Page last updated: 2024-10-29

ifosfamide and Adult Fanconi Syndrome

ifosfamide has been researched along with Adult Fanconi Syndrome in 48 studies

Research Excerpts

ExcerptRelevanceReference
"The renal tubular Fanconi syndrome developed in five patients with Wilms tumor after treatment with ifosfamide, a derivative of cyclophosphamide."7.68Ifosfamide-induced renal tubular dysfunction and rickets in children with Wilms tumor. ( Burk, CD; Kaplan, BS; Meadows, AT; Restaino, I, 1990)
"Diabetes insipidus is also a rare complication of ifosfamide-induced renal disease."6.50Ifosfamide-induced Fanconi syndrome with diabetes insipidus. ( Kang, BD; Kim, HS; Kim, MH; Leem, AY; Rha, SY; Yoo, BW, 2014)
" In addition, the chemotherapeutic agent ifosfamide caused a decrease in plasma GPx activity in pediatric osteosarcoma patients."3.70Plasma glutathione peroxidase and its relationship to renal proximal tubule function. ( Avissar, N; Bhamre, S; Cohen, HJ; Ornt, DB; Salvatierra, O; Scandling, JD; Tham, DM; Tune, BM; Whitin, JC, 1998)
"A 20-year old man was treated for an osteosarcoma with a chemotherapy regimen that included ifosfamide, methotrexate, and doxorubicin."3.69Ifosfamide-induced Fanconi syndrome. ( Garcia, AA, 1995)
"The renal tubular Fanconi syndrome developed in five patients with Wilms tumor after treatment with ifosfamide, a derivative of cyclophosphamide."3.68Ifosfamide-induced renal tubular dysfunction and rickets in children with Wilms tumor. ( Burk, CD; Kaplan, BS; Meadows, AT; Restaino, I, 1990)
"Diabetes insipidus is also a rare complication of ifosfamide-induced renal disease."2.50Ifosfamide-induced Fanconi syndrome with diabetes insipidus. ( Kang, BD; Kim, HS; Kim, MH; Leem, AY; Rha, SY; Yoo, BW, 2014)
" In most clinical pharmacokinetic studies, the phenomenon of autoinduction has been observed, but the mechanism is not completely understood."2.41Clinical pharmacokinetics and pharmacodynamics of ifosfamide and its metabolites. ( Beijnen, JH; de Kraker, J; Groen, HJ; Jansen, RL; Keizer, HJ; Kerbusch, T; Schellens, JH; van Putten, JW, 2001)
"Ifosfamide (IFA) is a powerful chemotherapeutic drug that is active against a variety of paediatric malignancies."1.37Ifosfamide induced Fanconi syndrome. ( Buttemer, S; Lau, KK; Pai, M, 2011)
"The renal Fanconi syndrome is a defect of proximal tubular function causing aminoaciduria and low-molecular-weight proteinuria."1.34Combined proteomic and metabonomic studies in three genetic forms of the renal Fanconi syndrome. ( Capasso, G; Cutillas, PR; Holmes, E; Maher, AD; Nicholson, JK; Norden, AW; Unwin, RJ; Vilasi, A; Zirah, SF, 2007)
"Five patients developed renal Fanconi syndrome during follow-up, and another seven patients developed a generalized subclinical tubulopathy."1.30Development of ifosfamide-induced nephrotoxicity: prospective follow-up in 75 patients. ( Deufel, T; Jürgens, H; Kleta, R; Kuhn, N; Pleyer, J; Rossi, R; Schäfers, P, 1999)
"Ifosfamide is a derivative of cyclophosphamide and is used to treat malignant tumours."1.29Hypophosphataemic rickets after ifosfamide treatment in children. ( Sweeney, LE, 1993)
"Two patients developed renal Fanconi syndrome (RFS) after intensive long-term chemotherapy for metastatic Ewing sarcoma and disseminated neuroblastoma."1.28Tubular function and histological findings in ifosfamide-induced renal Fanconi syndrome--a report of two cases. ( Helmchen, U; Rossi, R; Schellong, G, 1992)

Research

Studies (48)

TimeframeStudies, this research(%)All Research%
pre-19905 (10.42)18.7374
1990's30 (62.50)18.2507
2000's7 (14.58)29.6817
2010's5 (10.42)24.3611
2020's1 (2.08)2.80

