idelalisib and Leukemia--Hairy-Cell

Hairy cell leukemia (HCL) cells engage in complex cellular and molecular interactions with accessory cells, matrix proteins, and various cytokines in the bone marrow and spleen, collectively referred to as the tissue microenvironment. Chemokine receptors and adhesion molecules are critical players for homing and retention within these microenvironments. Engagement of B cell antigen receptors and CD40 on HCL cells promote survival and proliferation. In this chapter, we summarize the current knowledge about the cellular and molecular interactions between HCL cells and their supportive tissue microenvironment, and provide insight into new therapeutic approaches targeting B cell receptor signaling in HCL.

Topics: Adenine; Antineoplastic Agents; B-Lymphocytes; Bone Marrow; CD40 Antigens; Gene Expression Regulation, Leukemic; Humans; Intercellular Adhesion Molecule-1; Leukemia, Hairy Cell; Piperidines; Purines; Pyrazoles; Pyrimidines; Quinazolinones; Receptors, Antigen, B-Cell; Receptors, CXCR4; Signal Transduction; Spleen; Tumor Microenvironment; Vascular Cell Adhesion Molecule-1