ifenprodil has been researched along with Cerebral Ischemia in 18 studies
ifenprodil: NMDA receptor antagonist
| Excerpt | Relevance | Reference |
|---|---|---|
| "To explore the effects of mild hypothermia combined with ifenprodil on the survival of neuronal and translocation of apoptosis inducing factor (AIF) following global cerebral ischemia-reperfusion to understand the mechanism of combination in cerebral resuscitation." | 7.80 | [Effects of mild hypothermia plus ifenprodil on apoptosis inducing factor translocation after global cerebral ischemia-reperfusion in rats]. ( Duan, M; Gao, W; Hui, K; Xu, J; Xu, M; Zeng, Q; Zhou, Y; Zou, Y, 2014) |
| "Ifenprodil reduces CA-elicited brain edema." | 7.72 | Effect of ifenprodil, a polyamine site NMDA receptor antagonist, on brain edema formation following asphyxial cardiac arrest in rats. ( Alexander, JS; Arnold, T; Carden, D; Conrad, S; Monroe, J; Pardue, S; Sharp, CD; Turnage, R; Xiao, F, 2004) |
| "Ifenprodil, a polyamine site N-methyl-D-aspartate receptor/channel antagonist, has been reported to decrease infarction volume after cerebral ischemia." | 7.69 | Protective effects of ifenprodil on ischemic injury size, blood-brain barrier breakdown, and edema formation in focal cerebral ischemia. ( Başkaya, MK; Dempsey, RJ; Donaldson, D; Prasad, MR; Rao, AM, 1997) |
| "Ifenprodil was encapsulated into liposomes by a remote loading method using pH gradient between internal and external water phases of liposomes, focusing on differences of its solubility in water depending on pH." | 5.51 | Suppression of Cerebral Ischemia/Reperfusion Injury by Efficient Release of Encapsulated Ifenprodil From Liposomes Under Weakly Acidic pH Conditions. ( Agato, Y; Asai, T; Fukuta, T; Ishii, T; Kikuchi, T; Koide, H; Oku, N; Shimizu, K; Yanagida, Y, 2019) |
| "Pretreatment with ifenprodil or flunarizine, 1 mg/kg i." | 5.28 | Selective dysfunction of the vagal component of the baroreflex following cerebral ischemia: protection by ifenprodil and flunarizine. ( Kato, H; Kurihara, J; Oda, N; Sahara, T; Tomita, H, 1990) |
| "To explore the effects of mild hypothermia combined with ifenprodil on the survival of neuronal and translocation of apoptosis inducing factor (AIF) following global cerebral ischemia-reperfusion to understand the mechanism of combination in cerebral resuscitation." | 3.80 | [Effects of mild hypothermia plus ifenprodil on apoptosis inducing factor translocation after global cerebral ischemia-reperfusion in rats]. ( Duan, M; Gao, W; Hui, K; Xu, J; Xu, M; Zeng, Q; Zhou, Y; Zou, Y, 2014) |
| " In this context, we analyzed the effect of Ifenprodil, an NR2b selective NMDAR antagonist and its combination at lower doses with flurbiprofen, a selective ASIC1a inhibitor on rat model of focal cerebral ischemia." | 3.77 | The neuroprotective effects of NMDAR antagonist, ifenprodil and ASIC1a inhibitor, flurbiprofen on post-ischemic cerebral injury. ( Mishra, V; Raghubir, R; Singh, N; Verma, R, 2011) |
| "Ifenprodil reduces CA-elicited brain edema." | 3.72 | Effect of ifenprodil, a polyamine site NMDA receptor antagonist, on brain edema formation following asphyxial cardiac arrest in rats. ( Alexander, JS; Arnold, T; Carden, D; Conrad, S; Monroe, J; Pardue, S; Sharp, CD; Turnage, R; Xiao, F, 2004) |
