ifenprodil has been researched along with Chronic Disease in 6 studies
ifenprodil: NMDA receptor antagonist
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mechanical hyperalgesia was clearly observed during ethanol consumption and even after ethanol withdrawal, and lasted for 14 weeks." | 1.34 | Changes in function of NMDA receptor NR2B subunit in spinal cord of rats with neuropathy following chronic ethanol consumption. ( Miyoshi, K; Narita, M; Suzuki, T, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huo, XL | 1 |
| Min, JJ | 1 |
| Pan, CY | 1 |
| Zhao, CC | 1 |
| Pan, LL | 1 |
| Gui, FF | 1 |
| Jin, L | 1 |
| Wang, XT | 1 |
| Narita, M | 2 |
| Miyoshi, K | 1 |
| Suzuki, T | 1 |
| Katsumata, T | 1 |
| Katayama, Y | 1 |
| Guitton, MJ | 1 |
| Dudai, Y | 1 |
| Hirsch, JL | 1 |
| Chevalier, J | 1 |
| Vallat, G | 1 |
| Branchereau, A | 1 |
| Rouffy, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Nitrous Oxide as Treatment for Tinnitus: A Randomized Crossover Trial[NCT03365011] | Phase 4 | 40 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Change of participant-reported tinnitus symptoms 1 week after each intervention.~The Tinnitus Functional Index (TFI) is a 25-question survey assessing tinnitus impact on quality of life. Participants were asked to rate on a scale from 0-10 the degree of unpleasantness, cognitive interference, sleep disturbance, auditory difficulties, interference with relaxation, and emotional distress associated with their tinnitus. Subscores are summed and scaled to a score of 0-100. A score less than 25 indicates mild problems due to tinnitus and little need for intervention, while a score between 25-50 indicates significant problems due to tinnitus with potential need for intervention.~A decrease in TFI score indicates decreased bother due to tinnitus over time, a better outcome. An increase in TFI score indicates increased bother due to tinnitus over time, a worse outcome." (NCT03365011)
Timeframe: Pre-intervention and 1 week post-intervention
| Intervention | score on a scale (Mean) |
|---|---|
| Placebo | -1.8 |
| Nitrous Oxide | -2.5 |
"Change in participant-reported tinnitus bother after each intervention.~Global Bothersome Scale (GBS) measured participant's self-assessment of tinnitus bother on a 5-point scale ranging from Not bothered, 0 to Extremely bothered, 5.~A change of 0 indicates no change in tinnitus bother over time. A change of -1 indicates somewhat improved tinnitus bother, and a change of positive 1 indicates somewhat worsened tinnitus bother. A change of positive 2 indicates significantly worsened tinnitus bother." (NCT03365011)
Timeframe: Pre-intervention and 1 week post-intervention
| Intervention | participants (Number) | |||
|---|---|---|---|---|
| Somewhat improved, -1 | No change, 0 | Somewhat worsened, 1 | Significantly worsened, 2 | |
| Nitrous Oxide | 2 | 34 | 2 | 0 |
| Placebo | 5 | 28 | 5 | 1 |
1 review available for ifenprodil and Chronic Disease
| Article | Year |
|---|---|
[Treatment by medicine which improves cerebral circulation and metabolism].
Topics: Brain; Cerebrovascular Circulation; Cerebrovascular Disorders; Chronic Disease; Humans; Nicergoline; | 2006 |
1 trial available for ifenprodil and Chronic Disease
| Article | Year |
|---|---|
[Double-blind randomized controlled trial of ifenprodil tartrate versus placebo in chronic arterial occlusive disease of the legs at stage II of the Leriche and Fontaine classification].
Topics: Aged; Arterial Occlusive Diseases; Chronic Disease; Double-Blind Method; Female; Humans; Leg; Male; | 1995 |
4 other studies available for ifenprodil and Chronic Disease
| Article | Year |
|---|---|
Efficacy of lovastatin on learning and memory deficits caused by chronic intermittent hypoxia-hypercapnia: through regulation of NR2B-containing NMDA receptor-ERK pathway.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Chronic Disease; Disease Models, Animal | 2014 |
Changes in function of NMDA receptor NR2B subunit in spinal cord of rats with neuropathy following chronic ethanol consumption.
Topics: Alcohol Drinking; Animals; Chronic Disease; Disease Models, Animal; Ethanol; Hyperalgesia; Immunoblo | 2007 |
Blockade of cochlear NMDA receptors prevents long-term tinnitus during a brief consolidation window after acoustic trauma.
Topics: Acoustic Stimulation; Animals; Audiometry; Chronic Disease; Cochlea; Excitatory Amino Acid Antagonis | 2007 |
[Role of gamma cineangiography in the evaluation of chronic cerebral arteriopathies].
Topics: Adult; Aged; Cerebral Arterial Diseases; Chronic Disease; Female; Gamma Rays; Humans; Male; Middle A | 1983 |