iduronate and Asthma

iduronate has been researched along with Asthma* in 1 studies

Other Studies

1 other study(ies) available for iduronate and Asthma

Article	Year
Synthetic di-sulfated iduronic acid attenuates asthmatic response by blocking T-cell recruitment to inflammatory sites. Proceedings of the National Academy of Sciences of the United States of America, 2014, Jun-03, Volume: 111, Issue:22 Identification of carbohydrate sequences that determine affinity to specific chemokines is a critical step for strategies to interfere with chemokine-mediated leukocyte trafficking. Here, we first characterized the development of allergic asthma in Tie2-dependent and inducible Ext1-knockout (Tie2-Ext1(iKO)) mice. We showed that heparan sulfate is essential for leukocyte recruitment in the peribronchial region and bronchoalveolar lavage fluid (BALF), and is crucial for induction of airway hyperresponsiveness. Our glycan microarray showed a unique affinity profile of chemokine CCL20 to substructures of heparin and heparin-like oligo/di/monosaccharides. Among them, we identified a synthetic and not naturally occurring monosaccharide, 2,4-O-di-sulfated iduronic acid (Di-S-IdoA), as a potential inhibitor for CCL20-heparan sulfate interaction. Mice injected with Di-S-IdoA via tail vain or nasal inhalation showed attenuated leukocyte recruitment into inflammatory sites and BALF. These results demonstrate a critical role of chemokine-heparan sulfate interaction in the asthma development and Di-S-IdoA as a potential drug for asthma treatment. Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Carbohydrate Sequence; Chemokine CCL20; Chemotaxis; Disease Models, Animal; Eosinophils; Heparitin Sulfate; Iduronic Acid; Lung; Mice; Mice, Knockout; N-Acetylglucosaminyltransferases; Ovalbumin; Polysaccharides; Receptor, TIE-2; Sulfates; T-Lymphocytes	2014

Article

Year

Synthetic di-sulfated iduronic acid attenuates asthmatic response by blocking T-cell recruitment to inflammatory sites.

Proceedings of the National Academy of Sciences of the United States of America, 2014, Jun-03, Volume: 111, Issue:22

Identification of carbohydrate sequences that determine affinity to specific chemokines is a critical step for strategies to interfere with chemokine-mediated leukocyte trafficking. Here, we first characterized the development of allergic asthma in Tie2-dependent and inducible Ext1-knockout (Tie2-Ext1(iKO)) mice. We showed that heparan sulfate is essential for leukocyte recruitment in the peribronchial region and bronchoalveolar lavage fluid (BALF), and is crucial for induction of airway hyperresponsiveness. Our glycan microarray showed a unique affinity profile of chemokine CCL20 to substructures of heparin and heparin-like oligo/di/monosaccharides. Among them, we identified a synthetic and not naturally occurring monosaccharide, 2,4-O-di-sulfated iduronic acid (Di-S-IdoA), as a potential inhibitor for CCL20-heparan sulfate interaction. Mice injected with Di-S-IdoA via tail vain or nasal inhalation showed attenuated leukocyte recruitment into inflammatory sites and BALF. These results demonstrate a critical role of chemokine-heparan sulfate interaction in the asthma development and Di-S-IdoA as a potential drug for asthma treatment.

Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Carbohydrate Sequence; Chemokine CCL20; Chemotaxis; Disease Models, Animal; Eosinophils; Heparitin Sulfate; Iduronic Acid; Lung; Mice; Mice, Knockout; N-Acetylglucosaminyltransferases; Ovalbumin; Polysaccharides; Receptor, TIE-2; Sulfates; T-Lymphocytes

2014