ifenprodil has been researched along with Brain Ischemia in 18 studies
ifenprodil: NMDA receptor antagonist
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To explore the effects of mild hypothermia combined with ifenprodil on the survival of neuronal and translocation of apoptosis inducing factor (AIF) following global cerebral ischemia-reperfusion to understand the mechanism of combination in cerebral resuscitation." | 7.80 | [Effects of mild hypothermia plus ifenprodil on apoptosis inducing factor translocation after global cerebral ischemia-reperfusion in rats]. ( Duan, M; Gao, W; Hui, K; Xu, J; Xu, M; Zeng, Q; Zhou, Y; Zou, Y, 2014) |
| "Ifenprodil reduces CA-elicited brain edema." | 7.72 | Effect of ifenprodil, a polyamine site NMDA receptor antagonist, on brain edema formation following asphyxial cardiac arrest in rats. ( Alexander, JS; Arnold, T; Carden, D; Conrad, S; Monroe, J; Pardue, S; Sharp, CD; Turnage, R; Xiao, F, 2004) |
| "Ifenprodil, a polyamine site N-methyl-D-aspartate receptor/channel antagonist, has been reported to decrease infarction volume after cerebral ischemia." | 7.69 | Protective effects of ifenprodil on ischemic injury size, blood-brain barrier breakdown, and edema formation in focal cerebral ischemia. ( Başkaya, MK; Dempsey, RJ; Donaldson, D; Prasad, MR; Rao, AM, 1997) |
| "Ifenprodil was encapsulated into liposomes by a remote loading method using pH gradient between internal and external water phases of liposomes, focusing on differences of its solubility in water depending on pH." | 5.51 | Suppression of Cerebral Ischemia/Reperfusion Injury by Efficient Release of Encapsulated Ifenprodil From Liposomes Under Weakly Acidic pH Conditions. ( Agato, Y; Asai, T; Fukuta, T; Ishii, T; Kikuchi, T; Koide, H; Oku, N; Shimizu, K; Yanagida, Y, 2019) |
| "Pretreatment with ifenprodil or flunarizine, 1 mg/kg i." | 5.28 | Selective dysfunction of the vagal component of the baroreflex following cerebral ischemia: protection by ifenprodil and flunarizine. ( Kato, H; Kurihara, J; Oda, N; Sahara, T; Tomita, H, 1990) |
| "To explore the effects of mild hypothermia combined with ifenprodil on the survival of neuronal and translocation of apoptosis inducing factor (AIF) following global cerebral ischemia-reperfusion to understand the mechanism of combination in cerebral resuscitation." | 3.80 | [Effects of mild hypothermia plus ifenprodil on apoptosis inducing factor translocation after global cerebral ischemia-reperfusion in rats]. ( Duan, M; Gao, W; Hui, K; Xu, J; Xu, M; Zeng, Q; Zhou, Y; Zou, Y, 2014) |
| " In this context, we analyzed the effect of Ifenprodil, an NR2b selective NMDAR antagonist and its combination at lower doses with flurbiprofen, a selective ASIC1a inhibitor on rat model of focal cerebral ischemia." | 3.77 | The neuroprotective effects of NMDAR antagonist, ifenprodil and ASIC1a inhibitor, flurbiprofen on post-ischemic cerebral injury. ( Mishra, V; Raghubir, R; Singh, N; Verma, R, 2011) |
| "Ifenprodil reduces CA-elicited brain edema." | 3.72 | Effect of ifenprodil, a polyamine site NMDA receptor antagonist, on brain edema formation following asphyxial cardiac arrest in rats. ( Alexander, JS; Arnold, T; Carden, D; Conrad, S; Monroe, J; Pardue, S; Sharp, CD; Turnage, R; Xiao, F, 2004) |
