Page last updated: 2024-10-28

ifenprodil and Aging

ifenprodil has been researched along with Aging in 15 studies

ifenprodil: NMDA receptor antagonist

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Pretreatment with ifenprodil resulted in an anticonvulsant effect in 15-day-old rats only, on the contrary, proconvulsant action was found in 18- and 25-day-old animals (decrease of thresholds especially for transition into the second, limbic type of ADs and increase in duration of ADs)."1.40Age and activation determines the anticonvulsant effect of ifenprodil in rats. ( Mareš, P, 2014)
" Ifenprodil dose-response curves for all receptors were biphasic."1.31Electrophysiological analysis of NMDA receptor subunit changes in the aging mouse cortex. ( Kuehl-Kovarik, MC; Magnusson, KR; Partin, KM; Premkumar, LS, 2000)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (26.67)18.2507
2000's8 (53.33)29.6817
2010's3 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kumar, A1
Thinschmidt, JS1
Foster, TC1
Morales, M1
Spear, LP1
Mareš, P1
de Marchena, J1
Roberts, AC1
Middlebrooks, PG1
Valakh, V1
Yashiro, K1
Wilfley, LR1
Philpot, BD1
Richter, A1
Morrison, LD1
Kuehl-Kovarik, MC2
Partin, KM2
Magnusson, KR2
Bellone, C1
Nicoll, RA1
Barron, S1
Mulholland, PJ1
Littleton, JM1
Prendergast, MA1
Zhong, J1
Carrozza, DP1
Williams, K1
Pritchett, DB1
Molinoff, PB1
Ramoa, AS1
Prusky, G1
Tsuda, M1
Suzuki, T1
Misawa, M1
Kew, JN1
Richards, JG1
Mutel, V1
Kemp, JA1
Premkumar, LS1
Green, GM1
Gibb, AJ1
Joshi, I1
Wang, LY1

Reviews

1 review available for ifenprodil and Aging

ArticleYear
Developmental changes in NMDA receptor glycine affinity and ifenprodil sensitivity reveal three distinct populations of NMDA receptors in individual rat cortical neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Mar-15, Volume: 18, Issue:6

    Topics: Aging; Animals; Binding, Competitive; Cerebral Cortex; Excitatory Amino Acid Antagonists; Glycine; N

1998

Other Studies

14 other studies available for ifenprodil and Aging

ArticleYear
Subunit contribution to NMDA receptor hypofunction and redox sensitivity of hippocampal synaptic transmission during aging.
    Aging, 2019, 07-24, Volume: 11, Issue:14

    Topics: Aging; Animals; CA1 Region, Hippocampal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Dithiot

2019
The effects of an acute challenge with the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, on social inhibition in adolescent and adult male rats.
    Psychopharmacology, 2014, Volume: 231, Issue:8

    Topics: Aging; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagon

2014
Age and activation determines the anticonvulsant effect of ifenprodil in rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 2014, Volume: 387, Issue:8

    Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Electric Stimulation; Male; Pentylenetetrazole; P

2014
NMDA receptor antagonists reveal age-dependent differences in the properties of visual cortical plasticity.
    Journal of neurophysiology, 2008, Volume: 100, Issue:4

    Topics: Aging; Animals; Blotting, Western; Electrophysiology; Evoked Potentials, Visual; Excitatory Amino Ac

2008
Polyamines in a genetic animal model of paroxysmal dyskinesia.
    Brain research, 2003, Aug-15, Volume: 981, Issue:1-2

    Topics: Aging; Animals; Brain; Case-Control Studies; Chorea; Cricetinae; Disease Models, Animal; Dose-Respon

2003
Acute dissociation for analyses of NMDA receptor function in cortical neurons during aging.
    Journal of neuroscience methods, 2003, Oct-15, Volume: 129, Issue:1

    Topics: Aging; Animals; Calcium; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Excitat

2003
Rapid bidirectional switching of synaptic NMDA receptors.
    Neuron, 2007, Sep-06, Volume: 55, Issue:5

    Topics: Aging; Animals; Brain; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutam

2007
Age and gender differences in response to neonatal ethanol withdrawal and polyamine challenge in organotypic hippocampal cultures.
    Alcoholism, clinical and experimental research, 2008, Volume: 32, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Ethanol; Female; Hippocampus; Male; Organ Culture Techniques; Pipe

2008
Expression of mRNAs encoding subunits of the NMDA receptor in developing rat brain.
    Journal of neurochemistry, 1995, Volume: 64, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Brain; Dizocilpine Maleate; Piperidines; Rats; Receptors, N-Methyl

1995
Retinal activity regulates developmental switches in functional properties and ifenprodil sensitivity of NMDA receptors in the lateral geniculate nucleus.
    Brain research. Developmental brain research, 1997, Jul-18, Volume: 101, Issue:1-2

    Topics: Action Potentials; Aging; Animals; Electrophysiology; Excitatory Amino Acid Antagonists; Ferrets; Ge

1997
Age-related decrease in the antiseizure effect of ifenprodil against pentylenetetrazole in mice.
    Brain research. Developmental brain research, 1997, Dec-19, Volume: 104, Issue:1-2

    Topics: Aging; Animals; Anticonvulsants; Convulsants; Dizocilpine Maleate; Excitatory Amino Acid Antagonists

1997
Electrophysiological analysis of NMDA receptor subunit changes in the aging mouse cortex.
    Mechanisms of ageing and development, 2000, May-18, Volume: 115, Issue:1-2

    Topics: Aging; Animals; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Electric Conductivi

2000
Characterization of the single-channel properties of NMDA receptors in laminae I and II of the dorsal horn of neonatal rat spinal cord.
    The European journal of neuroscience, 2001, Volume: 14, Issue:10

    Topics: Aging; Animals; Excitatory Amino Acid Antagonists; Ion Channels; Magnesium; Membrane Potentials; N-M

2001
Developmental profiles of glutamate receptors and synaptic transmission at a single synapse in the mouse auditory brainstem.
    The Journal of physiology, 2002, May-01, Volume: 540, Issue:Pt 3

    Topics: Aging; Animals; Auditory Pathways; Brain Stem; Ethylenediamines; Excitatory Postsynaptic Potentials;

2002