Page last updated: 2024-10-28

ifosfamide and Brain Diseases

ifosfamide has been researched along with Brain Diseases in 69 studies

Brain Diseases: Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.

Research Excerpts

ExcerptRelevanceReference
"The study was designed to assess the toxicity and activity of high-dose ifosfamide (HDI) administered by continuous infusion at a dose of 4 g/m2/d over 3 days every 4 weeks in adult patients with advanced soft tissue sarcomas (ASTS) pretreated with doxorubicin and/or a standard-dose ifosfamide (SDI)-containing regimen."9.08High-dose ifosfamide: circumvention of resistance to standard-dose ifosfamide in advanced soft tissue sarcomas. ( Antoine, E; Brain, E; Fontaine, F; Genin, J; Janin, N; Kayitalire, L; Le Cesne, A; Le Chevalier, T; Spielmann, M; Toussaint, C, 1995)
"Following the 20th week of ifosfamide treatment, the patient's follow-up with the diagnosis of osteosarcoma developed neurological findings."8.02Ifosfamide induced encephalopathy in a child with osteosarcoma. ( Atay, AA; Demir, ÜF; Malbora, B; Sarbay, H; Yılmaz, G, 2021)
"Ifosfamide and methotrexate are widely used for the treatment of pediatric osteosarcoma."7.80Hearing loss during osteosarcoma chemotherapy: when acute ifosfamide toxicity revealed unnoticed methotrexate encephalopathy. ( Bruneau, B; Chappé, C; Gandemer, V; Robert, G; Taque, S, 2014)
"Methylene blue has been used not only as a diagnostic agent, but also as an agent in the treatment of ifosfamide-induced encephalopathy (IIE) for several years."5.38Suspected serotonin syndrome in a patient being treated with methylene blue for ifosfamide encephalopathy. ( Fisher, DC; McDonnell, AM; Rybak, I; Wadleigh, M, 2012)
"The study was designed to assess the toxicity and activity of high-dose ifosfamide (HDI) administered by continuous infusion at a dose of 4 g/m2/d over 3 days every 4 weeks in adult patients with advanced soft tissue sarcomas (ASTS) pretreated with doxorubicin and/or a standard-dose ifosfamide (SDI)-containing regimen."5.08High-dose ifosfamide: circumvention of resistance to standard-dose ifosfamide in advanced soft tissue sarcomas. ( Antoine, E; Brain, E; Fontaine, F; Genin, J; Janin, N; Kayitalire, L; Le Cesne, A; Le Chevalier, T; Spielmann, M; Toussaint, C, 1995)
"In summary, female sex, low total bilirubin, albumin and haemoglobin levels, and obesity appear to be associated with ifosfamide-induced encephalopathy."4.84Encephalopathy after high-dose Ifosfamide: a retrospective cohort study and review of the literature. ( Beri, R; Shord, SS; Sweiss, KI, 2008)
"Following the 20th week of ifosfamide treatment, the patient's follow-up with the diagnosis of osteosarcoma developed neurological findings."4.02Ifosfamide induced encephalopathy in a child with osteosarcoma. ( Atay, AA; Demir, ÜF; Malbora, B; Sarbay, H; Yılmaz, G, 2021)
"To determine whether thiamine prophylaxis decreases the incidence of ifosfamide-induced encephalopathy in patients receiving ifosfamide for the treatment of lymphoma."3.96Evaluation of thiamine for the prevention of ifosfamide-induced encephalopathy. ( Ayarza, M; Clark, SM; Hairston, A; Lentz, KL; Liu, B; Morgan, KP; Wind, LS, 2020)
" This is a report of a 64-year-old female with relapsed double-hit diffuse large B-cell lymphoma who developed severe altered mental status and neurological symptoms after receiving a second dose of ifosfamide as part of her salvage standard dose R-IE (rituximab, ifosfamide, etoposide), in preparation for chimeric antigen receptor T-cell therapy."3.91Hydration, methylene blue, and thiamine as a prevention regimen for ifosfamide-induced encephalopathy. ( Gharaibeh, EZ; Powers, BC; Salacz, ME; Telfah, M, 2019)
