ifosfamide and Benign Neoplasms, Brain studies

Research Excerpts

Excerpt	Relevance	Reference
"27 patients with recurrent high grade glioma following surgery and radiation therapy were treated with 100 mg/m2 cisplatin and 6 g/m2 ifosfamide per cycle, administered on days 1-3 in 4 week cycles, for a maximum of six cycles."	9.08	Phase II study on cisplatin and ifosfamide in recurrent high grade gliomas. ( Jansen, RL; Kros, JM; Loosveld, OJ; Ma, J; Schellens, JH; Sillevis Smit, PA; Tijssen, CC; van den Bent, MJ; Vecht, CJ; Verweij, J, 1998)
"The regimen of doxorubicin (DOX), ifosfamide (IFF), and dacarbazine (DTIC) (AID) for previously untreated inoperable or metastatic sarcoma has acceptable toxicity with significant activity."	9.06	Doxorubicin, ifosfamide, and dacarbazine (AID) with mesna uroprotection for advanced untreated sarcoma: a phase I study. ( Antman, KH; Elias, AD, 1986)
"In this phase II trial, 105 eligible patients with no prior chemotherapy and advanced sarcoma received doxorubicin, ifosfamide, and dacarbazine (DTIC) with mesna uroprotection (MAID)."	9.06	Response to mesna, doxorubicin, ifosfamide, and dacarbazine in 108 patients with metastatic or unresectable sarcoma and no prior chemotherapy. ( Aisner, J; Antman, KH; Collins, J; Elias, A; Ryan, L; Sulkes, A, 1989)
"Ifosfamide, Carboplatin and Etoposide (ICE) therapy was used to treat 4 patients, 2 with refractory osteosarcoma, and one each with relapsed brain tumor and newly diagnosed brain tumor."	7.70	[Pilot study of relapsed osteosarcoma and brain tumor with ifosfamide, carboplatin and etoposide (ICE therapy)]. ( Agata, H; Fujimoto, T; Hamaguchi, N; Hirota, T; Iwata, A; Katano, N; Kitagawa, S; Kobayashi, S; Konno, K; Sato, T; Sawada, K; Takeuchi, M, 1998)
"The mesna, doxorubicin, ifosfamide, dacarbazine regimen produced a 47% response rate (including 10% complete responses) in 105 eligible adults with advanced sarcoma."	7.68	Mesna, doxorubicin, ifosfamide, dacarbazine (MAID) regimen for adults with advanced sarcoma. ( Aisner, J; Antman, KH; Elias, A; Ryan, L, 1990)
"Sixteen patients who developed CT or MRI scan evidence of recurrent diffuse astrocytoma after radiation therapy and nitrosourea-containing chemotherapy received ifosfamide (2500 mg/m2/day for 3 consecutive days) and mesna (500 mg/m2/dose, 5 doses/day for 3 consecutive days)."	7.68	Phase II study of ifosfamide with mesna in adult patients with recurrent diffuse astrocytoma. ( Buckner, JC; Cascino, TL; Elliott, TE; Levitt, R; O'Fallon, JR; Scheithauer, BW, 1991)
"Grade 3-4 leukopenia was much more frequent in the HIT GBM-C/D cohort (n = 88, 52%) vs."	5.48	Concurrent radiotherapy with temozolomide vs. concurrent radiotherapy with a cisplatinum-based polychemotherapy regimen : Acute toxicity in pediatric high-grade glioma patients. ( Bison, B; Bojko, S; Gielen, GH; Hoffmann, M; Kortmann, RD; Kramm, CM; Pietsch, T; Seidel, C; von Bueren, AO; Warmuth-Metz, M, 2018)
" In the present analysis, we retrospectively investigated the feasibility and effectiveness of bevacizumab combined with ICE in patients with glioblastoma at second relapse during ICE treatment."	5.39	Retrospective analysis of bevacizumab in combination with ifosfamide, carboplatin, and etoposide in patients with second recurrence of glioblastoma. ( Arakawa, Y; Fujimoto, K; Kikuchi, T; Kunieda, T; Miyamoto, S; Mizowaki, T; Murata, D; Takagi, Y; Takahashi, JC, 2013)
" All 21 patients with DI required daily change in dosage and schedule of DDAVP."	5.36	Challenges in management of patients with intracranial germ cell tumor and diabetes insipidus treated with cisplatin and/or ifosfamide based chemotherapy. ( Afzal, S; Bartels, U; Bouffet, E; Huang, A; Stephens, D; Tabori, U; Wherrett, D, 2010)
"Six cases with recurrent or refractory primary central nervous system lymphoma were treated with a new chemotherapeutic regimen "DeVIC (dexamethasone, VP16, ifosfamide, carboplatin)"."	5.09	[Effectiveness of DeVIC chemotherapy for recurrent primary central nervous system lymphoma]. ( Hatano, H; Hatano, N; Kajita, Y; Kinoshita, T; Takasu, S; Usui, T; Wakabayashi, T; Yoshida, J, 2000)
"27 patients with recurrent high grade glioma following surgery and radiation therapy were treated with 100 mg/m2 cisplatin and 6 g/m2 ifosfamide per cycle, administered on days 1-3 in 4 week cycles, for a maximum of six cycles."	5.08	Phase II study on cisplatin and ifosfamide in recurrent high grade gliomas. ( Jansen, RL; Kros, JM; Loosveld, OJ; Ma, J; Schellens, JH; Sillevis Smit, PA; Tijssen, CC; van den Bent, MJ; Vecht, CJ; Verweij, J, 1998)
"The regimen of doxorubicin (DOX), ifosfamide (IFF), and dacarbazine (DTIC) (AID) for previously untreated inoperable or metastatic sarcoma has acceptable toxicity with significant activity."	5.06	Doxorubicin, ifosfamide, and dacarbazine (AID) with mesna uroprotection for advanced untreated sarcoma: a phase I study. ( Antman, KH; Elias, AD, 1986)
"In this phase II trial, 105 eligible patients with no prior chemotherapy and advanced sarcoma received doxorubicin, ifosfamide, and dacarbazine (DTIC) with mesna uroprotection (MAID)."	5.06	Response to mesna, doxorubicin, ifosfamide, and dacarbazine in 108 patients with metastatic or unresectable sarcoma and no prior chemotherapy. ( Aisner, J; Antman, KH; Collins, J; Elias, A; Ryan, L; Sulkes, A, 1989)
"Patients with localized germinoma received either CSI or 2 courses of carboplatin and etoposide alternating with etoposide and ifosfamide, followed by local radiotherapy."	3.79	SIOP CNS GCT 96: final report of outcome of a prospective, multinational nonrandomized trial for children and adults with intracranial germinoma, comparing craniospinal irradiation alone with chemotherapy followed by focal primary site irradiation for pat ( Alapetite, C; Calaminus, G; Frappaz, D; Garrè, ML; Kortmann, R; Nicholson, JC; Patte, C; Ricardi, U; Saran, F; Worch, J, 2013)
" Six patients with solitary pure germinomas were treated with three or four cycles of cisplatin and etoposide (EP regimen) followed by 24-Gy local radiation therapy."	3.70	Induction chemotherapy followed by reduced-volume radiation therapy for newly diagnosed central nervous system germinoma. ( Abe, H; Fujieda, K; Ikeda, J; Ishii, N; Kato, T; Sawamura, Y; Shirato, H; Tada, M, 1998)
"Following etoposide and cisplatin with or without ifosfamide, 13 patients with nondisseminated disease received involved-field irradiation of 24 Gy in 12 fractions within 3 weeks and 2 patients with disseminated germinoma received 24 Gy craniospinal irradiation (CSI)."	3.70	Preirradiation evaluation and technical assessment of involved-field radiotherapy using computed tomographic (CT) simulation and neoadjuvant chemotherapy for intracranial germinoma. ( Ikeda, J; Kitamura, K; Miyasaka, K; Sawamura, Y; Shirato, H; Suzuki, K, 1999)
"Ifosfamide, Carboplatin and Etoposide (ICE) therapy was used to treat 4 patients, 2 with refractory osteosarcoma, and one each with relapsed brain tumor and newly diagnosed brain tumor."	3.70	[Pilot study of relapsed osteosarcoma and brain tumor with ifosfamide, carboplatin and etoposide (ICE therapy)]. ( Agata, H; Fujimoto, T; Hamaguchi, N; Hirota, T; Iwata, A; Katano, N; Kitagawa, S; Kobayashi, S; Konno, K; Sato, T; Sawada, K; Takeuchi, M, 1998)