| "Ifenprodil, a polyamine site N-methyl-D-aspartate receptor/channel antagonist, has been reported to decrease infarction volume after cerebral ischemia." | 3.69 | Protective effects of ifenprodil on ischemic injury size, blood-brain barrier breakdown, and edema formation in focal cerebral ischemia. ( Başkaya, MK; Dempsey, RJ; Donaldson, D; Prasad, MR; Rao, AM, 1997) |
| "Ifenprodil was encapsulated into liposomes by a remote loading method using pH gradient between internal and external water phases of liposomes, focusing on differences of its solubility in water depending on pH." | 1.51 | Suppression of Cerebral Ischemia/Reperfusion Injury by Efficient Release of Encapsulated Ifenprodil From Liposomes Under Weakly Acidic pH Conditions. ( Agato, Y; Asai, T; Fukuta, T; Ishii, T; Kikuchi, T; Koide, H; Oku, N; Shimizu, K; Yanagida, Y, 2019) |
| "Pretreatment with ifenprodil or flunarizine, 1 mg/kg i." | 1.28 | Selective dysfunction of the vagal component of the baroreflex following cerebral ischemia: protection by ifenprodil and flunarizine. ( Kato, H; Kurihara, J; Oda, N; Sahara, T; Tomita, H, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (22.22) | 18.7374 |
| 1990's | 4 (22.22) | 18.2507 |
| 2000's | 6 (33.33) | 29.6817 |
| 2010's | 4 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kikuchi, T | 1 |
| Fukuta, T | 1 |
| Agato, Y | 1 |
| Yanagida, Y | 1 |
| Ishii, T | 1 |
| Koide, H | 1 |
| Shimizu, K | 1 |
| Oku, N | 1 |
| Asai, T | 1 |
| Gutierrez-Vargas, JA | 1 |
| Muñoz-Manco, JI | 1 |
| Garcia-Segura, LM | 1 |
| Cardona-Gómez, GP | 1 |
| Zou, Y | 1 |
| Zhou, Y | 2 |
| Gao, W | 1 |
| Zeng, Q | 1 |
| Hui, K | 1 |
| Xu, M | 1 |
| Duan, M | 1 |
| Xu, J | 1 |
| Chen, M | 1 |
| Lu, TJ | 1 |
| Chen, XJ | 1 |
| Chen, Q | 1 |
| Feng, XY | 1 |
| Xu, L | 1 |
| Duan, WH | 1 |
| Xiong, ZQ | 1 |
| Mishra, V | 1 |
| Verma, R | 1 |
| Singh, N | 1 |
| Raghubir, R | 1 |
| Krebs, C | 1 |
| Fernandes, HB | 1 |
| Sheldon, C | 1 |
| Raymond, LA | 1 |
| Baimbridge, KG | 1 |
| Xiao, F | 1 |
| Pardue, S | 1 |
| Arnold, T | 1 |
| Carden, D | 1 |
| Alexander, JS | 1 |
| Monroe, J | 1 |
| Sharp, CD | 1 |
| Turnage, R | 1 |
| Conrad, S | 1 |
| Kirby, BP | 1 |
| Shaw, GG | 1 |
| Wang, CX | 1 |
| Shuaib, A | 1 |
| Gogas, KR | 1 |
| Tadano, T | 1 |
| Yonezawa, A | 1 |
| Oyama, K | 1 |
| Kisara, K | 1 |
| Arai, Y | 1 |
| Togashi, M | 1 |
| Kinemuchi, H | 1 |
| Bath, CP | 1 |
| Farrell, LN | 1 |
| Gilmore, J | 1 |
| Ward, MA | 1 |
| Hicks, CA | 1 |
| O'Neill, MJ | 1 |
| Bleakman, D | 1 |
| Başkaya, MK | 1 |
| Rao, AM | 1 |
| Donaldson, D | 1 |
| Prasad, MR | 1 |
| Dempsey, RJ | 1 |
| Kurihara, J | 1 |
| Sahara, T | 1 |
| Oda, N | 1 |
| Tomita, H | 1 |
| Kato, H | 1 |
| Goto, K | 1 |
| Suekawa, M | 1 |
| Hosoya, E | 1 |
| Carter, C | 2 |
| Benavides, J | 1 |
| Legendre, P | 1 |
| Vincent, JD | 1 |
| Noel, F | 1 |
| Thuret, F | 1 |
| Lloyd, KG | 1 |
| Arbilla, S | 1 |
| Zivkovic, B | 1 |
| MacKenzie, ET | 2 |
| Gotti, B | 1 |
| Duverger, D | 1 |
| Bertin, J | 1 |
| Dupont, R | 1 |
| Frost, J | 1 |
| Gaudilliere, B | 1 |
| Rousseau, J | 1 |
| Scatton, B | 1 |
| Egawa, M | 1 |
| Hashimoto, N | 1 |
| Tobe, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Triple-blind Placebo Controlled Trial of Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival and Neurological Outcome[NCT04009759] | Phase 1 | 240 participants (Anticipated) | Interventional | 2021-10-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for ifenprodil and Cerebral Ischemia
| Article | Year |
|---|---|
NMDA/NR2B selective antagonists in the treatment of ischemic brain injury.