Authors

AuthorsStudies
Krupadev, V1
Thomas, V1
Dahr, SE1
Warrier, R1
Kamran, SC1
Pendergraft, WF1
Harmon, DC1
Rubin, MF1
Leem, AY1
Kim, HS2
Yoo, BW1
Kang, BD1
Kim, MH1
Rha, SY1
Ingemi, AI1
Bota, VM1
Peguero, A1
Charpentier, M1
Buttemer, S1
Pai, M1
Lau, KK1
Sayed-Ahmed, MM1
Hafez, MM1
Aldelemy, ML1
Aleisa, AM1
Al-Rejaie, SS1
Al-Hosaini, KA1
Al-Harbi, NO1
Al-Harbi, MM1
Al-Shabanah, OA1
Sener, G2
Sehirli, O2
Yegen, BC2
Cetinel, S2
Gedik, N2
Sakarcan, A2
Duck, L1
Devogelaer, JP1
Persu, A1
Berlière, M1
Caussin, E1
Baurain, JF1
Machiels, JP1
Kołłataj, B1
Zajaczkowska, M1
Katski, K1
Sikora, P1
Pijanowska, M1
Majewski, M1
Kołłataj, W1
Velioğlu-Oğünç, A1
Vilasi, A1
Cutillas, PR1
Maher, AD1
Zirah, SF1
Capasso, G1
Norden, AW1
Holmes, E1
Nicholson, JK1
Unwin, RJ1
Phillips, RS1
Tyerman, K1
Al-Kassim, MI1
Picton, S1
Sangster, G1
Kaye, SB1
Calman, KC1
Dalton, JF1
Garcia, AA1
Segal, LS1
Palumbo, RC1
Robertson, WW1
Zamlauski-Tucker, MJ1
Morris, ME1
Springate, JE1
Hanquinet, S1
Wouters, M1
Devalck, C2
Perlmutter, N1
Sariban, E2
Rossi, RM1
Kist, C1
Wurster, U1
Külpmann, WR1
Ehrich, JH3
Rossi, R9
Kleinebrand, A3
Gödde, A3
Rath, B3
Jürgens, H5
Kiss, K1
Nagy, K1
Hunyadi, K1
Simkó, R1
Danzebrink, S1
Hillebrand, D1
Linnenbürger, K1
Ullrich, K2
Riepenhausen, M1
Boos, J1
Ritter, J1
Beckwith, C1
Flaharty, KK1
Cheung, AK1
Beatty, PG1
Sweeney, LE1
Nissim, I1
Weinberg, JM1
Ashraf, MS1
Skinner, R1
English, MW1
Craft, AW1
Pearson, AD1
Negro, A1
Regolisti, G1
Perazzoli, F1
Davoli, S1
Sani, C1
Rossi, E1
Whitin, JC1
Tham, DM1
Bhamre, S1
Ornt, DB1
Scandling, JD1
Tune, BM1
Salvatierra, O1
Avissar, N1
Cohen, HJ1
Badary, OA2
Pleyer, J1
Schäfers, P1
Kuhn, N1
Kleta, R1
Deufel, T1
Di Cataldo, A1
Palumbo, M1
Pittalà, D1
Renis, M1
Schilirò, G1
Russo, A1
Ragusa, R1
Mollica, F1
Li Volti, S1
Kerbusch, T1
de Kraker, J1
Keizer, HJ1
van Putten, JW1
Groen, HJ1
Jansen, RL1
Schellens, JH1
Beijnen, JH1
Helmchen, U1
Schellong, G1
Van Gool, S1
Brock, P1
Wijndaele, G1
Van de Casseye, W1
Kruger, M1
Proesmans, W1
Casteels-Van Daele, M1
Pratt, CB1
Meyer, WH1
Jenkins, JJ1
Avery, L1
McKay, CP1
Wyatt, RJ1
Hancock, ML1
Suarez, A1
McDowell, H1
Niaudet, P1
Comoy, E1
Flamant, F1
Ismaili, K1
Ferster, A1
De Schepper, J1
Stevens, G1
Verboven, M1
Baeta, C1
Otten, J1
Burk, CD1
Restaino, I1
Kaplan, BS1
Meadows, AT1
Newbury-Ecob, RA1
Noble, VW1
Barbor, PR1
Heney, D1
Lewis, IJ1
Bailey, CC1
Moncrieff, M1
Foot, A1
Smeitink, J1
Verreussel, M1
Schröder, C1
Lippens, R1

Reviews

4 reviews available for ifosfamide and Adult Fanconi Syndrome

ArticleYear
Ifosfamide-induced Fanconi syndrome with diabetes insipidus.
    The Korean journal of internal medicine, 2014, Volume: 29, Issue:2

    Topics: Acidosis; Antineoplastic Agents, Alkylating; Chemotherapy, Adjuvant; Diabetes Insipidus; Fanconi Syn

