ifenprodil has been researched along with Brain Edema in 7 studies
ifenprodil: NMDA receptor antagonist
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ifenprodil reduces CA-elicited brain edema." | 7.72 | Effect of ifenprodil, a polyamine site NMDA receptor antagonist, on brain edema formation following asphyxial cardiac arrest in rats. ( Alexander, JS; Arnold, T; Carden, D; Conrad, S; Monroe, J; Pardue, S; Sharp, CD; Turnage, R; Xiao, F, 2004) |
| " We studied the effects of ifenprodil, known as a noncompetitive inhibitor of polyamine sites at the NMDA receptor, on brain edema formation, blood-brain barrier breakdown, and volume of injury after TBI." | 7.70 | Attenuation of brain edema, blood-brain barrier breakdown, and injury volume by ifenprodil, a polyamine-site N-methyl-D-aspartate receptor antagonist, after experimental traumatic brain injury in rats. ( Başkaya, MK; Dempsey, RJ; Doğan, A, 2000) |
| "Ifenprodil, a polyamine site N-methyl-D-aspartate receptor/channel antagonist, has been reported to decrease infarction volume after cerebral ischemia." | 7.69 | Protective effects of ifenprodil on ischemic injury size, blood-brain barrier breakdown, and edema formation in focal cerebral ischemia. ( Başkaya, MK; Dempsey, RJ; Donaldson, D; Prasad, MR; Rao, AM, 1997) |
| " Six rats from each group were evaluated at 6 hours postocclusion for brain water content, an indicator of brain edema, and Evans blue dye extravasation for blood-brain barrier breakdown." | 7.69 | Effects of ifenprodil, a polyamine site NMDA receptor antagonist, on reperfusion injury after transient focal cerebral ischemia. ( Başkaya, MK; Dempsey, RJ; Doğan, A; Donaldson, D; Rao, AM; Rao, VL; Rastl, J, 1997) |
| "Ifenprodil, a NMDA receptor polyamine site antagonist, reduces experimental cardiac arrest (CA)-elicited brain edema, which is associated with an up-regulation of aquaporin 4 (AQP4), a brain water-selective channel." | 3.73 | Ifenprodil treatment is associated with a down-regulation of brain aquaporin 4 following cardiac arrest in rats. ( Alexander, JS; Arnold, TC; Carden, DL; Conrad, SA; Monroe, J; Pardue, S; Turnage, R; Xiao, F, 2005) |
| "Ifenprodil reduces CA-elicited brain edema." | 3.72 | Effect of ifenprodil, a polyamine site NMDA receptor antagonist, on brain edema formation following asphyxial cardiac arrest in rats. ( Alexander, JS; Arnold, T; Carden, D; Conrad, S; Monroe, J; Pardue, S; Sharp, CD; Turnage, R; Xiao, F, 2004) |
| " We studied the effects of ifenprodil, known as a noncompetitive inhibitor of polyamine sites at the NMDA receptor, on brain edema formation, blood-brain barrier breakdown, and volume of injury after TBI." | 3.70 | Attenuation of brain edema, blood-brain barrier breakdown, and injury volume by ifenprodil, a polyamine-site N-methyl-D-aspartate receptor antagonist, after experimental traumatic brain injury in rats. ( Başkaya, MK; Dempsey, RJ; Doğan, A, 2000) |
| "Ifenprodil, a polyamine site N-methyl-D-aspartate receptor/channel antagonist, has been reported to decrease infarction volume after cerebral ischemia." | 3.69 | Protective effects of ifenprodil on ischemic injury size, blood-brain barrier breakdown, and edema formation in focal cerebral ischemia. ( Başkaya, MK; Dempsey, RJ; Donaldson, D; Prasad, MR; Rao, AM, 1997) |
