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ifosfamide and Esophageal Neoplasms

ifosfamide has been researched along with Esophageal Neoplasms in 20 studies

Esophageal Neoplasms: Tumors or cancer of the ESOPHAGUS.

Research Excerpts

ExcerptRelevanceReference
"25 previously untreated patients with inoperable or metastatic adenocarcinoma of the oesophagus or oesophageal-gastric junction area were treated with ifosfamide 6 g/m2 over 48 hours, combined with mesna 6 g/m2."7.68Ifosfamide in advanced adenocarcinoma of the oesophagus or oesophageal-gastric junction area. Rotterdam Esophageal Tumor Study Group. ( Kok, TC; Splinter, TA; Tilanus, HW; van der Gaast, A, 1991)
"We have reported the results of a previous Phase II trial of two courses of neoadjuvant mitomycin (6 mg/m2), ifosfamide (3 g/m2) and cisplatin (50 mg/m2) (MIC) in squamous or anaplastic carcinoma of the oesophagus."5.08A phase II trial of four courses of preoperative chemotherapy in squamous or anaplastic carcinoma of the oesophagus. ( Cullen, MH; Darnton, SJ; Matthews, HR; McAleer, JA; McManus, KG; Steyn, RS, 1998)
" We report a patient who was cured of metastatic adenocarcinoma in Barrett's oesophagus by six courses of ifosfamide, a chemotherapeutic agent with little or no activity in other patients with adenocarcinoma of the oesophagus or gastro-oesophageal junction."3.71Cure of Barrett's carcinoma by ifosfamide chemotherapy. ( Hage, M; Kok, TC; Kuipers, EJ; Siersema, PD; Tilanus, HW; van Dekken, H; van der Gaast, A, 2002)
"The multidrug resistance gene product P-glycoprotein (P-GP) was assessed immunohistochemically (by antibody JSB-1) in biopsy specimens from 27 oesophageal squamous carcinomas and 10 adenocarcinomas before treatment with mitomycin, ifosfamide and cisplatin (MIC)."3.69Lack of correlation of P-glycoprotein expression with response to MIC chemotherapy in oesophageal cancer. ( Darnton, SJ; Ferry, DR; Jenner, K; Matthews, HR; Steyn, RS, 1995)
"Of 13 patients with adenocarcinoma treated with 5-fluorouracil, adriamycin, and mitomycin (FAM), nine showed minor histological changes compared with 14 control cases."3.68Histopathological findings in oesophageal carcinoma with and without preoperative chemotherapy. ( Allen, SM; Darnton, SJ; Edwards, CW; Matthews, HR, 1993)
"Ten resected oesophageal adenocarcinomas treated with preoperative chemotherapy--mitomycin-C, ifosfamide, and cisplatin (MIC)--were examined by transmission electron microscopy and their appearance compared with that of 13 concurrent untreated resected oesophageal adenocarcinomas."3.68Effects of chemotherapy on ultrastructure of oesophageal adenocarcinoma. ( Antonakopoulos, GN; Darnton, SJ; Matthews, HR; Newman, J, 1992)
"25 previously untreated patients with inoperable or metastatic adenocarcinoma of the oesophagus or oesophageal-gastric junction area were treated with ifosfamide 6 g/m2 over 48 hours, combined with mesna 6 g/m2."3.68Ifosfamide in advanced adenocarcinoma of the oesophagus or oesophageal-gastric junction area. Rotterdam Esophageal Tumor Study Group. ( Kok, TC; Splinter, TA; Tilanus, HW; van der Gaast, A, 1991)