2014
Fanconi's syndrome and nephrogenic diabetes insipidus in an adult treated with ifosfamide.
    Pharmacotherapy, 2012, Volume: 32, Issue:1

    Topics: Diabetes Insipidus, Nephrogenic; Diagnosis, Differential; Fanconi Syndrome; Humans; Ifosfamide; Male

2012
A systematic review of the accuracy and utility of early markers of Ifosfamide-induced proximal tubulopathy in survivors of childhood cancers.
    Pediatric hematology and oncology, 2008, Volume: 25, Issue:2

    Topics: Acute Disease; Adolescent; Adult; Antineoplastic Agents, Alkylating; Biomarkers; Child; Child, Presc

2008
Clinical pharmacokinetics and pharmacodynamics of ifosfamide and its metabolites.
    Clinical pharmacokinetics, 2001, Volume: 40, Issue:1

    Topics: Animals; Antineoplastic Agents, Alkylating; Area Under Curve; Cyclophosphamide; Cytochrome P-450 Enz

2001

Trials

1 trial available for ifosfamide and Adult Fanconi Syndrome

ArticleYear
[Ifosfamide-induced nephrotoxicity].
    Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1993, Volume: 141, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Child; Cisplatin; Creatinine

1993

Other Studies

43 other studies available for ifosfamide and Adult Fanconi Syndrome

ArticleYear
Developmental Delay and Refusal to Walk in an Infant.
    Clinical pediatrics, 2021, Volume: 60, Issue:2

    Topics: Antineoplastic Agents, Alkylating; Child, Preschool; Developmental Disabilities; Diagnosis, Differen

2021
Ifosfamide-induced Fanconi syndrome and desmopressin-responsive nephrogenic diabetes insipidus.
    The American journal of medicine, 2013, Volume: 126, Issue:7

    Topics: Administration, Intranasal; Adult; Antidiuretic Agents; Antineoplastic Agents, Alkylating; Deamino A

2013
Ifosfamide induced Fanconi syndrome.
    BMJ case reports, 2011, Dec-20, Volume: 2011

    Topics: Antineoplastic Agents, Alkylating; Child, Preschool; Fanconi Syndrome; Humans; Ifosfamide; Male

2011
Downregulation of oxidative and nitrosative apoptotic signaling by L-carnitine in Ifosfamide-induced Fanconi syndrome rat model.
    Oxidative medicine and cellular longevity, 2012, Volume: 2012

    Topics: Animals; Apoptosis; Blood Urea Nitrogen; Carnitine; Caspases; Catalase; Creatinine; Disease Models,

2012
Melatonin attenuates ifosfamide-induced Fanconi syndrome in rats.
    Journal of pineal research, 2004, Volume: 37, Issue:1

    Topics: Animals; Antineoplastic Agents, Alkylating; Antioxidants; Fanconi Syndrome; Female; Glucose; Glutath

2004
Osteomalacia due to chemotherapy-induced Fanconi syndrome in an adult patient.
    Gynecologic oncology, 2005, Volume: 98, Issue:2

    Topics: Carcinoma, Squamous Cell; Fanconi Syndrome; Female; Humans; Ifosfamide; Middle Aged; Osteomalacia; U

2005
[Acquired Fanconi-de Toni-Debre syndrome due to therapy for Ewing's sarcoma in 5-years old boy].
    Przeglad lekarski, 2006, Volume: 63 Suppl 3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child, Preschool; Dactinomycin; Doxo

2006
Resveratrol improves ifosfamide-induced Fanconi syndrome in rats.
    Toxicology and applied pharmacology, 2007, Jul-01, Volume: 222, Issue:1

    Topics: Animals; Antineoplastic Agents, Alkylating; Antioxidants; Blood Urea Nitrogen; Cytokines; Fanconi Sy

2007
Combined proteomic and metabonomic studies in three genetic forms of the renal Fanconi syndrome.
    American journal of physiology. Renal physiology, 2007, Volume: 293, Issue:2

    Topics: Adult; Antineoplastic Agents, Alkylating; Chloride Channels; DNA Fingerprinting; Fanconi Syndrome; F

2007
Failure of 2-mercaptoethane sulphonate sodium (mesna) to protect against ifosfamide nephrotoxicity.
    European journal of cancer & clinical oncology, 1984, Volume: 20, Issue:3

    Topics: Adult; Cyclophosphamide; Fanconi Syndrome; Female; Humans; Ifosfamide; Intestinal Neoplasms; Leiomyo

1984
Ifosfamide-induced Fanconi syndrome.
    The Annals of pharmacotherapy, 1995, Volume: 29, Issue:6

    Topics: Adult; Bone Neoplasms; Fanconi Syndrome; Humans; Ifosfamide; Male; Osteomalacia; Osteosarcoma

