ifenprodil has been researched along with Brain Injuries in 6 studies
ifenprodil: NMDA receptor antagonist
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We studied the effects of ifenprodil, known as a noncompetitive inhibitor of polyamine sites at the NMDA receptor, on brain edema formation, blood-brain barrier breakdown, and volume of injury after TBI." | 7.70 | Attenuation of brain edema, blood-brain barrier breakdown, and injury volume by ifenprodil, a polyamine-site N-methyl-D-aspartate receptor antagonist, after experimental traumatic brain injury in rats. ( Başkaya, MK; Dempsey, RJ; Doğan, A, 2000) |
| " We studied the effects of ifenprodil, known as a noncompetitive inhibitor of polyamine sites at the NMDA receptor, on brain edema formation, blood-brain barrier breakdown, and volume of injury after TBI." | 3.70 | Attenuation of brain edema, blood-brain barrier breakdown, and injury volume by ifenprodil, a polyamine-site N-methyl-D-aspartate receptor antagonist, after experimental traumatic brain injury in rats. ( Başkaya, MK; Dempsey, RJ; Doğan, A, 2000) |
| "Traumatic brain injuries introduce functional and structural circuit deficits that must be repaired for an organism to regain function." | 1.51 | Enhanced visual experience rehabilitates the injured brain in Xenopus tadpoles in an NMDAR-dependent manner. ( Cline, HT; Faulkner, RL; Gambrill, AC; McKeown, CR, 2019) |
| "11/vehicle), memory function, and cerebral edema (n=12/drug vs." | 1.30 | Effects of the NMDA antagonist CP-98,113 on regional cerebral edema and cardiovascular, cognitive, and neurobehavioral function following experimental brain injury in the rat. ( McIntosh, TK; Okiyama, K; Smith, DH; White, WF, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gambrill, AC | 1 |
| Faulkner, RL | 1 |
| McKeown, CR | 1 |
| Cline, HT | 1 |
| DiLeonardi, AM | 1 |
| Huh, JW | 1 |
| Raghupathi, R | 1 |
| Osteen, CL | 1 |
| Giza, CC | 1 |
| Hovda, DA | 1 |
| Trout, JJ | 1 |
| Lu, CY | 1 |
| Goldstone, AD | 1 |
| Sahgal, S | 1 |
| Okiyama, K | 1 |
| Smith, DH | 1 |
| White, WF | 1 |
| McIntosh, TK | 1 |
| Dempsey, RJ | 1 |
| Başkaya, MK | 1 |
| Doğan, A | 1 |
6 other studies available for ifenprodil and Brain Injuries
| Article | Year |
|---|---|
Enhanced visual experience rehabilitates the injured brain in Xenopus tadpoles in an NMDAR-dependent manner.
Topics: Animals; Brain Injuries; Excitatory Amino Acid Antagonists; Gene Knockdown Techniques; Green Fluores | 2019 |
Impaired axonal transport and neurofilament compaction occur in separate populations of injured axons following diffuse brain injury in the immature rat.
Topics: Amyloid beta-Protein Precursor; Animals; Axonal Transport; Axons; Brain; Brain Injuries; Excitatory | 2009 |
Injury-induced alterations in N-methyl-D-aspartate receptor subunit composition contribute to prolonged 45calcium accumulation following lateral fluid percussion.
Topics: Animals; Autoradiography; Behavior, Animal; Blotting, Western; Brain Injuries; Calcium; Calcium Radi | 2004 |
Polyamines and NMDA receptors modulate pericapillary astrocyte swelling following cerebral cryo-injury in the rat.
Topics: Animals; Astrocytes; Biogenic Polyamines; Brain; Brain Injuries; Capillaries; Cold Temperature; Dizo | 1995 |
Effects of the NMDA antagonist CP-98,113 on regional cerebral edema and cardiovascular, cognitive, and neurobehavioral function following experimental brain injury in the rat.
Topics: Animals; Behavior, Animal; Body Temperature; Brain Edema; Brain Injuries; Cardiovascular Physiologic | 1998 |
Attenuation of brain edema, blood-brain barrier breakdown, and injury volume by ifenprodil, a polyamine-site N-methyl-D-aspartate receptor antagonist, after experimental traumatic brain injury in rats.
Topics: Animals; Blood-Brain Barrier; Body Water; Brain; Brain Edema; Brain Injuries; Capillary Permeability | 2000 |