, S; Yonemori, K; Yoshida, A, 2023)
"" The regimen included an intensification of ifosfamide dosing from 1,800 mg/m(2) /day × 5 days per cycle to 2,800 mg/m(2) /day × 5 days per cycle."2.80Ifosfamide dose-intensification for patients with metastatic Ewing sarcoma. ( Chou, AJ; Goodbody, CM; Magnan, H; Pratilas, CA; Riedel, E; Wexler, LH, 2015)
"Patients <30 years old with Ewing sarcoma were eligible."2.80Carboplatin in the treatment of Ewing sarcoma: Results of the first Brazilian collaborative study group for Ewing sarcoma family tumors-EWING1. ( Abujamra, AL; Almeida, MT; Benites, E; Boldrini, E; Brunetto, AL; Castillo, LA; Costa, C; Gadelha, A; Gregianin, LJ; Kirst, D; Macedo, CD; Morais, V; Nakasato, A; Pereira, WV; Petrilli, AS; Pizza, M; Rodriguez-Galindo, C; Watanabe, FM, 2015)
" A novel five-drug combination of etoposide, vincristine, dactinomycin, ifosfamide, and doxorubicin (EVAIA) was evaluated for high-risk patients, but cumulative chemotherapy dosage and treatment duration were reduced for the remaining individuals as compared with that of the previous trial CWS-86."2.74Cooperative trial CWS-91 for localized soft tissue sarcoma in children, adolescents, and young adults. ( Bielack, SS; Brecht, I; Dantonello, TM; Dickerhoff, R; Gadner, H; Greiner, J; Greulich, M; Harms, D; Herbst, M; Int-Veen, C; Juergens, H; Kirsch, S; Klingebiel, T; Koscielniak, E; Leuschner, I; Marky, I; Scheel-Walter, HG; Schmelzle, R; Schmidt, BF; Treuner, J, 2009)
"The European Intergroup Cooperative Ewing's Sarcoma Study investigated whether cyclophosphamide has a similar efficacy as ifosfamide in standard-risk (SR) patients and whether the addition of etoposide improves survival in high-risk (HR) patients."2.73Results of the EICESS-92 Study: two randomized trials of Ewing's sarcoma treatment--cyclophosphamide compared with ifosfamide in standard-risk patients and assessment of benefit of etoposide added to standard treatment in high-risk patients. ( Cassoni, A; Craft, AW; Douglas, C; Dunst, J; Grimer, R; Hackshaw, A; Hunold, A; Jürgens, H; Köhler, G; Ladenstein, R; Lewis, I; McTiernan, A; Paulussen, M; Poremba, C; Schuck, A; Spooner, D; van den Berg, H; Whelan, J; Winkelmann, W; Zoubek, A, 2008)
"Median age at diagnosis of Ewing sarcoma was 12 years, and median length of follow-up, 8 years."2.73Therapy-related myelodysplasia and acute myeloid leukemia after Ewing sarcoma and primitive neuroectodermal tumor of bone: A report from the Children's Oncology Group. ( Askin, FB; Bhatia, S; Burden, L; Chen, Z; Dickman, PS; Grier, HE; Krailo, MD; Link, MP; Meyers, PA; Miser, JS; Perlman, EJ; Rausen, AR; Robison, LL; Vietti, TJ, 2007)
"Six hundred ninety Ewing tumor patients were treated between 1992 and 1999 with local therapy and vincristine."2.70Second malignancies after ewing tumor treatment in 690 patients from a cooperative German/Austrian/Dutch study. ( Ahrens, S; Aulitzky, WE; Dunst, J; Fölsch, UR; Göbel, U; Harms, D; Hense, HW; Henze, G; Jürgens, H; Kremens, B; Lehnert, M; Niemeyer, C; Paulussen, M; Reiter, A; Taeger, D; Voûte, PA; Wagner, A; Zoubek, A, 2001)
" These results indicate that there is no identifiable pharmacokinetic basis for insistence on either bolus or infusional methods of IFOS administration."2.69The pharmacokinetics and metabolism of ifosfamide during bolus and infusional administration: a randomized cross-over study. ( Brennan, C; Hartley, JM; Nicholson, PW; Singer, JM; Souhami, RL, 1998)
"Two hundred one patients had no metastases."2.69Ifosfamide-containing chemotherapy in Ewing's sarcoma: The Second United Kingdom Children's Cancer Study Group and the Medical Research Council Ewing's Tumor Study. ( Cotterill, S; Craft, A; Grimer, R; Imeson, J; Lewis, I; Malcolm, A; Souhami, R; Spooner, D, 1998)
"The Cooperative Ewing Sarcoma Study (CESS 86), conducted by the German Society of Pediatric Oncology and Hematology (GPOH), was planned on the basis of the results of the preceding CESS 81 study."2.69Evaluation of prognostic factors in a tumor volume-adapted treatment strategy for localized Ewing sarcoma of bone: the CESS 86 experience. Cooperative Ewing Sarcoma Study. ( Ahrens, S; Braun-Munzinger, G; Dunst, J; Göbel, U; Harms, D; Heinecke, A; Hoffmann, C; Jabar, S; Jürgens, H; Paulussen, M; Rübe, C; Treuner, J; Winkelmann, W; Winkler, K, 1999)
"The first Scandinavian protocol for Ewing's sarcoma, SSG IV, resulted in a local control rate of 74% and 5-year metastasis-free survival (MFS) of 43%."2.69Five-year results in Ewing's sarcoma. The Scandinavian Sarcoma Group experience with the SSG IX protocol. ( Akerman, M; Alvegård, TA; Björk, O; Blomqvist, CP; Elomaa, I; Saeter, G; Stenwig, E; Wiebe, T, 2000)
"Consolidation of remissions of pPNET metastatic to bone and bone marrow remains a therapeutic challenge."2.68Very-high-dose short-term chemotherapy for poor-risk peripheral primitive neuroectodermal tumors, including Ewing's sarcoma, in children and young adults. ( Aledo, A; Boland, P; Casper, ES; Gerald, WL; Healey, JH; Heller, G; Kushner, BH; La Quaglia, MP; Meyers, PA; Wollner, N, 1995)
"The Cooperative Ewing's Sarcoma Studies, CESS 81 and CESS 86, are multiinstitutional trials with more than 80 participating institutions from Germany, the Netherlands, Austria, and Switzerland."2.67Radiation therapy as local treatment in Ewing's sarcoma. Results of the Cooperative Ewing's Sarcoma Studies CESS 81 and CESS 86. ( Burgers, JM; Dunst, J; Hawliczek, R; Jürgens, H; Kürten, R; Müschenich, M; Salzer-Kuntschik, M; Sauer, R; Winkelmann, W, 1991)
"Extraosseous Ewing sarcoma is a rare, poorly differentiated round-cell tumour that is part of the Ewing sarcoma family of tumours."2.61Primary Ewing sarcoma of the larynx with distant metastasis: a case report and review of the literature. ( Khalifeh, I; Maroun, CA; Moukarbel, RV; Tfayli, A, 2019)
"The occurrence of primary extraskeletal Ewing's sarcoma (EES) of the spinal epidural space has been rarely reported in the literature."2.47Extraskeletal Ewing's sarcoma of the thoracic epidural space: case report and review of the literature. ( Bridge, JA; Hori, T; Huang, D; Kanamori, M; Kimura, T; Suzuki, K; Yasuda, T, 2011)
"A 17-year-old woman with Ewing sarcoma was treated with a combination of doxorubicin (Adriamycin) and ifosfamide during the 25th to 30th week of gestation, and the baby was delivered at the 32nd week."2.42Good outcome for infant of mother treated with chemotherapy for ewing sarcoma at 25 to 30 weeks' gestation. ( Hirayama, M; Ishida, A; Nakajima, W; Ogawa, M; Okada, K; Takahashi, M; Takahashi, S; Washino, N, 2004)
"Extraskeletal Ewing's sarcoma (EES) is rare and has not been previously described about the cervical spine."2.41Extraskeletal Ewing's sarcoma: a case report and review of the literature. ( Caulfield, R; Eustace, S; Fennelly, DJ; Hurson, B; Kennedy, JG; O'Rourke, KS, 2000)
"Here, we present an approach to the treatment of Ewing sarcoma in a patient with PFIC1."1.91Successful Treatment of Patient With Ewing Sarcoma in the Setting of Inherited Cholestatic Liver Disease. ( Bailey, KM; Daley, J; Friehling, E; Halligan, K; Howrie, D; Salgado, CM; Superdock, A, 2023)
"Ewing sarcoma is one of the most frequent soft-tissue tumors in pediatric patients."1.72Analysis of stem cell collections in adult patients with Ewing sarcoma. ( Bach, E; Brückner, M; Franke, GN; Heyn, S; Jentzsch, M; Leiblein, S; Niederwieser, D; Pfannes, R; Platzbecker, U; Pönisch, W; Remane, Y; Rieprecht, S; Schwind, S; Vucinic, V, 2022)
"Pancreatic Ewing's sarcoma is not reported commonly, with inconsistent clinical manifestations."1.72Rare presentation in a rare case of pancreatic extraosseous Ewing's sarcoma: A case report. ( Chan, WT; Hou, JY; Jiang, CB; Lee, HC; Liu, HC; Liu, YC; Sheu, JC; Wu, PS; Yeh, TC; Yeung, CY, 2022)
"Adult Ewing sarcoma (ES) is a rare disease, the optimal treatment model is unknown."1.51Impact of chemotherapy cycles and intervals on outcomes of nonspinal Ewing sarcoma in adults: a real-world experience. ( He, A; Hu, H; Huang, Y; Shen, Z; Sun, Y; Yao, Y; Zhang, J; Zhou, Y, 2019)
"Our study showed that the outpatient administration of interval-compressed regimen is safe and associated with acceptable adherence to this regimen."1.51Safety and Cost-effectiveness of Outpatient Administration of High-dose Chemotherapy in Children With Ewing Sarcoma. ( Alnassan, A; Elshahoubi, A; Sultan, I, 2019)
"In patients with Ewing sarcoma and some distinct subgroups of soft tissue sarcoma (STS), a quantitatively sufficient autologous peripheral blood stem cell (PBSC) collection for stem cell support might facilitate treatment continuation, dose-intensification, and high-dose chemotherapy."1.46Successful collection of peripheral blood stem cells upon VIDE chemomobilization in sarcoma patients. ( Bruckner, T; Cremer, M; Egerer, G; Heilig, C; Kriegsmann, K; Kriegsmann, M; Müller-Tidow, C; Novotny, P; Wuchter, P, 2017)
"The incidence of Ewing sarcoma is lower in non-Caucasian populations, compared with Caucasian populations, for unknown reasons."1.43Treatment outcomes of Japanese patients with Ewing sarcoma: differences between skeletal and extraskeletal Ewing sarcoma. ( Aoki, Y; Araki, N; Hamada, K; Imura, Y; Joyama, S; Kakunaga, S; Naka, N; Obata, H; Takenaka, S; Ueda, T; Yoshikawa, H, 2016)
"Ewing sarcoma is the second most common bone tumor, occurring mainly in children and young adults."1.43Maturation toward neuronal tissue in a Ewing sarcoma of bone after chemotherapy. ( Brons, P; Flucke, U; Salet, MC; Schreuder, B; Vogels, R, 2016)
"Data on patients with localized Ewing sarcoma family of tumors (ESFT) who have received a uniform chemotherapy protocol are minimal."1.42Developing a prognostic model for localized Ewing sarcoma family of tumors: A single institutional experience of 224 cases treated with uniform chemotherapy protocol. ( Agarwala, S; Bakhshi, S; Biswas, B; Deo, SV; Khan, SA; Mohanti, BK; Rastogi, S; Sharma, MC; Shukla, NK; Vishnubhatla, S, 2015)
"Ewing sarcoma has recently been reported to be sensitive to poly(ADP)-ribose polymerase (PARP) inhibitors."1.42PARP Inhibitors Sensitize Ewing Sarcoma Cells to Temozolomide-Induced Apoptosis via the Mitochondrial Pathway. ( Engert, F; Fulda, S; Probst, M; Schneider, C; Weiβ, LM, 2015)
"Extraskeletal Ewing's sarcoma is a rare malignant soft tissue tumor, classified within the Ewing's Sarcoma Family Tumors."1.39Extraskeletal Ewing's Sarcoma: insight into a ten years follow-up. ( Angelici, A; Brunotti, G; Manfredelli, S; Marcantonio, M; Pontone, S; Zitelli, A, 2013)
"A 9-year-old girl with Ewing sarcoma had one ovary excised and cryopreserved prior to chemo- and radiotherapy."1.39Case report: stimulation of puberty in a girl with chemo- and radiation therapy induced ovarian failure by transplantation of a small part of her frozen/thawed ovarian tissue. ( Andersen, CY; Birkebæk, NH; Clausen, N; Ernst, E; Kjærsgaard, M, 2013)
"Data of patients with extraskeletal Ewing's sarcoma followed up at our center between 1997 and 2010 were retrospectively analyzed."1.38Extraskeletal Ewing's sarcoma family of tumors in adults: prognostic factors and clinical outcome. ( Colpan Oksuz, D; Dervisoglu, S; Hiz, M; Kantarci, F; Koca, S; Molinas Mandel, N; Oner Dincbas, F; Selcukbiricik, F; Tural, D; Turna, H, 2012)