"A retrospective study of sarcoma and lymphoma patients receiving ifosfamide chemotherapy was performed at the participating institutions."3.81An assessment of risk factors associated with ifosfamide-induced encephalopathy in a large academic cancer center. ( Butrynski, J; Cirrone, F; Feng, Y; Fisher, DC; Harris, C; McDonnell, AM; Neuberg, D; Szabatura, AH; Voit, D, 2015)
"Ifosfamide and methotrexate are widely used for the treatment of pediatric osteosarcoma."3.80Hearing loss during osteosarcoma chemotherapy: when acute ifosfamide toxicity revealed unnoticed methotrexate encephalopathy. ( Bruneau, B; Chappé, C; Gandemer, V; Robert, G; Taque, S, 2014)
"IFO-induced encephalopathy (IIE) is one of the serious side effects, but there is not enough evidence regarding the clinical features of IIE in children."2.90Analysis of the clinical characteristics of pediatric patients who experience ifosfamide-induced encephalopathy. ( Honda, T; Ide, Y; Kubota, N; Nakamura, T; Sakashita, K; Tozuka, M; Yanagisawa, R, 2019)
"Prolonged encephalopathy and MB therapy has not been described in the literature as lasting longer than 30 days following treatment."2.82A novel case of prolonged Ifosfamide encephalopathy and long-term treatment with methylene blue: a case report and review of literature. ( Campino, GA; Chain, G; Kalia, M; Kestenbaum, K; Pappas, L; Sechser-Perl, A; Zaghloul, N, 2022)
"Ifosfamide is an important part of chemotherapeutic regimens used to treat a variety of malignancies."2.43Evaluating risk factors for the development of ifosfamide encephalopathy. ( David, KA; Picus, J, 2005)
"Two developed milder encephalopathy; one had no CNS depression at all."2.41Methylene blue in the treatment and prevention of ifosfamide-induced encephalopathy: report of 12 cases and a review of the literature. ( De Vos, F; Pelgrims, J; Prové, A; Schrijvers, D; Van den Brande, J; Vermorken, JB, 2000)
"We describe an episode of encephalopathy developed at the third cycle of ifosfamide treatment in a child with Ewing sarcoma."1.72Ifosfamide-induced Encephalopathy With Rapid Response to Thiamine: A Pediatric Case. ( Anlar, B; Aydin, B; Günbey, C; Müngen, E; Öz, S; Yaman Bajin, İ, 2022)
"Ifosfamide-induced encephalopathy (IIE) is a rare and serious adverse reaction."1.62Methylene blue and ifosfamide-induced encephalopathy: Myth or reality? ( Abahssain, H; Errihani, H; Essangri, H; Fadhil, FZ; Guessous, F; Meddah, B; Moukafih, B; Mrabti, H; Souadka, A, 2021)
"Ifosfamide is an alkylating agent, mostly used against variety of solid tumors in pediatric oncology practice."1.62Ifosfamide-related encephalopathy with severe clinical presentations in children with cancer. ( Ataseven, E; Göktepe, ŞÖ; Kantar, M, 2021)
"Ifosfamide-related encephalopathy commonly results in a distinct pattern of generalized periodic discharges admixed with intermittent background attenuation on EEG."1.51Clinical and EEG Characteristics of Ifosfamide-Related Encephalopathy. ( Chen, X; Gusdon, AM; Malani, R, 2019)
"Ifosfamide-induced encephalopathy occurred in 11 patients (5."1.51Ifosfamide-induced encephalopathy: Brand-name (HOLOXAN®) vs generic formulation (IFOSFAMIDE EG®). ( Chambord, J; Demore, B; Henny, F; Hombourger, B; Lider, P; Rios, M; Salleron, J; Vallance, C; Vigneron, J, 2019)
"Ifosfamide (IFA) is a potent alkylating antitumoral agent, but its use is limited by neurological side effects."1.48Possible role of CYP2B6 genetic polymorphisms in ifosfamide-induced encephalopathy: report of three cases. ( Bellien, J; Duflot, T; Filhon, B; Joannidès, R; Lamoureux, F; Marie-Cardine, A; Massy-Guillemant, N; Pereira, T; Verstuyft, C, 2018)
"Ifosfamid-related encephalopathy (IRE) is a rare but severe adverse event, without clearly identified risk factors."1.46[Incidence and risk factors for ifosfamide-related encephalopathy in sarcoma patients]. ( Defachelles, AS; Deplanque, D; Lervat, C; Marliot, G; Penel, N; Peugniez, C; Ryckewaert, T; Sakji, I; Stern, N, 2017)