| " Six rats from each group were evaluated at 6 hours postocclusion for brain water content, an indicator of brain edema, and Evans blue dye extravasation for blood-brain barrier breakdown." | 3.69 | Effects of ifenprodil, a polyamine site NMDA receptor antagonist, on reperfusion injury after transient focal cerebral ischemia. ( Başkaya, MK; Dempsey, RJ; Doğan, A; Donaldson, D; Rao, AM; Rao, VL; Rastl, J, 1997) |
| "11/vehicle), memory function, and cerebral edema (n=12/drug vs." | 1.30 | Effects of the NMDA antagonist CP-98,113 on regional cerebral edema and cardiovascular, cognitive, and neurobehavioral function following experimental brain injury in the rat. ( McIntosh, TK; Okiyama, K; Smith, DH; White, WF, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xiao, F | 2 |
| Pardue, S | 2 |
| Arnold, T | 1 |
| Carden, D | 1 |
| Alexander, JS | 2 |
| Monroe, J | 2 |
| Sharp, CD | 1 |
| Turnage, R | 2 |
| Conrad, S | 1 |
| Arnold, TC | 1 |
| Carden, DL | 1 |
| Conrad, SA | 1 |
| Başkaya, MK | 3 |
| Rao, AM | 2 |
| Donaldson, D | 2 |
| Prasad, MR | 1 |
| Dempsey, RJ | 3 |
| Doğan, A | 2 |
| Rao, VL | 1 |
| Rastl, J | 1 |
| Okiyama, K | 1 |
| Smith, DH | 1 |
| White, WF | 1 |
| McIntosh, TK | 1 |
| Häntzschel, A | 1 |
| Andreas, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Triple-blind Placebo Controlled Trial of Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival and Neurological Outcome[NCT04009759] | Phase 1 | 240 participants (Anticipated) | Interventional | 2021-10-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for ifenprodil and Brain Edema
| Article | Year |
|---|---|
Effect of ifenprodil, a polyamine site NMDA receptor antagonist, on brain edema formation following asphyxial cardiac arrest in rats.
Topics: Animals; Asphyxia; Brain Edema; Brain Ischemia; Cardiopulmonary Resuscitation; Disease Models, Anima | 2004 |
Ifenprodil treatment is associated with a down-regulation of brain aquaporin 4 following cardiac arrest in rats.
Topics: Animals; Brain; Brain Edema; Down-Regulation; Heart Arrest; Phosphorylation; Piperidines; Rats; Rats | 2005 |
Protective effects of ifenprodil on ischemic injury size, blood-brain barrier breakdown, and edema formation in focal cerebral ischemia.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Brain Ischemia; Capillary Permeability; Cats; Cere | 1997 |
Effects of ifenprodil, a polyamine site NMDA receptor antagonist, on reperfusion injury after transient focal cerebral ischemia.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Blood-Brain Barrier; Body Temperature; Body W | 1997 |
Effects of the NMDA antagonist CP-98,113 on regional cerebral edema and cardiovascular, cognitive, and neurobehavioral function following experimental brain injury in the rat.
Topics: Animals; Behavior, Animal; Body Temperature; Brain Edema; Brain Injuries; Cardiovascular Physiologic | 1998 |
Non-N-methyl-D-aspartate (NMDA) receptor antagonist 1,2,3, 4-tetrahydro-6-nitro-2,3-dioxo-benzo(f)quinoxaline-7-sulphonamide (NBQX) decreases functional disorders in cytotoxic brain oedema.
Topics: Animals; Behavior, Animal; Brain; Brain Edema; Excitatory Amino Acid Antagonists; Hexachlorophene; M | 2000 |
Attenuation of brain edema, blood-brain barrier breakdown, and injury volume by ifenprodil, a polyamine-site N-methyl-D-aspartate receptor antagonist, after experimental traumatic brain injury in rats.
Topics: Animals; Blood-Brain Barrier; Body Water; Brain; Brain Edema; Brain Injuries; Capillary Permeability | 2000 |