"Mice implanted with Ewing's sarcoma tumours received the following treatments: saline, ifosfamide, ifosfamide + NAC concurrently, pre-treatment with NAC + ifosfamide, or NAC alone."1.38The Effects of N-acetylcysteine on ifosfamide efficacy in a mouse xenograft model. ( Figueredo, R; Hanly, L; Koren, G; Koropatnick, J; Rieder, MJ, 2012)
"We evaluated whether Korean Ewing sarcoma family of tumors patients have poorer outcomes than Euro-American patients."1.37Treatment outcome of Korean patients with localized Ewing sarcoma family of tumors: a single institution experience. ( Cho, J; Cho, WH; Jeon, DG; Kim, DH; Kim, MS; Koh, JS; Kong, CB; Lee, JA; Lee, SY; Lim, JS; Song, WS; Yoo, JY, 2011)
"We report a case of primary cutaneous Ewing's sarcoma in a 21-year-old woman."1.37[Primitive cutaneous Ewing's sarcoma: a diagnostic and therapeutic dilemma]. ( Delaplace, M; Goré, C; Machet, L; Mélard, P; Perrinaud, A; Vergier, B, 2011)
"A primitive neuroectodermal tumor (PNET) is a small round cell tumor that arises from the nerve crest."1.36Primary Ewing's sarcoma/primitive neuroectodermal tumor of the kidney that responded to low-dose chemotherapy with ifosfamide, etoposide, and doxorubicin. ( Horiuchi, K; Kondo, Y; Mizutani, S; Ohgaki, K; Sato, M, 2010)
"The emergence of a primitive neuroectodermal tumor (PNET) within a germ-cell tumor (GCT) is rare."1.36Outcome analysis of patients with transformed teratoma to primitive neuroectodermal tumor. ( Andreoiu, M; Beck, SDW; Brames, MJ; Cheng, L; Ehrlich, Y; Einhorn, LH; Foster, RS; Ulbright, TM, 2010)
"Extraskeletal Ewing's sarcoma (EES) is a rare form of soft tissue sarcoma."1.36Extraskeletal Ewing's sarcoma family of tumours in adults: analysis of 57 patients from a single institution. ( Ajarim, D; Al Dayel, F; Allam, A; Bazarbashi, S; El Weshi, A; Memon, M; Pant, R, 2010)
"The outcome of Ewing's sarcoma depends on the anatomical site of the tumor."1.35Long-lasting multiagent chemotherapy in adult high-risk Ewing's sarcoma of bone. ( Arpaci, F; Ataergin, S; Beyzadeoglu, M; Komurcu, S; Oysul, K; Ozet, A; Ozturk, M; Solchaga, L; Surenkok, S; Turan, M, 2009)
"After a search for Ewing tumors in the database of a single institution over a period of 20 years, 16 out of 192 cases were found to have extra-osseous primary tumors."1.35Extra-osseous Ewing sarcoma. ( Heinen, RC; Merks, JH; van den Berg, H; van der Pal, HJ, 2009)
"Advances in the treatment of Ewing sarcoma family of tumors (ESFT) are the result of improvements in systemic and local therapies."1.35Prognostic factors for local and distant control in Ewing sarcoma family of tumors. ( Billups, CA; Krasin, MJ; Liu, T; Navid, F; Rao, BN; Rodríguez-Galindo, C, 2008)
"Forty patients with localized Ewing sarcoma (ES) were treated with primary site RT at one institution."1.34Dose response and local control using radiotherapy in non-metastatic Ewing sarcoma. ( Mai, WY; Nguyen, TX; Paulino, AC; Teh, BS; Wen, BC, 2007)
"From 1979 to 2002, 27 patients with Ewing's sarcoma (20) or PNET (7) were treated."1.34Ewing's sarcoma and primitive neuroectodermal tumour in adults: single-centre experience in The Netherlands. ( Boven, E; Meijer, OW; Smorenburg, CH; van Groeningen, CJ; Visser, M, 2007)
"The local management of Ewing sarcoma family of tumors (ESFT) often centers on the surgical resectability of the primary lesion and physician biases regarding differences in the morbidity between primary surgical and radiotherapeutic management."1.33Definitive surgery and multiagent systemic therapy for patients with localized Ewing sarcoma family of tumors: local outcome and prognostic factors. ( Billups, CA; Davidoff, AM; Fuller, CE; Krasin, MJ; Merchant, TE; Neel, MD; Rodriguez-Galindo, C, 2005)
" Adverse reactions (AR) were evaluated; quality assurance of data collection reviewed."1.33Safety assessment of intensive induction with vincristine, ifosfamide, doxorubicin, and etoposide (VIDE) in the treatment of Ewing tumors in the EURO-E.W.I.N.G. 99 clinical trial. ( Craft, A; Juergens, C; Juergens, H; Lewis, I; Michon, J; Oberlin, O; Paulussen, M; Weston, C; Whelan, J; Zoubek, A, 2006)
"Etoposide dose was reduced, or omitted, in 24% of cycles."1.32Single center experience of a new intensive induction therapy for ewing's family of tumors: feasibility, toxicity, and stem cell mobilization properties. ( Briggs, T; Cannon, S; Cassoni, AM; Cobb, J; Driver, D; Hall-Craggs, M; Kilby, A; McTiernan, A; Michelagnoli, M; Pringle, J; Sandison, A; Strauss, SJ; Whelan, JS; Witt, J, 2003)
"An ileoilealic intussusception was found, caused by a small bowel tumour, which almost completely obstructed the intestinal lumen."1.32Ileoileal intussusception caused by a Ewing sarcoma tumour. An unusual case report. ( Boehm, R; Joppich, I; Landes, J; Schmid, I; Till, H, 2003)
"Here we report a patient treated for Ewing sarcoma with multiple pulmonary and osseous metastases who repeatedly developed a supraventricular tachyarrhythmia following administration of ifosfamide as part of a polychemotherapy regimen."1.32Recurrent atrial ectopic tachycardia following chemotherapy with ifosfamide. ( Kramm, CM; Lawrenz, W; Müller, L; Schmidt, KG; Wessalowski, R, 2004)
"Ewing sarcoma is a relatively uncommon malignant bone neoplasm that usually occurs in children and young adults and involves the major long bones, pelvis, and ribs."1.32Extraskeletal Ewing sarcoma of the diaphragm presenting with hemothorax. ( Alper, F; Eroğlu, A; Gündoğdu, C; Karaoğlanoğlu, N; Kürkçüoğlu, IC, 2004)
"Despite the fact that Ewing sarcoma family of tumors (ET) is chemosensitive, long-term survival is extremely rare for patients with primary refractory or recurrent disease."1.32VIP (etoposide, ifosfamide, cisplatin) in adult patients with recurrent or refractory Ewing sarcoma family of tumors. ( Allam, A; Bazarbashi, S; El Foudeh, M; El Hassan, I; El Weshi, A; Ezzat, A; Memon, M; Pai, C; Rahal, M; Raja, M, 2004)
"Older age and axial location of Ewing's sarcoma have been reported as unfavorable prognostic factors."1.32Ewing's sarcoma of the axial system in patients older than 15 years: dismal prognosis despite intensive multiagent chemotherapy and aggressive local treatment. ( Argon, A; Basaran, M; Bavbek, SE; Camlica, H; Darendeliler, E; Dizdar, Y; Onat, H; Ozger, H; Sakar, B; Yaman, F, 2004)
"Ewing sarcoma is the second most common bone tumor in childhood."1.32Downregulation of angiogenic factors in Ewing tumor xenografts by the combination of human interferon-alpha or interferon-beta with ifosfamide. ( Sancéau, J; Wietzerbin, J, 2004)
"Although the overall results of treatment of Ewing's tumors have improved, patients with high-risk factors, including metastatic disease at diagnosis, bulky primary tumors, axial sites, and age >15 years, continue to have poor prognoses."1.31High-dose chemotherapy and autologous peripheral blood stem-cell transfusion after conventional chemotherapy for patients with high-risk Ewing's tumors. ( Iwamoto, Y; Matsuda, S; Matsunobu, T; Sakamoto, A; Tanaka, K, 2002)
"Ewing sarcoma is the second most common bone tumor in childhood."1.31Strong inhibition of Ewing tumor xenograft growth by combination of human interferon-alpha or interferon-beta with ifosfamide. ( Delattre, O; Poupon, MF; Sancéau, J; Sastre-Garau, X; Wietzerbin, J, 2002)
"Data on 359 patients with nonmetastatic Ewing's sarcoma of bone treated at a single institution between January 1979 and April 1995 were retrospectively considered."1.31Prognostic factors in nonmetastatic Ewing's sarcoma of bone treated with adjuvant chemotherapy: analysis of 359 patients at the Istituto Ortopedico Rizzoli. ( Bacchini, P; Bacci, G; Bertoni, F; Donati, D; Ferrari, S; Forni, C; Longhi, A; Manfrini, M; Picci, P; Rimondini, S, 2000)
"Patients had Ewing's sarcoma/primitive neuroectodermal tumour (PNET), rhabdomyosarcoma, non-rhabdo soft tissue sarcomas or other advanced soft tissue tumours."1.31Granulocyte colony stimulating factor permits dose intensification by interval compression in the treatment of Ewing's sarcomas and soft tissue sarcomas in children. ( Daller, RT; Fenton, JG; Miser, JS; Womer, RB, 2000)
"Cooperative Ewing's Sarcoma Study (CESS) 86 aimed at improving event-free survival (EFS) in patients with high-risk localized Ewing tumor of bone."1.31Localized Ewing tumor of bone: final results of the cooperative Ewing's Sarcoma Study CESS 86. ( Ahrens, S; Amann, G; Dockhorn-Dworniczak, B; Dunst, J; Exner, GU; Gadner, H; Göbel, U; Harms, D; Janka-Schaub, G; Jürgens, H; Kornhuber, B; Kotz, R; Müller-Weihrich, S; Paulussen, M; Treuner, J; Voûte, PA; Welte, K; Winkelmann, W; Zoubek, A, 2001)
"We describe a 16-year-old girl with a Ewing sarcoma who was given post-operative treatment with HDI (15 mg/m(2) infused over 5 days)."1.31Painful peripheral neuropathy after treatment with high-dose ifosfamide. ( Frisk, P; Stålberg, E; Strömberg, B, 2001)
"Since 1985, 54 with localized Ewing's sarcoma of bone were treated at the Onco-Orthopedics Clinic of the Sofia University Hospital (Sofia, Bulgaria)."1.31[Treatment of Ewing's sarcoma with 2 different protocols]. ( Mihova, A; Mumdjiev, I; Sokolov, T; Stoianova, A, 2001)
"Records of 34 patients with ES/PNET who received the IVAD chemotherapy regimens were reviewed."1.30The use of paediatric chemotherapy protocols at full dose is both a rational and feasible treatment strategy in adults with Ewing's family tumours. ( Fisher, C; Harmer, CL; Judson, IR; Thomas, JM; Verrill, MW; Wiltshaw, E, 1997)
"The interval between diagnosis of Ewing's sarcoma and the diagnosis of the SM was 17-78 months for the four AMLs, 96 months for the MDS and 82-136 months for the three sarcomas."1.30Second malignancies after treatment for Ewing's sarcoma: a report of the CESS-studies. ( Ahrens, S; Dunst, J; Harms, D; Jürgens, H; Paulussen, M; Rübe, C; Winkelmann, W; Zoubek, A, 1998)
"Extraskeletal Ewing's sarcoma is rare, and very few data are available addressing optimal surgical and oncologic treatment modalities."1.30Extraskeletal Ewing's sarcoma. ( Ahmad, R; Davis, M; Mayol, BR; Rougraff, BT, 1999)
"Ifosfamide is an alkylating agent which has been incorporated into frontline therapy for a number of malignant paediatric tumours."1.29Ifosfamide nephrotoxicity in paediatric cancer patients. ( Ashraf, MS; Brady, J; Breatnach, F; Deasy, PF; O'Meara, A, 1994)
" Moreover, a dose-response relationship was detectable: 1/6 patients without lung irradiation vs."1.29Lung irradiation for Ewing's sarcoma with pulmonary metastases at diagnosis: results of the CESS-studies. ( Dunst, J; Jürgens, H; Paulussen, M, 1993)
"Seventeen patients with Ewing's sarcoma were divided into 3 groups according to treatment."1.29Ewing's sarcoma: evaluation of chemotherapy in 17 cases. ( Hamada, M; Inoue, H; Nakagawa, Y; Ozaki, T; Sugihara, S; Taguchi, K, 1993)
"Ifosfamide is a derivative of cyclophosphamide and is used to treat malignant tumours."1.29Hypophosphataemic rickets after ifosfamide treatment in children. ( Sweeney, LE, 1993)
"Twelve patients with localized Ewing's sarcoma were treated between 1980-1990 at the Istanbul School of Medicine, Department of Pediatric Oncology-Hematology, Oncology Research and Treatment Center and Our Children Leukemia Foundation."1.28Ewing's sarcoma: experience with 12 cases. ( Gedikoğlu, G; Zülfikar, B, 1992)
"Two cases of Ewing's sarcoma originating from the adult rib were reported."1.28[Two cases of Ewing's sarcoma originating from the adult rib]. ( Akiba, Y; Fujita, Y; Ikushima, Y; Ishida, S; Ohosaki, Y; Onodera, S; Sakai, E; Saotome, K; Shimizu, T; Tagaki, S, 1991)