"Neuroblastomas, nephroblastomas, malignant mesenchymal tumors, including rhabdomyosarcomas, Ewing's sarcomas, osteosarcomas, brain tumors, and non-Hodgkin's lymphomas respond to ifosfamide monotherapy."	3.69	Ifosfamide in the treatment of pediatric malignancies. ( Behrendt, H; de Kraker, J; Michiels, E; van den Berg, H; Voûte, PA, 1996)
"The mesna, doxorubicin, ifosfamide, dacarbazine regimen produced a 47% response rate (including 10% complete responses) in 105 eligible adults with advanced sarcoma."	3.68	Mesna, doxorubicin, ifosfamide, dacarbazine (MAID) regimen for adults with advanced sarcoma. ( Aisner, J; Antman, KH; Elias, A; Ryan, L, 1990)
"Sixteen patients who developed CT or MRI scan evidence of recurrent diffuse astrocytoma after radiation therapy and nitrosourea-containing chemotherapy received ifosfamide (2500 mg/m2/day for 3 consecutive days) and mesna (500 mg/m2/dose, 5 doses/day for 3 consecutive days)."	3.68	Phase II study of ifosfamide with mesna in adult patients with recurrent diffuse astrocytoma. ( Buckner, JC; Cascino, TL; Elliott, TE; Levitt, R; O'Fallon, JR; Scheithauer, BW, 1991)
"We studied two children with recurrent cancer, who during treatment with ifosfamide developed severe encephalopathy characterized by coma of several days duration."	3.67	Severe encephalopathy associated with ifosfamide administration in two children with metastatic tumors. ( Barak, LS; Estrada, J; Gieron, MA, 1988)
"Brain metastases were strongly associated with more advanced-stage disease, developing in eight of 16 patients with either bulky tumors (> or = cT3b) or metastatic disease (P = ."	2.74	Phase II clinical trial of neoadjuvant alternating doublet chemotherapy with ifosfamide/doxorubicin and etoposide/cisplatin in small-cell urothelial cancer. ( Dinney, CP; Grossman, HB; Kamat, AM; Millikan, RE; Qiao, W; Siefker-Radtke, AO; Thall, PF; Williams, DL, 2009)
"Twenty-two patients with brain metastases at initial diagnosis were identified within a cohort of two hundred thirty-one consecutive patients with advanced metastatic disease, entered on a German multicenter trial between January 1993 and July 1998."	2.69	First-line high-dose chemotherapy +/- radiation therapy in patients with metastatic germ-cell cancer and brain metastases. ( Bamberg, M; Beyer, J; Böhlke, I; Bokemeyer, C; Derigs, G; Hartmann, JT; Kanz, L; Kollmannsberger, C; Nichols, C; Rüther, U; Schleucher, N; Schmoll, HJ; Schöfski, P, 2000)
"The role of chemotherapy in the treatment of ependymoma has not been established."	2.68	Adjuvant chemotherapy for the treatment of intracranial ependymoma of childhood. ( Bergman, I; Cnaan, A; Garvin, JH; Goldwein, JW; Grass, J; Molloy, P; Needle, MN; Phillips, PC; Sutton, L; Zhao, H, 1997)
"All six patients with widespread metastases had major responses, including eradication of extensive bone marrow involvement, but distant relapses ensued."	2.68	Very-high-dose short-term chemotherapy for poor-risk peripheral primitive neuroectodermal tumors, including Ewing's sarcoma, in children and young adults. ( Aledo, A; Boland, P; Casper, ES; Gerald, WL; Healey, JH; Heller, G; Kushner, BH; La Quaglia, MP; Meyers, PA; Wollner, N, 1995)
"The patients were assigned to dosage cohorts separated on the basis of prior exposure to cisplatin (n = 10) or the absence of such exposure (n = 10)."	2.67	A phase I study of ifosfamide given on alternate days to treat children with brain tumors. ( Avery, L; Douglass, EC; Heideman, R; Kellie, SJ; Kovnar, EH; Kun, L; Pratt, CB, 1993)
"Interdigitating dendritic cell sarcoma is an extremely rare tumor."	2.52	Braf mutation in interdigitating dendritic cell sarcoma: a case report and review of the literature. ( Bonanno, L; Conte, P; Dei Tos, AP; Di Liso, E; Ghiotto, C; Lodovichetti, G; Pennelli, N, 2015)
"The present case, a CNS PNET, is suspected as a secondary brain tumor induced by radiation therapy previously used to treat a medulloblastoma, and it represents a rare late-onset complication of radiation therapy."	2.50	[CNS primitive neuroectodermal tumor suspected as a secondary recurrence after radiation therapy for medulloblastoma:a case report]. ( Endo, S; Kato, S; Koizumi, T; Sato, H; Shibuya, K, 2014)
"Brain metastases are rare in the natural history of Wilms tumor."	2.41	Brain metastases in Wilms' tumor: case report and literature review. ( Grimard, L; Halton, JM; Hsu, E; MacRae, R; Nizalik, E, 2002)
"Esthesioneuroblastoma (olfactory neuroblastoma) is a rare neuroendocrine tumor that arises in the upper nasal cavity from the olfactory epithelium."	2.40	Chemotherapy for advanced esthesioneuroblastoma: the Mayo Clinic experience. ( Buckner, JC; Lewis, JE; McElroy, EA, 1998)
"Thoracic and abdominal irradiation for Hodgkin's disease was performed concomitantly with chemotherapy for the non-Hodgkin's lymphoma."	2.38	Cerebral non-Hodgkin's lymphoma discovered when treating Hodgkin's disease. ( Bergeron, C; Chatel, M; Darcel, F; Edan, C; Faivre, J; Jouan, H; Le Moine, P; Le Prise-Fleury, E; Patte, C; Tass, P, 1993)
"When diagnosed with pulmonary metastasis, the patient received combined chemotherapy regimen of MAID (mesna, adriamycin, ifosfamide and dacarbazine) for 6 cycles."	1.51	MAID chemotherapy regimen as a treatment strategy for metastatic malignant ameloblastoma: A case report. ( Li, D; Liu, Y; Qiao, L; Sun, M; Wang, L; Xu, S, 2019)
"Grade 3-4 leukopenia was much more frequent in the HIT GBM-C/D cohort (n = 88, 52%) vs."	1.48	Concurrent radiotherapy with temozolomide vs. concurrent radiotherapy with a cisplatinum-based polychemotherapy regimen : Acute toxicity in pediatric high-grade glioma patients. ( Bison, B; Bojko, S; Gielen, GH; Hoffmann, M; Kortmann, RD; Kramm, CM; Pietsch, T; Seidel, C; von Bueren, AO; Warmuth-Metz, M, 2018)
"Malignant meningioma has a bad prognosis."	1.43	A successful case of an anaplastic meningioma treated with chemotherapy for soft tissue sarcomas. ( Buccoliero, AM; Farina, S; Favre, C; Fonte, C; Genitori, L; Guidi, M; Lucchesi, M; Sardi, I; Scoccianti, S, 2016)
"OBJECT Primary CNS sarcomas are very rare pediatric tumors with no defined standard of care."	1.43	Successful treatment of primary intracranial sarcoma with the ICE chemotherapy regimen and focal radiation in children. ( Bartels, U; Bouffet, E; Hader, W; Hawkins, C; Lafay-Cousin, L; Laperriere, N; Laughlin, S; Lindzon, G; Nordal, R; Taylor, MD, 2016)
"Patients with bones or brain metastases were treated with palliative radiotherapy only or combined with Doxorubicin."	1.43	Treatment of Patients with Distant Metastases from Phyllodes Tumor of the Breast. ( Blecharz, P; Jakubowicz, J; Kulpa, J; Mituś, JW; Reinfuss, M; Walasek, T, 2016)