" In contrast to previous studies, ifosfamide dosage and brain metastasis are not significant contributing factors."1.43Risk factors of ifosfamide-related encephalopathy in adult patients with cancer: A retrospective analysis. ( Chen, WH; Dong, YH; Lo, Y; Shen, LJ; Wu, FL, 2016)
"Methylene blue and thiamine have been occasionally successful as treatment."1.43The Use of Continuous Veno-Venous Hemodiafiltration in the Management of Ifosfamide-induced Encephalopathy: A Case Report. ( HaDuong, JH; Yeo, KK, 2016)
"Ifosfamide is an alkylating agent useful in the treatment of a wide range of cancers including sarcomas, lymphoma, gynecologic and testicular cancers."1.40Ifosfamide related encephalopathy: the need for a timely EEG evaluation. ( Feyissa, AM; Tummala, S, 2014)
"Ifosfamide is an alkylating agent used to treat different types of malignancies including lymphomas, sarcomas and germinal cell tumors."1.39Ifosfamide-induced neurotoxicity reversal with continuous veno-venous hemodialysis. A case report. ( Bhardwaj, H; Cherry, MA; Hopps, S; Pant, S; Srour, S, 2013)
"Methylene blue has been used not only as a diagnostic agent, but also as an agent in the treatment of ifosfamide-induced encephalopathy (IIE) for several years."1.38Suspected serotonin syndrome in a patient being treated with methylene blue for ifosfamide encephalopathy. ( Fisher, DC; McDonnell, AM; Rybak, I; Wadleigh, M, 2012)
"Ifosfamide is a widely used chemotherapeutic agent for the treatment of a broad spectrum of solid tumors."1.36Ifosfamide-induced encephalopathy and movement disorder. ( Ames, B; Chaffee, S; Kim, J; Lewis, LD; Morse, R, 2010)
"Ifosfamide is an oxazophosphorine widely used in the treatment of cancer in children and adults."1.30Urinary proton magnetic resonance studies of early ifosfamide-induced nephrotoxicity and encephalopathy. ( Foxall, PJ; Hartley, JM; Lapsley, M; Neild, GH; Nicholson, JK; Singer, JM; Souhami, RL, 1997)
"Ifosfamide-related encephalopathy has polymorphous and non-specific clinical picture."1.30[Ifosfamide-related encephalopathy. Report of two cases]. ( Coutant, G; Daly, JP; Desrame, J; Dourthe, LM; Merrer, J, 1999)
"The authors report a case of encephalopathy after treatment with ifosfamide treated by a methylene blue infusion."1.29[Treatment of ifosfamide induced encephalopathy with methylene-blue]. ( Dreyfus, G; Eftekari, P; Ferrero, JM; Largillier, R; Namer, M, 1995)
"Acute encephalopathy following treatment with ifosfamide and mesna was observed in 5 (4 women and 1 men) of 28 patients (17."1.28Encephalopathy in ifosfamide-treated patients. ( Chaitchik, S; Merimsky, O; Reider-Groswasser, I; Wigler, N, 1992)
"We describe a case of reversible encephalopathy caused by the recently released anticancer drug Ifosfamide."1.28Ifosfamide encephalopathy. ( Beydoun, SR; Danesh, MM; De Giorgio, CM; Kemp, RA, 1989)
"Eighteen consecutive cases of encephalopathy occurring after ifosfamide/mesna chemotherapy were prospectively assessed."1.28Ifosfamide encephalopathy: a reappraisal. ( Green, JA; Husband, DJ; Warenius, HM; Watkin, SW, 1989)
"Ifosfamide and mesna were administered to 77 patients with advanced malignancies."1.27Prediction of ifosfamide/mesna associated encephalopathy. ( Blackledge, G; Blake, AE; Honigsberger, L; Kelly, KA; Meanwell, CA, 1986)
"A case of reversible encephalopathy after one dose of ifosfamide/mesna in an epileptic 15-year-old girl is reported."1.27Ifosfamide/mesna related encephalopathy: a case report with a possible role of phenobarbital in enhancing neurotoxicity. ( Carde, P; Droz, JP; Flamant, F; Friedman, S; Ghosn, M; Hayat, M; Leclerq, B, 1988)