1995
The development of rickets as a complication of chemotherapy for the treatment of Wilms' tumor.
    Orthopedics, 1995, Volume: 18, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bicarbonates; Calcitriol; Child; Child, Preschool; F

1995
Ifosfamide metabolite chloroacetaldehyde causes Fanconi syndrome in the perfused rat kidney.
    Toxicology and applied pharmacology, 1994, Volume: 129, Issue:1

    Topics: Absorption; Acetaldehyde; Acrolein; Animals; Chemotherapy, Cancer, Regional Perfusion; Disease Model

1994
Increased renal parenchymal echogenicity in ifosfamide-induced renal Fanconi syndrome.
    Medical and pediatric oncology, 1995, Volume: 24, Issue:2

    Topics: Child; Child, Preschool; Fanconi Syndrome; Female; Humans; Ifosfamide; Infant; Kidney Diseases; Ultr

1995
Estimation of ifosfamide/cisplatinum-induced renal toxicity by urinary protein analysis.
    Pediatric nephrology (Berlin, Germany), 1994, Volume: 8, Issue:2

    Topics: Adolescent; Adult; Child; Child, Preschool; Cisplatin; Drug Therapy, Combination; Electrophoresis, P

1994
Increased risk of ifosfamide-induced renal Fanconi's syndrome after unilateral nephrectomy.
    Lancet (London, England), 1993, Mar-20, Volume: 341, Issue:8847

    Topics: Child, Preschool; Fanconi Syndrome; Humans; Ifosfamide; Infant; Nephrectomy; Risk Factors

1993
[Nephropathy in patients treated with ifosfamide].
    Orvosi hetilap, 1994, May-08, Volume: 135, Issue:19

    Topics: Acidosis, Renal Tubular; Adolescent; Child; Child, Preschool; Fanconi Syndrome; Female; Humans; Ifos

1994
Ifosfamide-induced subclinical nephrotoxicity and its potentiation by cisplatinum.
    Medical and pediatric oncology, 1994, Volume: 22, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cisplatin; Drug

1994
Unilateral nephrectomy and cisplatin as risk factors of ifosfamide-induced nephrotoxicity: analysis of 120 patients.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1994, Volume: 12, Issue:1

    Topics: Adolescent; Adult; Child; Child, Preschool; Cisplatin; Fanconi Syndrome; Humans; Ifosfamide; Infant;

1994
Fanconi's syndrome due to ifosfamide.
    Bone marrow transplantation, 1993, Volume: 11, Issue:1

    Topics: Adult; Bone Marrow Transplantation; Combined Modality Therapy; Electrolytes; Fanconi Syndrome; Femal

1993
Partial and complete de Toni-Debré-Fanconi syndrome after ifosfamide chemotherapy of childhood malignancy.
    European journal of clinical pharmacology, 1993, Volume: 44 Suppl 1

    Topics: Child; Cisplatin; Fanconi Syndrome; Humans; Ifosfamide; Kidney Function Tests; Kidney Glomerulus; Ki

1993
Hypophosphataemic rickets after ifosfamide treatment in children.
    Clinical radiology, 1993, Volume: 47, Issue:5

    Topics: Child; Fanconi Syndrome; Female; Humans; Ifosfamide; Knee Joint; Male; Phosphates; Radiography; Rick

1993
Concentrating capacity in ifosfamide-induced severe renal dysfunction.
    Renal failure, 1995, Volume: 17, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Child; Creatinine; Cross-Sectional Studies; Fa

1995
Glycine attenuates Fanconi syndrome induced by maleate or ifosfamide in rats.
    Kidney international, 1996, Volume: 49, Issue:3

    Topics: Administration, Oral; Animals; Bicarbonates; Blood Urea Nitrogen; Creatinine; Fanconi Syndrome; Glyc

1996
Late reversibility of chronic ifosfamide-associated nephrotoxicity in a child.
    Medical and pediatric oncology, 1997, Volume: 28, Issue:1

    Topics: Antineoplastic Agents, Alkylating; Child, Preschool; Chronic Disease; Fanconi Syndrome; Glomerular F

1997
Nephrotoxicity of ifosfamide--moving towards understanding the molecular mechanisms.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1997, Volume: 12, Issue:6

    Topics: Animals; Antineoplastic Agents, Alkylating; Cyclophosphamide; DNA; Fanconi Syndrome; Humans; Ifosfam

1997
Ifosfamide-induced renal Fanconi syndrome with associated nephrogenic diabetes insipidus in an adult patient.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1998, Volume: 13, Issue:6