Research

Studies (188)

TimeframeStudies, this research(%)All Research%
pre-19905 (2.66)18.7374
1990's45 (23.94)18.2507
2000's64 (34.04)29.6817
2010's55 (29.26)24.3611
2020's19 (10.11)2.80

Authors

AuthorsStudies
Sarfraz, S1
Saeed, H1
Sparber-Sauer, M2
Ferrari, A2
Kosztyla, D1
Ladenstein, R5
Cecchetto, G1
Kazanowska, B2
Scarzello, G1
Ljungman, G2
Milano, GM2
Niggli, F2
Alaggio, R1
Vokuhl, C2
Casanova, M1
Klingebiel, T3
Zin, A1
Koscielniak, E3
Bisogno, G3
Zandaki, D1
Ismael, T1
Halalsheh, H2
Ibrahimi, AKH1
Sarhan, N1
Ghandour, K1
Shehadeh, A2
Sultan, I3
Laskar, S2
Sinha, S1
Chatterjee, A1
Khanna, N2
Manjali, JJ1
Puri, A1
Gulia, A1
Nayak, P1
Vora, T1
Chinnaswamy, G2
Prasad, M1
Bajpai, J2
Juvekar, S1
Desai, S1
Janu, A1
Rangarajan, V1
Purandare, N1
Shah, S1
Rekhi, B2
Jambhekar, N1
Muckaden, MA1
Kurkure, P1
Franke, GN1
Pfannes, R1
Heyn, S1
Brückner, M1
Rieprecht, S1
Bach, E1
Remane, Y1
Leiblein, S1
Pönisch, W1
Niederwieser, D1
Schwind, S1
Platzbecker, U1
Jentzsch, M1
Vucinic, V1
Lucari, B1
Tallis, E1
Sutton, VR1
Porea, T1
Corvest, V1
Marec-Bérard, P6
Lervat, C1
Pacquement, H1
Toulmonde, M1
Gentet, JC4
Laurence, V5
Cleirec, M1
Mansuy, L1
Bompas, E1
Castex, MP1
Taque, S1
Filhon, B1
Tabone, MD1
Verité, C1
Entz-Werle, N1
Saumet, L1
Guimard, G1
Pondrom, M1
Chevreau, C1
Flandrin, J1
Duranteau, L1
Rousset-Jablonski, C1
Brugières, L1
Jimenez, M1
Le Deley, MC4
Gaspar, N6
Fresneau, B1
Liu, YC3
Yeh, TC3
Wu, PS3
Sheu, JC3
Lee, HC3
Yeung, CY3
Jiang, CB3
Liu, HC3
Hou, JY3
Chan, WT3
Brennan, B5
Kirton, L2
Martín-Broto, J3
Sastre, A3
Gelderblom, H4
Owens, C3
Fenwick, N3
Strauss, S3
Moroz, V3
Whelan, J9
Wheatley, K5
Daley, J1
Halligan, K1
Howrie, D1
Salgado, CM1
Superdock, A1
Friehling, E1
Bailey, KM1
Aiba, H1
Kojima, Y1
Shimoi, T1
Sudo, K1
Yazaki, S1
Imai, T1
Yoshida, A1
Iwata, S2
Kobayashi, E1
Kawai, A2
Arakawa, A1
Ogawa, C2
Kimura, H1
Yonemori, K1
Cash, T1
Krailo, MD7
Buxton, AB1
Pawel, BR2
Healey, JH5
Binitie, O1
Marcus, KJ2
Grier, HE10
Grohar, PJ1
Reed, DR1
Weiss, AR2
Gorlick, R3
Janeway, KA2
DuBois, SG4
Womer, RB6
Salah, S1
Abuhijla, F1
Ismail, T1
Yaser, S1
Abdelal, S1
Almousa, A1
Jaber, O1
Abu-Hijlih, R1
Maroun, CA1
Khalifeh, I1
Tfayli, A1
Moukarbel, RV1
Zhang, J1
Huang, Y1
Sun, Y1
He, A1
Zhou, Y1
Hu, H1
Yao, Y1
Shen, Z1
Anderton, J1
Kaiser, S1
Fernández-Pinto, M1
Evans, A1
Totadri, S1
Bansal, D1
Rao, KLN1
Jain, R1
Saxena, AK1
Kapoor, R1
Samujh, R1
Trehan, A1
Imai, K1
Yamasaki, T1
Sakamoto, H1
Nakamura, K1
Mizowaki, T1
Ogawa, O1
Aoyama, T1
Howe, AS1
Pearce, J1
Lian, F1
Ribbons, L1
Chumbalkar, V1
Nazeer, T1
Kogan, BA1
Panda, GS1
Chandrasekharan, A1
Bhargava, P1
Srinivas, S1
Dandekar, S1
Mokal, S1
Menon, N1
Patil, V1
Noronha, V1
Joshi, A1
Prabhash, K1
Banavali, SD1
Gupta, S1
Scheer, M1
Paulussen, M14
Bielack, SS2
Seitz, G1
Fuchs, J1
Hallmen, E1
Wagner, MJ1
Gopalakrishnan, V1
Ravi, V1
Livingston, JA1
Conley, AP1
Araujo, D1
Somaiah, N1
Zarzour, MA1
Ratan, R1
Wang, WL1
Patel, SR2
Lazar, A1
Ludwig, JA1
Benjamin, RS2
Kriegsmann, K1
Heilig, C1
Cremer, M1
Novotny, P1
Kriegsmann, M1
Bruckner, T1
Müller-Tidow, C1
Egerer, G2
Wuchter, P1
Ahmed, SK1
Randall, RL1
Harmsen, WS1
Krailo, M4
Geller, DS1
Sorger, JI1
Granowetter, L3
Gorlick, RG1
Laack, NNI1
Jamshidi, K1
Ramezan Shirazi, M1
Bagherifard, A1
Mirzaei, A1
Elshahoubi, A1
Alnassan, A1
Lim, SH1
Lee, JY2
Kim, JH1
Choi, KH1
Hyun, JY1
Ko, YH1
Lee, J1
Kim, SJ1
Kim, WS1
Yamaoka, M1
Akiyama, M1
Yokokawa, Y1
Terao, Y1
Yokoi, K1
Kato, T1
Fukushima, T1
Sakurai, H1
Ida, H1
Clement, J1
Varlotto, J1
Rybka, W1
Frauenhoffer, E1
Drabick, JJ1
Lionel, AP1
John, RR1
Mathai, S1
Paioli, A1
Luksch, R3
Fagioli, F4
Tamburini, A3
Cesari, M3
Palmerini, E3
Abate, ME2
Marchesi, E1
Balladelli, A3
Pratelli, L1
Ferrari, S11
Zitelli, A1
Manfredelli, S1
Brunotti, G1
Marcantonio, M1
Pontone, S1
Angelici, A1
Lewis, I6
Ranft, A2
Le Teuff, G2
Michon, J3
van den Berg, H6
Hjorth, L3
Judson, I2
Juergens, H4
Craft, A5
Oberlin, O7
Dirksen, U4
Raciborska, A1
Bilska, K1
Drabko, K1
Chaber, R1
Sobol, G1
Pogorzała, M1
Wyrobek, E1
Połczyńska, K1
Rogowska, E1
Rodriguez-Galindo, C5
Wożniak, W1
Biswas, B1
Rastogi, S1
Khan, SA1
Shukla, NK1
Deo, SV1
Agarwala, S1
Mohanti, BK1
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Clinical Trials (17)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Analyzing Engagement Trends in Rhabdomyosarcoma Clinical Trials: A Study of Participation Patterns Among Those Affected by the Disorder[NCT06029465]500 participants (Anticipated)Observational2024-10-31Not yet recruiting
European Ewing Tumour Working Initiative of National Groups Ewing Tumour Studies 1999 (EURO-E.W.I.N.G.99)[NCT00020566]Phase 31,200 participants (Anticipated)Interventional2001-02-28Recruiting
Phase 3, Open Label, Multi-centre, Randomised Controlled International Study in Ewing Sarcoma[NCT00987636]Phase 3907 participants (Actual)Interventional2009-10-01Completed
Functional and Clinical Long-Term Outcome of Ewing Sarcoma Treatment[NCT00824083]950 participants (Actual)Observational2009-07-31Completed
Chemotherapy-induced Necrosis in Ewing Sarcoma: Which is the Best Scoring Tool[NCT03968471]474 participants (Actual)Observational2019-05-13Completed
EUROPEAN INTERGROUP COOPERATIVE EWING'S SARCOMA STUDY [EICESS 92][NCT00002516]Phase 30 participants Interventional1992-07-31Active, not recruiting
A Randomised Phase-III Trial of the Cooperative Weichteilsarkom Study Group (CWS) for Localised High-risk Rhabdomyosarcoma and Localised Rhabdomyosarcoma-like Soft Tissue Sarcoma in Children, Adolescents, and Young Adults[NCT00876031]Phase 3195 participants (Actual)Interventional2009-07-01Completed
Observational Study on Treatment of Skeletal Ewing Sarcoma at Diagnosis[NCT04845893]100 participants (Anticipated)Observational2021-06-01Recruiting
A Pilot Study of Low-Dose Antiangiogenic Chemotherapy in Combination With Standard Multiagent Chemotherapy for Patients With Newly Diagnosed Metastatic Ewing Sarcoma Family of Tumors[NCT00061893]Phase 238 participants (Actual)Interventional2004-04-30Completed
Trial of Chemotherapy Intensification Through Compression in Ewing's Sarcoma and Related Tumors[NCT00006734]Phase 3587 participants (Actual)Interventional2001-05-31Completed
Prospective Evaluation of the Prognostic Relevance of PCR Positivity in Blood and Bone Marrow in Non-Metastatic Ewings Sarcoma[NCT00339898]414 participants (Actual)Observational2004-03-12Completed
A Pilot Study of Tumor Vaccination and R-hIL-7 Following Standard Multimodality Therapy in Patients With High Risk Pediatric Solid Tumors[NCT00923351]Phase 1/Phase 244 participants (Actual)Interventional2007-06-02Completed
Phase II Study of Cyclophosphamide, Doxorubicin, Vincristine, Etoposide, and Ifosfamide, Followed by Resection and Radiotherapy in Patients With Peripheral Primitive Neuroectodermal Tumors or Ewing's Sarcoma[NCT00002466]Phase 20 participants Interventional1990-05-31Completed
INTENSIVE THERAPY WITH GROWTH FACTOR SUPPORT FOR PATIENTS WITH EWING'S TUMOR METASTATIC AT DIAGNOSIS: A PEDIATRIC ONCOLOGY GROUP PHASE II STUDY[NCT00002643]Phase 2130 participants (Actual)Interventional1995-04-30Completed
Assessment of MGMT Promoter Methylation and Clinical Benefit From Temozolomide-based Therapy in Ewing Sarcoma Patients[NCT03542097]82 participants (Actual)Observational2014-04-15Completed
A Pilot Study Investigating Neoadjuvant Temozolomide-based Proton Chemoradiotherapy for High-Risk Soft Tissue Sarcomas[NCT00881595]Phase 20 participants (Actual)Interventional2009-02-28Withdrawn (stopped due to No patients accrued since study opened)
Pilot Study of Allogeneic/Syngeneic Blood Stem Cell Transplantation in Patients With High-Risk and Recurrent Pediatric Sarcomas[NCT00043979]Phase 260 participants (Actual)Interventional2002-09-19Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Event Free Survival

