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ifosfamide and Aging

ifosfamide has been researched along with Aging in 8 studies

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
" To assess the impact of adjuvant chemotherapy, we reviewed the overall survival of consecutive patients with anaplastic ependymoma treated over a 10-year period with surgery and ICE (ifosfamide+ VP 16+carboplatin) chemotherapy with or without radiation at our institution."3.70Use of adjuvant ICE chemotherapy in the treatment of anaplastic ependymomas. ( Baruchel, S; Chan, H; Fouladi, M; Grant, R; Greenberg, ML; Malkin, D; Weitzman, S, 1998)
"Ifosfamide has been in use as an effective antineoplastic agent for solid tumors in both children and adults since the late 1960s."2.41Young age and the risk for ifosfamide-induced nephrotoxicity: a critical review of two opposing studies. ( Aleksa, K; Koren, G; Woodland, C, 2001)
"Ifosfamide is a prodrug that requires biotransformation to become cytotoxic."2.39Ifosfamide clinical pharmacokinetics. ( Wagner, T, 1994)
" This will adversely affect the health and well-being of children, especially when the developing kidney is exposed to toxic agents that may lead to acute glomerular, tubular or combined toxicity."1.33Cytochrome P450 3A and 2B6 in the developing kidney: implications for ifosfamide nephrotoxicity. ( Aleksa, K; Gelboin, H; Ito, S; Koren, G; Krausz, K; Matsell, D, 2005)
" A positive correlation was found between the elimination half-life of ifosfamide and age (r = 0."1.28The effect of age on the pharmacokinetics of ifosfamide. ( Cerny, T; Lind, MJ; Margison, JM; Thatcher, N; Wilkinson, PM, 1990)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (50.00)18.2507
2000's4 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Misiura, K1
Zubowska, M1
ZieliƄska, E1
Aleksa, K3
Matsell, D1
Krausz, K1
Gelboin, H1
Ito, S2
Koren, G3
Wagner, T1
Fouladi, M1
Baruchel, S1
Chan, H1
Grant, R1
Malkin, D1
Weitzman, S1
Greenberg, ML1
Woodland, C1
Lewis, LD1
Lind, MJ1
Margison, JM1
Cerny, T1
Thatcher, N1
Wilkinson, PM1

Reviews

3 reviews available for ifosfamide and Aging

ArticleYear
Ifosfamide clinical pharmacokinetics.
    Clinical pharmacokinetics, 1994, Volume: 26, Issue:6

    Topics: Administration, Oral; Aging; Animals; Central Nervous System; Drug Interactions; Half-Life; Humans;

1994
Young age and the risk for ifosfamide-induced nephrotoxicity: a critical review of two opposing studies.
    Pediatric nephrology (Berlin, Germany), 2001, Volume: 16, Issue:12

    Topics: Aging; Dose-Response Relationship, Drug; Humans; Ifosfamide; Immunosuppressive Agents; Kidney; Risk

2001
Ifosfamide pharmacokinetics.
    Investigational new drugs, 1991, Volume: 9, Issue:4

    Topics: Administration, Oral; Aging; Brain Diseases; Dose-Response Relationship, Drug; Humans; Ifosfamide

1991

Trials

1 trial available for ifosfamide and Aging

ArticleYear
Analysis of the urinary excretion of ifosfamide and its N-dechloroethylated metabolites in children using 31P-NMR spectroscopy.
    Arzneimittel-Forschung, 2003, Volume: 53, Issue:5

    Topics: Adolescent; Aging; Antineoplastic Agents, Alkylating; Biotransformation; Child; Child, Preschool; Fe

2003

Other Studies

4 other studies available for ifosfamide and Aging

ArticleYear
Cytochrome P450 3A and 2B6 in the developing kidney: implications for ifosfamide nephrotoxicity.
    Pediatric nephrology (Berlin, Germany), 2005, Volume: 20, Issue:7

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Antibodies, Monoclonal; Antineoplastic Agents, Al

2005
Enantioselective metabolism of ifosfamide by the kidney.
    Chirality, 2006, Volume: 18, Issue:6

    Topics: Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Aging; Animals; Antineoplastic Agents,

2006
Use of adjuvant ICE chemotherapy in the treatment of anaplastic ependymomas.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 1998, Volume: 14, Issue:10

    Topics: Aging; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cerebellar Neoplasms; Child; Chi

1998
The effect of age on the pharmacokinetics of ifosfamide.
    British journal of clinical pharmacology, 1990, Volume: 30, Issue:1

    Topics: Adult; Aged; Aging; Body Water; Carcinoma, Non-Small-Cell Lung; Half-Life; Humans; Ifosfamide; Lung

1990