Research

Studies (69)

TimeframeStudies, this research(%)All Research%
pre-199012 (17.39)18.7374
1990's24 (34.78)18.2507
2000's7 (10.14)29.6817
2010's17 (24.64)24.3611
2020's9 (13.04)2.80

Authors

AuthorsStudies
Chain, G1
Kalia, M1
Kestenbaum, K1
Pappas, L1
Sechser-Perl, A1
Campino, GA1
Zaghloul, N1
Müngen, E1
Yaman Bajin, İ1
Öz, S1
Günbey, C1
Anlar, B1
Aydin, B1
Idle, JR2
Beyoğlu, D1
Sano, T1
Setsu, N1
Kobayashi, E1
Kawai, A1
Ide, Y1
Yanagisawa, R1
Kubota, N1
Sakashita, K1
Tozuka, M1
Nakamura, T1
Honda, T1
Sarbay, H1
Demir, ÜF1
Yılmaz, G1
Atay, AA1
Malbora, B1
Abahssain, H1
Moukafih, B1
Essangri, H1
Mrabti, H1
Meddah, B1
Guessous, F1
Fadhil, FZ1
Souadka, A1
Errihani, H1
Modi, JN1
Cimino, SK1
Ataseven, E1
Göktepe, ŞÖ1
Kantar, M1
Duflot, T1
Marie-Cardine, A1
Verstuyft, C1
Filhon, B2
Pereira, T1
Massy-Guillemant, N1
Joannidès, R1
Bellien, J1
Lamoureux, F1
Gharaibeh, EZ1
Telfah, M1
Powers, BC1
Salacz, ME1
Gusdon, AM1
Malani, R1
Chen, X1
Chambord, J1
Henny, F1
Salleron, J1
Hombourger, B1
Lider, P1
Vigneron, J1
Demore, B1
Vallance, C1
Rios, M1
Lentz, KL1
Clark, SM1
Ayarza, M1
Liu, B1
Morgan, KP1
Wind, LS1
Hairston, A1
Feyissa, AM1
Tummala, S1
Robert, G1
Chappé, C1
Taque, S1
Bruneau, B1
Gandemer, V1
Szabatura, AH1
Cirrone, F1
Harris, C1
McDonnell, AM2
Feng, Y1
Voit, D1
Neuberg, D1
Butrynski, J1
Fisher, DC2
Miri-Aliabad, G1
Lo, Y1
Shen, LJ1
Chen, WH1
Dong, YH1
Wu, FL1
Lacarra, B1
Hervouet, C1
Jaffray, M1
Schneider, P1
Vannier, JP1
Tsukamoto, S1
Kurematsu, Y1
Honoki, K1
Kido, A1
Somekawa, S1
Kaya, D1
Sadamitsu, T1
Fukui, H1
Tanaka, Y1
Yeo, KK1
HaDuong, JH1
Stern, N1
Sakji, I1
Defachelles, AS1
Lervat, C1
Ryckewaert, T1
Marliot, G1
Peugniez, C1
Deplanque, D1
Penel, N1
Sweiss, KI1
Beri, R1
Shord, SS1
Ames, B1
Lewis, LD2
Chaffee, S1
Kim, J1
Morse, R1
Rybak, I1
Wadleigh, M1
Cherry, MA1
Bhardwaj, H1
Hopps, S1
Srour, S1
Pant, S1
Buesa, JM1
García-Teijido, P1
Losa, R1
Fra, J1
David, KA1
Picus, J1
Lerch, S1
Küpfer, A6
Lauterburg, BH1
Durand, JP1
Gourmel, B1
Mir, O1
Goldwasser, F1
Aeschlimann, C3
Wermuth, B1
Cerny, T5
Le Cesne, A1
Antoine, E1
Spielmann, M1
Le Chevalier, T1
Brain, E1
Toussaint, C1
Janin, N1
Kayitalire, L1
Fontaine, F1
Genin, J1
Ferrero, JM1
Eftekari, P1
Largillier, R1
Dreyfus, G1
Namer, M1
Cain, JW1
Bender, CM1
Zulian, GB1
Tullen, E1
Maton, B1
Gilbert, GJ1
Simonian, NA1
Gilliam, FG1
Chiappa, KH1
Cameron, JC1
Demandt, M1
Wandt, H1
Alonso, JL1
Nieto, Y1
López, JA1
Martín, M1
Díaz-Rubio, E1
Koschuth, A1
Späth-Schwalbe, PE1
Possinger, K1
Foxall, PJ1
Singer, JM1
Hartley, JM1
Neild, GH1
Lapsley, M1
Nicholson, JK1
Souhami, RL1
Gurm, HS1
Budd, GT1
Dourthe, LM1
Coutant, G1
Desrame, J1
Merrer, J1
Daly, JP1
Pelgrims, J1
De Vos, F1
Van den Brande, J1
Schrijvers, D1
Prové, A1
Vermorken, JB1
Jain, S1
Moger, V1
Kumari, S1
Varma, S1
Merimsky, O2
Reider-Groswasser, I2
Wigler, N1
Chaitchik, S2
Inbar, M1
Scharf, M1
Goldsmith, K1
Castiglione, M1
Brunner, K1
Martinelli, G1
Lind, M1
Antman, KH1
Elias, A1
Ryan, L1
Cantwell, BM2
Idle, M1
Millward, MJ1
Hall, G1
Lind, MJ1
Verdeguer, A1
Castel, V1
Esquembre, C1
Ferris, J1
Fernandez, JM1
Ruiz, JG1
Danesh, MM1
De Giorgio, CM1
Beydoun, SR1
Kemp, RA1
Watkin, SW1
Husband, DJ1
Green, JA1
Warenius, HM1
Meanwell, CA3
Blake, AE2
Latief, TN1
Blackledge, G3
Mould, JJ1
Blake, DR1
Shaw, IC1
Honigsberger, L2
Spooner, D1
Williams, AC1
Harris, AL1
Kelly, KA2
Perren, TJ1
Turner, RC1
Smith, IE1
Beuzeboc, P1
Dorval, T1
Garcia-Giralt, E1
Jouve, M1
Livartowski, A1
Palangie, T1
Scholl, S1
Pouillart, P1
Salloum, E1
Flamant, F2
Ghosn, M2
Taleb, N1
Akatchereian, C1
Carde, P1
Leclerq, B1
Friedman, S1
Droz, JP1
Hayat, M1

