Page last updated: 2024-10-28

ifenprodil and Epilepsy

ifenprodil has been researched along with Epilepsy in 11 studies

ifenprodil: NMDA receptor antagonist

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research Excerpts

ExcerptRelevanceReference
"Using models of acute and chronic seizures in C57BL/6 mice, we discovered a proconvulsant pathway involving high-mobility group box-1 (HMGB1) release from neurons and glia and its interaction with Toll-like receptor 4 (TLR4), a key receptor of innate immunity."1.36Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. ( Aronica, E; Balosso, S; Bianchi, ME; Casalgrandi, M; Iyer, AM; Liu, J; Manfredi, AA; Maroso, M; Molteni, M; Ravizza, T; Rossetti, C; Vezzani, A, 2010)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (9.09)18.2507
2000's6 (54.55)29.6817
2010's4 (36.36)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wang, FX1
Xiong, XY1
Zhong, Q1
Meng, ZY1
Yang, H1
Yang, QW1
Schidlitzki, A1
Twele, F1
Klee, R1
Waltl, I1
Römermann, K1
Bröer, S1
Meller, S1
Gerhauser, I1
Rankovic, V1
Li, D1
Brandt, C1
Bankstahl, M1
Töllner, K1
Löscher, W1
Zhu, X1
Dong, J1
Shen, K1
Bai, Y1
Zhang, Y1
Lv, X1
Chao, J1
Yao, H1
Maroso, M1
Balosso, S1
Ravizza, T1
Liu, J1
Aronica, E1
Iyer, AM1
Rossetti, C1
Molteni, M1
Casalgrandi, M1
Manfredi, AA1
Bianchi, ME1
Vezzani, A1
Galvan, CD1
Wenzel, JH1
Dineley, KT1
Lam, TT1
Schwartzkroin, PA1
Sweatt, JD1
Swann, JW1
André, VM1
Flores-Hernández, J1
Cepeda, C1
Starling, AJ1
Nguyen, S1
Lobo, MK1
Vinters, HV1
Levine, MS1
Mathern, GW1
Calcagnotto, ME1
Baraban, SC1
De Sarro, GB1
De Sarro, A1
DeFazio, RA2
Hablitz, JJ2
Woodhall, G1
Evans, DI1
Cunningham, MO1
Jones, RS1

Trials

1 trial available for ifenprodil and Epilepsy

ArticleYear
NMDA receptor alterations in neurons from pediatric cortical dysplasia tissue.
    Cerebral cortex (New York, N.Y. : 1991), 2004, Volume: 14, Issue:6

    Topics: Adolescent; Cells, Cultured; Cerebral Cortex; Child; Child, Preschool; Epilepsy; Humans; Infant; Mag

2004

Other Studies

10 other studies available for ifenprodil and Epilepsy

ArticleYear
Foxp3 exhibits antiepileptic effects in ictogenesis involved in TLR4 signaling.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017, Volume: 31, Issue:7

    Topics: Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Cells, Cultured; Epilepsy; Forkhead Transcri

2017
A combination of NMDA and AMPA receptor antagonists retards granule cell dispersion and epileptogenesis in a model of acquired epilepsy.
    Scientific reports, 2017, 09-22, Volume: 7, Issue:1

    Topics: Animals; Anticonvulsants; Dentate Gyrus; Disease Models, Animal; Drug Administration Schedule; Drug

2017
NMDA receptor NR2B subunits contribute to PTZ-kindling-induced hippocampal astrocytosis and oxidative stress.
    Brain research bulletin, 2015, Volume: 114

    Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Cell Death; Epilepsy; Excitatory Amino Acid

2015
Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures.
    Nature medicine, 2010, Volume: 16, Issue:4

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Hippoc

2010
Postsynaptic contributions to hippocampal network hyperexcitability induced by chronic activity blockade in vivo.
    The European journal of neuroscience, 2003, Volume: 18, Issue:7

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Anesthetics, Local; Animals; Animals, Newborn; Axons; Disease

2003
Prolonged NMDA-mediated responses, altered ifenprodil sensitivity, and epileptiform-like events in the malformed hippocampus of methylazoxymethanol exposed rats.
    Journal of neurophysiology, 2005, Volume: 94, Issue:1

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interaction

2005
Anticonvulsant properties of non-competitive antagonists of the N-methyl-D-aspartate receptor in genetically epilepsy-prone rats: comparison with CPPene.
    Neuropharmacology, 1993, Volume: 32, Issue:1

    Topics: Acoustic Stimulation; Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Dextromethorphan; Dizo

1993
Alterations in NMDA receptors in a rat model of cortical dysplasia.
    Journal of neurophysiology, 2000, Volume: 83, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Cerebral Cortex; Epilepsy; Evoked Potentials; Excitator

2000
Altered receptor subunit expression in rat neocortical malformations.
    Epilepsia, 2000, Volume: 41 Suppl 6

    Topics: Animals; Disease Models, Animal; Epilepsy; Excitatory Postsynaptic Potentials; Freezing; Neocortex;

2000
NR2B-containing NMDA autoreceptors at synapses on entorhinal cortical neurons.
    Journal of neurophysiology, 2001, Volume: 86, Issue:4

    Topics: 2-Amino-5-phosphonovalerate; Animals; Autoreceptors; Calcium; Entorhinal Cortex; Epilepsy; Excitator

2001