(NCT00061893)
Timeframe: 24 months after start of protocol therapy

Interventionpercentage of participants (Number)
Combination Chemotherapy35

Occurrence of Severe Toxicity

An incidence of severe toxicity is defined to be the occurrence of grade 3 or higher infection or grade 3 or higher sensory neuropathy during cycles 1-2 of protocol therapy. If 12 or more patients experience grade 3 or higher infection or five or more patients experience grade 3 or higher sensory neuropathy during cycles 1-2 of protocol therapy, the regimen will be flagged as being associated with an excessive rate of severe toxicity. (NCT00061893)
Timeframe: The first two cycles (6 weeks) of protocol chemotherapy

Interventionparticipants (Number)
Grade 3 or Higher InfectionGrade 3 or Higher Sensory Neuropathy
Combination Chemotherapy11

Number of Participants With a Positive Immune Response as Evidenced by the Delayed Type of Hypersensitivity (DTH) Reaction Assay

"A positive response to the tumor vaccine requires a positive reaction in at least one of the two assays below (immune responses to tumor lysates using ex vivo and delayed type of hypersensitivity (DTH).~The presence of a positive delayed type of hypersensitivity (DTH) reaction to the tumor lysate in a patient who did not show a positive DTH reaction prior to immunotherapy. A positive reaction is induration of at least 0.5 cm.~Immunotherapy administered to patients with recurrent or metastatic pediatric solid tumors such as Ewing's sarcoma, rhabdomyosarcoma, or neuroblastoma. Each vaccine is given as 6 separate injections. Three intradermal on one arm or leg and three subcutaneous on the other arm or leg." (NCT00923351)
Timeframe: Week 8, 14, 20 (Arm A) and on Days 42, 84 and 126 (± 7 days) (Arm B)

InterventionParticipants (Count of Participants)
Arm A - Participants Who Did Not Receive rhIL-70
Arm B - Participants Who Received rhIL-715

Overall Survival

Overall survival is defined as the time between the first day of treatment to the day of death. (NCT00923351)
Timeframe: Time between the first day of treatment to the day of death or at the conclusion of 5 years of follow-up, whichever comes first, assessed up to approximately 11 years.

Interventionyears (Median)
Arm A - Participants Who Did Not Receive rhIL-72.4
Arm B - Participants Who Received rhIL-74.3

Toxicity

Here is the number of participants with adverse events. For a detailed list of adverse events, see the adverse event module. (NCT00923351)
Timeframe: Date treatment consent signed to date off study, approximately 49.5 months

InterventionParticipants (Count of Participants)
Arm A - Participants Who Did Not Receive rhIL-76
Arm B - Participants Who Received rhIL-724

Cluster of Differentiation 4 (CD4) Reconstitution

The median CD4 count with a range of 85-1565 (absolute count) was used to determine recovery and were considered recovered if in this range. The CD4 count was established by flow cytometry testing. (NCT00043979)
Timeframe: Day +28-42

Interventionmm(3) (Median)
Arm 2-Recipients284

Early Post Transplantation Relapse

Participants who experienced recurrence or progression of disease following transplant. (NCT00043979)
Timeframe: up to 300 days

InterventionDays (Median)
Arm 2-Recipients100

Median Progression Free Survival

Progression free survival was based on the time from on-study date until progression or last follow-up. (NCT00043979)
Timeframe: up to 77 months

InterventionMonths (Median)
Arm 2-Recipients15.9

Median Time to Reach a Platelet Count of 50,000/mm(3)

Days for participants to achieve a platelet count of 50,000/mm(3). (NCT00043979)
Timeframe: up to 43 days

InterventionDays (Median)
Arm 2-Recipients15

Median Time to Reach Absolute Neutrophil Count of 500/mm(3)

Days for participants to achieve a neutrophil count of 500/mm(3). (NCT00043979)
Timeframe: up to 12 days

InterventionDays (Median)
Arm 2-Recipients9

Number of Participants Who Experienced Graft Versus Tumor Effect (GVT)

GVT is defined as tumor response after day 42 post-transplantation without cytotoxic therapy. (NCT00043979)
Timeframe: up to day 100

InterventionParticipants (Count of Participants)
Arm 2-Recipients0

Number of Participants With Engraftment

Engraftment is defined as rapid conversion to complete donor chimerism and is assessed by blood counts and chimerism, >95% donor engraftment at day 100 in >75% of patients. (NCT00043979)
Timeframe: 100 days

InterventionParticipants (Number)
Arm 2-Recipients23

Toxicity

Here is the number of participants with adverse events. For a detailed list of adverse events see the adverse event module. (NCT00043979)
Timeframe: 16.5 months

InterventionParticipants (Number)
Arm 2-Recipients30

Best Response Post-Hematopoietic Stem Cell Transplant EOCH (Etoposide, Vincristine, Cyclophosphamide, and Doxorubicin)

Response is defined by the Response Evaluation Criteria in Solid Tumors (RECIST). RECIST criteria offer a simplified, conservative, extraction of imaging data for wide application in clinical trials. They presume that linear measures are an adequate substitute for 2-D (dimensional) methods and registers four response categories: Complete response (CR) is disappearance of all target lesions. Partial response (PR) is 30% increase in the sum of the longest diameter of target lesions. Progressive disease (PD) is 20% increase in the sum of the longest diameter of target lesions. Stable disease (SD) is small changes that do not meet above criteria. For the purposes of this study very good partial response ((VGPR) is >75% reduction in disease) was also employed. (NCT00043979)
Timeframe: up to 10 cycles of therapy or 280 days

InterventionParticipants (Count of Participants)
Complete Response (CR)Progressive Disease (PD)Partial Response (PR)Very Good Partial Response (VGPR)
Arm 2-Recipients2442

Median Survival From Date of Progression

Median survival from date of progression is based on the time from on-study date until progression or last follow-up. (NCT00043979)
Timeframe: up to 77 months

InterventionMonths (Median)
Participants who did not receive a transplant(n=7)Participants who received a transplant (n=23)
Arm 2-Recipients3.319.1

Number of Participants to Complete Conversion to >95% Donor Chimerism

Participants who tolerated the transplantation regimen and accepted >95% of the donors blood, marrow, and/or tissue. (NCT00043979)
Timeframe: up to 30 days

InterventionParticipants (Count of Participants)
Day +14Day +28
Arm 2-Recipients2323

Number of Participants With Acute and Chronic GVHD

Acute GVHD as by Modified Glucksberg Criteria occurring before day 100. Chronic GVHD as per Seattle criteria occurring after day 100. (NCT00043979)
Timeframe: up to 5 years or death

,
Interventionparticipants (Number)
acute GVHDchronic GVHD
Recipients -Cyclosporine GVHD Prophylaxis1212
Recipients -Tacrolimus/Sirolimus GVHD Prophylaxis55

Post-Hematopoietic Stem Cell Transplant (HSCT) Radiotherapy

Site of radiotherapy (high energy radiation) and/or toxicity experienced by the participants post HSCT radiotherapy. Grading was preformed using the Modified Glucksberg Criteria. (NCT00043979)
Timeframe: up to 6 cycles or 168 days

InterventionParticipants (Count of Participants)
Chest wall; G2 skinAbdomen; G4 GIPancreas; G4 LFTs, G4 pancreatitisPleura, mediastinum; G4 LFTs, G2 mucositisChest wall; G4 skin, G3 mucositisSpine, skull; G2 nausea+vomiting, G2 fatiguePelvis; G4 enteritisPulmonary (cyberknife)Brain; B3 mucositisWhole lung; G3 mucositis, G3 skin, G5 lungL arm, R shoulder, B/L femur
Arm 2-Recipients11111111111

Two Year Survival Rate for Patients Undergoing Allo-Hematopoietic Stem Cell Transplant

Participants who are alive at two years following Allo-Hematopoietic Stem Cell Transplant. (NCT00043979)
Timeframe: 2 years

Interventionpercentage of participants (Number)
From date of enrollmentFrom date of transplantation
Arm 2-Recipients39.134.8

Reviews

15 reviews available for ifosfamide and Ewing Sarcoma

ArticleYear
Clinical characteristics of primary cutaneous and subcutaneous Ewing sarcoma.
    Japanese journal of clinical oncology, 2023, Jun-29, Volume: 53, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cyclophosphamide; Doxorubicin; Etopo

2023
Primary Ewing sarcoma of the larynx with distant metastasis: a case report and review of the literature.
    Current oncology (Toronto, Ont.), 2019, Volume: 26, Issue:4

    Topics: Antineoplastic Agents; Bone Neoplasms; Chemoradiotherapy; Cyclophosphamide; Dactinomycin; Etoposide;

2019
Unusual presentation of Ewing sarcoma in the adrenal gland: a secondary malignancy from a survivor of Burkitt lymphoma.
    Japanese journal of clinical oncology, 2013, Volume: 43, Issue:6

    Topics: Adrenal Gland Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Cyclophos

2013
Efficacy Comparison of Six Chemotherapeutic Combinations for Osteosarcoma and Ewing's Sarcoma Treatment: A Network Meta-Analysis.
    Journal of cellular biochemistry, 2018, Volume: 119, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Disease-Free Survival; Etoposide; Fe

2018
Extraskeletal Ewing's sarcoma of the thoracic epidural space: case report and review of the literature.
    Oncology reports, 2011, Volume: 26, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Epidural Neopl

