idebenone has been researched along with Electron Transport Chain Deficiencies, Mitochondrial in 14 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " CoQ10 along with its synthetic analogue, idebenone, is used largely to treat various neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis, and Friedreich's ataxia and additional brain disease condition like autism, multiple sclerosis, epilepsy, depression, and bipolar disorder, which are related to mitochondrial impairment." | 9.12 | Coenzyme Q10 a mitochondrial restorer for various brain disorders. ( Pradhan, N; Singh, A; Singh, C, 2021) |
| " CoQ10 along with its synthetic analogue, idebenone, is used largely to treat various neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis, and Friedreich's ataxia and additional brain disease condition like autism, multiple sclerosis, epilepsy, depression, and bipolar disorder, which are related to mitochondrial impairment." | 5.12 | Coenzyme Q10 a mitochondrial restorer for various brain disorders. ( Pradhan, N; Singh, A; Singh, C, 2021) |
| " Idebenone treatment significantly corrected cardiac diastolic dysfunction and prevented mortality from cardiac pump failure induced by dobutamine stress testing in vivo, significantly reduced cardiac inflammation and fibrosis, and significantly improved voluntary running performance in mdx mice." | 3.75 | Long-term blinded placebo-controlled study of SNT-MC17/idebenone in the dystrophin deficient mdx mouse: cardiac protection and improved exercise performance. ( Barzaghi, P; Buyse, GM; Courdier-Fruh, I; D'hooge, J; Erb, M; Herijgers, P; Jara, A; Meier, T; Mertens, L; Van Den Bergh, A; Van der Mieren, G; Verbeken, E, 2009) |
| "Mitochondrial diseases are a group of devastating disorders for which there is no transformative cure." | 1.48 | Patient-derived lymphoblastoid cell lines harboring mitochondrial DNA mutations as tool for small molecule drug discovery. ( Brown, JM; Chin, RM; Johnson, KK; Panavas, T, 2018) |
| "Idebenone is a hydrophilic short-chain coenzyme (Co) Q analogue, which has been used as a potential bypass of defective complex I in both Leber Hereditary Optic Neuropathy and OPA1-dependent Dominant Optic Atrophy." | 1.48 | The idebenone metabolite QS10 restores electron transfer in complex I and coenzyme Q defects. ( Acosta Lopez, MJ; Argenton, F; Bernardi, P; Carelli, V; Carini, M; Da Ros, T; Galber, C; Giorgio, V; Petronilli, V; Prato, M; Salviati, L; Schiavone, M, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 11 (78.57) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Pradhan, N | 1 |
| Singh, C | 1 |
| Singh, A | 2 |
| Faccenda, D | 1 |
| Campanella, M | 1 |
| Bianco, A | 1 |
| Bisceglia, L | 1 |
| Russo, L | 1 |
| Palese, LL | 1 |
| D'Agruma, L | 1 |
| Emperador, S | 1 |
| Montoya, J | 1 |
| Guerriero, S | 1 |
| Petruzzella, V | 1 |
| Chin, RM | 1 |
| Panavas, T | 1 |
| Brown, JM | 1 |
| Johnson, KK | 1 |
| Giorgio, V | 1 |
| Schiavone, M | 1 |
| Galber, C | 1 |
| Carini, M | 1 |
| Da Ros, T | 1 |
| Petronilli, V | 1 |
| Argenton, F | 1 |
| Carelli, V | 1 |
| Acosta Lopez, MJ | 1 |
| Salviati, L | 1 |
| Prato, M | 1 |
| Bernardi, P | 1 |
| Kleiner, G | 1 |
| Barca, E | 1 |
| Ziosi, M | 1 |
| Emmanuele, V | 1 |
| Xu, Y | 1 |
| Hidalgo-Gutierrez, A | 1 |
| Qiao, C | 1 |
| Tadesse, S | 1 |
| Area-Gomez, E | 1 |
| Lopez, LC | 1 |
| Quinzii, CM | 1 |
| Liu, J | 1 |
| Wang, LN | 1 |
| Hargreaves, IP | 1 |
| Buyse, GM | 1 |
| Van der Mieren, G | 1 |
| Erb, M | 2 |
| D'hooge, J | 1 |
| Herijgers, P | 1 |
| Verbeken, E | 1 |
| Jara, A | 1 |
| Van Den Bergh, A | 1 |
| Mertens, L | 1 |
| Courdier-Fruh, I | 1 |
| Barzaghi, P | 1 |
| Meier, T | 1 |
| Mancuso, M | 1 |
| Orsucci, D | 1 |
| Volpi, L | 1 |
| Calsolaro, V | 1 |
| Siciliano, G | 1 |
| Kerr, DS | 2 |
| Koopman, WJ | 1 |
| Willems, PH | 1 |
| Smeitink, JA | 1 |
| Hoffmann-Enger, B | 1 |
| Deppe, H | 1 |
| Soeberdt, M | 1 |
| Haefeli, RH | 1 |
| Rummey, C | 1 |
| Feurer, A | 1 |
| Gueven, N | 1 |
8 reviews available for idebenone and Electron Transport Chain Deficiencies, Mitochondrial
| Article | Year |
|---|---|
Coenzyme Q10 a mitochondrial restorer for various brain disorders.
