idebenone has been researched along with Alloxan Diabetes in 6 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " Of the 7 drugs, idebenone dose-dependently bound Shc protein in the 50-100 nM range, and induced insulin sensitivity and cytoprotection in this same 100 nM range that clinically dosed idebenone reaches in human plasma." | 3.88 | Idebenone is a cytoprotective insulin sensitizer whose mechanism is Shc inhibition. ( Allen, S; Bettaieb, A; Cortopassi, G; Hui, CK; Tomilov, A, 2018) |
| "This study investigates the effect of insulin combined with idebenone on blood-brain barrier (BBB) permeability in experimental streptozotocin-induced diabetic rats as well as the underlying mechanisms." | 1.42 | Effects of insulin combined with idebenone on blood-brain barrier permeability in diabetic rats. ( Liu, LB; Sun, YN; Wang, P; Xue, YX, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Hui, C | 1 |
| Tomilov, A | 2 |
| Garcia, C | 1 |
| Jiang, X | 1 |
| Fash, DM | 1 |
| Khdour, OM | 1 |
| Rosso, C | 1 |
| Filippini, G | 1 |
| Prato, M | 1 |
| Graham, J | 1 |
| Hecht, S | 1 |
| Havel, P | 1 |
| Cortopassi, G | 2 |
| Linenberg, I | 1 |
| Fornes, D | 2 |
| Higa, R | 3 |
| Jawerbaum, A | 3 |
| Capobianco, E | 2 |
| Roberti, SL | 1 |
| White, V | 2 |
| Roberti, S | 1 |
| Mazzucco, MB | 1 |
| Allen, S | 1 |
| Hui, CK | 1 |
| Bettaieb, A | 1 |
| Sun, YN | 1 |
| Liu, LB | 1 |
| Xue, YX | 1 |
| Wang, P | 1 |
6 other studies available for idebenone and Alloxan Diabetes
| Article | Year |
|---|---|
Novel idebenone analogs block Shc's access to insulin receptor to improve insulin sensitivity.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Insulin; Insulin Resistance; Mi | 2020 |
Intergenerational effects of the antioxidant Idebenone on the placentas of rats with gestational diabetes mellitus.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetes, Gestational; Female; Fetal Macroso | 2021 |
Pro-oxidant/pro-inflammatory alterations in the offspring´s heart of mild diabetic rats are regulated by maternal treatments with a mitochondrial antioxidant.
Topics: Animals; Antioxidants; Connective Tissue Growth Factor; Diabetes Mellitus, Experimental; Female; Mal | 2017 |
Effect of the antioxidant idebenone on maternal diabetes-induced embryo alterations during early organogenesis.
Topics: Animals; Antioxidants; Apoptosis; Diabetes Mellitus, Experimental; Electron Transport Complex IV; Em | 2018 |
Idebenone is a cytoprotective insulin sensitizer whose mechanism is Shc inhibition.
Topics: Animals; Cell Line; Cytoprotection; Diabetes Mellitus, Experimental; Drug Repositioning; Female; Hig | 2018 |
Effects of insulin combined with idebenone on blood-brain barrier permeability in diabetic rats.
Topics: Animals; Antioxidants; Blood-Brain Barrier; Capillary Permeability; Diabetes Mellitus, Experimental; | 2015 |