ifenprodil has been researched along with Brain Swelling in 7 studies
ifenprodil: NMDA receptor antagonist
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ifenprodil reduces CA-elicited brain edema." | 7.72 | Effect of ifenprodil, a polyamine site NMDA receptor antagonist, on brain edema formation following asphyxial cardiac arrest in rats. ( Alexander, JS; Arnold, T; Carden, D; Conrad, S; Monroe, J; Pardue, S; Sharp, CD; Turnage, R; Xiao, F, 2004) |
| " We studied the effects of ifenprodil, known as a noncompetitive inhibitor of polyamine sites at the NMDA receptor, on brain edema formation, blood-brain barrier breakdown, and volume of injury after TBI." | 7.70 | Attenuation of brain edema, blood-brain barrier breakdown, and injury volume by ifenprodil, a polyamine-site N-methyl-D-aspartate receptor antagonist, after experimental traumatic brain injury in rats. ( Başkaya, MK; Dempsey, RJ; Doğan, A, 2000) |
| "Ifenprodil, a polyamine site N-methyl-D-aspartate receptor/channel antagonist, has been reported to decrease infarction volume after cerebral ischemia." | 7.69 | Protective effects of ifenprodil on ischemic injury size, blood-brain barrier breakdown, and edema formation in focal cerebral ischemia. ( Başkaya, MK; Dempsey, RJ; Donaldson, D; Prasad, MR; Rao, AM, 1997) |
| " Six rats from each group were evaluated at 6 hours postocclusion for brain water content, an indicator of brain edema, and Evans blue dye extravasation for blood-brain barrier breakdown." | 7.69 | Effects of ifenprodil, a polyamine site NMDA receptor antagonist, on reperfusion injury after transient focal cerebral ischemia. ( Başkaya, MK; Dempsey, RJ; Doğan, A; Donaldson, D; Rao, AM; Rao, VL; Rastl, J, 1997) |
| "Ifenprodil, a NMDA receptor polyamine site antagonist, reduces experimental cardiac arrest (CA)-elicited brain edema, which is associated with an up-regulation of aquaporin 4 (AQP4), a brain water-selective channel." | 3.73 | Ifenprodil treatment is associated with a down-regulation of brain aquaporin 4 following cardiac arrest in rats. ( Alexander, JS; Arnold, TC; Carden, DL; Conrad, SA; Monroe, J; Pardue, S; Turnage, R; Xiao, F, 2005) |
| "Ifenprodil reduces CA-elicited brain edema." | 3.72 | Effect of ifenprodil, a polyamine site NMDA receptor antagonist, on brain edema formation following asphyxial cardiac arrest in rats. ( Alexander, JS; Arnold, T; Carden, D; Conrad, S; Monroe, J; Pardue, S; Sharp, CD; Turnage, R; Xiao, F, 2004) |
| " We studied the effects of ifenprodil, known as a noncompetitive inhibitor of polyamine sites at the NMDA receptor, on brain edema formation, blood-brain barrier breakdown, and volume of injury after TBI." | 3.70 | Attenuation of brain edema, blood-brain barrier breakdown, and injury volume by ifenprodil, a polyamine-site N-methyl-D-aspartate receptor antagonist, after experimental traumatic brain injury in rats. ( Başkaya, MK; Dempsey, RJ; Doğan, A, 2000) |
| "Ifenprodil, a polyamine site N-methyl-D-aspartate receptor/channel antagonist, has been reported to decrease infarction volume after cerebral ischemia." | 3.69 | Protective effects of ifenprodil on ischemic injury size, blood-brain barrier breakdown, and edema formation in focal cerebral ischemia. ( Başkaya, MK; Dempsey, RJ; Donaldson, D; Prasad, MR; Rao, AM, 1997) |