" In the present analysis, we retrospectively investigated the feasibility and effectiveness of bevacizumab combined with ICE in patients with glioblastoma at second relapse during ICE treatment."	1.39	Retrospective analysis of bevacizumab in combination with ifosfamide, carboplatin, and etoposide in patients with second recurrence of glioblastoma. ( Arakawa, Y; Fujimoto, K; Kikuchi, T; Kunieda, T; Miyamoto, S; Mizowaki, T; Murata, D; Takagi, Y; Takahashi, JC, 2013)
"Alveolar soft part sarcomas are rarely seen and highly malignant tumors, and the prognosis of stage IV ASPS is poor."	1.38	[Treatment and prognosis of stage IV alveolar soft part sarcoma]. ( Yang, Y; Zhao, J, 2012)
"All patients revealed intracranial metastases manifesting as rapidly progressing neurological symptoms caused by mass effect in the posterior fossa."	1.37	Infratentorial brain metastases of pediatric non-epithelial malignant tumors: three case reports. ( Kumabe, T; Niizuma, H; Osawa, S; Saito, R; Sonoda, Y; Tominaga, T; Watanabe, M, 2011)
"Neuroblastoma is the most common extracranial solid malignancy in children but rarely described in adults, being 10% of all cases diagnosed after the first decade of life."	1.36	Neuroblastoma in an adult: case report. ( Ferreti Bonan, PR; Martelli-Júnior, H; Miranda Soares, PB; Pereira DE Souza, W; Quirino Filho, S, 2010)
"The high rate of adverse effects requires close follow up and dose reduction."	1.36	[The safety of combination chemotherapy with ifosfamide, cisplatin, and etoposide (ICE): single-institution retrospective review of 108 cases]. ( Kanamori, M; Kumabe, T; Saito, R; Sonoda, Y; Tominaga, T; Yamashita, Y, 2010)
" All 21 patients with DI required daily change in dosage and schedule of DDAVP."	1.36	Challenges in management of patients with intracranial germ cell tumor and diabetes insipidus treated with cisplatin and/or ifosfamide based chemotherapy. ( Afzal, S; Bartels, U; Bouffet, E; Huang, A; Stephens, D; Tabori, U; Wherrett, D, 2010)
"A 30-year-old man was diagnosed with testicular cancer, and underwent a radical orchiectomy."	1.35	[A case of recurrent metastatic testicular cancer, successfully treated with paclitaxel, ifomide and cisplatin]. ( Egawa, S; Hatano, T; Ito, H; Kishimoto, K; Tomita, M; Wada, T; Yanada, S, 2008)
"Hemangiopericytoma (HPC) is an uncommon primary brain tumor with an almost invariable tendency to recur and metastasize."	1.35	Sequential salvage chemotherapy for recurrent intracranial hemangiopericytoma. ( Chamberlain, MC; Glantz, MJ, 2008)
"We present a case of pleomorphic malignant fibrous histiocytoma arising from the left forearm in a 45-year-old man who had undergone resection and radiotherapy for a tumor 3 years previously."	1.35	Pleomorphic malignant fibrous histiocytoma: response of bone, lung, and brain metastases to chemotherapy. ( Hoshi, M; Ieguchi, M; Takami, M, 2008)
"Medulloblastoma is a common paediatric brain tumor."	1.35	[Frontal relapse of medulloblastoma. Causes and consequences (a case report)]. ( Besbes, M; Chaari, N; Ghorbel, I; Kochbati, L; Maalej, M, 2008)
" The authors' multidimensional analysis model revealed that besides the total ifosfamide dose and co-administration of other toxic drugs, polymorphic locus of GSTP1 gene may be one of the factors determining a higher toxicity of the cytostatic agent."	1.33	Role of GSTM1, GSTP1, and GSTT1 gene polymorphism in ifosfamide metabolism affecting neurotoxicity and nephrotoxicity in children. ( Misiura, K; Zielińska, E; Zubowska, M, 2005)
"A young woman presented with a pineoblastoma treated initially with whole neuraxis radiotherapy."	1.31	Long-term survival following extra-neural metastasis from a pineoblastoma. ( Fraser, G; Nicoll, J; Rampling, R; Smith, C; Stephen, M, 2000)
"The response rate in brain metastases was 50."	1.31	Combination chemotherapy of cisplatin, ifosfamide, and irinotecan with rhG-CSF support in patients with brain metastases from non-small cell lung cancer. ( Fujita, A; Fukuoka, S; Sekine, K; Tagaki, S; Takabatake, H, 2000)
"Records of 34 patients with ES/PNET who received the IVAD chemotherapy regimens were reviewed."	1.30	The use of paediatric chemotherapy protocols at full dose is both a rational and feasible treatment strategy in adults with Ewing's family tumours. ( Fisher, C; Harmer, CL; Judson, IR; Thomas, JM; Verrill, MW; Wiltshaw, E, 1997)
" The in vivo modulation of these alternative, competing pathways of P-450 metabolism was investigated in pharmacokinetic studies carried out in the rat model."	1.30	In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: impact on pharmacokinetics and antitumor activity. ( Brain, EG; Drewes, P; Gustafsson, K; Hecht, JE; Waxman, DJ; Yu, LJ, 1999)
"The patient died due to brain metastases 20 months after the start of intra-arterial chemotherapy."	1.30	[A case of metastatic liver tumors from prostatic cancer responding to intra-arterial infusion chemotherapy with CDDP and ifosfamide using implantable port]. ( Hasegawa, N; Kazama, A; Kondo, N; Tomita, M, 1999)
"A case of malignant fibrous histiocytoma (MFH) of jejunal origin with brain and lung metastases was treated by jejunal resection."	1.29	[A case of malignant fibrous histiocytoma of jejunal origin with marked response to cisplatin, ifosfamide and adriamycin]. ( Fujita, A; Isai, H; Kondo, M; Minase, T; Sekine, K; Tagaki, S, 1993)
"11 months later brain metastases were diagnosed."	1.29	Undifferentiated (embryonal) sarcoma of the liver in an adult patient with metastasis of the heart and brain. ( Fehske, W; Fischer, HP; Hartlapp, JH; Reichel, C, 1994)
" These results compare favourably with other combined modality studies, using multiple radiotherapy fractions with cisplatin-based combinations and dosage reduction for patients staged in more anatomical detail."	1.29	Therapy for small cell lung cancer using carboplatin, ifosfamide, etoposide (without dose reduction), mid-cycle vincristine with thoracic and cranial irradiation. ( Burt, P; Hicks, F; Leahy, B; Lorigan, P; Prendiville, J; Stout, R; Thatcher, N, 1994)
"The standard treatment of dysgerminoma is currently first line chemotherapy followed by relatively low-dose and limited irradiation; the standard treatment of non-seminomatous cerebral germ cell tumor is chemotherapy, the study of which is warranted with the aim to decrease the toxicity and to increase the efficacy."	1.29	[Cerebral germ cell tumors in adults. A retrospective study of 19 cases]. ( Agranat, P; Epardeau, B; Extra, JM; Jedynak, P; Mignot, L, 1995)
"Combination chemotherapy is widely employed in clinical oncology; however, there is no generally accepted model to evaluate individual tumour susceptibility to a given drug combination protocol."	1.28	In vitro studies on drug interaction of ifosfamide and ACNU in primary and metastatic human brain tumours. ( Apfel, R; Behl, C; Bogdahn, U; Drenkard, D; Lutz, M, 1991)
" With future identification of effective chemotherapy, new studies may be focused upon patients with localized disease to reduce radiation dosage or the need for immediate surgical resection of all involved eyes."	1.27	The use of chemotherapy for extraocular retinoblastoma. ( Crom, DB; Howarth, C; Pratt, CB, 1985)

