ifenprodil has been researched along with Epilepsy in 11 studies
ifenprodil: NMDA receptor antagonist
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Using models of acute and chronic seizures in C57BL/6 mice, we discovered a proconvulsant pathway involving high-mobility group box-1 (HMGB1) release from neurons and glia and its interaction with Toll-like receptor 4 (TLR4), a key receptor of innate immunity." | 1.36 | Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. ( Aronica, E; Balosso, S; Bianchi, ME; Casalgrandi, M; Iyer, AM; Liu, J; Manfredi, AA; Maroso, M; Molteni, M; Ravizza, T; Rossetti, C; Vezzani, A, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 6 (54.55) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, FX | 1 |
| Xiong, XY | 1 |
| Zhong, Q | 1 |
| Meng, ZY | 1 |
| Yang, H | 1 |
| Yang, QW | 1 |
| Schidlitzki, A | 1 |
| Twele, F | 1 |
| Klee, R | 1 |
| Waltl, I | 1 |
| Römermann, K | 1 |
| Bröer, S | 1 |
| Meller, S | 1 |
| Gerhauser, I | 1 |
| Rankovic, V | 1 |
| Li, D | 1 |
| Brandt, C | 1 |
| Bankstahl, M | 1 |
| Töllner, K | 1 |
| Löscher, W | 1 |
| Zhu, X | 1 |
| Dong, J | 1 |
| Shen, K | 1 |
| Bai, Y | 1 |
| Zhang, Y | 1 |
| Lv, X | 1 |
| Chao, J | 1 |
| Yao, H | 1 |
| Maroso, M | 1 |
| Balosso, S | 1 |
| Ravizza, T | 1 |
| Liu, J | 1 |
| Aronica, E | 1 |
| Iyer, AM | 1 |
| Rossetti, C | 1 |
| Molteni, M | 1 |
| Casalgrandi, M | 1 |
| Manfredi, AA | 1 |
| Bianchi, ME | 1 |
| Vezzani, A | 1 |
| Galvan, CD | 1 |
| Wenzel, JH | 1 |
| Dineley, KT | 1 |
| Lam, TT | 1 |
| Schwartzkroin, PA | 1 |
| Sweatt, JD | 1 |
| Swann, JW | 1 |
| André, VM | 1 |
| Flores-Hernández, J | 1 |
| Cepeda, C | 1 |
| Starling, AJ | 1 |
| Nguyen, S | 1 |
| Lobo, MK | 1 |
| Vinters, HV | 1 |
| Levine, MS | 1 |
| Mathern, GW | 1 |
| Calcagnotto, ME | 1 |
| Baraban, SC | 1 |
| De Sarro, GB | 1 |
| De Sarro, A | 1 |
| DeFazio, RA | 2 |
| Hablitz, JJ | 2 |
| Woodhall, G | 1 |
| Evans, DI | 1 |
| Cunningham, MO | 1 |
| Jones, RS | 1 |
1 trial available for ifenprodil and Epilepsy
| Article | Year |
|---|---|
NMDA receptor alterations in neurons from pediatric cortical dysplasia tissue.
Topics: Adolescent; Cells, Cultured; Cerebral Cortex; Child; Child, Preschool; Epilepsy; Humans; Infant; Mag | 2004 |
10 other studies available for ifenprodil and Epilepsy
| Article | Year |
|---|---|
Foxp3 exhibits antiepileptic effects in ictogenesis involved in TLR4 signaling.
Topics: Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Cells, Cultured; Epilepsy; Forkhead Transcri | 2017 |
A combination of NMDA and AMPA receptor antagonists retards granule cell dispersion and epileptogenesis in a model of acquired epilepsy.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Disease Models, Animal; Drug Administration Schedule; Drug | 2017 |
NMDA receptor NR2B subunits contribute to PTZ-kindling-induced hippocampal astrocytosis and oxidative stress.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Cell Death; Epilepsy; Excitatory Amino Acid | 2015 |
Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Hippoc | 2010 |
Postsynaptic contributions to hippocampal network hyperexcitability induced by chronic activity blockade in vivo.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Anesthetics, Local; Animals; Animals, Newborn; Axons; Disease | 2003 |
Prolonged NMDA-mediated responses, altered ifenprodil sensitivity, and epileptiform-like events in the malformed hippocampus of methylazoxymethanol exposed rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interaction | 2005 |
Anticonvulsant properties of non-competitive antagonists of the N-methyl-D-aspartate receptor in genetically epilepsy-prone rats: comparison with CPPene.
Topics: Acoustic Stimulation; Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Dextromethorphan; Dizo | 1993 |
Alterations in NMDA receptors in a rat model of cortical dysplasia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Cerebral Cortex; Epilepsy; Evoked Potentials; Excitator | 2000 |
Altered receptor subunit expression in rat neocortical malformations.
Topics: Animals; Disease Models, Animal; Epilepsy; Excitatory Postsynaptic Potentials; Freezing; Neocortex; | 2000 |
NR2B-containing NMDA autoreceptors at synapses on entorhinal cortical neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoreceptors; Calcium; Entorhinal Cortex; Epilepsy; Excitator | 2001 |