"Grade 3/4 neutropenia was observed in 21 % of patients and grade 3/4 febrile neutropenia was seen in only one patient."2.73Salvage chemotherapy with mitomycin C, ifosfamide, and cisplatin (MIC) for previously treated metastatic or recurrent esophageal squamous cell carcinoma. ( Ahn, JS; Ahn, MJ; Hwang, IG; Im, YH; Kang, WK; Lee, SC; Lim, HY; Park, BB; Park, K, 2008)
"Neo-adjuvant therapy with MIC in squamous carcinoma of the oesophagus has shown encouraging early results, with acceptable toxicity."2.67A phase II study of mitomycin, ifosfamide and cisplatin in operable and inoperable squamous cell carcinoma of the oesophagus. ( Allen, SM; Cullen, MH; Darnton, SJ; Duffy, JP; Matthews, HR; Walker, SJ, 1994)
"Esophageal cancer is the ninth most common malignancy in the world and the seventh leading cause of death in American men."2.43Docetaxel in the treatment of esophageal cancer. ( Bubis, JA; Dragnev, KH; Rigas, JR, 2005)
"The mainstay of curative treatment for oesophageal cancer is currently surgery with neoadjuvant chemotherapy or radiotherapy."1.31Curing oesophageal cancer: one swallow does not make a summer. ( Anderson, MR; Jankowski, JA, 2002)
"Seven oesophageal squamous carcinomas, treated with pre-operative chemotherapy (mitomycin-C, ifosfamide and cisplatin-MIC), with a course finishing 21 days prior to resection, were examined by electronmicroscopy."1.29Effects of chemotherapy on ultrastructure of oesophageal squamous cell carcinoma. ( Antonakopoulos, GN; Darnton, SJ; Duffy, JP; Matthews, HR; Newman, J, 1994)
"Ifosfamide has minimal activity in esophageal cancer and causes severe myelosuppression."1.27Phase II trial of ifosfamide in epidermoid carcinoma of the esophagus: unexpectant severe toxicity. ( Eisenberger, M; Kelsen, DP; Lipperman, R; Nanus, DM, 1988)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19902 (10.00)18.7374
1990's9 (45.00)18.2507
2000's8 (40.00)29.6817
2010's1 (5.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gallo, K1
Brickman, A1
Warren, WH1
Gattuso, P1
Seder, CW1
Blot, E1
Decaudin, D1
Veyradier, A1
Bardier, A1
Zagame, OL1
Pouillart, P1
Anderson, MR1
Jankowski, JA1
Siersema, PD2
Hage, M2
van der Gaast, A2
van Dekken, H2
Kok, TC2
Tilanus, HW2
Kuipers, EJ1
Darnton, SJ9
Archer, VR2
Stocken, DD2
Mulholland, PJ2
Casson, AG1
Ferry, DR3
Rigas, JR1
Dragnev, KH1
Bubis, JA1
Park, BB1
Im, YH1
Hwang, IG1
Lee, SC1
Ahn, JS1
Ahn, MJ1
Lim, HY1
Kang, WK1
Park, K1
Antonakopoulos, GN2
Newman, J2
Duffy, JP3
Matthews, HR7
Allen, SM3
Walker, SJ1
Cullen, MH3
Edwards, CW1
Jenner, K1
Steyn, RS2
Sur, M1
Taylor, L1
Cooper, K1
Sur, RK1
McManus, KG1
McAleer, JA1
Splinter, TA1
Ansell, SM1
Alberts, AS1
Falkson, G1
Nanus, DM1
Kelsen, DP1
Lipperman, R1
Eisenberger, M1