2011
Ifosfamide in pediatric solid tumors.
    Oncology, 2003, Volume: 65 Suppl 2

    Topics: Antineoplastic Agents, Alkylating; Bone Neoplasms; Child; Cyclophosphamide; Germinoma; Humans; Ifosf

2003
Good outcome for infant of mother treated with chemotherapy for ewing sarcoma at 25 to 30 weeks' gestation.
    Journal of pediatric hematology/oncology, 2004, Volume: 26, Issue:5

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Female; Gestational Age; Hu

2004
[Soft tissue sarcoma: postoperative chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Combined Modality Therapy; Cyclophos

2004
Long-term follow up of high-dose chemotherapy with autologous stem cell rescue in adults with Ewing tumor.
    American journal of clinical oncology, 2005, Volume: 28, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols

2005
Extraskeletal Ewing's sarcoma: a case report and review of the literature.
    Spine, 2000, Aug-01, Volume: 25, Issue:15

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cervical Vertebrae; Combined Modality Therapy

2000
How effective is dose-intensive/myeloablative therapy against Ewing's sarcoma/primitive neuroectodermal tumor metastatic to bone or bone marrow? The Memorial Sloan-Kettering experience and a literature review.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Feb-01, Volume: 19, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Neoplasms; Bone Neopl

2001
Concurrent ifosfamide-based chemotherapy and irradiation. Analysis of treatment-related toxicity in 43 patients with sarcoma.
    Cancer, 2001, Sep-15, Volume: 92, Issue:6

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Bone Neoplasms; Child; Child, Preschool; Combined Mo

2001
Chemotherapy of advanced sarcomas of bone and soft tissue.
    Seminars in oncology, 1992, Volume: 19, Issue:6 Suppl 12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Clinical Trials as Topic; Dacarbazin

1992
The role of ifosfamide in the treatment of adult soft tissue sarcomas, Ewing's sarcoma, and osteosarcoma: a review.
    Seminars in oncology, 1990, Volume: 17, Issue:2 Suppl 4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Humans; Ifosfamide; Osteosarcoma; Sarcoma; Sarcoma,

1990
The role of ifosfamide in the treatment of sarcomas.
    Seminars in oncology, 1989, Volume: 16, Issue:1 Suppl 3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Humans; Ifosfamide; Osteosarcoma; Sarcoma; Sa

1989

Trials

50 trials available for ifosfamide and Ewing Sarcoma

ArticleYear
Long-term results from the multicentric European randomized phase 3 trial CWS/RMS-96 for localized high-risk soft tissue sarcoma in children, adolescents, and young adults.
    Pediatric blood & cancer, 2022, Volume: 69, Issue:9

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Dactinomycin; Doxorubicin; Humans

2022
Radiation Therapy Dose Escalation in Unresectable Ewing Sarcoma: Final Results of a Phase 3 Randomized Controlled Trial.
    International journal of radiation oncology, biology, physics, 2022, 08-01, Volume: 113, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Etoposide; Fema

2022
Late toxicity comparison of alkylating-based maintenance regimen with cyclophosphamide (VAC) vs ifosfamide (VAI) in Ewing sarcoma survivors treated in the randomized clinical trial Euro-EWING99-R1 in France.
    International journal of cancer, 2023, 04-15, Volume: 152, Issue:8

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cyclophosphamide; Dactin

2023
Comparison of two chemotherapy regimens in patients with newly diagnosed Ewing sarcoma (EE2012): an open-label, randomised, phase 3 trial.
    Lancet (London, England), 2022, 10-29, Volume: 400, Issue:10362

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bayes Theorem; Bone Neoplasms; Busulfan; Cyclophosph

2022
Comparison of two chemotherapy regimens in patients with newly diagnosed Ewing sarcoma (EE2012): an open-label, randomised, phase 3 trial.
    Lancet (London, England), 2022, 10-29, Volume: 400, Issue:10362

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bayes Theorem; Bone Neoplasms; Busulfan; Cyclophosph

2022
Comparison of two chemotherapy regimens in patients with newly diagnosed Ewing sarcoma (EE2012): an open-label, randomised, phase 3 trial.
    Lancet (London, England), 2022, 10-29, Volume: 400, Issue:10362

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bayes Theorem; Bone Neoplasms; Busulfan; Cyclophosph

2022
Comparison of two chemotherapy regimens in patients with newly diagnosed Ewing sarcoma (EE2012): an open-label, randomised, phase 3 trial.
    Lancet (London, England), 2022, 10-29, Volume: 400, Issue:10362

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bayes Theorem; Bone Neoplasms; Busulfan; Cyclophosph

2022
Long-Term Outcomes in Patients With Localized Ewing Sarcoma Treated With Interval-Compressed Chemotherapy on Children's Oncology Group Study AEWS0031.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2023, 10-20, Volume: 41, Issue:30

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Doxorubicin; Etoposide; Human

2023
International randomised controlled trial for the treatment of newly diagnosed EWING sarcoma family of tumours - EURO EWING 2012 Protocol.
    Trials, 2020, Jan-17, Volume: 21, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Density Conservation Agents;

2020
Extraskeletal Ewing sarcoma in children, adolescents, and young adults. An analysis of three prospective studies of the Cooperative Weichteilsarkomstudiengruppe (CWS).
    Pediatric blood & cancer, 2021, Volume: 68, Issue:10

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cyclophosphamide;

2021
Chemotherapy-related toxicity in patients with non-metastatic Ewing sarcoma: influence of sex and age.
    Journal of chemotherapy (Florence, Italy), 2014, Volume: 26, Issue:1

    Topics: Adolescent; Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chil

2014
Cyclophosphamide compared with ifosfamide in consolidation treatment of standard-risk Ewing sarcoma: results of the randomized noninferiority Euro-EWING99-R1 trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Aug-10, Volume: 32, Issue:23

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Consolidation Chemotherapy; C

2014
Ifosfamide dose-intensification for patients with metastatic Ewing sarcoma.
    Pediatric blood & cancer, 2015, Volume: 62, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Bone Neoplasms; Child; Disease-Free Survival;

2015
Carboplatin in the treatment of Ewing sarcoma: Results of the first Brazilian collaborative study group for Ewing sarcoma family tumors-EWING1.
    Pediatric blood & cancer, 2015, Volume: 62, Issue:10

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Brazil; Carboplatin; Chi

2015
Tandem high-dose chemotherapy strategy as first-line treatment of primary disseminated multifocal Ewing sarcomas in children, adolescents and young adults.
    Bone marrow transplantation, 2015, Volume: 50, Issue:8

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Child; Child,

2015
Impact of gender on efficacy and acute toxicity of alkylating agent -based chemotherapy in Ewing sarcoma: secondary analysis of the Euro-Ewing99-R1 trial.
    European journal of cancer (Oxford, England : 1990), 2015, Volume: 51, Issue:16

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bone

2015
Results of the EICESS-92 Study: two randomized trials of Ewing's sarcoma treatment--cyclophosphamide compared with ifosfamide in standard-risk patients and assessment of benefit of etoposide added to standard treatment in high-risk patients.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Sep-20, Volume: 26, Issue:27

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Pre

2008
Results of the EICESS-92 Study: two randomized trials of Ewing's sarcoma treatment--cyclophosphamide compared with ifosfamide in standard-risk patients and assessment of benefit of etoposide added to standard treatment in high-risk patients.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Sep-20, Volume: 26, Issue:27

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Pre

2008
Results of the EICESS-92 Study: two randomized trials of Ewing's sarcoma treatment--cyclophosphamide compared with ifosfamide in standard-risk patients and assessment of benefit of etoposide added to standard treatment in high-risk patients.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Sep-20, Volume: 26, Issue:27

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Pre

2008
Results of the EICESS-92 Study: two randomized trials of Ewing's sarcoma treatment--cyclophosphamide compared with ifosfamide in standard-risk patients and assessment of benefit of etoposide added to standard treatment in high-risk patients.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Sep-20, Volume: 26, Issue:27

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Pre

2008
Results of the EICESS-92 Study: two randomized trials of Ewing's sarcoma treatment--cyclophosphamide compared with ifosfamide in standard-risk patients and assessment of benefit of etoposide added to standard treatment in high-risk patients.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Sep-20, Volume: 26, Issue:27

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Pre

2008
Results of the EICESS-92 Study: two randomized trials of Ewing's sarcoma treatment--cyclophosphamide compared with ifosfamide in standard-risk patients and assessment of benefit of etoposide added to standard treatment in high-risk patients.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Sep-20, Volume: 26, Issue:27

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Pre

2008
Results of the EICESS-92 Study: two randomized trials of Ewing's sarcoma treatment--cyclophosphamide compared with ifosfamide in standard-risk patients and assessment of benefit of etoposide added to standard treatment in high-risk patients.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Sep-20, Volume: 26, Issue:27

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Pre

2008
Results of the EICESS-92 Study: two randomized trials of Ewing's sarcoma treatment--cyclophosphamide compared with ifosfamide in standard-risk patients and assessment of benefit of etoposide added to standard treatment in high-risk patients.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Sep-20, Volume: 26, Issue:27

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Pre

2008
Results of the EICESS-92 Study: two randomized trials of Ewing's sarcoma treatment--cyclophosphamide compared with ifosfamide in standard-risk patients and assessment of benefit of etoposide added to standard treatment in high-risk patients.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Sep-20, Volume: 26, Issue:27

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Pre

2008
Cooperative trial CWS-91 for localized soft tissue sarcoma in children, adolescents, and young adults.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Mar-20, Volume: 27, Issue:9

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined

2009
Dose-intensified compared with standard chemotherapy for nonmetastatic Ewing sarcoma family of tumors: a Children's Oncology Group Study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, May-20, Volume: 27, Issue:15

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool;

2009
Chemotherapy: The role of ifosfamide and etoposide in Ewing sarcoma.
    Nature reviews. Clinical oncology, 2009, Volume: 6, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dactinomycin; Disease-Free Surviva

2009
Tandem high-dose chemotherapy followed by autologous transplantation in patients with locally advanced or metastatic sarcoma.
    Anticancer research, 2009, Volume: 29, Issue:8

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Combined Modality

2009
Results of RS-99 protocol for childhood solid tumors.
    World journal of pediatrics : WJP, 2010, Volume: 6, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant;

2010
Primary disseminated multifocal Ewing sarcoma: results of the Euro-EWING 99 trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Jul-10, Volume: 28, Issue:20

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined

2010
Primary disseminated multifocal Ewing sarcoma: results of the Euro-EWING 99 trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Jul-10, Volume: 28, Issue:20

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined

2010
Primary disseminated multifocal Ewing sarcoma: results of the Euro-EWING 99 trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Jul-10, Volume: 28, Issue:20

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined

2010
Primary disseminated multifocal Ewing sarcoma: results of the Euro-EWING 99 trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Jul-10, Volume: 28, Issue:20

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined

2010
Nonmetastatic Ewing family tumors: high-dose chemotherapy with stem cell rescue in poor responder patients. Results of the Italian Sarcoma Group/Scandinavian Sarcoma Group III protocol.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2011, Volume: 22, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Busulfan; Child;

2011
Treatment of Ewing sarcoma family of tumors with a modified P6 protocol in children and adolescents.
    Pediatric blood & cancer, 2011, Jul-15, Volume: 57, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamid

2011
A pilot study of low-dose anti-angiogenic chemotherapy in combination with standard multiagent chemotherapy for patients with newly diagnosed metastatic Ewing sarcoma family of tumors: A Children's Oncology Group (COG) Phase II study NCT00061893.
    Pediatric blood & cancer, 2013, Volume: 60, Issue:3

    Topics: Adolescent; Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Celecoxib; Chil

2013
Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012, Nov-20, Volume: 30, Issue:33

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Pre

2012
Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012, Nov-20, Volume: 30, Issue:33

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Pre

2012
Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012, Nov-20, Volume: 30, Issue:33

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Pre

2012
Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012, Nov-20, Volume: 30, Issue:33