| "Ifenprodil, a polyamine site N-methyl-D-aspartate receptor/channel antagonist, has been reported to decrease infarction volume after cerebral ischemia." | 3.69 | Protective effects of ifenprodil on ischemic injury size, blood-brain barrier breakdown, and edema formation in focal cerebral ischemia. ( Başkaya, MK; Dempsey, RJ; Donaldson, D; Prasad, MR; Rao, AM, 1997) |
| "Ifenprodil was encapsulated into liposomes by a remote loading method using pH gradient between internal and external water phases of liposomes, focusing on differences of its solubility in water depending on pH." | 1.51 | Suppression of Cerebral Ischemia/Reperfusion Injury by Efficient Release of Encapsulated Ifenprodil From Liposomes Under Weakly Acidic pH Conditions. ( Agato, Y; Asai, T; Fukuta, T; Ishii, T; Kikuchi, T; Koide, H; Oku, N; Shimizu, K; Yanagida, Y, 2019) |
| "Pretreatment with ifenprodil or flunarizine, 1 mg/kg i." | 1.28 | Selective dysfunction of the vagal component of the baroreflex following cerebral ischemia: protection by ifenprodil and flunarizine. ( Kato, H; Kurihara, J; Oda, N; Sahara, T; Tomita, H, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (22.22) | 18.7374 |
| 1990's | 4 (22.22) | 18.2507 |
| 2000's | 6 (33.33) | 29.6817 |
| 2010's | 4 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kikuchi, T | 1 |
| Fukuta, T | 1 |
| Agato, Y | 1 |
| Yanagida, Y | 1 |
| Ishii, T | 1 |
| Koide, H | 1 |
| Shimizu, K | 1 |
| Oku, N | 1 |
| Asai, T | 1 |
| Gutierrez-Vargas, JA | 1 |
| Muñoz-Manco, JI | 1 |
| Garcia-Segura, LM | 1 |
| Cardona-Gómez, GP | 1 |
| Zou, Y | 1 |
| Zhou, Y | 2 |
| Gao, W | 1 |
| Zeng, Q | 1 |
| Hui, K | 1 |
| Xu, M | 1 |
| Duan, M | 1 |
| Xu, J | 1 |
| Chen, M | 1 |
| Lu, TJ | 1 |
| Chen, XJ | 1 |
| Chen, Q | 1 |
| Feng, XY | 1 |
| Xu, L | 1 |
| Duan, WH | 1 |
| Xiong, ZQ | 1 |
| Mishra, V | 1 |
| Verma, R | 1 |
| Singh, N | 1 |
| Raghubir, R | 1 |
| Krebs, C | 1 |
| Fernandes, HB | 1 |
| Sheldon, C | 1 |
| Raymond, LA | 1 |
| Baimbridge, KG | 1 |
| Xiao, F | 1 |
| Pardue, S | 1 |
| Arnold, T | 1 |
| Carden, D | 1 |
| Alexander, JS | 1 |
| Monroe, J | 1 |
| Sharp, CD | 1 |
| Turnage, R | 1 |
| Conrad, S | 1 |
| Kirby, BP | 1 |
| Shaw, GG | 1 |
| Wang, CX | 1 |
| Shuaib, A | 1 |
| Gogas, KR | 1 |
| Tadano, T | 1 |
| Yonezawa, A | 1 |
| Oyama, K | 1 |
| Kisara, K | 1 |
| Arai, Y | 1 |
| Togashi, M | 1 |
| Kinemuchi, H | 1 |
| Bath, CP | 1 |
| Farrell, LN | 1 |
| Gilmore, J | 1 |
| Ward, MA | 1 |
| Hicks, CA | 1 |
| O'Neill, MJ | 1 |
| Bleakman, D | 1 |
| Başkaya, MK | 1 |
| Rao, AM | 1 |
| Donaldson, D | 1 |
| Prasad, MR | 1 |
| Dempsey, RJ | 1 |
| Kurihara, J | 1 |
| Sahara, T | 1 |
| Oda, N | 1 |
| Tomita, H | 1 |
| Kato, H | 1 |
| Goto, K | 1 |
| Suekawa, M | 1 |
| Hosoya, E | 1 |
| Carter, C | 2 |
| Benavides, J | 1 |
| Legendre, P | 1 |
| Vincent, JD | 1 |
| Noel, F | 1 |
| Thuret, F | 1 |
| Lloyd, KG | 1 |
| Arbilla, S | 1 |
| Zivkovic, B | 1 |
| MacKenzie, ET | 2 |
| Gotti, B | 1 |
| Duverger, D | 1 |
| Bertin, J | 1 |
| Dupont, R | 1 |
| Frost, J | 1 |
| Gaudilliere, B | 1 |
| Rousseau, J | 1 |
| Scatton, B | 1 |
| Egawa, M | 1 |
| Hashimoto, N | 1 |
| Tobe, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Triple-blind Placebo Controlled Trial of Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival and Neurological Outcome[NCT04009759] | Phase 1 | 240 participants (Anticipated) | Interventional | 2021-10-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for ifenprodil and Brain Ischemia
| Article | Year |
|---|---|
NMDA/NR2B selective antagonists in the treatment of ischemic brain injury.