Reviews

7 reviews available for ifosfamide and Brain Diseases

ArticleYear
A novel case of prolonged Ifosfamide encephalopathy and long-term treatment with methylene blue: a case report and review of literature.
    BMC pediatrics, 2022, 02-02, Volume: 22, Issue:1

    Topics: Brain Diseases; Child; Female; Humans; Ifosfamide; Methylene Blue; Neurotoxicity Syndromes; Sleepine

2022
Ifosfamide - History, efficacy, toxicity and encephalopathy.
    Pharmacology & therapeutics, 2023, Volume: 243

    Topics: Antineoplastic Agents; Brain Diseases; Cyclophosphamide; Humans; Ifosfamide; Methylene Blue

2023
Encephalopathy after high-dose Ifosfamide: a retrospective cohort study and review of the literature.
    Drug safety, 2008, Volume: 31, Issue:11

    Topics: Adult; Albumins; Antineoplastic Agents, Alkylating; Bilirubin; Brain Diseases; Cohort Studies; Enzym

2008
Evaluating risk factors for the development of ifosfamide encephalopathy.
    American journal of clinical oncology, 2005, Volume: 28, Issue:3

    Topics: Adult; Aged; Akathisia, Drug-Induced; Antineoplastic Agents, Alkylating; Brain Diseases; Cohort Stud

2005
Ifosfamide-induced neurotoxicity: associated symptoms and nursing implications.
    Oncology nursing forum, 1995, Volume: 22, Issue:4

    Topics: Brain Diseases; Cognition Disorders; Female; Humans; Ifosfamide; Middle Aged; Oncology Nursing; Ovar

1995
Methylene blue in the treatment and prevention of ifosfamide-induced encephalopathy: report of 12 cases and a review of the literature.
    British journal of cancer, 2000, Volume: 82, Issue:2

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Diseases; Dose-Response Relationsh

2000
Ifosfamide pharmacokinetics.
    Investigational new drugs, 1991, Volume: 9, Issue:4

    Topics: Administration, Oral; Aging; Brain Diseases; Dose-Response Relationship, Drug; Humans; Ifosfamide

1991

Trials

3 trials available for ifosfamide and Brain Diseases

ArticleYear
Analysis of the clinical characteristics of pediatric patients who experience ifosfamide-induced encephalopathy.
    Pediatric blood & cancer, 2019, Volume: 66, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Carboplatin; Child; Child, Preschool

2019
High-dose ifosfamide: circumvention of resistance to standard-dose ifosfamide in advanced soft tissue sarcomas.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:7

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Dacarbazine; Doxorubici

1995
Ifosfamide and mesna: response and toxicity at standard- and high-dose schedules.
    Seminars in oncology, 1990, Volume: 17, Issue:2 Suppl 4

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Child; Chil

1990

Other Studies

59 other studies available for ifosfamide and Brain Diseases

ArticleYear
Ifosfamide-induced Encephalopathy With Rapid Response to Thiamine: A Pediatric Case.
    Journal of pediatric hematology/oncology, 2022, 10-01, Volume: 44, Issue:7

    Topics: Antineoplastic Agents, Alkylating; Brain Diseases; Child; Cisplatin; Creatinine; Humans; Ifosfamide;

2022
[Errata: A Case of Encephalopathy Caused by Drug Interaction between Ifosfamide and Aprepitant].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2023, Volume: 143, Issue:7

    Topics: Antiemetics; Aprepitant; Brain Diseases; Drug Interactions; Humans; Ifosfamide

2023
Ifosfamide induced encephalopathy in a child with osteosarcoma.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2021, Volume: 27, Issue:5

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Bone Neoplasms; Brain Diseases; Female; Humans; Ifosf

2021
Methylene blue and ifosfamide-induced encephalopathy: Myth or reality?
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2021, Volume: 27, Issue:1

    Topics: Aged; Antineoplastic Agents, Alkylating; Brain; Brain Diseases; Creatinine; Drug-Related Side Effect

2021
Incidence of ifosfamide induced encephalopathy in patients receiving concomitant fosaprepitant.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2021, Volume: 27, Issue:8

    Topics: Adult; Brain Diseases; Humans; Ifosfamide; Incidence; Morpholines; Retrospective Studies; Sarcoma

2021
Ifosfamide-related encephalopathy with severe clinical presentations in children with cancer.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2021, Volume: 27, Issue:8