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Pre

2012
Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone.
    The New England journal of medicine, 2003, Feb-20, Volume: 348, Issue:8

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cyclophosp

2003
Long-term event-free survival after intensive chemotherapy for Ewing's family of tumors in children and young adults.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Sep-15, Volume: 21, Issue:18

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Pre

2003
Treatment of metastatic Ewing's sarcoma or primitive neuroectodermal tumor of bone: evaluation of combination ifosfamide and etoposide--a Children's Cancer Group and Pediatric Oncology Group study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Jul-15, Volume: 22, Issue:14

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Pre

2004
High histologic and overall response to dose intensification of ifosfamide, carboplatin, and etoposide with cyclophosphamide, doxorubicin, and vincristine in patients with high-risk Ewing sarcoma family tumors: the Bambino Gesù Children's Hospital experie
    Cancer, 2006, Apr-15, Volume: 106, Issue:8

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Carboplatin; Child; Chil

2006
Concomitant administration of vincristine, doxorubicin, cyclophosphamide, ifosfamide, and etoposide for high-risk sarcomas: the St. Jude Children's Research Hospital experience.
    Cancer, 2006, Apr-15, Volume: 106, Issue:8

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Combined M

2006
Local control in pelvic Ewing sarcoma: analysis from INT-0091--a report from the Children's Oncology Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Aug-20, Volume: 24, Issue:24

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child

2006
Therapy-related myelodysplasia and acute myeloid leukemia after Ewing sarcoma and primitive neuroectodermal tumor of bone: A report from the Children's Oncology Group.
    Blood, 2007, Jan-01, Volume: 109, Issue:1

    Topics: Acute Disease; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Ch

2007
[Preliminary evaluation of the effectiveness of holoxan in the treatment of malignant soft tissue and bone neoplasms].
    Nowotwory, 1981, Volume: 31, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Agents; Bone Neoplasms; Child; Child, Preschool; Clinical Trials a

1981
Very-high-dose short-term chemotherapy for poor-risk peripheral primitive neuroectodermal tumors, including Ewing's sarcoma, in children and young adults.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:11

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Pr

1995
Radiation therapy in Ewing's sarcoma: an update of the CESS 86 trial.
    International journal of radiation oncology, biology, physics, 1995, Jul-15, Volume: 32, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Combined M

1995
Salvage chemotherapy for recurrent Ewing's sarcomas.
    Neoplasma, 1995, Volume: 42, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cyclophosphamide;

1995
No advantages in the addition of ifosfamide and VP-16 to the standard four-drug regimen in the maintenance phase of neoadjuvant chemotherapy of Ewing's sarcoma of bone: results of two sequential studies.
    Journal of chemotherapy (Florence, Italy), 1993, Volume: 5, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adj

1993
Ifosfamide and etoposide plus vincristine, doxorubicin, and cyclophosphamide for newly diagnosed Ewing's sarcoma family of tumors.
    Cancer, 1996, Aug-15, Volume: 78, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cyclophosp

1996
Neoadjuvant chemotherapy for Ewing's sarcoma of bone: no benefit observed after adding ifosfamide and etoposide to vincristine, actinomycin, cyclophosphamide, and doxorubicin in the maintenance phase--results of two sequential studies.
    Cancer, 1998, Mar-15, Volume: 82, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adj

1998
The pharmacokinetics and metabolism of ifosfamide during bolus and infusional administration: a randomized cross-over study.
    British journal of cancer, 1998, Volume: 77, Issue:6

    Topics: Adult; Aged; Antineoplastic Agents; Biotransformation; Cross-Over Studies; Cyclophosphamide; Dexamet

1998
A Southwest Oncology Group and Cancer and Leukemia Group B phase II study of doxorubicin, dacarbazine, ifosfamide, and mesna in adults with advanced osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma.
    Cancer, 1998, Apr-01, Volume: 82, Issue:7

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Doxorubicin; F

1998
Ifosfamide-containing chemotherapy in Ewing's sarcoma: The Second United Kingdom Children's Cancer Study Group and the Medical Research Council Ewing's Tumor Study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:11

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Pre

1998
Radiotherapy in Ewing's sarcoma and PNET of the chest wall: results of the trials CESS 81, CESS 86 and EICESS 92.
    International journal of radiation oncology, biology, physics, 1998, Dec-01, Volume: 42, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Combined Modality Therapy; Cyclophos

1998
Ifosfamide and actinomycin-D, added in the induction phase to vincristine, cyclophosphamide and doxorubicin, improve histologic response and prognosis in patients with non metastatic Ewing's sarcoma of the extremity.
    Journal of chemotherapy (Florence, Italy), 1998, Volume: 10, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols

1998
Evaluation of prognostic factors in a tumor volume-adapted treatment strategy for localized Ewing sarcoma of bone: the CESS 86 experience. Cooperative Ewing Sarcoma Study.
    Medical and pediatric oncology, 1999, Volume: 32, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Pre

1999
Chemotherapy dose-intensification for pediatric patients with Ewing's family of tumors and desmoplastic small round-cell tumors: a feasibility study at St. Jude Children's Research Hospital.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Volume: 17, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Pre

1999
WR-2721 (amifostine) infusion in patients with Ewing's sarcoma receiving ifosfamide and cyclophosphamide with mesna: drug and thiol levels in plasma and blood cells, a Pediatric Oncology Group study.
    Cancer chemotherapy and pharmacology, 1999, Volume: 44, Issue:6

    Topics: Adolescent; Adult; Amifostine; Antineoplastic Combined Chemotherapy Protocols; Blood Cells; Bone Neo

1999
Five-year results in Ewing's sarcoma. The Scandinavian Sarcoma Group experience with the SSG IX protocol.
    European journal of cancer (Oxford, England : 1990), 2000, Volume: 36, Issue:7

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Chil

2000
Second malignancies after ewing tumor treatment in 690 patients from a cooperative German/Austrian/Dutch study.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2001, Volume: 12, Issue:11

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Pre

2001
Radiation therapy as local treatment in Ewing's sarcoma. Results of the Cooperative Ewing's Sarcoma Studies CESS 81 and CESS 86.
    Cancer, 1991, Jun-01, Volume: 67, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclophosphamide; Dactino

1991
Initial chemotherapy including ifosfamide in the management of Ewing's sarcoma: preliminary results. A protocol of the French Pediatric Oncology Society (SFOP).
    Cancer chemotherapy and pharmacology, 1989, Volume: 24 Suppl 1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool;

1989

Other Studies

123 other studies available for ifosfamide and Ewing Sarcoma

ArticleYear
Feasibility and safety of outpatient administration of ifosfamide and etoposide for pediatric patients with Ewing sarcoma in a resource-limited setting amid the COVID-19 pandemic.
    Pediatric blood & cancer, 2022, Volume: 69, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; COVID-19 Drug Treatment; Etoposide; Feasibili

2022
Outcomes of Pediatric Patients With Metastatic Ewing Sarcoma Treated With Interval Compression.
    Journal of pediatric hematology/oncology, 2023, 04-01, Volume: 45, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool;

2023
Analysis of stem cell collections in adult patients with Ewing sarcoma.
    Transfusion, 2022, Volume: 62, Issue:8

    Topics: Adult; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Child; Doxorubic

2022
Dual enzyme therapy improves adherence to chemotherapy in a patient with gaucher disease and Ewing sarcoma.
    Pediatric hematology and oncology, 2023, Volume: 40, Issue:4

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cyclophosphamide;

2023
Rare presentation in a rare case of pancreatic extraosseous Ewing's sarcoma: A case report.
    Medicine, 2022, Nov-25, Volume: 101, Issue:47

    Topics: Adolescent; Cyclophosphamide; Dysuria; Epirubicin; Etoposide; Flank Pain; Humans; Ifosfamide; Male;

2022
Rare presentation in a rare case of pancreatic extraosseous Ewing's sarcoma: A case report.
    Medicine, 2022, Nov-25, Volume: 101, Issue:47

    Topics: Adolescent; Cyclophosphamide; Dysuria; Epirubicin; Etoposide; Flank Pain; Humans; Ifosfamide; Male;

2022
Rare presentation in a rare case of pancreatic extraosseous Ewing's sarcoma: A case report.
    Medicine, 2022, Nov-25, Volume: 101, Issue:47

    Topics: Adolescent; Cyclophosphamide; Dysuria; Epirubicin; Etoposide; Flank Pain; Humans; Ifosfamide; Male;

2022
Rare presentation in a rare case of pancreatic extraosseous Ewing's sarcoma: A case report.
    Medicine, 2022, Nov-25, Volume: 101, Issue:47

    Topics: Adolescent; Cyclophosphamide; Dysuria; Epirubicin; Etoposide; Flank Pain; Humans; Ifosfamide; Male;

2022
Successful Treatment of Patient With Ewing Sarcoma in the Setting of Inherited Cholestatic Liver Disease.
    Journal of pediatric hematology/oncology, 2023, Jul-01, Volume: 45, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cholestasis; Cholestasis, Intrahepat

2023
Outcomes of extraskeletal vs. skeletal Ewing sarcoma patients treated with standard chemotherapy protocol.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2020, Volume: 22, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Combined Modality Therapy; Cyclophos

2020
Impact of chemotherapy cycles and intervals on outcomes of nonspinal Ewing sarcoma in adults: a real-world experience.
    BMC cancer, 2019, Dec-02, Volume: 19, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adj

2019
Challenges in the management of localized Ewing sarcoma in a developing country.
    Pediatric hematology and oncology, 2020, Volume: 37, Issue:7

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool;

2020
[A Case of Primary Ewing Sarcoma of the Kidney Treated with Multidisciplinary Approach].
    Hinyokika kiyo. Acta urologica Japonica, 2020, Volume: 66, Issue:9

    Topics: Female; Homeobox Protein Nkx-2.2; Homeodomain Proteins; Humans; Ifosfamide; In Situ Hybridization, F

2020
A Case of Ewing Sarcoma of the Bladder Presenting in Early Infancy.
    Journal of pediatric hematology/oncology, 2021, 05-01, Volume: 43, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cyclophosphamide; Doxorubicin; Etopo

2021
Adolescent-adult nonmetastatic Ewing sarcoma-Experience from a large developing country.
    Pediatric blood & cancer, 2021, Volume: 68, Issue:9

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cyclophosphamide;

2021
Vincristine, Ifosfamide, and Doxorubicin for Initial Treatment of Ewing Sarcoma in Adults.
    The oncologist, 2017, Volume: 22, Issue:10

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Disease-Free Survival; Doxorubici

2017
Successful collection of peripheral blood stem cells upon VIDE chemomobilization in sarcoma patients.
    European journal of haematology, 2017, Volume: 99, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Cell Separation; Doxorubicin; Eto

2017
Identification of Patients With Localized Ewing Sarcoma at Higher Risk for Local Failure: A Report From the Children's Oncology Group.
    International journal of radiation oncology, biology, physics, 2017, 12-01, Volume: 99, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Pre

2017
Curettage, phenolization, and cementation in paediatric Ewing's sarcoma with a complete radiological response to neoadjuvant chemotherapy.
    International orthopaedics, 2019, Volume: 43, Issue:2

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Bone Neoplasms; Case-

2019
Safety and Cost-effectiveness of Outpatient Administration of High-dose Chemotherapy in Children With Ewing Sarcoma.
    Journal of pediatric hematology/oncology, 2019, Volume: 41, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cost-Benefit An

2019
Multidisciplinary therapy including proton beam radiotherapy for a Ewing sarcoma family tumor of maxillary sinus in a 4-year-old girl.
    Head & neck, 2013, Volume: 35, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Combined Modality Therapy; Cycloph

2013
Unusual case of recurrent extraneural metastatic medulloblastoma in a young adult: durable complete remission with Ewing sarcoma chemotherapy regimen and consolidation with autologous bone marrow transplantation and local radiation.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013, Jul-01, Volume: 31, Issue:19