    Topics: Adult; Antineoplastic Agents, Alkylating; Breast Neoplasms; Diabetes Insipidus, Nephrogenic; Electro

1998
Plasma glutathione peroxidase and its relationship to renal proximal tubule function.
    Molecular genetics and metabolism, 1998, Volume: 65, Issue:3

    Topics: Adult; Animals; Antibodies; Cephaloglycin; Child; Creatinine; Fanconi Syndrome; Glutathione Peroxida

1998
Taurine attenuates fanconi syndrome induced by ifosfamide without compromising its antitumor activity.
    Oncology research, 1998, Volume: 10, Issue:7

    Topics: Animals; Carcinoma, Ehrlich Tumor; Fanconi Syndrome; Female; Ifosfamide; Male; Mice; Neoplasm Transp

1998
Development of ifosfamide-induced nephrotoxicity: prospective follow-up in 75 patients.
    Medical and pediatric oncology, 1999, Volume: 32, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Child; Child, Preschool; Fanconi Syndrome; Fol

1999
Deletions in the mitochondrial DNA and decrease in the oxidative phosphorylation activity of children with Fanconi syndrome secondary to antiblastic therapy.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1999, Volume: 34, Issue:1

    Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Blotting, Southern; Carboplatin; Case-Cont

1999
Thymoquinone attenuates ifosfamide-induced Fanconi syndrome in rats and enhances its antitumor activity in mice.
    Journal of ethnopharmacology, 1999, Nov-01, Volume: 67, Issue:2

    Topics: Administration, Oral; Analysis of Variance; Animals; Antineoplastic Agents; Antineoplastic Agents, A

1999
Tubular function and histological findings in ifosfamide-induced renal Fanconi syndrome--a report of two cases.
    European journal of pediatrics, 1992, Volume: 151, Issue:5

    Topics: Adolescent; Child; Fanconi Syndrome; Female; Humans; Ifosfamide; Kidney Tubules; Male

1992
Reversible hypophosphatemic rickets following ifosfamide treatment.
    Medical and pediatric oncology, 1992, Volume: 20, Issue:3

    Topics: Abdominal Neoplasms; Child; Fanconi Syndrome; Humans; Ifosfamide; Male; Neoplasm Recurrence, Local;

1992
Ifosfamide, Fanconi's syndrome, and rickets.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1991, Volume: 9, Issue:8

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Chronic Kidney Disease-Mineral an

1991
Long-term follow-up of ifosfamide renal toxicity in children treated for malignant mesenchymal tumors: an International Society of Pediatric Oncology report.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1991, Volume: 9, Issue:12

    Topics: Acute Kidney Injury; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Presc

1991
Acute ifosfamide-induced proximal tubular toxic reaction.
    The Journal of pediatrics, 1991, Volume: 118, Issue:2

    Topics: Child; Fanconi Syndrome; Female; Humans; Ifosfamide

1991
Ifosfamide-induced Fanconi's syndrome with growth failure in a 2-year-old child.
    The American journal of pediatric hematology/oncology, 1991,Spring, Volume: 13, Issue:1

    Topics: Child, Preschool; Fanconi Syndrome; Female; Growth Disorders; Humans; Ifosfamide; Rickets

1991
Ifosfamide-induced renal tubular dysfunction and rickets in children with Wilms tumor.
    The Journal of pediatrics, 1990, Volume: 117, Issue:2 Pt 1

    Topics: Child; Child, Preschool; Chronic Kidney Disease-Mineral and Bone Disorder; Fanconi Syndrome; Female;

1990
Ifosfamide-induced Fanconi syndrome.
    Lancet (London, England), 1989, Jun-10, Volume: 1, Issue:8650

    Topics: Child, Preschool; Facial Neoplasms; Fanconi Syndrome; Female; Humans; Ifosfamide; Rhabdomyosarcoma

1989
Acute ifosfamide-induced tubular toxicity.
    Lancet (London, England), 1989, Jul-08, Volume: 2, Issue:8654

    Topics: Fanconi Syndrome; Female; Humans; Ifosfamide; Infant

1989
Fanconi syndrome after ifosfamide.
    Cancer chemotherapy and pharmacology, 1989, Volume: 23, Issue:2

    Topics: Child, Preschool; Fanconi Syndrome; Humans; Ifosfamide; Male

1989
Nephrotoxicity associated with ifosfamide.
    European journal of pediatrics, 1988, Volume: 148, Issue:2

    Topics: Adolescent; Child, Preschool; Fanconi Syndrome; Female; Glomerular Filtration Rate; Humans; Ifosfami

1988