idebenone has been researched along with Brain Ischemia in 17 studies
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Using a repeated acquisition procedure in a three-panel runway apparatus, the effects of minaprine on the impairment of working memory produced by scopolamine, ethylcholine aziridinium ion (AF64A) or cerebral ischemia were investigated in rats." | 7.68 | Minaprine improves impairment of working memory induced by scopolamine and cerebral ischemia in rats. ( Furuya, Y; Kitajima, I; Ohno, M; Ueki, S; Yamamoto, T; Yatsugi, S, 1990) |
| "The concentrations of acetylcholine (Ach) and choline in various brain regions of rats with and without cerebral ischemia and the effects of 6-(10-hydroxy-decyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone, CV-2619) on the levels of these parameters were investigated." | 7.67 | Effects of idebenone (CV-2619) on the concentrations of acetylcholine and choline in various brain regions of rats with cerebral ischemia. ( Kakihana, M; Nagaoka, A; Yamazaki, N, 1984) |
| "An experimental model of amnesia induced by cerebral ischemia after one-trial passive avoidance learning was established to test the effects of a novel compound, 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone, CV-2619), and some commonly used drugs in rats." | 7.67 | Beneficial effect of idebenone (CV-2619) on cerebral ischemia-induced amnesia in rats. ( Nagaoka, A; Nagawa, Y; Take, Y; Yamazaki, N, 1984) |
| " In the present study, the effects of 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone) on neurological signs, such as ischemic seizures, lactate and ATP contents of the cerebral cortex, and local cerebral blood flow, were assessed in stroke-prone spontaneously hypertensive rats (SHRSP) with experimentally induced cerebral ischemia." | 7.67 | Effects of idebenone on neurological deficits, local cerebral blood flow, and energy metabolism in rats with experimental cerebral ischemia. ( Kakihana, M; Nagaoka, A; Shibota, M; Suno, M, 1989) |
| "Pretreatment with idebenone (10 mg/kg, i." | 5.28 | Effects of idebenone on the levels of acetylcholine, choline, free fatty acids, and energy metabolites in the brains of rats with cerebral ischemia. ( Kakihana, M; Nagaoka, A; Yamazaki, N, 1989) |
| "In rats with cerebral ischemia, a low dose (10 mg/kg, i." | 5.27 | Effects of idebenone (CV-2619) on metabolism of monoamines, especially serotonin, in the brain of normal rats and rats with cerebral ischemia. ( Kakihana, M; Nagai, Y; Nagaoka, A; Nagawa, Y; Narumi, S; Yamazaki, N, 1985) |
| "Idebenone is a well-appreciated mitochondrial protectant while the mechanisms underlying the neuroprotection in cerebral ischemia and reperfusion (I/R) remain elusive." | 3.96 | Idebenone attenuates cerebral inflammatory injury in ischemia and reperfusion via dampening NLRP3 inflammasome activity. ( Gong, Z; He, L; Li, X; Pan, J; Peng, J; Peng, Y; Shen, Q; Wang, H, 2020) |
| "Effect of WEB 1881 FU (nebracetam) on hypoxia and ischemia-induced impairment of 2-deoxyglucose (2DG) uptake and CA1 field potentials induced by hypoxia and hypoxia/hypoglycemia (ischemia) in rat brain slices was evaluated and compared to the findings obtained with pentobarbital and idebenone." | 3.68 | Neuroprotective effect of WEB 1881 FU (nebracetam) on an ischemia-induced deficit of glucose uptake in rat hippocampal and cerebral cortical slices and CA1 field potential in hippocampal slices. ( Kagami-ishi, Y; Shibata, S; Ueki, S; Watanabe, S, 1992) |
| "Using a repeated acquisition procedure in a three-panel runway apparatus, the effects of minaprine on the impairment of working memory produced by scopolamine, ethylcholine aziridinium ion (AF64A) or cerebral ischemia were investigated in rats." | 3.68 | Minaprine improves impairment of working memory induced by scopolamine and cerebral ischemia in rats. ( Furuya, Y; Kitajima, I; Ohno, M; Ueki, S; Yamamoto, T; Yatsugi, S, 1990) |
