ifenprodil and Aging
ifenprodil has been researched along with Aging in 15 studies
ifenprodil: NMDA receptor antagonist
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pretreatment with ifenprodil resulted in an anticonvulsant effect in 15-day-old rats only, on the contrary, proconvulsant action was found in 18- and 25-day-old animals (decrease of thresholds especially for transition into the second, limbic type of ADs and increase in duration of ADs)." | 1.40 | Age and activation determines the anticonvulsant effect of ifenprodil in rats. ( Mareš, P, 2014) |
| " Ifenprodil dose-response curves for all receptors were biphasic." | 1.31 | Electrophysiological analysis of NMDA receptor subunit changes in the aging mouse cortex. ( Kuehl-Kovarik, MC; Magnusson, KR; Partin, KM; Premkumar, LS, 2000) |
Research
Studies (15)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 8 (53.33) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Kumar, A | 1 |
| Thinschmidt, JS | 1 |
| Foster, TC | 1 |
| Morales, M | 1 |
| Spear, LP | 1 |
| Mareš, P | 1 |
| de Marchena, J | 1 |
| Roberts, AC | 1 |
| Middlebrooks, PG | 1 |
| Valakh, V | 1 |
| Yashiro, K | 1 |
| Wilfley, LR | 1 |
| Philpot, BD | 1 |
| Richter, A | 1 |
| Morrison, LD | 1 |
| Kuehl-Kovarik, MC | 2 |
| Partin, KM | 2 |
| Magnusson, KR | 2 |
| Bellone, C | 1 |
| Nicoll, RA | 1 |
| Barron, S | 1 |
| Mulholland, PJ | 1 |
| Littleton, JM | 1 |
| Prendergast, MA | 1 |
| Zhong, J | 1 |
| Carrozza, DP | 1 |
| Williams, K | 1 |
| Pritchett, DB | 1 |
| Molinoff, PB | 1 |
| Ramoa, AS | 1 |
| Prusky, G | 1 |
| Tsuda, M | 1 |
| Suzuki, T | 1 |
| Misawa, M | 1 |
| Kew, JN | 1 |
| Richards, JG | 1 |
| Mutel, V | 1 |
| Kemp, JA | 1 |
| Premkumar, LS | 1 |
| Green, GM | 1 |
| Gibb, AJ | 1 |
| Joshi, I | 1 |
| Wang, LY | 1 |
Reviews
1 review available for ifenprodil and Aging
| Article | Year |
|---|---|
Developmental changes in NMDA receptor glycine affinity and ifenprodil sensitivity reveal three distinct populations of NMDA receptors in individual rat cortical neurons.
Topics: Aging; Animals; Binding, Competitive; Cerebral Cortex; Excitatory Amino Acid Antagonists; Glycine; N | 1998 |
Other Studies
14 other studies available for ifenprodil and Aging
| Article | Year |
|---|---|
Subunit contribution to NMDA receptor hypofunction and redox sensitivity of hippocampal synaptic transmission during aging.
Topics: Aging; Animals; CA1 Region, Hippocampal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Dithiot | 2019 |
The effects of an acute challenge with the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, on social inhibition in adolescent and adult male rats.
Topics: Aging; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagon | 2014 |
Age and activation determines the anticonvulsant effect of ifenprodil in rats.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Electric Stimulation; Male; Pentylenetetrazole; P | 2014 |
NMDA receptor antagonists reveal age-dependent differences in the properties of visual cortical plasticity.
Topics: Aging; Animals; Blotting, Western; Electrophysiology; Evoked Potentials, Visual; Excitatory Amino Ac | 2008 |
Polyamines in a genetic animal model of paroxysmal dyskinesia.
Topics: Aging; Animals; Brain; Case-Control Studies; Chorea; Cricetinae; Disease Models, Animal; Dose-Respon | 2003 |
Acute dissociation for analyses of NMDA receptor function in cortical neurons during aging.
Topics: Aging; Animals; Calcium; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Excitat | 2003 |
Rapid bidirectional switching of synaptic NMDA receptors.
Topics: Aging; Animals; Brain; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutam | 2007 |
Age and gender differences in response to neonatal ethanol withdrawal and polyamine challenge in organotypic hippocampal cultures.
Topics: Aging; Animals; Animals, Newborn; Ethanol; Female; Hippocampus; Male; Organ Culture Techniques; Pipe | 2008 |
Expression of mRNAs encoding subunits of the NMDA receptor in developing rat brain.
Topics: Aging; Animals; Animals, Newborn; Brain; Dizocilpine Maleate; Piperidines; Rats; Receptors, N-Methyl | 1995 |
Retinal activity regulates developmental switches in functional properties and ifenprodil sensitivity of NMDA receptors in the lateral geniculate nucleus.
Topics: Action Potentials; Aging; Animals; Electrophysiology; Excitatory Amino Acid Antagonists; Ferrets; Ge | 1997 |
Age-related decrease in the antiseizure effect of ifenprodil against pentylenetetrazole in mice.
Topics: Aging; Animals; Anticonvulsants; Convulsants; Dizocilpine Maleate; Excitatory Amino Acid Antagonists | 1997 |
Electrophysiological analysis of NMDA receptor subunit changes in the aging mouse cortex.
Topics: Aging; Animals; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Electric Conductivi | 2000 |
Characterization of the single-channel properties of NMDA receptors in laminae I and II of the dorsal horn of neonatal rat spinal cord.
Topics: Aging; Animals; Excitatory Amino Acid Antagonists; Ion Channels; Magnesium; Membrane Potentials; N-M | 2001 |
Developmental profiles of glutamate receptors and synaptic transmission at a single synapse in the mouse auditory brainstem.
Topics: Aging; Animals; Auditory Pathways; Brain Stem; Ethylenediamines; Excitatory Postsynaptic Potentials; | 2002 |