| " Six rats from each group were evaluated at 6 hours postocclusion for brain water content, an indicator of brain edema, and Evans blue dye extravasation for blood-brain barrier breakdown." | 3.69 | Effects of ifenprodil, a polyamine site NMDA receptor antagonist, on reperfusion injury after transient focal cerebral ischemia. ( Başkaya, MK; Dempsey, RJ; Doğan, A; Donaldson, D; Rao, AM; Rao, VL; Rastl, J, 1997) |
| "11/vehicle), memory function, and cerebral edema (n=12/drug vs." | 1.30 | Effects of the NMDA antagonist CP-98,113 on regional cerebral edema and cardiovascular, cognitive, and neurobehavioral function following experimental brain injury in the rat. ( McIntosh, TK; Okiyama, K; Smith, DH; White, WF, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xiao, F | 2 |
| Pardue, S | 2 |
| Arnold, T | 1 |
| Carden, D | 1 |
| Alexander, JS | 2 |
| Monroe, J | 2 |
| Sharp, CD | 1 |
| Turnage, R | 2 |
| Conrad, S | 1 |
| Arnold, TC | 1 |
| Carden, DL | 1 |
| Conrad, SA | 1 |
| Başkaya, MK | 3 |
| Rao, AM | 2 |
| Donaldson, D | 2 |
| Prasad, MR | 1 |
| Dempsey, RJ | 3 |
| Doğan, A | 2 |
| Rao, VL | 1 |
| Rastl, J | 1 |
| Okiyama, K | 1 |
| Smith, DH | 1 |
| White, WF | 1 |
| McIntosh, TK | 1 |
| Häntzschel, A | 1 |
| Andreas, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Triple-blind Placebo Controlled Trial of Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival and Neurological Outcome[NCT04009759] | Phase 1 | 240 participants (Anticipated) | Interventional | 2021-10-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for ifenprodil and Brain Swelling
| Article | Year |
|---|---|
Effect of ifenprodil, a polyamine site NMDA receptor antagonist, on brain edema formation following asphyxial cardiac arrest in rats.
Topics: Animals; Asphyxia; Brain Edema; Brain Ischemia; Cardiopulmonary Resuscitation; Disease Models, Anima | 2004 |
Ifenprodil treatment is associated with a down-regulation of brain aquaporin 4 following cardiac arrest in rats.
Topics: Animals; Brain; Brain Edema; Down-Regulation; Heart Arrest; Phosphorylation; Piperidines; Rats; Rats | 2005 |
Protective effects of ifenprodil on ischemic injury size, blood-brain barrier breakdown, and edema formation in focal cerebral ischemia.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Brain Ischemia; Capillary Permeability; Cats; Cere | 1997 |
Effects of ifenprodil, a polyamine site NMDA receptor antagonist, on reperfusion injury after transient focal cerebral ischemia.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Blood-Brain Barrier; Body Temperature; Body W | 1997 |
Effects of the NMDA antagonist CP-98,113 on regional cerebral edema and cardiovascular, cognitive, and neurobehavioral function following experimental brain injury in the rat.
Topics: Animals; Behavior, Animal; Body Temperature; Brain Edema; Brain Injuries; Cardiovascular Physiologic | 1998 |
Non-N-methyl-D-aspartate (NMDA) receptor antagonist 1,2,3, 4-tetrahydro-6-nitro-2,3-dioxo-benzo(f)quinoxaline-7-sulphonamide (NBQX) decreases functional disorders in cytotoxic brain oedema.
Topics: Animals; Behavior, Animal; Brain; Brain Edema; Excitatory Amino Acid Antagonists; Hexachlorophene; M | 2000 |
Attenuation of brain edema, blood-brain barrier breakdown, and injury volume by ifenprodil, a polyamine-site N-methyl-D-aspartate receptor antagonist, after experimental traumatic brain injury in rats.
Topics: Animals; Blood-Brain Barrier; Body Water; Brain; Brain Edema; Brain Injuries; Capillary Permeability | 2000 |