Topics: Animals; Brain; Brain Ischemia; Conotoxins; Drug Design; Excitatory Amino Acid Antagonists; Felbamat | 2005 |
Glutamate-based therapeutic approaches: NR2B receptor antagonists.
Topics: Animals; Brain Ischemia; Clinical Trials as Topic; Disease Models, Animal; Excitatory Amino Acid Ant | 2006 |
16 other studies available for ifenprodil and Cerebral Ischemia
| Article | Year |
|---|---|
Suppression of Cerebral Ischemia/Reperfusion Injury by Efficient Release of Encapsulated Ifenprodil From Liposomes Under Weakly Acidic pH Conditions.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Ischemia; Disease Models, Animal; Hydrogen-Ion Concentrat | 2019 |
GluN2B N-methyl-D-aspartic acid receptor subunit mediates atorvastatin-Induced neuroprotection after focal cerebral ischemia.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Brain Ischemia; Cells, Cultured; Cerebral Cortex; D | 2014 |
[Effects of mild hypothermia plus ifenprodil on apoptosis inducing factor translocation after global cerebral ischemia-reperfusion in rats].
Topics: Animals; Apoptosis Inducing Factor; Brain Ischemia; Disease Models, Animal; Hypothermia, Induced; Ma | 2014 |
Differential roles of NMDA receptor subtypes in ischemic neuronal cell death and ischemic tolerance.
Topics: Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cell Death; Cyclic AMP Response Element- | 2008 |
The neuroprotective effects of NMDAR antagonist, ifenprodil and ASIC1a inhibitor, flurbiprofen on post-ischemic cerebral injury.
Topics: Animals; Apoptosis; Brain Ischemia; Drug Therapy, Combination; Flurbiprofen; In Situ Nick-End Labeli | 2011 |
Functional NMDA receptor subtype 2B is expressed in astrocytes after ischemia in vivo and anoxia in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Astrocytes; Axotomy; Brain Ischemia; Calcium; Cell Hypoxia; Ce | 2003 |
Effect of ifenprodil, a polyamine site NMDA receptor antagonist, on brain edema formation following asphyxial cardiac arrest in rats.
Topics: Animals; Asphyxia; Brain Edema; Brain Ischemia; Cardiopulmonary Resuscitation; Disease Models, Anima | 2004 |
The neuroprotective effects of N1-dansyl-spermine in the gerbil model of cerebral ischaemia.
Topics: Analysis of Variance; Animals; Behavior, Animal; Body Temperature; Brain Ischemia; Cell Count; Dansy | 2004 |
Effects of transient global ischemia and a monoamine oxidase inhibitor ifenprodil on rat brain monoamine metabolism.
Topics: Animals; Brain; Brain Ischemia; Hippocampus; Male; Monoamine Oxidase Inhibitors; Piperidines; Rats; | 1995 |
The effects of ifenprodil and eliprodil on voltage-dependent Ca2+ channels and in gerbil global cerebral ischaemia.
Topics: Animals; Body Temperature; Brain Ischemia; Calcium Channels; Cell Line; Dose-Response Relationship, | 1996 |
Protective effects of ifenprodil on ischemic injury size, blood-brain barrier breakdown, and edema formation in focal cerebral ischemia.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Brain Ischemia; Capillary Permeability; Cats; Cere | 1997 |
Selective dysfunction of the vagal component of the baroreflex following cerebral ischemia: protection by ifenprodil and flunarizine.
Topics: Animals; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Dogs; Female; Flunarizine; Hea | 1990 |
[Pharmacological study of TJ-8007 (tsumura-zokumeito) (II): Protective effect of TJ-8007 against cerebral ischemia].
Topics: Animals; Brain Ischemia; Carotid Artery, Internal; Dogs; Drugs, Chinese Herbal; Female; Gerbillinae; | 1989 |
Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. II. Evidence for N-methyl-D-aspartate receptor antagonist properties.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cells, Cultured; Cerebellum; Corpus Striatum; Cyclic GMP; Do | 1988 |
Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cats; Female; Male; Models, Cardiovascular; N-Methylaspartat | 1988 |
[Effect of MCI-2016 (bifemelane hydrochloride) on cerebral ischemia following ligation of both common carotid arteries in Mongolian gerbils].
Topics: Administration, Oral; Age Factors; Animals; Benzhydryl Compounds; Brain Ischemia; Carotid Artery Dis | 1985 |