| "The concentrations of acetylcholine (Ach) and choline in various brain regions of rats with and without cerebral ischemia and the effects of 6-(10-hydroxy-decyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone, CV-2619) on the levels of these parameters were investigated." | 3.67 | Effects of idebenone (CV-2619) on the concentrations of acetylcholine and choline in various brain regions of rats with cerebral ischemia. ( Kakihana, M; Nagaoka, A; Yamazaki, N, 1984) |
| "An experimental model of amnesia induced by cerebral ischemia after one-trial passive avoidance learning was established to test the effects of a novel compound, 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone, CV-2619), and some commonly used drugs in rats." | 3.67 | Beneficial effect of idebenone (CV-2619) on cerebral ischemia-induced amnesia in rats. ( Nagaoka, A; Nagawa, Y; Take, Y; Yamazaki, N, 1984) |
| " In the present study, the effects of 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone) on neurological signs, such as ischemic seizures, lactate and ATP contents of the cerebral cortex, and local cerebral blood flow, were assessed in stroke-prone spontaneously hypertensive rats (SHRSP) with experimentally induced cerebral ischemia." | 3.67 | Effects of idebenone on neurological deficits, local cerebral blood flow, and energy metabolism in rats with experimental cerebral ischemia. ( Kakihana, M; Nagaoka, A; Shibota, M; Suno, M, 1989) |
| "Idebenone treatment did not affect APP and Apo E alterations in this condition." | 1.30 | Changes in amyloid precursor protein and apolipoprotein E immunoreactivity following ischemic brain injury in rat with long-term survival: influence of idebenone treatment. ( Barcikowska, M; Debicki, G; Januszewski, S; Pluta, R; Ryba, M, 1997) |
| "In rats with cerebral ischemia, idebenone (10 mg/kg, i." | 1.28 | Effects of idebenone on metabolism of monoamines and cyclic AMP formation in rats. ( Kakihana, M; Nagai, Y; Nagaoka, A; Nagawa, Y; Narumi, S; Yamazaki, N, 1989) |
| "Transient and global cerebral ischemia in rats, produced by 4-vessel occlusion for 200 s immediately after the acquisition trial of passive avoidance learning, shortened the latencies in the retention test trial performed 24 h later." | 1.28 | Effects of idebenone on memory impairment induced in ischemic and embolization models of cerebrovascular disturbance in rats. ( Kiyota, Y; Miyamoto, M; Nagaoka, A; Nagawa, Y; Take, Y; Yamazaki, N, 1989) |
| "Pretreatment with idebenone (10 mg/kg, i." | 1.28 | Effects of idebenone on the levels of acetylcholine, choline, free fatty acids, and energy metabolites in the brains of rats with cerebral ischemia. ( Kakihana, M; Nagaoka, A; Yamazaki, N, 1989) |
| "In rats with cerebral ischemia, a low dose (10 mg/kg, i." | 1.27 | Effects of idebenone (CV-2619) on metabolism of monoamines, especially serotonin, in the brain of normal rats and rats with cerebral ischemia. ( Kakihana, M; Nagai, Y; Nagaoka, A; Nagawa, Y; Narumi, S; Yamazaki, N, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (52.94) | 18.7374 |
| 1990's | 7 (41.18) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Peng, J | 1 |
| Wang, H | 1 |
| Gong, Z | 1 |
| Li, X | 1 |
| He, L | 1 |
| Shen, Q | 1 |
| Pan, J | 1 |
| Peng, Y | 1 |
| Nagaoka, A | 8 |
| Suno, M | 2 |
| Shibota, M | 2 |
| Kakihana, M | 6 |
| Yamazaki, N | 6 |
| Take, Y | 2 |
| Nagawa, Y | 4 |
| Tsuruo, Y | 1 |
| Ishimura, K | 1 |
| Tamura, M | 1 |
| Kagawa, S | 1 |
| Morita, K | 1 |
| Latini, S | 1 |
| Pedata, F | 1 |
| Pepeu, G | 1 |
| Amano, M | 1 |
| Goto, A | 1 |
| Takahashi, N | 1 |
| Hasegawa, T | 1 |
| Nabeshima, T | 1 |
| Pluta, R | 1 |
| Barcikowska, M | 1 |
| Debicki, G | 1 |
| Ryba, M | 1 |
| Januszewski, S | 1 |
| Shibata, S | 1 |
| Kagami-ishi, Y | 1 |
| Ueki, S | 2 |
| Watanabe, S | 1 |
| Haba, K | 2 |
| Ogawa, N | 2 |
| Asanuma, M | 1 |
| Hirata, H | 1 |
| Mori, A | 1 |
| Yamamoto, T | 1 |
| Yatsugi, S | 1 |
| Ohno, M | 1 |
| Furuya, Y | 1 |
| Kitajima, I | 1 |
| Nagai, Y | 2 |
| Narumi, S | 2 |
| Kiyota, Y | 1 |
| Miyamoto, M | 1 |
| Yoshikawa, H | 1 |
| Ono, T | 1 |
| Mizukawa, K | 1 |
17 other studies available for idebenone and Brain Ischemia
| Article | Year |
|---|---|
Idebenone attenuates cerebral inflammatory injury in ischemia and reperfusion via dampening NLRP3 inflammasome activity.
