ifenprodil has been researched along with Huntington Disease in 4 studies
ifenprodil: NMDA receptor antagonist
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Trippier, PC | 1 |
| Jansen Labby, K | 1 |
| Hawker, DD | 1 |
| Mataka, JJ | 1 |
| Silverman, RB | 1 |
| Tallaksen-Greene, SJ | 1 |
| Janiszewska, A | 1 |
| Benton, K | 1 |
| Ruprecht, L | 1 |
| Albin, RL | 1 |
| Milnerwood, AJ | 1 |
| Kaufman, AM | 1 |
| Sepers, MD | 1 |
| Gladding, CM | 1 |
| Zhang, L | 1 |
| Wang, L | 1 |
| Fan, J | 1 |
| Coquinco, A | 1 |
| Qiao, JY | 1 |
| Lee, H | 1 |
| Wang, YT | 1 |
| Cynader, M | 1 |
| Raymond, LA | 1 |
| Gogas, KR | 1 |
2 reviews available for ifenprodil and Huntington Disease
| Article | Year |
|---|---|
Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers.
Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Antioxidants; Calcium Channels; Drug Combinations; | 2013 |
Glutamate-based therapeutic approaches: NR2B receptor antagonists.
Topics: Animals; Brain Ischemia; Clinical Trials as Topic; Disease Models, Animal; Excitatory Amino Acid Ant | 2006 |
2 other studies available for ifenprodil and Huntington Disease
| Article | Year |
|---|---|
Lack of efficacy of NMDA receptor-NR2B selective antagonists in the R6/2 model of Huntington disease.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Female; Huntington Disease; Kaplan-Meier Estimate; | 2010 |
Mitigation of augmented extrasynaptic NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington's disease mice.
Topics: Animals; Apoptosis; Cerebral Cortex; Coculture Techniques; Corpus Striatum; Disease Models, Animal; | 2012 |