Research

Studies (107)

Authors

Clinical Trials (6)

Trial Overview

Trial Outcomes

Number of Participants With Serious and/or Non-serious Adverse Events Assessed by the Common Terminology Criteria for Adverse Events (CTCAE v4.0)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (6.54)	18.7374
1990's	42 (39.25)	18.2507
2000's	29 (27.10)	29.6817
2010's	29 (27.10)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Seidel, C	1
von Bueren, AO	1
Bojko, S	1
Hoffmann, M	1
Pietsch, T	2
Gielen, GH	1
Warmuth-Metz, M	1
Bison, B	1
Kortmann, RD	2
Kramm, CM	1
Calaminus, G	2
Frappaz, D	4
Krefeld, B	1
Saran, F	2
Vasiljevic, A	1
Garre, ML	3
Ricardi, U	2
Mann, JR	1
Göbel, U	1
Alapetite, C	3
Murray, MJ	1
Nicholson, JC	2
Li, D	1
Xu, S	1
Sun, M	1
Qiao, L	1
Wang, L	1
Liu, Y	1
Kortmann, R	1
Worch, J	1
Patte, C	4
Wernhart, S	1
Woernle, CM	1
Neidert, MC	1
Bode, B	1
Rushing, EJ	2
Studer, G	1
Fuchs, I	1
Regli, L	1
Sürücü, O	1
Arakawa, Y	1
Mizowaki, T	1
Murata, D	1
Fujimoto, K	1
Kikuchi, T	1
Kunieda, T	1
Takahashi, JC	1
Takagi, Y	1
Miyamoto, S	1
Sato, H	1
Shibuya, K	1
Koizumi, T	1
Kato, S	1
Endo, S	1
Di Liso, E	1
Pennelli, N	1
Lodovichetti, G	1
Ghiotto, C	1
Dei Tos, AP	1
Conte, P	1
Bonanno, L	1
Goldman, S	1
Bouffet, E	5
Fisher, PG	1
Allen, JC	1
Robertson, PL	1
Chuba, PJ	1
Donahue, B	2
Kretschmar, CS	1
Zhou, T	1
Buxton, AB	1
Pollack, IF	1
Mituś, JW	1
Blecharz, P	1
Walasek, T	1
Reinfuss, M	1
Jakubowicz, J	1
Kulpa, J	1
Lafay-Cousin, L	1
Lindzon, G	1
Taylor, MD	1
Hader, W	1
Hawkins, C	1
Nordal, R	1
Laperriere, N	1
Laughlin, S	1
Bartels, U	2
Gramatzki, D	1
Roth, P	1
Felsberg, J	1
Hofer, S	1
Hentschel, B	1
Westphal, M	1
Krex, D	1
Simon, M	2
Schnell, O	1
Wick, W	1
Reifenberger, G	1
Weller, M	1
Lucchesi, M	1
Buccoliero, AM	1
Scoccianti, S	1
Guidi, M	1
Farina, S	1
Fonte, C	1
Favre, C	1
Genitori, L	1
Sardi, I	1
Pagliaro, LC	1
Kochbati, L	1
Ghorbel, I	1
Chaari, N	1
Besbes, M	1
Maalej, M	1
Yasuda, K	1
Taguchi, H	1
Sawamura, Y	4
Ikeda, J	4
Aoyama, H	2
Fujieda, K	3
Ishii, N	2
Kashiwamura, M	1
Iwasaki, Y	1
Shirato, H	4
Hoshi, M	1
Takami, M	1
Ieguchi, M	1
Chamberlain, MC	1
Glantz, MJ	1
Fidani, P	1
De Ioris, MA	1
Serra, A	1
De Sio, L	1
Ilari, I	1
Cozza, R	1
Boldrini, R	1
Milano, GM	1
Donfrancesco, A	1
Siefker-Radtke, AO	1
Kamat, AM	1
Grossman, HB	1
Williams, DL	1
Qiao, W	1
Thall, PF	1
Dinney, CP	1
Millikan, RE	1
Aoki, T	1
Mizutani, T	1
Nojima, K	1
Takagi, T	1
Okumura, R	1
Yuba, Y	1
Ueba, T	1
Takahashi, JA	1
Miyatake, S	1
Nozaki, K	1
Taki, W	1
Matsutani, M	1
Afzal, S	1
Wherrett, D	1
Tabori, U	1
Huang, A	1
Stephens, D	1
Zambrana, F	1
Vicente, F	1
García-Manrique, T	1
Pereira, S	1
Sáinz De Zaitigui, J	1
De La Cruz Merino, L	1
Pauly-Takacs, K	1
Moulin, CJ	1
Estlin, EJ	1
Brisse, H	1
Raquin, MA	1
Gaboriaud, G	1
Carrie, C	1
Habrand, JL	1
Thiesse, P	1
Cuilliere, JC	1
Bernier, V	1
Ben-Hassel, M	1
Baranzelli, MC	3
Kanamori, M	2
Kumabe, T	3
Saito, R	3
Yamashita, Y	2
Sonoda, Y	3
Tominaga, T	3
Ohno, M	1
Narita, Y	1
Osawa, S	1
Niizuma, H	1
Watanabe, M	2
Miranda Soares, PB	1
Quirino Filho, S	1
Pereira DE Souza, W	1
Ferreti Bonan, PR	1
Martelli-Júnior, H	1
Takahashi, S	1
Yoshida, K	1
Kawase, T	1
Schäfer, N	1
Tichy, J	1
Thanendrarajan, S	1
Kim, Y	1
Stuplich, M	1
Mack, F	1
Rieger, J	1
Scheffler, B	1
Boström, J	1
Steinbach, JP	1
Herrlinger, U	1
Glas, M	1
Schwitter, M	1
Potocnik, P	1
von Moos, R	1
Frick, H	1
Furrer, M	1
Cathomas, R	1
Sugimoto, K	1
Ideguchi, M	1
Sadahiro, H	1
Yoshikawa, K	1
Goto, H	1
Nomura, S	1
Fujii, M	1
Suzuki, M	1
Zhao, J	1
Yang, Y	1
Arellano-Rodrigo, E	1
López-Guillermo, A	1
Bessell, EM	1
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Montserrat, E	1
Graus, F	1
van den Bent, MJ	2
Grisold, W	1
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Lesimple, T	1
Dittrich, C	1
de Jonge, MJ	1
Brandes, A	1
Frenay, M	1
Carpentier, AF	1
Chollet, P	1
Oliveira, J	1
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Lacombe, D	1
Schuessler, M	1
Fumoleau, P	1
Kounami, S	1
Aoyagi, N	1
Nakayama, K	1
Yoshiyama, M	1
Boshi, H	1
Sakiyama, M	1
Takeuchi, T	1
Yoshikawa, N	1
Merimsky, O	1
Kollender, Y	1
Inbar, M	1
Meller, I	1
Bickels, J	1
Kunishio, K	1
Okada, M	2
Miyake, K	1
Matsumoto, Y	1
Nagao, S	1
Nishiyama, Y	1
Ohkawa, M	1
Ishizuka, O	1
Satoh, T	1
Mizuno, H	1
Mizusawa, H	1
Seki, S	1
Nishizawa, O	1
Esquerdo, G	1
Llorca, C	1
Cervera, JM	1
Briceño, H	1
Boutemy, M	1
Mispelaere, D	1
Krzisch, C	1
Jounieaux, V	1
Jahnke, K	1
Korfel, A	1
Komm, J	1
Bechrakis, NE	1
Stein, H	1
Thiel, E	1
Coupland, SE	1
Geyer, JR	1
Sposto, R	1
Jennings, M	1
Boyett, JM	1
Axtell, RA	1
Breiger, D	1
Broxson, E	1
Finlay, JL	1
Goldwein, JW	2
Heier, LA	1
Johnson, D	1
Mazewski, C	1
Miller, DC	1
Packer, R	1
Puccetti, D	1
Radcliffe, J	1
Tao, ML	1
Shiminski-Maher, T	1
Zielińska, E	1
Zubowska, M	1
Misiura, K	1
Bedano, PM	1
Bonnin, J	1
Einhorn, LH	2
Yanada, S	1
Ito, H	1
Tomita, M	2
Wada, T	1
Hatano, T	1
Kishimoto, K	1
Egawa, S	1
Burkert, H	1
Agranat, P	1
Jedynak, P	1
Epardeau, B	1
Extra, JM	1
Mignot, L	1
Simmonds, PD	1
Mead, GM	1
Whitehouse, JM	1
Loehrer, PJ	1
Ansari, R	1
Gonin, R	1
Monaco, F	1
Fisher, W	1
Sandler, A	1
Kushner, BH	2
Meyers, PA	2
Gerald, WL	1
Healey, JH	1
La Quaglia, MP	1
Boland, P	1
Wollner, N	1
Casper, ES	1
Aledo, A	1
Heller, G	1
Brewster, AE	1
Hopwood, P	1
Stout, R	2
Burt, PA	1
Thatcher, N	2
Cumin, I	1
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Dabouis, G	1
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Fischer, HP	1
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Fujita, A	2
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Minase, T	1
Tagaki, S	2
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Chastagner, P	3
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Brunat-Mentigny, M	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
ERibulin in Advanced Solitary Fibrous Tumor, an ItaliaN Sarcoma Group Phase II Study (ERASING)[NCT03840772]	Phase 2	16 participants (Anticipated)	Interventional	2019-07-17	Recruiting
Clinical Efficacy and Safety of IBER Salvage Treatment Followed by Ibrutinib Maintenance for Transplant-ineligible Patients With Relapsed or Refractory Primary Central Nervous System Lymphoma (PCNSL): a Multicenter, Single-arm, Prospective Phase II Study[NCT04066920]	Phase 2	30 participants (Anticipated)	Interventional	2019-10-01	Not yet recruiting
Phase II Multicenter Study Evaluating the Efficacy of Carboplatin-Etoposide Combination in Hormone-resistant Prostate Cancers With Neuroendocrine Differentiation.[NCT00973882]	Phase 2	60 participants (Actual)	Interventional	2005-04-30	Completed
Phase II Study of Cyclophosphamide, Doxorubicin, Vincristine, Etoposide, and Ifosfamide, Followed by Resection and Radiotherapy in Patients With Peripheral Primitive Neuroectodermal Tumors or Ewing's Sarcoma[NCT00002466]	Phase 2	0 participants	Interventional	1990-05-31	Completed
Assessment of MGMT Promoter Methylation and Clinical Benefit From Temozolomide-based Therapy in Ewing Sarcoma Patients[NCT03542097]		82 participants (Actual)	Observational	2014-04-15	Completed
A Phase 2 Study of Cabozantinib (XL184), a Dual Inhibitor of MET and VEGFR, in Patients With Metastatic Refractory Soft Tissue Sarcoma[NCT01755195]	Phase 2	55 participants (Actual)	Interventional	2013-01-15	Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Here is the number of participants with serious and/or non-serious adverse events assessed by the Common Terminology Criteria for Adverse Events (CTCAE v4.0). A non-serious adverse event is any untoward medical occurrence. A serious adverse event is an adverse event or suspected adverse reaction that results in death, a life-threatening adverse drug experience, hospitalization, disruption of the ability to conduct normal life functions, congenital anomaly/birth defect or important medical events that jeopardize the patient or subject and may require medical or surgical intervention to prevent one of the previous outcomes mentioned. (NCT01755195)
Timeframe: Date treatment consent signed to date off study, approximately 86 months and 3 days.