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Brain Diseases; Child; Female; Humans; Ifosfamide; Me

2021
Possible role of CYP2B6 genetic polymorphisms in ifosfamide-induced encephalopathy: report of three cases.
    Fundamental & clinical pharmacology, 2018, Volume: 32, Issue:3

    Topics: Administration, Intravenous; Adolescent; Antineoplastic Agents, Alkylating; Bone Neoplasms; Brain Di

2018
Hydration, methylene blue, and thiamine as a prevention regimen for ifosfamide-induced encephalopathy.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2019, Volume: 25, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Etoposide; Female; Humans; Ifosfamid

2019
Clinical and EEG Characteristics of Ifosfamide-Related Encephalopathy.
    Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society, 2019, Volume: 36, Issue:2

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Diseases; Electroencephalography;

2019
Ifosfamide-induced encephalopathy: Brand-name (HOLOXAN®) vs generic formulation (IFOSFAMIDE EG®).
    Journal of clinical pharmacy and therapeutics, 2019, Volume: 44, Issue:3

    Topics: Adult; Aged; Brain Diseases; Drugs, Generic; Female; France; Humans; Ifosfamide; Incidence; Male; Mi

2019
Evaluation of thiamine for the prevention of ifosfamide-induced encephalopathy.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2020, Volume: 26, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Carboplatin; Cohort Studies; Etoposi

2020
Ifosfamide related encephalopathy: the need for a timely EEG evaluation.
    Journal of the neurological sciences, 2014, Jan-15, Volume: 336, Issue:1-2

    Topics: Adult; Antineoplastic Agents, Alkylating; Brain Diseases; Electroencephalography; Female; Humans; If

2014
Hearing loss during osteosarcoma chemotherapy: when acute ifosfamide toxicity revealed unnoticed methotrexate encephalopathy.
    Journal of pediatric hematology/oncology, 2014, Volume: 36, Issue:2

    Topics: Adolescent; Antineoplastic Agents; Bone Neoplasms; Brain; Brain Diseases; Female; Hearing Loss; Huma

2014
An assessment of risk factors associated with ifosfamide-induced encephalopathy in a large academic cancer center.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2015, Volume: 21, Issue:3

    Topics: Antineoplastic Agents, Alkylating; Brain Diseases; Cancer Care Facilities; Cisplatin; Female; Humans

2015
Green urine secondary to methylene blue.
    Indian journal of pediatrics, 2014, Volume: 81, Issue:11

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemot

2014
Risk factors of ifosfamide-related encephalopathy in adult patients with cancer: A retrospective analysis.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2016, Volume: 115, Issue:9

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Diseases; Creatinine; Female; Humans; Ifosfami

2016
Ifosfamide-induced encephalopathy due to a novel formulation of ifosfamide.
    Pediatric blood & cancer, 2016, Volume: 63, Issue:2

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Brain Diseases; Chemistry, Pharmaceutical; Child; Chi

2016
Severe toxicity of chemotherapy against advanced soft tissue sarcoma in Werner's syndrome: Ifosfamide-induced encephalopathy with central diabetes insipidus.
    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 2016, Volume: 21, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Diabetes Insipidus, Neurogenic; Doxo

2016
The Use of Continuous Veno-Venous Hemodiafiltration in the Management of Ifosfamide-induced Encephalopathy: A Case Report.
    Journal of pediatric hematology/oncology, 2016, Volume: 38, Issue:6

    Topics: Antineoplastic Agents, Alkylating; Brain Diseases; Child; Female; Hemodiafiltration; Humans; Ifosfam

2016
[Incidence and risk factors for ifosfamide-related encephalopathy in sarcoma patients].
    Bulletin du cancer, 2017, Volume: 104, Issue:3

    Topics: Adolescent; Adult; Aged; Analysis of Variance; Antineoplastic Agents, Alkylating; Brain Diseases; Ch

2017
Ifosfamide-induced encephalopathy and movement disorder.
    Pediatric blood & cancer, 2010, Volume: 54, Issue:4

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Bone Neoplasms; Brain Diseases; Child; Female; Humans

2010
Suspected serotonin syndrome in a patient being treated with methylene blue for ifosfamide encephalopathy.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2012, Volume: 18, Issue:4

    Topics: Brain Diseases; Humans; Ifosfamide; Methylene Blue; Serotonin Syndrome

2012
Ifosfamide-induced neurotoxicity reversal with continuous veno-venous hemodialysis. A case report.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2013, Volume: 19, Issue:3

    Topics: Acute Kidney Injury; Aged; Antineoplastic Agents, Alkylating; Brain Diseases; Humans; Ifosfamide; Ly

2013
Treatment of ifosfamide encephalopathy with intravenous thiamin.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Oct-01, Volume: 9, Issue:12