Topics: Animals; Brain; Brain Ischemia; Conotoxins; Drug Design; Excitatory Amino Acid Antagonists; Felbamat | 2005 |
Glutamate-based therapeutic approaches: NR2B receptor antagonists.
Topics: Animals; Brain Ischemia; Clinical Trials as Topic; Disease Models, Animal; Excitatory Amino Acid Ant | 2006 |
16 other studies available for ifenprodil and Brain Ischemia
| Article | Year |
|---|---|
Suppression of Cerebral Ischemia/Reperfusion Injury by Efficient Release of Encapsulated Ifenprodil From Liposomes Under Weakly Acidic pH Conditions.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Ischemia; Disease Models, Animal; Hydrogen-Ion Concentrat | 2019 |
GluN2B N-methyl-D-aspartic acid receptor subunit mediates atorvastatin-Induced neuroprotection after focal cerebral ischemia.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Brain Ischemia; Cells, Cultured; Cerebral Cortex; D | 2014 |
[Effects of mild hypothermia plus ifenprodil on apoptosis inducing factor translocation after global cerebral ischemia-reperfusion in rats].
Topics: Animals; Apoptosis Inducing Factor; Brain Ischemia; Disease Models, Animal; Hypothermia, Induced; Ma | 2014 |
Differential roles of NMDA receptor subtypes in ischemic neuronal cell death and ischemic tolerance.
Topics: Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cell Death; Cyclic AMP Response Element- | 2008 |
The neuroprotective effects of NMDAR antagonist, ifenprodil and ASIC1a inhibitor, flurbiprofen on post-ischemic cerebral injury.
Topics: Animals; Apoptosis; Brain Ischemia; Drug Therapy, Combination; Flurbiprofen; In Situ Nick-End Labeli | 2011 |
Functional NMDA receptor subtype 2B is expressed in astrocytes after ischemia in vivo and anoxia in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Astrocytes; Axotomy; Brain Ischemia; Calcium; Cell Hypoxia; Ce | 2003 |
Effect of ifenprodil, a polyamine site NMDA receptor antagonist, on brain edema formation following asphyxial cardiac arrest in rats.
Topics: Animals; Asphyxia; Brain Edema; Brain Ischemia; Cardiopulmonary Resuscitation; Disease Models, Anima | 2004 |
The neuroprotective effects of N1-dansyl-spermine in the gerbil model of cerebral ischaemia.
Topics: Analysis of Variance; Animals; Behavior, Animal; Body Temperature; Brain Ischemia; Cell Count; Dansy | 2004 |
Effects of transient global ischemia and a monoamine oxidase inhibitor ifenprodil on rat brain monoamine metabolism.
Topics: Animals; Brain; Brain Ischemia; Hippocampus; Male; Monoamine Oxidase Inhibitors; Piperidines; Rats; | 1995 |
The effects of ifenprodil and eliprodil on voltage-dependent Ca2+ channels and in gerbil global cerebral ischaemia.
Topics: Animals; Body Temperature; Brain Ischemia; Calcium Channels; Cell Line; Dose-Response Relationship, | 1996 |
Protective effects of ifenprodil on ischemic injury size, blood-brain barrier breakdown, and edema formation in focal cerebral ischemia.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Brain Ischemia; Capillary Permeability; Cats; Cere | 1997 |
Selective dysfunction of the vagal component of the baroreflex following cerebral ischemia: protection by ifenprodil and flunarizine.
Topics: Animals; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Dogs; Female; Flunarizine; Hea | 1990 |
[Pharmacological study of TJ-8007 (tsumura-zokumeito) (II): Protective effect of TJ-8007 against cerebral ischemia].
Topics: Animals; Brain Ischemia; Carotid Artery, Internal; Dogs; Drugs, Chinese Herbal; Female; Gerbillinae; | 1989 |
Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. II. Evidence for N-methyl-D-aspartate receptor antagonist properties.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cells, Cultured; Cerebellum; Corpus Striatum; Cyclic GMP; Do | 1988 |
Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cats; Female; Male; Models, Cardiovascular; N-Methylaspartat | 1988 |
[Effect of MCI-2016 (bifemelane hydrochloride) on cerebral ischemia following ligation of both common carotid arteries in Mongolian gerbils].
Topics: Administration, Oral; Age Factors; Animals; Benzhydryl Compounds; Brain Ischemia; Carotid Artery Dis | 1985 |