Objective Response (Complete Response (CR)+Partial Response (PR) of Cabozantinib in Patients With Soft Tissue Sarcomas

Intervention	Participants (Count of Participants)
Cabozantinib	53

Objective response was assessed by the Response Evaluation Criteria in Solid Tumors RECIST) v1.1. Complete Response is disappearance of all target lesions. Any pathological lymph nodes (whether target or non-target) must have reduction in short axis to <10 mm. Partial Response is at least a 30% decrease in the sum of the diameters of target lesions, taking as reference the baseline sum diameters. (NCT01755195)
Timeframe: Date treatment consent signed to date off study, approximately 86 months and 3 days.

Percentage of Participants With 6 Month Progression Free Survival (PFS)

Intervention	percentage of particpants (Number)
Cabozantinib	11.1

Progression in participants with soft tissue sarcomas treated with cabozantinib was assessed by the Response Evaluation Criteria in Solid Tumors (RECIST) v1.1. Progression is defined as at least a 20% increase in the sum of the diameters of target lesions, taking as reference the smallest sum on study. The appearance of one or more new lesions is also considered progressions. (NCT01755195)
Timeframe: 6 months

Mean Change From Baseline in Levels of Circulating Hepatocyte Growth Factor (HGF)

Intervention	percentage of participants (Number)
Cabozantinib	49.3

Blood samples were collected before treatment on the first day of cycles 1 and 2 to determine circulating levels of HGF. HGF protein content (in picograms; pg) in blood plasma (in milliliters; mL) was measured for each sample with a two-site immunoassay and the difference from before to after treatment for each patient was reported. A change in this biomarker from the baseline value has not been linked to clinical outcomes; that is, it is neither a good or a bad outcome. (NCT01755195)
Timeframe: Baseline to Cycle 1 Day 1 and baseline to Cycle 2 Day 1

Mean Change From Baseline in Levels of Circulating Soluble Mesenchymal Epithelial Transition Factor (sMET)

Intervention	pg/mL (Mean)
	Baseline to Cycle 1 Day 1	Baseline to Cycle 2 Day 1
Cabozantinib	-51.3	344.8

Blood samples were collected before treatment on the first day of cycles 1 and 2 to determine circulating levels of soluble MET (sMET). sMET protein content (in nanograms; ng) in blood plasma (in milliliters; mL) was measured for each sample with a two-site immunoassay and the difference from before to after treatment for each patient was reported. A change in this biomarker from the baseline value has not been linked to clinical outcomes; that is, it is neither a good or a bad outcome. (NCT01755195)
Timeframe: Baseline to Cycle 1 Day 1 and baseline to Cycle 2 Day 1

Mean Change From Baseline in Levels of Circulating Soluble Vascular Endothelial Growth Factor Receptor 2 (sVEGFR-2)

Intervention	ng/mL (Mean)
	Baseline to Cycle 1 Day 1	Baseline to Cycle 2 Day1
Cabozantinib	-6.1	16.4

Blood samples were collected before treatment on the first day of cycles 1 and 2 to determine circulating levels of soluble VEGFR2 (sVEGFR-2). sVEGFR-2 protein content (in nanograms; ng) in blood plasma (in milliliters; mL) was measured for each sample with a two-site immunoassay and the difference from before to after treatment for each patient was reported. A change in this biomarker from the baseline value has not been linked to clinical outcomes; that is, it is neither a good or a bad outcome.. (NCT01755195)
Timeframe: Baseline to Cycle 1 Day 1 and baseline to Cycle 2 Day 1

Mean Change From Baseline in Levels of Circulating Vascular Endothelial Growth Factor A (VEGF-A)

Intervention	ng/mL (Mean)
	Baseline to Cycle 1 Day 1	Baseline to Cycle 2 Day 1
Cabozantinib	-1.0	-10.9

Blood samples were collected before treatment on the first day of cycles 1 and 2 to determine circulating levels of VEGF-A. VEGF-A protein content (in picograms; pg) in blood plasma (in milliliters; mL) was measured for each sample with a two-site immunoassay and the difference from before to after treatment for each patient was reported. A change in this biomarker from the baseline value has not been linked to clinical outcomes; that is, it is neither a good or a bad outcome. (NCT01755195)
Timeframe: Baseline to Cycle 1 Day 1 and baseline to Cycle 2 Day 1