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Axilla; Biopsy; Cerebellar Neoplasms; Cycloph

2013
Ifosfamide induced renal rickets.
    Indian journal of pediatrics, 2014, Volume: 81, Issue:9

    Topics: Antineoplastic Agents, Alkylating; Bone Neoplasms; Child, Preschool; Chronic Kidney Disease-Mineral

2014
Extraskeletal Ewing's Sarcoma: insight into a ten years follow-up.
    La Clinica terapeutica, 2013, Volume: 164, Issue:5

    Topics: Abdominal Neoplasms; Abdominal Pain; Adult; Antineoplastic Combined Chemotherapy Protocols; Biomarke

2013
Validation of a multi-modal treatment protocol for Ewing sarcoma--a report from the polish pediatric oncology group.
    Pediatric blood & cancer, 2014, Volume: 61, Issue:12

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Pre

2014
Developing a prognostic model for localized Ewing sarcoma family of tumors: A single institutional experience of 224 cases treated with uniform chemotherapy protocol.
    Journal of surgical oncology, 2015, Volume: 111, Issue:6

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant;

2015
[VDC (A) + IE alternate chemotherapy].
    Nihon rinsho. Japanese journal of clinical medicine, 2015, Volume: 73 Suppl 2

    Topics: Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Humans; Ifosfamide; Prognosis; Sarcoma,

2015
Identification of Discrete Prognostic Groups in Ewing Sarcoma.
    Pediatric blood & cancer, 2016, Volume: 63, Issue:1

    Topics: Adolescent; Adult; Age Factors; Bone Neoplasms; Child; Child, Preschool; Databases, Factual; Etoposi

2016
PARP Inhibitors Sensitize Ewing Sarcoma Cells to Temozolomide-Induced Apoptosis via the Mitochondrial Pathway.
    Molecular cancer therapeutics, 2015, Volume: 14, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Dacarbazine; Dactinomyc

2015
Pilot Study of Adding Vincristine, Topotecan, and Cyclophosphamide to Interval-Compressed Chemotherapy in Newly Diagnosed Patients With Localized Ewing Sarcoma: A Report From the Children's Oncology Group.
    Pediatric blood & cancer, 2016, Volume: 63, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cyclophosphamide; Doxorubicin

2016
Ewing Sarcoma: A 15-Year Experience of a Single Center With the MSKCC P6 Treatment Protocol.
    Journal of pediatric hematology/oncology, 2016, Volume: 38, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool;

2016
Marriage and fertility in long-term survivors of childhood, adolescent and young adult (AYA) high-grade sarcoma.
    International journal of clinical oncology, 2016, Volume: 21, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols

2016
Treatment outcomes of Japanese patients with Ewing sarcoma: differences between skeletal and extraskeletal Ewing sarcoma.
    Japanese journal of clinical oncology, 2016, Volume: 46, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asian People; Bone Neoplasms; Chi

2016
Ewing sarcoma/primitive neuroectodermal tumor of the kidney treated with chemotherapy including ifosfamide.
    Pediatrics international : official journal of the Japan Pediatric Society, 2016, Volume: 58, Issue:8

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Female; Humans; Ifosfamide; Kidney Neoplasms; Magneti

2016
Maturation toward neuronal tissue in a Ewing sarcoma of bone after chemotherapy.
    Diagnostic pathology, 2016, Aug-09, Volume: 11, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Calmodulin-Binding Proteins; Cell Differentiation; C

2016
Ewing Sarcoma of the Bone With EWS/FLI1 Translocation After Successful Treatment of Primary Osteosarcoma.
    Journal of pediatric hematology/oncology, 2017, Volume: 39, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Cisplatin; Combined Modality The

2017
Myeloablative chemotherapy with autologous stem cell rescue for Ewing sarcoma.
    Bone marrow transplantation, 2008, Volume: 42, Issue:11

    Topics: Combined Modality Therapy; Etoposide; Humans; Ifosfamide; Myeloablative Agonists; Neoplasm Metastasi

2008
Long-lasting multiagent chemotherapy in adult high-risk Ewing's sarcoma of bone.
    Medical oncology (Northwood, London, England), 2009, Volume: 26, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Combined Modality

2009
Response to high-dose ifosfamide in patients with advanced/recurrent Ewing sarcoma.
    Pediatric blood & cancer, 2009, Volume: 52, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Agents; Child; Female; Humans; Ifosfamide; Male; Middle Aged; Neop

2009
Extra-osseous Ewing sarcoma.
    Pediatric hematology and oncology, 2009, Volume: 26, Issue:4

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Bone Neoplasms; Ch

2009
Local and systemic control of Ewing's bone sarcoma family tumors of the ribs.
    Journal of surgical oncology, 2009, Sep-01, Volume: 100, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Bone Plates; Chil

2009
Late effects surveillance system after childhood cancer in Germany, austria and parts of Switzerland--update 2009.
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2009, Volume: 185 Suppl 2

    Topics: Adolescent; Aftercare; Antineoplastic Combined Chemotherapy Protocols; Austria; Bone Neoplasms; Card

2009
Radiation toxicity following busulfan/melphalan high-dose chemotherapy in the EURO-EWING-99-trial: review of GPOH data.
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2009, Volume: 185 Suppl 2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Busulfan; Chemotherapy,

2009
Primary intradural Ewing's sarcoma of the cauda equina presenting with acute bleeding.
    Acta neurochirurgica, 2010, Volume: 152, Issue:3

    Topics: Acute Disease; Adult; Antineoplastic Combined Chemotherapy Protocols; Cauda Equina; Decompression, S

2010
Long-term evaluation of Ifosfamide-related nephrotoxicity in children.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Nov-10, Volume: 27, Issue:32

    Topics: Antineoplastic Agents, Alkylating; Child; Follow-Up Studies; Humans; Ifosfamide; Kidney; Kidney Dise

2009
Synergistic antitumor effect of melatonin with several chemotherapeutic drugs on human Ewing sarcoma cancer cells: potentiation of the extrinsic apoptotic pathway.
    Journal of pineal research, 2010, Volume: 48, Issue:1

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western;

2010
Primary Ewing's sarcoma/primitive neuroectodermal tumor of the kidney that responded to low-dose chemotherapy with ifosfamide, etoposide, and doxorubicin.
    International journal of clinical oncology, 2010, Volume: 15, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biopsy; Doxorubicin; Etoposide; Humans; Ifosfamide;

2010
Outcome analysis of patients with transformed teratoma to primitive neuroectodermal tumor.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2010, Volume: 21, Issue:9

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cyclophosph

2010
Extraskeletal Ewing's sarcoma family of tumours in adults: analysis of 57 patients from a single institution.
    Clinical oncology (Royal College of Radiologists (Great Britain)), 2010, Volume: 22, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Dactin

2010
Chest wall Ewing sarcoma family of tumors: long-term outcomes.
    International journal of radiation oncology, biology, physics, 2011, Sep-01, Volume: 81, Issue:1

    Topics: Adolescent; Adult; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Bone Neopla

2011
Zoledronic acid as a new adjuvant therapeutic strategy for Ewing's sarcoma patients.
    Cancer research, 2010, Oct-01, Volume: 70, Issue:19

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bone Neoplasms; Cell Line, Tumor

2010
Treatment outcome of Korean patients with localized Ewing sarcoma family of tumors: a single institution experience.
    Japanese journal of clinical oncology, 2011, Volume: 41, Issue:6

    Topics: Adolescent; Adult; Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Bleom

2011
Karyomegalic-like nephropathy, Ewing's sarcoma and ifosfamide therapy.
    Pediatric nephrology (Berlin, Germany), 2011, Volume: 26, Issue:7

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Biopsy; Cell Nucleus Shape; Chronic Disease; Disease

2011
[Primitive cutaneous Ewing's sarcoma: a diagnostic and therapeutic dilemma].
    Annales de dermatologie et de venereologie, 2011, Volume: 138, Issue:5

    Topics: 12E7 Antigen; Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Calmo

2011
Ewing sarcoma/primitive neuroectodermal tumor arising from the adrenal gland in an adolescent.
    Pediatric blood & cancer, 2011, Volume: 57, Issue:4

    Topics: Adolescent; Adrenal Cortex Neoplasms; Adrenalectomy; Antineoplastic Combined Chemotherapy Protocols;

2011
Extraskeletal Ewing's sarcoma family of tumors in adults: prognostic factors and clinical outcome.
    Japanese journal of clinical oncology, 2012, Volume: 42, Issue:5

    Topics: Adolescent; Adult; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Biomarkers,

2012
Metastatic extraosseous Ewing's sarcoma (EES)/primitive neuroectodermal tumor (PNET) of the kidney: 8-year durable response after induction and maintenance chemotherapy.
    Clinical genitourinary cancer, 2012, Volume: 10, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Doxorubicin; Etoposide; Humans; Ifosfamid

2012
Primary metastatic Ewing's family tumors: results of the Italian Sarcoma Group and Scandinavian Sarcoma Group ISG/SSG IV Study including myeloablative chemotherapy and total-lung irradiation.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2012, Volume: 23, Issue:11

    Topics: Adolescent; Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Neopl

2012
Regression of mesenchymal hamartoma of the liver with sarcoma chemotherapy.
    Journal of pediatric hematology/oncology, 2013, Volume: 35, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cyclophosphamide; Dactinomyci

2013
The Effects of N-acetylcysteine on ifosfamide efficacy in a mouse xenograft model.
    Anticancer research, 2012, Volume: 32, Issue:9

    Topics: Acetylcysteine; Animals; Antineoplastic Agents, Alkylating; Bone Neoplasms; Cell Growth Processes; C

2012
Case report: stimulation of puberty in a girl with chemo- and radiation therapy induced ovarian failure by transplantation of a small part of her frozen/thawed ovarian tissue.
    European journal of cancer (Oxford, England : 1990), 2013, Volume: 49, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cryopreservation; Cyclophosphamide;

2013
High-dose chemotherapy and autologous peripheral blood stem-cell transfusion after conventional chemotherapy for patients with high-risk Ewing's tumors.
    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 2002, Volume: 7, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Carboplatin; Chil

2002
Peripheral blood stem cell support reduces the toxicity of intensive chemotherapy for children and adolescents with metastatic sarcomas.
    Cancer, 2002, Sep-15, Volume: 95, Issue:6

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined Modali

2002
Strong inhibition of Ewing tumor xenograft growth by combination of human interferon-alpha or interferon-beta with ifosfamide.
    Oncogene, 2002, Oct-31, Volume: 21, Issue:50

    Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bone Neo

2002
Single center experience of a new intensive induction therapy for ewing's family of tumors: feasibility, toxicity, and stem cell mobilization properties.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Aug-01, Volume: 21, Issue:15

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Doxorubicin; Etoposide; Fe

2003
Ileoileal intussusception caused by a Ewing sarcoma tumour. An unusual case report.
    European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie, 2003, Volume: 13, Issue:4

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Combined Moda

2003
Prophylactic treatment of known ifosfamide-induced encephalopathy for chemotherapy with high-dose ifosfamide?
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2004, Volume: 12, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemoprevention; Female; Huma

2004
Recurrent atrial ectopic tachycardia following chemotherapy with ifosfamide.
    Pediatric hematology and oncology, 2004, Volume: 21, Issue:4

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Child; Electrocardiography; H

2004
Extraskeletal Ewing sarcoma of the diaphragm presenting with hemothorax.
    The Annals of thoracic surgery, 2004, Volume: 78, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Child; Combined Modality The

2004
Definitive irradiation in multidisciplinary management of localized Ewing sarcoma family of tumors in pediatric patients: outcome and prognostic factors.
    International journal of radiation oncology, biology, physics, 2004, Nov-01, Volume: 60, Issue:3

    Topics: Adolescent; Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chil

2004
VIP (etoposide, ifosfamide, cisplatin) in adult patients with recurrent or refractory Ewing sarcoma family of tumors.
    American journal of clinical oncology, 2004, Volume: 27, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Drug R

