idelalisib and Polyradiculopathy

idelalisib has been researched along with Polyradiculopathy* in 1 studies

Other Studies

1 other study(ies) available for idelalisib and Polyradiculopathy

ArticleYear
Acute polyradiculopathy secondary to idelalisib in Relapsed Classical Hodgkin's lymphoma.
    Current research in translational medicine, 2018, Volume: 66, Issue:3

    Patients with relapsed or refractory Hodgkin's lymphoma are likely incurable with standard treatment. Idelalisib, a delta-isoform specific Phosphatidyl-inositol-3-kinase (PI3K) inhibitor has shown its efficacy in other hematopoietic B malignancies. We report the case of a 51-years old patient with relapsed and refractory Hodgkin's Lymphoma receiving idelalisib after several regimens of chemotherapy. He achieved a good partial response for several months, unfortunately, idelalisib had to be stopped because of the onset of a severe polyradiculoneuritis attributed to this treatment. We assume here that the polyradiculoneuritis could be caused by T cell mediated autoimmunity to myelin proteins. To our knowledge, this adverse event has never been described so far with idelalisib.

    Topics: Acute Disease; Adult; Hodgkin Disease; Humans; Male; Polyradiculopathy; Purines; Quinazolinones; Recurrence

2018