Reviews

1 review available for ifosfamide and Esophageal Neoplasms

ArticleYear
Docetaxel in the treatment of esophageal cancer.
    Seminars in oncology, 2005, Volume: 32, Issue:2 Suppl 4

    Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cap

2005

Trials

6 trials available for ifosfamide and Esophageal Neoplasms

ArticleYear
Preoperative mitomycin, ifosfamide, and cisplatin followed by esophagectomy in squamous cell carcinoma of the esophagus: pathologic complete response induced by chemotherapy leads to long-term survival.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Nov-01, Volume: 21, Issue:21

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Co

2003
Salvage chemotherapy with mitomycin C, ifosfamide, and cisplatin (MIC) for previously treated metastatic or recurrent esophageal squamous cell carcinoma.
    Investigational new drugs, 2008, Volume: 26, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Di

2008
A phase II study of mitomycin, ifosfamide and cisplatin in operable and inoperable squamous cell carcinoma of the oesophagus.
    Clinical oncology (Royal College of Radiologists (Great Britain)), 1994, Volume: 6, Issue:2

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Esophagea

1994
Phase II study of mitomycin, ifosfamide and cisplatin in adenocarcinoma of the oesophagus.
    Cancer chemotherapy and pharmacology, 1996, Volume: 37, Issue:5

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant;

1996
A phase II trial of four courses of preoperative chemotherapy in squamous or anaplastic carcinoma of the oesophagus.
    Clinical oncology (Royal College of Radiologists (Great Britain)), 1998, Volume: 10, Issue:3

    Topics: Adult; Aged; Alopecia; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Al

1998
Combined results from three phase II trials of neoadjuvant chemotherapy in operable adenocarcinoma of the oesophagus.
    Clinical oncology (Royal College of Radiologists (Great Britain)), 2001, Volume: 13, Issue:3

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cisp

2001

Other Studies

13 other studies available for ifosfamide and Esophageal Neoplasms

ArticleYear
Unresectable Middle Mediastinal Biphasic Pulmonary Blastoma.
    Anticancer research, 2015, Volume: 35, Issue:11

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Esophageal Neoplasms; Etoposide; H

2015
Cancer-related thrombotic microangiopathy secondary to Von Willebrand factor-cleaving protease deficiency.
    Thrombosis research, 2002, Apr-15, Volume: 106, Issue:2

    Topics: ADAM Proteins; ADAMTS13 Protein; Adenocarcinoma; Anemia, Hemolytic; Antineoplastic Combined Chemothe

2002
Curing oesophageal cancer: one swallow does not make a summer.
    European journal of gastroenterology & hepatology, 2002, Volume: 14, Issue:11

    Topics: Antineoplastic Agents, Alkylating; Chemotherapy, Adjuvant; Drug Resistance, Neoplasm; Esophageal Neo

2002
Cure of Barrett's carcinoma by ifosfamide chemotherapy.
    European journal of gastroenterology & hepatology, 2002, Volume: 14, Issue:11

    Topics: Adenocarcinoma; Aged; Antineoplastic Agents, Alkylating; Barrett Esophagus; Esophageal Neoplasms; Fo

2002
Cure of Barrett's carcinoma by ifosfamide chemotherapy.
    European journal of gastroenterology & hepatology, 2003, Volume: 15, Issue:7

    Topics: Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Esophageal Neoplasms; Humans; Ifosfamide; Kera

2003
Effects of chemotherapy on ultrastructure of oesophageal squamous cell carcinoma.
    Histopathology, 1994, Volume: 25, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous

1994
Histopathological findings in oesophageal carcinoma with and without preoperative chemotherapy.
    Journal of clinical pathology, 1993, Volume: 46, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carc

1993
Lack of correlation of P-glycoprotein expression with response to MIC chemotherapy in oesophageal cancer.
    Journal of clinical pathology, 1995, Volume: 48, Issue:11

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Tr

1995
Lack of correlation of P-glycoprotein expression with response to MIC chemotherapy in oesophageal cancer.
    Journal of clinical pathology, 1997, Volume: 50, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Membe

1997
Effects of chemotherapy on ultrastructure of oesophageal adenocarcinoma.
    Journal of clinical pathology, 1992, Volume: 45, Issue:11

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cell Nucleolus; Cisplat

1992
Ifosfamide in advanced adenocarcinoma of the oesophagus or oesophageal-gastric junction area. Rotterdam Esophageal Tumor Study Group.
    European journal of cancer (Oxford, England : 1990), 1991, Volume: 27, Issue:9

    Topics: Adenocarcinoma; Adult; Aged; Esophageal Neoplasms; Esophagogastric Junction; Female; Humans; Ifosfam

1991
Ifosfamide in advanced carcinoma of the esophagus: a phase II trial with severe toxicity.
    American journal of clinical oncology, 1989, Volume: 12, Issue:3

    Topics: Carcinoma, Squamous Cell; Drug Administration Schedule; Drug Evaluation; Esophageal Neoplasms; Femal

1989
Phase II trial of ifosfamide in epidermoid carcinoma of the esophagus: unexpectant severe toxicity.
    Investigational new drugs, 1988, Volume: 6, Issue:3

    Topics: Adult; Aged; Carcinoma, Squamous Cell; Drug Evaluation; Esophageal Neoplasms; Female; Hematologic Te

1988