Topics: Animals; Animals, Newborn; Brain Ischemia; Cells, Cultured; Encephalitis; Inflammasomes; Male; Mice; | 2020 |
[Effects of idebenone (CV-2619) on neurological deficits, local cerebral blood flow, and energy metabolism in rats with experimental cerebral ischemia].
Topics: Adenosine Triphosphate; Animals; Benzoquinones; Brain Ischemia; Cerebral Cortex; Cerebrovascular Cir | 1984 |
Effects of idebenone (CV-2619) on the concentrations of acetylcholine and choline in various brain regions of rats with cerebral ischemia.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Benzoquinones; Brain; Brain Ischemia; Choline; Energ | 1984 |
Beneficial effect of idebenone (CV-2619) on cerebral ischemia-induced amnesia in rats.
Topics: Amnesia; Animals; Arginine Vasopressin; Avoidance Learning; Benzoquinones; Brain Ischemia; Condition | 1984 |
Biochemical and histochemical studies of the effects of cerebral metabolism-improving drugs on NADPH diaphorase activity in mouse brain.
Topics: Amino Acid Oxidoreductases; Animals; Benzoquinones; Brain; Brain Ischemia; Cerebral Cortex; Choroid | 1994 |
Effect of idebenone on adenosine outflow and adenine nucleotide level in hippocampal slices under ischemia-like conditions.
Topics: Adenine Nucleotides; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphospha | 1993 |
Effects of BMY-21502 on anoxia in mice.
Topics: Animals; Atmospheric Pressure; Benzoquinones; Brain Ischemia; Disease Models, Animal; Hypoxia, Brain | 1993 |
Changes in amyloid precursor protein and apolipoprotein E immunoreactivity following ischemic brain injury in rat with long-term survival: influence of idebenone treatment.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Apolipoproteins E; Benzoquinones; Br | 1997 |
Neuroprotective effect of WEB 1881 FU (nebracetam) on an ischemia-induced deficit of glucose uptake in rat hippocampal and cerebral cortical slices and CA1 field potential in hippocampal slices.
Topics: Animals; Benzoquinones; Brain Ischemia; Cerebral Cortex; Deoxyglucose; Electrophysiology; Evoked Pot | 1992 |
Comparison of the effects of bifemelane hydrochloride, idebenone and indeloxazine hydrochloride on ischemia-induced changes in brain monoamines and their metabolites in gerbils.
Topics: Animals; Benzhydryl Compounds; Benzoquinones; Biogenic Monoamines; Brain Chemistry; Brain Ischemia; | 1992 |
Minaprine improves impairment of working memory induced by scopolamine and cerebral ischemia in rats.
Topics: Animals; Aziridines; Benzoquinones; Brain Ischemia; Choline; Hippocampus; Injections; Male; Memory; | 1990 |
Effects of idebenone on metabolism of monoamines and cyclic AMP formation in rats.
Topics: Animals; Benzoquinones; Biogenic Monoamines; Brain; Brain Ischemia; Cyclic AMP; Disease Models, Anim | 1989 |
Effects of idebenone (CV-2619) on metabolism of monoamines, especially serotonin, in the brain of normal rats and rats with cerebral ischemia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzoquinones; Biogenic Amines; Brain; Brain Ischemia; Chro | 1985 |
Effects of idebenone on neurological deficits, local cerebral blood flow, and energy metabolism in rats with experimental cerebral ischemia.
Topics: Animals; Benzoquinones; Brain; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; | 1989 |
Effects of idebenone on memory impairment induced in ischemic and embolization models of cerebrovascular disturbance in rats.
Topics: Administration, Oral; Animals; Avoidance Learning; Benzoquinones; Brain Ischemia; Cerebrovascular Di | 1989 |
Effects of idebenone on the levels of acetylcholine, choline, free fatty acids, and energy metabolites in the brains of rats with cerebral ischemia.
Topics: Acetylcholine; Animals; Benzoquinones; Brain; Brain Ischemia; Choline; Disease Models, Animal; Energ | 1989 |
Comparison of the effects of bifemelane hydrochloride, idebenone and indeloxazine hydrochloride on ischemia-induced depletion of brain acetylcholine levels in gerbils.
Topics: Acetylcholine; Animals; Benzhydryl Compounds; Benzoquinones; Brain Chemistry; Brain Ischemia; Cerebr | 1988 |