ifetroban and Graft-Occlusion--Vascular

ifetroban has been researched along with Graft-Occlusion--Vascular* in 1 studies

Other Studies

1 other study(ies) available for ifetroban and Graft-Occlusion--Vascular

Article	Year
Thromboxane A2 receptor density increases during chronic exposure to thromboxane A2 receptor antagonists after porcine carotid bypass. Cardiovascular surgery (London, England), 1997, Volume: 5, Issue:1 Domestic swine (n=12 in each group) were randomized to daily treatment with the thromboxane A2 (TXA2) receptor antagonist BMS-180291 (group I), aspirin (group II), or no drug (group III) prior to prosthetic carotid graft implantation. Platelet and arterial wall receptor density were measured by equilibrium binding using 125I-BOP. At 6 weeks, means (s.e.m.) platelet receptor density (pmol/mg) had increased in groups I (3.3(0.6) versus 1.8(0.3); P<0.05) and II (2.6(0.6) versus 1.7(0.2); P<0.05), but not in group III (1.3(0.3) versus 1.2(0.2)). Aortic membrane TXA2 receptor density (fmol/mg) was significantly greater (P<0.05) in groups I (150(50)) and II (68(10)) compared with group III (39(6)). Chronic exposure to a TXA2 receptor antagonist or aspirin is associated with increased platelet and aortic receptor density in pigs. Topics: Animals; Aspirin; Blood Vessel Prosthesis; Bridged Bicyclo Compounds, Heterocyclic; Carotid Arteries; Dose-Response Relationship, Drug; Female; Graft Occlusion, Vascular; Oxazoles; Platelet Aggregation Inhibitors; Polyethylene Terephthalates; Polytetrafluoroethylene; Receptors, Thromboxane; Swine; Tunica Intima	1997

Article

Year

Thromboxane A2 receptor density increases during chronic exposure to thromboxane A2 receptor antagonists after porcine carotid bypass.

Cardiovascular surgery (London, England), 1997, Volume: 5, Issue:1

Domestic swine (n=12 in each group) were randomized to daily treatment with the thromboxane A2 (TXA2) receptor antagonist BMS-180291 (group I), aspirin (group II), or no drug (group III) prior to prosthetic carotid graft implantation. Platelet and arterial wall receptor density were measured by equilibrium binding using 125I-BOP. At 6 weeks, means (s.e.m.) platelet receptor density (pmol/mg) had increased in groups I (3.3(0.6) versus 1.8(0.3); P<0.05) and II (2.6(0.6) versus 1.7(0.2); P<0.05), but not in group III (1.3(0.3) versus 1.2(0.2)). Aortic membrane TXA2 receptor density (fmol/mg) was significantly greater (P<0.05) in groups I (150(50)) and II (68(10)) compared with group III (39(6)). Chronic exposure to a TXA2 receptor antagonist or aspirin is associated with increased platelet and aortic receptor density in pigs.

Topics: Animals; Aspirin; Blood Vessel Prosthesis; Bridged Bicyclo Compounds, Heterocyclic; Carotid Arteries; Dose-Response Relationship, Drug; Female; Graft Occlusion, Vascular; Oxazoles; Platelet Aggregation Inhibitors; Polyethylene Terephthalates; Polytetrafluoroethylene; Receptors, Thromboxane; Swine; Tunica Intima

1997