Article	Year
[CNS primitive neuroectodermal tumor suspected as a secondary recurrence after radiation therapy for medulloblastoma:a case report]. No shinkei geka. Neurological surgery, 2014, Volume: 42, Issue:7 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherapy; Cisplatin	2014
Braf mutation in interdigitating dendritic cell sarcoma: a case report and review of the literature. Cancer biology & therapy, 2015, Volume: 16, Issue:8 Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dendritic Cell Sarcoma, Interdigita	2015
Role of High-Dose Chemotherapy With Autologous Stem-Cell Rescue in Men With Previously Treated Germ Cell Tumors. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017, Apr-01, Volume: 35, Issue:10 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Combined Modality	2017
Yolk sac tumor of the bilateral basal ganglia in a patient with Down syndrome. Brain tumor pathology, 2013, Volume: 30, Issue:4 Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Basal Ganglia; Brain Neoplasms; Chemorad	2013
Palliative treatment for advanced or metastatic osteosarcoma. The Israel Medical Association journal : IMAJ, 2004, Volume: 6, Issue:1 Topics: Amputation, Surgical; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic A	2004
Ifosfamide: European perspective. Seminars in oncology, 1982, Volume: 9, Issue:4 Suppl 1 Topics: Antineoplastic Agents; Brain Neoplasms; Clinical Trials as Topic; Cyclophosphamide; Drug Administrat	1982
Cerebral non-Hodgkin's lymphoma discovered when treating Hodgkin's disease. Medical and pediatric oncology, 1993, Volume: 21, Issue:4 Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Brain Neoplasms; Carmustine; Cyc	1993
Remission of refractory gestational trophoblastic disease in the brain with ifosfamide, carboplatin, and etoposide (ICE): first report and review of literature. European journal of gynaecological oncology, 1997, Volume: 18, Issue:6 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Dose-Response Rel	1997
Chemotherapy for advanced esthesioneuroblastoma: the Mayo Clinic experience. Neurosurgery, 1998, Volume: 42, Issue:5 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Cisplatin;	1998
How effective is dose-intensive/myeloablative therapy against Ewing's sarcoma/primitive neuroectodermal tumor metastatic to bone or bone marrow? The Memorial Sloan-Kettering experience and a literature review. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Feb-01, Volume: 19, Issue:3 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Neoplasms; Bone Neopl	2001
Brain metastases in Wilms' tumor: case report and literature review. Journal of pediatric hematology/oncology, 2002, Volume: 24, Issue:2 Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Combined Modality Ther	2002
Current studies of ifosfamide for pediatric solid tumors and leukemia in the United States. Seminars in oncology, 1992, Volume: 19, Issue:6 Suppl 12 Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Child; Chil	1992

Article	Year
Phase II Trial Assessing the Ability of Neoadjuvant Chemotherapy With or Without Second-Look Surgery to Eliminate Measurable Disease for Nongerminomatous Germ Cell Tumors: A Children's Oncology Group Study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015, Aug-01, Volume: 33, Issue:22 Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Brain Neoplasms; Carb	2015
Low-dose craniospinal irradiation and ifosfamide, cisplatin and etoposide for non-metastatic embryonal tumors in the central nervous system. Japanese journal of clinical oncology, 2008, Volume: 38, Issue:7 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Pr	2008
A multimodal strategy based on surgery, radiotherapy, ICE regimen and high dose chemotherapy in atypical teratoid/rhabdoid tumours: a single institution experience. Journal of neuro-oncology, 2009, Volume: 92, Issue:2 Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Child; Child, Preschoo	2009
Phase II clinical trial of neoadjuvant alternating doublet chemotherapy with ifosfamide/doxorubicin and etoposide/cisplatin in small-cell urothelial cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Jun-01, Volume: 27, Issue:16 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Car	2009
Phase II study of ifosfamide, carboplatin, and etoposide in patients with a first recurrence of glioblastoma multiforme. Journal of neurosurgery, 2010, Volume: 112, Issue:1 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms;	2010
European Organization for Research and Treatment of Cancer (EORTC) open label phase II study on glufosfamide administered as a 60-minute infusion every 3 weeks in recurrent glioblastoma multiforme. Annals of oncology : official journal of the European Society for Medical Oncology, 2003, Volume: 14, Issue:12 Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Disease-Free Survival; Female; Glioblastoma; Gl	2003
Intraocular lymphoma 2000-2005: results of a retrospective multicentre trial. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2006, Volume: 244, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cyclophosphamide	2006
Multiagent chemotherapy and deferred radiotherapy in infants with malignant brain tumors: a report from the Children's Cancer Group. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Oct-20, Volume: 23, Issue:30 Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child, Preschool; Cisplatin; Combin	2005
Ifosfamide: European perspective. Seminars in oncology, 1982, Volume: 9, Issue:4 Suppl 1 Topics: Antineoplastic Agents; Brain Neoplasms; Clinical Trials as Topic; Cyclophosphamide; Drug Administrat	1982
Cisplatin plus etoposide with and without ifosfamide in extensive small-cell lung cancer: a Hoosier Oncology Group study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:10 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carcinoma, Small Cell;	1995
Very-high-dose short-term chemotherapy for poor-risk peripheral primitive neuroectodermal tumors, including Ewing's sarcoma, in children and young adults. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:11 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Pr	1995
Single fraction prophylactic cranial irradiation for small cell carcinoma of the lung. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1995, Volume: 34, Issue:2 Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Carcinoma, Small Cell;	1995
Phase II study of ifosfamide in childhood brain tumors: a report by the French Society of Pediatric Oncology (SFOP). Medical and pediatric oncology, 1993, Volume: 21, Issue:1 Topics: Adolescent; Adult; Brain Neoplasms; Child; Child, Preschool; Female; Humans; Ifosfamide; Infant; Mal	1993
A phase I study of ifosfamide given on alternate days to treat children with brain tumors. Cancer, 1993, Jun-01, Volume: 71, Issue:11 Topics: Adolescent; Brain Neoplasms; Child; Child, Preschool; Cisplatin; Drug Administration Schedule; Femal	1993
A phase II study of every other day high-dose ifosfamide in pediatric brain tumors: a Pediatric Oncology Group Study. Journal of neuro-oncology, 1995, Volume: 25, Issue:1 Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Carcinoma; Child	1995
Adjuvant chemotherapy for the treatment of intracranial ependymoma of childhood. Cancer, 1997, Jul-15, Volume: 80, Issue:2 Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Chemothera	1997
Synchronous radiochemotherapy in unfavorable brain tumors of children and young adults. Journal of neuro-oncology, 1998, Volume: 39, Issue:1 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Che	1998
Phase II study on cisplatin and ifosfamide in recurrent high grade gliomas. European journal of cancer (Oxford, England : 1990), 1998, Volume: 34, Issue:10 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Female; Glioma; H	1998
Combined treatment modality for intracranial germinomas: results of a multicentre SFOP experience. Société Française d'Oncologie Pédiatrique. British journal of cancer, 1999, Volume: 79, Issue:7-8 Topics: Adolescent; Adult; Antineoplastic Agents; Brain Neoplasms; Carboplatin; Child; Child, Preschool; Cho	1999
First-line high-dose chemotherapy +/- radiation therapy in patients with metastatic germ-cell cancer and brain metastases. Annals of oncology : official journal of the European Society for Medical Oncology, 2000, Volume: 11, Issue:5 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Combined Modality	2000
[Effectiveness of DeVIC chemotherapy for recurrent primary central nervous system lymphoma]. No shinkei geka. Neurological surgery, 2000, Volume: 28, Issue:9 Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplati	2000
Second-line carboplatin-based chemotherapy for small cell lung cancer: the Groningen experience. Seminars in oncology, 1992, Volume: 19, Issue:1 Suppl 2 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Car	1992
BOP/VIP--a new platinum-intensive chemotherapy regimen for poor prognosis germ cell tumours. Annals of oncology : official journal of the European Society for Medical Oncology, 1991, Volume: 2, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Brain Neoplasms; Chorioni	1991
Treatment of relapsed acute lymphocytic leukemia in adults. Haematology and blood transfusion, 1990, Volume: 33 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transpl	1990
Response to mesna, doxorubicin, ifosfamide, and dacarbazine in 108 patients with metastatic or unresectable sarcoma and no prior chemotherapy. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1989, Volume: 7, Issue:9 Topics: Actuarial Analysis; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Bra	1989
Doxorubicin, ifosfamide, and dacarbazine (AID) with mesna uroprotection for advanced untreated sarcoma: a phase I study. Cancer treatment reports, 1986, Volume: 70, Issue:7 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Doxorubic	1986

