ifenprodil has been researched along with Aura in 11 studies
ifenprodil: NMDA receptor antagonist
| Excerpt | Relevance | Reference |
|---|---|---|
| "Using models of acute and chronic seizures in C57BL/6 mice, we discovered a proconvulsant pathway involving high-mobility group box-1 (HMGB1) release from neurons and glia and its interaction with Toll-like receptor 4 (TLR4), a key receptor of innate immunity." | 1.36 | Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. ( Aronica, E; Balosso, S; Bianchi, ME; Casalgrandi, M; Iyer, AM; Liu, J; Manfredi, AA; Maroso, M; Molteni, M; Ravizza, T; Rossetti, C; Vezzani, A, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 6 (54.55) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, FX | 1 |
| Xiong, XY | 1 |
| Zhong, Q | 1 |
| Meng, ZY | 1 |
| Yang, H | 1 |
| Yang, QW | 1 |
| Schidlitzki, A | 1 |
| Twele, F | 1 |
| Klee, R | 1 |
| Waltl, I | 1 |
| Römermann, K | 1 |
| Bröer, S | 1 |
| Meller, S | 1 |
| Gerhauser, I | 1 |
| Rankovic, V | 1 |
| Li, D | 1 |
| Brandt, C | 1 |
| Bankstahl, M | 1 |
| Töllner, K | 1 |
| Löscher, W | 1 |
| Zhu, X | 1 |
| Dong, J | 1 |
| Shen, K | 1 |
| Bai, Y | 1 |
| Zhang, Y | 1 |
| Lv, X | 1 |
| Chao, J | 1 |
| Yao, H | 1 |
| Maroso, M | 1 |
| Balosso, S | 1 |
| Ravizza, T | 1 |
| Liu, J | 1 |
| Aronica, E | 1 |
| Iyer, AM | 1 |
| Rossetti, C | 1 |
| Molteni, M | 1 |
| Casalgrandi, M | 1 |
| Manfredi, AA | 1 |
| Bianchi, ME | 1 |
| Vezzani, A | 1 |
| Galvan, CD | 1 |
| Wenzel, JH | 1 |
| Dineley, KT | 1 |
| Lam, TT | 1 |
| Schwartzkroin, PA | 1 |
| Sweatt, JD | 1 |
| Swann, JW | 1 |
| André, VM | 1 |
| Flores-Hernández, J | 1 |
| Cepeda, C | 1 |
| Starling, AJ | 1 |
| Nguyen, S | 1 |
| Lobo, MK | 1 |
| Vinters, HV | 1 |
| Levine, MS | 1 |
| Mathern, GW | 1 |
| Calcagnotto, ME | 1 |
| Baraban, SC | 1 |
| De Sarro, GB | 1 |
| De Sarro, A | 1 |
| DeFazio, RA | 2 |
| Hablitz, JJ | 2 |
| Woodhall, G | 1 |
| Evans, DI | 1 |
| Cunningham, MO | 1 |
| Jones, RS | 1 |
1 trial available for ifenprodil and Aura
| Article | Year |
|---|---|
NMDA receptor alterations in neurons from pediatric cortical dysplasia tissue.
Topics: Adolescent; Cells, Cultured; Cerebral Cortex; Child; Child, Preschool; Epilepsy; Humans; Infant; Mag | 2004 |
10 other studies available for ifenprodil and Aura
| Article | Year |
|---|---|
Foxp3 exhibits antiepileptic effects in ictogenesis involved in TLR4 signaling.
Topics: Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Cells, Cultured; Epilepsy; Forkhead Transcri | 2017 |
A combination of NMDA and AMPA receptor antagonists retards granule cell dispersion and epileptogenesis in a model of acquired epilepsy.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Disease Models, Animal; Drug Administration Schedule; Drug | 2017 |
NMDA receptor NR2B subunits contribute to PTZ-kindling-induced hippocampal astrocytosis and oxidative stress.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Cell Death; Epilepsy; Excitatory Amino Acid | 2015 |
Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Hippoc | 2010 |
Postsynaptic contributions to hippocampal network hyperexcitability induced by chronic activity blockade in vivo.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Anesthetics, Local; Animals; Animals, Newborn; Axons; Disease | 2003 |
Prolonged NMDA-mediated responses, altered ifenprodil sensitivity, and epileptiform-like events in the malformed hippocampus of methylazoxymethanol exposed rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interaction | 2005 |
Anticonvulsant properties of non-competitive antagonists of the N-methyl-D-aspartate receptor in genetically epilepsy-prone rats: comparison with CPPene.
Topics: Acoustic Stimulation; Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Dextromethorphan; Dizo | 1993 |
Alterations in NMDA receptors in a rat model of cortical dysplasia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Cerebral Cortex; Epilepsy; Evoked Potentials; Excitator | 2000 |
Altered receptor subunit expression in rat neocortical malformations.
Topics: Animals; Disease Models, Animal; Epilepsy; Excitatory Postsynaptic Potentials; Freezing; Neocortex; | 2000 |
NR2B-containing NMDA autoreceptors at synapses on entorhinal cortical neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoreceptors; Calcium; Entorhinal Cortex; Epilepsy; Excitator | 2001 |