    Topics: Adult; Antineoplastic Agents, Alkylating; Brain Diseases; Humans; Ifosfamide; Infusions, Intravenous

2003
Cerebral formation in situ of S-carboxymethylcysteine after ifosfamide administration to mice: a further clue to the mechanism of ifosfamide encephalopathy.
    Toxicology letters, 2006, Mar-01, Volume: 161, Issue:3

    Topics: Animals; Antineoplastic Agents, Alkylating; Brain; Brain Diseases; Carbocysteine; Drug Interactions;

2006
Antiemetic neurokinin-1 antagonist aprepitant and ifosfamide-induced encephalopathy.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2007, Volume: 18, Issue:4

    Topics: Antiemetics; Antineoplastic Agents, Alkylating; Aprepitant; Brain Diseases; Cytochrome P-450 CYP3A;

2007
Prophylaxis and reversal of ifosfamide encephalopathy with methylene-blue.
    Lancet (London, England), 1994, Mar-26, Volume: 343, Issue:8900

    Topics: Administration, Oral; Adolescent; Antidotes; Bone Neoplasms; Brain Diseases; Drug Overdose; Female;

1994
[Treatment of ifosfamide induced encephalopathy with methylene-blue].
    Bulletin du cancer, 1995, Volume: 82, Issue:7

    Topics: Aged; Antineoplastic Agents, Alkylating; Brain Diseases; Female; Humans; Ifosfamide; Methylene Blue;

1995
Methylene blue for ifosfamide-associated encephalopathy.
    The New England journal of medicine, 1995, May-04, Volume: 332, Issue:18

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Carcinoma, Squamous Cell; Cisp

1995
Diazepam-sensitive encephalopathy.
    Neurology, 1994, Volume: 44, Issue:11

    Topics: Brain Diseases; Dialysis; Diazepam; Humans; Ifosfamide

1994
Ifosfamide causes a diazepam-sensitive encephalopathy.
    Neurology, 1993, Volume: 43, Issue:12

    Topics: Adult; Brain Diseases; Consciousness; Diazepam; Electroencephalography; Female; Humans; Ifosfamide;

1993
Ifosfamide neurotoxicity. A challenge for nurses, a potential nightmare for patients.
    Cancer nursing, 1993, Volume: 16, Issue:1

    Topics: Brain Diseases; Carcinoma, Small Cell; Central Nervous System; Female; Humans; Ifosfamide; Lung Neop

1993
[Successful treatment with methylene blue of ifosfamide-induced central nervous system effects].
    Deutsche medizinische Wochenschrift (1946), 1996, Apr-26, Volume: 121, Issue:17

    Topics: Antidotes; Antineoplastic Agents, Alkylating; Brain Diseases; Humans; Ifosfamide; Male; Methylene Bl

1996
Methylene blue and the neurotoxic mechanisms of ifosfamide encephalopathy.
    European journal of clinical pharmacology, 1996, Volume: 50, Issue:4

    Topics: Administration, Oral; Animals; Antidotes; Antineoplastic Agents, Alkylating; Brain Diseases; Drug Th

1996
Ifosfamide encephalopathy and methylene-blue: a case report.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1996, Volume: 7, Issue:6

    Topics: Brain Diseases; Female; Humans; Ifosfamide; Methylene Blue; Middle Aged

1996
[Methylene blue in ifosfamide-induced encephalopathy].
    Deutsche medizinische Wochenschrift (1946), 1996, Sep-27, Volume: 121, Issue:39

    Topics: Antineoplastic Agents, Alkylating; Brain Diseases; Female; Humans; Ifosfamide; Methylene Blue; Middl

1996
Inhibition of (mono)amine oxidase activity and prevention of ifosfamide encephalopathy by methylene blue.
    Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:12

    Topics: Alkylation; Animals; Antidotes; Antineoplastic Agents; Brain Diseases; Cattle; Ifosfamide; In Vitro

1996
Urinary proton magnetic resonance studies of early ifosfamide-induced nephrotoxicity and encephalopathy.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1997, Volume: 3, Issue:9

    Topics: Adult; Amino Acids; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocol

1997
A 47-year-old man with leiomyosarcoma and altered mental status.
    Cleveland Clinic journal of medicine, 1999, Volume: 66, Issue:1

    Topics: Brain Diseases; Fatal Outcome; Humans; Ifosfamide; Leiomyosarcoma; Male; Methylene Blue; Middle Aged

1999
[Ifosfamide-related encephalopathy. Report of two cases].
    La Revue de medecine interne, 1999, Volume: 20, Issue:3

    Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Dise

1999
Ifosfamide induced encephalopathy following chemotherapy of Non-Hodgkin's Lymphoma.
    Neurology India, 2001, Volume: 49, Issue:4

