ifenprodil has been researched along with Idiopathic Parkinson Disease in 6 studies
ifenprodil: NMDA receptor antagonist
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatments for Parkinson's disease based on replacement of lost dopamine have several problems." | 1.31 | Characterisation of striatal NMDA receptors involved in the generation of parkinsonian symptoms: intrastriatal microinjection studies in the 6-OHDA-lesioned rat. ( Brotchie, JM; Nash, JE, 2002) |
| "In animal models of Parkinson's disease, loss of striatal dopamine leads to enhanced excitation of striatal NR2B-containing NMDA receptors." | 1.31 | Antiparkinsonian actions of ifenprodil in the MPTP-lesioned marmoset model of Parkinson's disease. ( Brotchie, JM; Crossman, AR; Fox, SH; Henry, B; Hill, MP; Hille, C; Maneuf, Y; McGuire, S; Nash, JE; Peggs, D, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Trippier, PC | 1 |
| Jansen Labby, K | 1 |
| Hawker, DD | 1 |
| Mataka, JJ | 1 |
| Silverman, RB | 1 |
| Nash, JE | 2 |
| Brotchie, JM | 2 |
| Kornhuber, J | 1 |
| Riederer, P | 1 |
| Montastruc, JL | 2 |
| Rascol, O | 2 |
| Senard, JM | 2 |
| Fox, SH | 1 |
| Henry, B | 1 |
| Hill, MP | 1 |
| Peggs, D | 1 |
| McGuire, S | 1 |
| Maneuf, Y | 1 |
| Hille, C | 1 |
| Crossman, AR | 1 |
| Rascol, A | 1 |
2 reviews available for ifenprodil and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers.
Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Antioxidants; Calcium Channels; Drug Combinations; | 2013 |
Glutamate antagonists and Parkinson's disease: a review of clinical data.
Topics: Antiparkinson Agents; Dextromethorphan; Excitatory Amino Acid Antagonists; Humans; Parkinson Disease | 1997 |
4 other studies available for ifenprodil and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Characterisation of striatal NMDA receptors involved in the generation of parkinsonian symptoms: intrastriatal microinjection studies in the 6-OHDA-lesioned rat.
Topics: Animals; Antiparkinson Agents; Behavior, Animal; Corpus Striatum; Dopamine; Dose-Response Relationsh | 2002 |
N-methyl-D-aspartate (NMDA) antagonists in Parkinson's disease.
Topics: Adrenergic alpha-Antagonists; Humans; Parkinson Disease; Piperidines; Receptors, N-Methyl-D-Aspartat | 1993 |
Antiparkinsonian actions of ifenprodil in the MPTP-lesioned marmoset model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Behavior, Animal; Calli | 2000 |
A pilot study of N-methyl-D-aspartate (NMDA) antagonist in Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Drug Therapy, Combination; Humans; Levodopa; Neurologic Examination; Par | 1992 |