Article	Year
Concurrent radiotherapy with temozolomide vs. concurrent radiotherapy with a cisplatinum-based polychemotherapy regimen : Acute toxicity in pediatric high-grade glioma patients. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2018, Volume: 194, Issue:3 Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherapy; Chil	2018
Outcome of patients with intracranial non-germinomatous germ cell tumors-lessons from the SIOP-CNS-GCT-96 trial. Neuro-oncology, 2017, Nov-29, Volume: 19, Issue:12 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Brain Neoplasm	2017
MAID chemotherapy regimen as a treatment strategy for metastatic malignant ameloblastoma: A case report. Medicine, 2019, Volume: 98, Issue:25 Topics: Adult; Ameloblastoma; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine;	2019
SIOP CNS GCT 96: final report of outcome of a prospective, multinational nonrandomized trial for children and adults with intracranial germinoma, comparing craniospinal irradiation alone with chemotherapy followed by focal primary site irradiation for pat Neuro-oncology, 2013, Volume: 15, Issue:6 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Che	2013
A deeply seated brain metastasis from a primary myxofibrosarcoma: case report. Clinical neurology and neurosurgery, 2013, Volume: 115, Issue:10 Topics: Aged; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemot	2013
Retrospective analysis of bevacizumab in combination with ifosfamide, carboplatin, and etoposide in patients with second recurrence of glioblastoma. Neurologia medico-chirurgica, 2013, Volume: 53, Issue:11 Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Beva	2013
Treatment of Patients with Distant Metastases from Phyllodes Tumor of the Breast. World journal of surgery, 2016, Volume: 40, Issue:2 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Brain Neoplasms; Breast Neopla	2016
Successful treatment of primary intracranial sarcoma with the ICE chemotherapy regimen and focal radiation in children. Journal of neurosurgery. Pediatrics, 2016, Volume: 17, Issue:3 Topics: Adolescent; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms;	2016
Chemotherapy for intracranial ependymoma in adults. BMC cancer, 2016, Apr-23, Volume: 16 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Dis	2016
A successful case of an anaplastic meningioma treated with chemotherapy for soft tissue sarcomas. CNS oncology, 2016, Volume: 5, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child, Preschool; Doxorubicin; Huma	2016
[Frontal relapse of medulloblastoma. Causes and consequences (a case report)]. Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique, 2008, Volume: 12, Issue:8 Topics: Brain Neoplasms; Cerebellar Neoplasms; Child; Combined Modality Therapy; Humans; Ifosfamide; Male; M	2008
Pleomorphic malignant fibrous histiocytoma: response of bone, lung, and brain metastases to chemotherapy. Radiation medicine, 2008, Volume: 26, Issue:8 Topics: Acetabulum; Antineoplastic Combined Chemotherapy Protocols; Bone and Bones; Bone Neoplasms; Brain; B	2008
Sequential salvage chemotherapy for recurrent intracranial hemangiopericytoma. Neurosurgery, 2008, Volume: 63, Issue:4 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Cyclophosphamide;	2008
Challenges in management of patients with intracranial germ cell tumor and diabetes insipidus treated with cisplatin and/or ifosfamide based chemotherapy. Journal of neuro-oncology, 2010, Volume: 97, Issue:3 Topics: Adolescent; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms;	2010
Primary intracranial malignant peripheral nerve sheath tumour responding to chemotherapy. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2010, Volume: 12, Issue:3 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Doxorubicin; Humans; Ifosfam	2010
SenseCam as a rehabilitation tool in a child with anterograde amnesia. Memory (Hove, England), 2011, Volume: 19, Issue:7 Topics: Adolescent; Amnesia, Anterograde; Antineoplastic Combined Chemotherapy Protocols; Brain Damage, Chro	2011
Pattern of relapse and outcome of non-metastatic germinoma patients treated with chemotherapy and limited field radiation: the SFOP experience. Neuro-oncology, 2010, Volume: 12, Issue:12 Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Case-Control Studies;	2010
[The safety of combination chemotherapy with ifosfamide, cisplatin, and etoposide (ICE): single-institution retrospective review of 108 cases]. No shinkei geka. Neurological surgery, 2010, Volume: 38, Issue:11 Topics: Adolescent; Adult; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents,	2010
A case of pathological complete remission of a brain metastasis from germ cell tumor of the testis after systemic chemotherapy. Japanese journal of clinical oncology, 2010, Volume: 40, Issue:12 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Chor	2010
Infratentorial brain metastases of pediatric non-epithelial malignant tumors: three case reports. Brain tumor pathology, 2011, Volume: 28, Issue:2 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin	2011
Neuroblastoma in an adult: case report. Revista medica de Chile, 2010, Volume: 138, Issue:9 Topics: Antineoplastic Combined Chemotherapy Protocols; Biopsy; Bone Neoplasms; Brain Neoplasms; Carboplatin	2010
Combination chemotherapy with ifosfamide, cisplatin, and etoposide for medulloblastoma: single-institute experience and differences in efficacy for subgroups of medulloblastoma. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2011, Volume: 27, Issue:9 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Pr	2011
Intracranial germ cell tumors: efficacy of neoadjuvant chemo-radiotherapy without surgical biopsy. The Keio journal of medicine, 2011, Volume: 60, Issue:2 Topics: Adolescent; Adult; alpha-Fetoproteins; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, T	2011
Ifosfamide, carboplatin and etoposide in recurrent malignant glioma. Oncology, 2011, Volume: 80, Issue:5-6 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carboplat	2011
Dyspnoea and a lung mass in a young female 2 weeks after Caesarean delivery. The European respiratory journal, 2011, Volume: 38, Issue:2 Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Neoplasms	2011
[Treatment and prognosis of stage IV alveolar soft part sarcoma]. Zhonghua zhong liu za zhi [Chinese journal of oncology], 2012, Volume: 34, Issue:12 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Brain Neoplasms; Dacarbazine;	2012
Salvage treatment with etoposide (VP-16), ifosfamide and cytarabine (Ara-C) for patients with recurrent primary central nervous system lymphoma. European journal of haematology, 2003, Volume: 70, Issue:4 Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine	2003
Fatal pulmonary thromboembolism after a second course of high-dose chemotherapy with autologous peripheral blood stem cell transplantation. Pediatric transplantation, 2003, Volume: 7, Issue:5 Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child, Preschool; Cisplatin; Cyclop	2003
[Report of two cases with germinoma treated by individual adjuvant chemotherapy based on the mRNA expression of drug-resistance gene]. No shinkei geka. Neurological surgery, 2004, Volume: 32, Issue:1 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Ad	2004
[A difficult case of advanced testicular choriocarcinoma effectively treated by chemotherapy and resection of lung metastasis]. Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:2 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Choriocarcinoma	2004
A rare case of breast sarcoma brain metastases. Journal of neuro-oncology, 2005, Volume: 72, Issue:2 Topics: Adult; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Fatal Outcome; Female; Humans; Ifos	2005
[Evaluation of combined chemotherapy with vinorelbine, ifosfamide and cisplatin in the treatment of metastatic non-small cell bronchial carcinoma]. Revue des maladies respiratoires, 2005, Volume: 22, Issue:3 Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carcin	2005
Role of GSTM1, GSTP1, and GSTT1 gene polymorphism in ifosfamide metabolism affecting neurotoxicity and nephrotoxicity in children. Journal of pediatric hematology/oncology, 2005, Volume: 27, Issue:11 Topics: Adolescent; Antineoplastic Agents, Alkylating; Brain Neoplasms; Child; Child, Preschool; Cyclophosph	2005
Metachronous intracranial germinoma in a patient with a previous primary mediastinal seminoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, May-20, Volume: 24, Issue:15 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Brain Neoplasms; Cisplatin; Combin	2006
[A case of recurrent metastatic testicular cancer, successfully treated with paclitaxel, ifomide and cisplatin]. Hinyokika kiyo. Acta urologica Japonica, 2008, Volume: 54, Issue:1 Topics: Adult; alpha-Fetoproteins; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic	2008
[Cerebral germ cell tumors in adults. A retrospective study of 19 cases]. Bulletin du cancer, 1995, Volume: 82, Issue:8 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Brain Neoplasms; Carbo	1995