Topics: Animals; Antioxidants; Brain Diseases; Humans; Mitochondria; Mitochondrial Diseases; Neurodegenerati | 2021 |
Pharmacological advances in mitochondrial therapy.
Topics: Antioxidants; Humans; Mitochondria; Mitochondrial Diseases; Mitochondrial Dynamics; Neurodegenerativ | 2021 |
Mitochondrial enhancement for neurodegenerative movement disorders: a systematic review of trials involving creatine, coenzyme Q10, idebenone and mitoquinone.
Topics: Animals; Creatine; Dose-Response Relationship, Drug; Humans; Mitochondria; Mitochondrial Diseases; N | 2014 |
Coenzyme Q10 as a therapy for mitochondrial disease.
Topics: Animals; Ataxia; Humans; Mitochondrial Diseases; Molecular Structure; Muscle Weakness; Treatment Out | 2014 |
Coenzyme Q10 in neuromuscular and neurodegenerative disorders.
Topics: Animals; Humans; Mitochondrial Diseases; Neurodegenerative Diseases; Neuromuscular Diseases; Ubiquin | 2010 |
Treatment of mitochondrial electron transport chain disorders: a review of clinical trials over the past decade.
Topics: Arginine; Clinical Trials as Topic; Dichloroacetic Acid; Humans; Mitochondrial Diseases; Randomized | 2010 |
Monogenic mitochondrial disorders.
Topics: Adenosine Triphosphate; Cyclosporine; Enzyme Replacement Therapy; Humans; Mitochondria; Mitochondria | 2012 |
Review of clinical trials for mitochondrial disorders: 1997-2012.
Topics: Antioxidants; Arginine; Clinical Trials as Topic; Creatine; Exercise Therapy; Humans; Mitochondrial | 2013 |
6 other studies available for idebenone and Electron Transport Chain Deficiencies, Mitochondrial
| Article | Year |
|---|---|
High Mitochondrial DNA Copy Number Is a Protective Factor From Vision Loss in Heteroplasmic Leber's Hereditary Optic Neuropathy (LHON).
Topics: Antioxidants; Blindness; DNA Copy Number Variations; DNA, Mitochondrial; Female; Genes, Mitochondria | 2017 |
Patient-derived lymphoblastoid cell lines harboring mitochondrial DNA mutations as tool for small molecule drug discovery.
Topics: Adult; Cell Line; Child; Child, Preschool; DNA, Mitochondrial; Drug Discovery; Female; Humans; Lymph | 2018 |
The idebenone metabolite QS10 restores electron transfer in complex I and coenzyme Q defects.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Ataxia; Cell Respiration; Cells, Cultured; Electron T | 2018 |
CoQ
Topics: Alkyl and Aryl Transferases; Animals; Antioxidants; Ataxia; Disease Models, Animal; HeLa Cells; Huma | 2018 |
Long-term blinded placebo-controlled study of SNT-MC17/idebenone in the dystrophin deficient mdx mouse: cardiac protection and improved exercise performance.
Topics: Animals; Antioxidants; Biomarkers; Cardiotonic Agents; Diastole; Dobutamine; Echocardiography; Fibro | 2009 |
Features of idebenone and related short-chain quinones that rescue ATP levels under conditions of impaired mitochondrial complex I.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Cell Line; Chemical Phenomena; Electron Transport Com | 2012 |