    Topics: Aged; Antineoplastic Agents, Alkylating; Brain Diseases; Female; Humans; Ifosfamide; Lymphoma, Non-H

2001
The enigma of ifosfamide encephalopathy.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1992, Volume: 3, Issue:9

    Topics: Acetaldehyde; Brain; Brain Diseases; Drug Administration Schedule; Female; Humans; Ifosfamide

1992
Encephalopathy in ifosfamide-treated patients.
    Acta neurologica Scandinavica, 1992, Volume: 86, Issue:5

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Diseases; Female; Humans; Ifosfam

1992
Ifosfamide-related acute encephalopathy: clinical and radiological aspects.
    European journal of cancer (Oxford, England : 1990), 1991, Volume: 27, Issue:9

    Topics: Aged; Aged, 80 and over; Brain; Brain Diseases; Female; Humans; Ifosfamide; Tomography, X-Ray Comput

1991
Ifosfamide administration recommendation questioned.
    Oncology nursing forum, 1991, Volume: 18, Issue:3

    Topics: Brain Diseases; Humans; Ifosfamide; Infusions, Intravenous

1991
Ifosfamide by continuous infusion to prevent encephalopathy.
    Lancet (London, England), 1990, Jan-20, Volume: 335, Issue:8682

    Topics: Brain Diseases; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Humans; If

1990
Encephalopathy with hyponatremia and inappropriate arginine vasopressin secretion following an intravenous ifosfamide infusion.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1990, Volume: 1, Issue:3

    Topics: Arginine Vasopressin; Brain Diseases; Female; Humans; Hyponatremia; Ifosfamide; Infusions, Intraveno

1990
Fatal encephalopathy with ifosfamide/mesna.
    Pediatric hematology and oncology, 1989, Volume: 6, Issue:4

    Topics: Brain Diseases; Child; Drug Therapy, Combination; Humans; Ifosfamide; Male; Mercaptoethanol; Mesna;

1989
Ifosfamide encephalopathy.
    Journal of toxicology. Clinical toxicology, 1989, Volume: 27, Issue:4-5

    Topics: Brain Diseases; Electroencephalography; Female; Humans; Ifosfamide; Middle Aged; Risk Factors

1989
Ifosfamide encephalopathy: a reappraisal.
    European journal of cancer & clinical oncology, 1989, Volume: 25, Issue:9

    Topics: Adult; Aged; Brain Diseases; Confusion; Female; Humans; Hypokalemia; Ifosfamide; Male; Middle Aged;

1989
Encephalopathy associated with ifosphamide/mesna therapy.
    Lancet (London, England), 1985, Feb-16, Volume: 1, Issue:8425

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Cyclophosphamide; Female; Humans; If

1985
Ifosfamide/mesa and encephalopathy.
    Lancet (London, England), 1985, Mar-30, Volume: 1, Issue:8431

    Topics: Brain Diseases; Carcinoma, Small Cell; Cyclophosphamide; Female; Humans; Ifosfamide; Lung Neoplasms;

1985
Ifosfamide, mesna, and encephalopathy.
    Lancet (London, England), 1985, Jun-15, Volume: 1, Issue:8442

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Child; Cyclophosphamide; Fema

1985
Avoiding ifosfamide/mesna encephalopathy.
    Lancet (London, England), 1986, Aug-16, Volume: 2, Issue:8503

    Topics: Adolescent; Adult; Aged; Brain Diseases; Drug Therapy, Combination; Female; Humans; Ifosfamide; Male

1986
Encephalopathy with rapid infusion ifosfamide/mesna.
    Lancet (London, England), 1987, Feb-14, Volume: 1, Issue:8529

    Topics: Brain Diseases; Drug Therapy, Combination; Humans; Ifosfamide; Infusions, Intravenous; Mercaptoethan

1987
[Encephalopathy caused by an ifosfamide-mesna combination].
    Presse medicale (Paris, France : 1983), 1988, Apr-02, Volume: 17, Issue:12

    Topics: Adult; Brain Diseases; Drug Therapy, Combination; Female; Humans; Ifosfamide; Mercaptoethanol; Mesna

1988
Prediction of ifosfamide/mesna associated encephalopathy.
    European journal of cancer & clinical oncology, 1986, Volume: 22, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Electroencephalography; Female; Huma

1986
Irreversible encephalopathy with ifosfamide/mesna.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1987, Volume: 5, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Child, Preschool; Dactinomycin; Fema

1987
Ifosfamide/mesna related encephalopathy: a case report with a possible role of phenobarbital in enhancing neurotoxicity.
    Bulletin du cancer, 1988, Volume: 75, Issue:4

    Topics: Adolescent; Brain Diseases; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans;

1988