A complicated case of metastatic teratoma. Growing teratoma syndrome and cerebral metastasis. Annals of oncology : official journal of the European Society for Medical Oncology, 1995, Volume: 6, Issue:2 Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bleomycin; Brain Neoplasms; Cispl	1995
[Efficacy of the combination of mitomycin, ifosfamide and cisplatin with irradiation for the treatment of cerebral metastasis in non small cell lung carcinoma]. Bulletin du cancer, 1995, Volume: 82, Issue:1 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carcinoma, Non-Small-C	1995
Therapy for small cell lung cancer using carboplatin, ifosfamide, etoposide (without dose reduction), mid-cycle vincristine with thoracic and cranial irradiation. European journal of cancer (Oxford, England : 1990), 1994, Volume: 30A, Issue:14 Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Carcinoma, Small Cell;	1994
Undifferentiated (embryonal) sarcoma of the liver in an adult patient with metastasis of the heart and brain. The Clinical investigator, 1994, Volume: 72, Issue:3 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Combined Modality Therapy; E	1994
[A case of malignant fibrous histiocytoma of jejunal origin with marked response to cisplatin, ifosfamide and adriamycin]. Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:13 Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Doxorubicin; Histiocytom	1993
Management of small-cell lung cancer. Clinics in chest medicine, 1993, Volume: 14, Issue:1 Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Carcinoma, Small Cell;	1993
Ifosfamide in the treatment of pediatric malignancies. Seminars in oncology, 1996, Volume: 23, Issue:3 Suppl 7 Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms;	1996
Complete remission of refractory gestational trophoblastic disease with brain metastases treated with multicycle ifosfamide, carboplatin, and etoposide (ICE) and stem cell rescue. Gynecologic oncology, 1997, Volume: 65, Issue:2 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Combined Modality	1997
Concomitant brain radiotherapy and high-dose ifosfamide in brain relapses of lung cancer. Annals of oncology : official journal of the European Society for Medical Oncology, 1997, Volume: 8, Issue:9 Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Cranial	1997
Induction chemotherapy followed by reduced-volume radiation therapy for newly diagnosed central nervous system germinoma. Journal of neurosurgery, 1998, Volume: 88, Issue:1 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Ad	1998
The use of paediatric chemotherapy protocols at full dose is both a rational and feasible treatment strategy in adults with Ewing's family tumours. Annals of oncology : official journal of the European Society for Medical Oncology, 1997, Volume: 8, Issue:11 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Brain Neoplasms;	1997
[Pilot study of relapsed osteosarcoma and brain tumor with ifosfamide, carboplatin and etoposide (ICE therapy)]. Gan to kagaku ryoho. Cancer & chemotherapy, 1998, Volume: 25, Issue:3 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Brain Neoplasms;	1998
Cyclophosphamide and ifosfamide metabolites in the cerebrospinal fluid of children. Clinical cancer research : an official journal of the American Association for Cancer Research, 1997, Volume: 3, Issue:11 Topics: Adolescent; Antineoplastic Agents; Biotransformation; Brain Neoplasms; Child; Child, Preschool; Cycl	1997
[Successful management for chemorefractory testicular cancer with brain and lung metastases. A case report]. Nihon Hinyokika Gakkai zasshi. The japanese journal of urology, 1998, Volume: 89, Issue:12 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Neoplasms; Carcinoma, Embryonal;	1998
In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: impact on pharmacokinetics and antitumor activity. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:3 Topics: Animals; Antineoplastic Agents; Area Under Curve; Brain Neoplasms; Cyclophosphamide; Cytochrome P-45	1999
Preirradiation evaluation and technical assessment of involved-field radiotherapy using computed tomographic (CT) simulation and neoadjuvant chemotherapy for intracranial germinoma. International journal of radiation oncology, biology, physics, 1999, Mar-01, Volume: 43, Issue:4 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Ad	1999
[A case of metastatic liver tumors from prostatic cancer responding to intra-arterial infusion chemotherapy with CDDP and ifosfamide using implantable port]. Hinyokika kiyo. Acta urologica Japonica, 1999, Volume: 45, Issue:6 Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Brain Neoplasm	1999
Concomitant brain radiotherapy and vinorelbine-ifosfamide-cisplatin chemotherapy in brain metastases of non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands), 1999, Volume: 26, Issue:1 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carcinoma, Non-Small-C	1999
[A successfully operated case of choriocarcinoma with recurrent intratumoral hemorrhage]. No shinkei geka. Neurological surgery, 2000, Volume: 28, Issue:1 Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cerebral Hemorrhage; Child; Chorioc	2000
Long-term survival following extra-neural metastasis from a pineoblastoma. Journal of neuro-oncology, 2000, Volume: 48, Issue:2 Topics: Acetabulum; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Brain Neopla	2000
Combination chemotherapy of cisplatin, ifosfamide, and irinotecan with rhG-CSF support in patients with brain metastases from non-small cell lung cancer. Oncology, 2000, Volume: 59, Issue:4 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Carcinom	2000
[Post-operative neoadjuvant chemotherapy before radiotherapy as compared to immediate radiotherapy followed by maintenance chemotherapy in the treatment of medulloblastoma in childhood: results of German prospective randomised trial HIT'91]. Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique, 2001, Volume: 5, Issue:2 Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant;	2001
Induction chemotherapy followed by low-dose involved-field radiotherapy for intracranial germ cell tumors. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Feb-01, Volume: 20, Issue:3 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Chorionic	2002
[An autopsy case of pulmonary and central nervous system metastatic osteosarcoma treated with thirty-six courses of chemotherapy over four years]. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2002, Volume: 40, Issue:1 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Brain Neoplasms; Carboplatin;	2002
[A case of adenocarcinoma of lung cancer with multiple brain metastasis and lymphangitis carcinomatosa responding well to chemotherapy with carboplatin, etoposide and ifosfamide]. Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:14 Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin;	1992
Palliative radio-chemotherapy with ifosfamide and BCNU for breast cancer patients with cerebral metastases. A 5-year experience. Cancer chemotherapy and pharmacology, 1990, Volume: 26 Suppl Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Breast Neoplasms; Carm	1990
In vitro studies on drug interaction of ifosfamide and ACNU in primary and metastatic human brain tumours. Journal of cancer research and clinical oncology, 1991, Volume: 117 Suppl 4 Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Drug Interactions; Humans; Ifosfami	1991
Phase II study of ifosfamide with mesna in adult patients with recurrent diffuse astrocytoma. Journal of neuro-oncology, 1991, Volume: 10, Issue:1 Topics: Adolescent; Adult; Aged; Astrocytoma; Blood Cell Count; Brain Neoplasms; Drug Evaluation; Humans; If	1991
Cyclophosphamide versus ifosfamide in paediatric oncology. Lancet (London, England), 1990, Oct-27, Volume: 336, Issue:8722 Topics: Brain Neoplasms; Child; Cyclophosphamide; Drug Administration Schedule; Humans; Ifosfamide; Neoplasm	1990
Mesna, doxorubicin, ifosfamide, dacarbazine (MAID) regimen for adults with advanced sarcoma. Seminars in oncology, 1990, Volume: 17, Issue:2 Suppl 4 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Combined Modality Ther	1990
[A case from practice (134). Patient: Mr. J.D., 1956, electrician]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1989, Mar-21, Volume: 78, Issue:12 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Doxorubicin; Heart Neoplasms	1989
Severe encephalopathy associated with ifosfamide administration in two children with metastatic tumors. Journal of neuro-oncology, 1988, Volume: 6, Issue:1 Topics: Brain Neoplasms; Child, Preschool; Coma; Electroencephalography; Female; Humans; Ifosfamide; Kidney	1988
Simultaneous radiotherapy and chemotherapy in the treatment of brain metastases of malignant solid tumours. International journal of clinical pharmacology research, 1987, Volume: 7, Issue:5 Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine	1987
The use of chemotherapy for extraocular retinoblastoma. Medical and pediatric oncology, 1985, Volume: 13, Issue:6 Topics: Bone Marrow Diseases; Brain Neoplasms; Child; Cyclophosphamide; Doxorubicin; Drug Evaluation; Eye Ne	1985

ifosfamide and Benign Neoplasms, Brain