2004
Ewing's sarcoma of the axial system in patients older than 15 years: dismal prognosis despite intensive multiagent chemotherapy and aggressive local treatment.
    Japanese journal of clinical oncology, 2004, Volume: 34, Issue:11

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cyclophosphamide;

2004
Downregulation of angiogenic factors in Ewing tumor xenografts by the combination of human interferon-alpha or interferon-beta with ifosfamide.
    Annals of the New York Academy of Sciences, 2004, Volume: 1030

    Topics: Angiogenesis Inducing Agents; Animals; Base Sequence; DNA Primers; Down-Regulation; Enzyme-Linked Im

2004
Definitive surgery and multiagent systemic therapy for patients with localized Ewing sarcoma family of tumors: local outcome and prognostic factors.
    Cancer, 2005, Jul-15, Volume: 104, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Combined Modalit

2005
Radiation therapy for Ewing's sarcoma: results from Memorial Sloan-Kettering in the modern era.
    International journal of radiation oncology, biology, physics, 2006, Feb-01, Volume: 64, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Pre

2006
Safety assessment of intensive induction with vincristine, ifosfamide, doxorubicin, and etoposide (VIDE) in the treatment of Ewing tumors in the EURO-E.W.I.N.G. 99 clinical trial.
    Pediatric blood & cancer, 2006, Volume: 47, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Clinical T

2006
Malignant mixed Mullerian tumors.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2006, Volume: 8, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Chemo

2006
Dose response and local control using radiotherapy in non-metastatic Ewing sarcoma.
    Pediatric blood & cancer, 2007, Volume: 49, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adj

2007
[Acquired Fanconi-de Toni-Debre syndrome due to therapy for Ewing's sarcoma in 5-years old boy].
    Przeglad lekarski, 2006, Volume: 63 Suppl 3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child, Preschool; Dactinomycin; Doxo

2006
Juvenile Ewing sarcoma presenting as a pelvic mass.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2007, Volume: 17, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Combined Modality Therap

2007
Clinical outcome of patients with Ewing sarcoma family of tumors of bone in Japan: the Japanese Musculoskeletal Oncology Group cooperative study.
    Cancer, 2007, Feb-15, Volume: 109, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asian People; Bone Neoplasms; Chi

2007
Does consolidation with autologous stem cell transplantation improve the outcome of children with metastatic or relapsed Ewing sarcoma?
    Pediatric blood & cancer, 2007, Volume: 49, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Camptothecin; Carboplatin; Combined

2007
Tandem high-dose chemotherapy with autologous peripheral hematopoietic progenitor cell rescue as consolidation therapy for patients with high-risk Ewing family tumors.
    Pediatric blood & cancer, 2007, Volume: 49, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Combined M

2007
Ewing's sarcoma and primitive neuroectodermal tumour in adults: single-centre experience in The Netherlands.
    The Netherlands journal of medicine, 2007, Volume: 65, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Combined Modality

2007
Translocation (X;10) in a child with therapy-related acute myeloid leukemia following chemotherapy for Ewing's Sarcoma.
    Cancer genetics and cytogenetics, 2007, Oct-15, Volume: 178, Issue:2

    Topics: Adolescent; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chromosomes, Huma

2007
Prognostic factors for local and distant control in Ewing sarcoma family of tumors.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2008, Volume: 19, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Agents; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Pres

2008
[Preoperative adjuvant therapy for primary malignant bone tumors].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cyclophosphamide; Dactinomycin; Doxo

2007
[A case of primary lung adenocarcinoma accompanied by Ewing's sarcoma successfully treated with ifosfamide].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2008, Volume: 35, Issue:5

    Topics: Adenocarcinoma; Antineoplastic Agents, Alkylating; Humans; Ifosfamide; Lung Neoplasms; Male; Middle

2008
[Clinical evaluation on the sensitivity test for anti-cancer agents in malignant bone and soft-tissue tumors].
    Gan no rinsho. Japan journal of cancer clinics, 1984, Volume: 30, Issue:9 Suppl

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cyclophosphamide;

1984
[Extraosseous Ewing's sarcoma].
    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 1995, Volume: 162, Issue:5

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Dactinomycin; Diag

1995
Ifosfamide nephrotoxicity in paediatric cancer patients.
    European journal of pediatrics, 1994, Volume: 153, Issue:2

    Topics: Adolescent; Child; Child, Preschool; Female; Glomerular Filtration Rate; Humans; Ifosfamide; Infant;

1994
Metabolism of ifosfamide during a 3 day infusion.
    British journal of cancer, 1994, Volume: 69, Issue:5

    Topics: Adenocarcinoma; Chromatography, Thin Layer; Female; Humans; Ifosfamide; Male; Neuroectodermal Tumors

1994
Lung irradiation for Ewing's sarcoma with pulmonary metastases at diagnosis: results of the CESS-studies.
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 1993, Volume: 169, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Combined Modality Therapy; Cyclophos

1993
Ewing's sarcoma: evaluation of chemotherapy in 17 cases.
    Hiroshima journal of medical sciences, 1993, Volume: 42, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Cyclophosphamide; Dactinom

1993
[Toxic effects of ifosfamide in the treatment of bone and soft tissue sarcomas].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:4

    Topics: Administration, Intravesical; Adolescent; Adult; Aluminum Hydroxide; Bone Neoplasms; Child, Preschoo

1993
Hypophosphataemic rickets after ifosfamide treatment in children.
    Clinical radiology, 1993, Volume: 47, Issue:5

    Topics: Child; Fanconi Syndrome; Female; Humans; Ifosfamide; Knee Joint; Male; Phosphates; Radiography; Rick

1993
Intense gallbladder uptake associated with chemotherapy. An unusual finding in pediatric skeletal scintigraphy.
    Clinical nuclear medicine, 1995, Volume: 20, Issue:11

    Topics: Adolescent; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone and Bones; B

1995
[Neoadjuvant treatment of Ewing's sarcoma: results obtained in 122 patients treated with a 6-drug chemotherapeutic protocol (vincristine, adriamycin, cyclophosphamide, dactinomycin, ifosfamide and etoposide)].
    Minerva pediatrica, 1995, Volume: 47, Issue:11

    Topics: Adolescent; Adult; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Ag

1995
Ifosfamide in the treatment of pediatric malignancies.
    Seminars in oncology, 1996, Volume: 23, Issue:3 Suppl 7

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms;

1996
[Ifosfamide in pediatric malignancy--experiences in the Northern Israel Oncology Center].
    Harefuah, 1996, Apr-15, Volume: 130, Issue:8

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; C

1996
[The type of local treatment conditions the prognosis in patients with nonmetastatic Ewing's sarcoma of the extremities treated with adjuvant chemotherapy].
    Minerva chirurgica, 1997, Volume: 52, Issue:4

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Arm; Bone Neoplasms; Chemotherapy, Adjuv

1997
Treatment of childhood post-irradiation sarcoma of bone in cancer survivors.
    Medical and pediatric oncology, 1997, Volume: 29, Issue:6

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool;

1997
[The effects of high-dose ifosfamide in the treatment of bone and soft tissue sarcomas].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:14

    Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Bone Neoplasms; Child; Drug Administration Sch

1997
The use of paediatric chemotherapy protocols at full dose is both a rational and feasible treatment strategy in adults with Ewing's family tumours.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1997, Volume: 8, Issue:11

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Brain Neoplasms;

1997
Second malignancies after treatment for Ewing's sarcoma: a report of the CESS-studies.
    International journal of radiation oncology, biology, physics, 1998, Sep-01, Volume: 42, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Combined Modality Therapy; Cyclophos

1998
Predictive factors of histological response to primary chemotherapy in Ewing's sarcoma.
    Acta oncologica (Stockholm, Sweden), 1998, Volume: 37, Issue:7-8

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adj

1998
Extraskeletal Ewing's sarcoma.
    Cancer, 1999, Feb-01, Volume: 85, Issue:3

    Topics: Adolescent; Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Presch

1999
Measurement of DNA cross-linking in patients on ifosfamide therapy using the single cell gel electrophoresis (comet) assay.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:3

    Topics: Antineoplastic Agents, Alkylating; Cross-Linking Reagents; DNA Damage; Electrophoresis; Humans; Ifos

1999
Management of cancer in pregnancy: a case of Ewing's sarcoma of the pelvis in the third trimester.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1999, Volume: 10, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cesarean Section; Disease-Fre

1999
RT-PCR evaluation of peripheral blood, bone marrow and peripheral blood stem cells in children and adolescents undergoing VACIME chemotherapy for Ewing's sarcoma and alveolar rhabdomyosarcoma.
    Bone marrow transplantation, 1999, Volume: 24, Issue:5

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Bone Marrow Purging; Bone N

1999
Prognostic factors in nonmetastatic Ewing's sarcoma of bone treated with adjuvant chemotherapy: analysis of 359 patients at the Istituto Ortopedico Rizzoli.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Volume: 18, Issue:1

    Topics: Adolescent; Adult; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Biomarkers,

2000
Local therapy and other factors influencing site of relapse in patients with localised Ewing's sarcoma. United Kingdom Children's Cancer Study Group (UKCCSG).
    European journal of cancer (Oxford, England : 1990), 1999, Volume: 35, Issue:12

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bone Neo

1999
Granulocyte colony stimulating factor permits dose intensification by interval compression in the treatment of Ewing's sarcomas and soft tissue sarcomas in children.
    European journal of cancer (Oxford, England : 1990), 2000, Volume: 36, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Pre

2000
Selective use of whole-lung irradiation for patients with Ewing sarcoma family tumors and pulmonary metastases at the time of diagnosis.
    Journal of pediatric hematology/oncology, 2001, Volume: 23, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Pre

2001
Localized Ewing tumor of bone: final results of the cooperative Ewing's Sarcoma Study CESS 86.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Mar-15, Volume: 19, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adj

2001
Successful pregnancy after high-dose cyclophosphamide and ifosfamide treatment in two postpubertal women.
    Pediatric hematology and oncology, 2001, Volume: 18, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols

2001
Painful peripheral neuropathy after treatment with high-dose ifosfamide.
    Medical and pediatric oncology, 2001, Volume: 37, Issue:4

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Bone Neoplasms; Combined Modality Therapy; Dose-Respo

2001
[Treatment of Ewing's sarcoma with 2 different protocols].
    Annales de medecine interne, 2001, Volume: 152, Issue:8

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Pre

2001
Postoperative radiotherapy in the treatment of Ewing tumors: influence of the interval between surgery and radiotherapy.
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2002, Volume: 178, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols

2002
Ifosfamide plus etoposide in newly diagnosed Ewing's sarcoma of bone.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1992, Volume: 10, Issue:11

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Pre

1992
Ewing's sarcoma: experience with 12 cases.
    Journal of chemotherapy (Florence, Italy), 1992, Volume: 4, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool;

1992
No benefit of ifosfamide in Ewing's sarcoma: a nonrandomized study of the French Society of Pediatric Oncology.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1992, Volume: 10, Issue:9

    Topics: Bone Neoplasms; Child; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Ifosfamide; Mal

1992
[Two cases of Ewing's sarcoma originating from the adult rib].
    Nihon Kyobu Shikkan Gakkai zasshi, 1991, Volume: 29, Issue:6

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Combined Modality

1991
Use of MR imaging to assess results of chemotherapy for Ewing sarcoma.
    AJR. American journal of roentgenology, 1990, Volume: 155, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cyclophosp

1990
Ifosfamide and mesna in combination with other cytostatic drugs in the treatment of patients with advanced cancer.
    Investigational new drugs, 1990, Volume: 8, Issue:2

    Topics: Adolescent; Adult; Aged; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small

1990
High-dose ifosfamide with mesna uroprotection in Ewing's sarcoma.
    Cancer chemotherapy and pharmacology, 1989, Volume: 24 Suppl 1

    Topics: Actuarial Analysis; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasm

1989