idelalisib and Tuberculosis

idelalisib has been researched along with Tuberculosis* in 1 studies

Other Studies

1 other study(ies) available for idelalisib and Tuberculosis

ArticleYear
RP105 Engages Phosphatidylinositol 3-Kinase p110δ To Facilitate the Trafficking and Secretion of Cytokines in Macrophages during Mycobacterial Infection.
    Journal of immunology (Baltimore, Md. : 1950), 2015, Oct-15, Volume: 195, Issue:8

    Cytokines are key regulators of adequate immune responses to infection with Mycobacterium tuberculosis. We demonstrate that the p110δ catalytic subunit of PI3K acts as a downstream effector of the TLR family member RP105 (CD180) in promoting mycobacteria-induced cytokine production by macrophages. Our data show that the significantly reduced release of TNF and IL-6 by RP105(-/-) macrophages during mycobacterial infection was not accompanied by diminished mRNA or protein expression. Mycobacteria induced comparable activation of NF-κB and p38 MAPK signaling in wild-type (WT) and RP105(-/-) macrophages. In contrast, mycobacteria-induced phosphorylation of Akt was abrogated in RP105(-/-) macrophages. The p110δ-specific inhibitor, Cal-101, and small interfering RNA-mediated knockdown of p110δ diminished mycobacteria-induced TNF secretion by WT but not RP105(-/-) macrophages. Such interference with p110δ activity led to reduced surface-expressed TNF in WT but not RP105(-/-) macrophages, while leaving TNF mRNA and protein expression unaffected. Activity of Bruton's tyrosine kinase was required for RP105-mediated activation of Akt phosphorylation and TNF release by mycobacteria-infected macrophages. These data unveil a novel innate immune signaling axis that orchestrates key cytokine responses of macrophages and provide molecular insight into the functions of RP105 as an innate immune receptor for mycobacteria.

    Topics: Animals; Antigens, CD; Class I Phosphatidylinositol 3-Kinases; Enzyme Inhibitors; MAP Kinase Signaling System; Mice; Mice, Knockout; Mycobacterium tuberculosis; p38 Mitogen-Activated Protein Kinases; Protein Transport; Proto-Oncogene Proteins c-akt; Purines; Quinazolinones; Tuberculosis; Tumor Necrosis Factor-alpha

2015