idazoxan has been researched along with Disease Models, Animal in 44 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.27) | 18.7374 |
| 1990's | 11 (25.00) | 18.2507 |
| 2000's | 14 (31.82) | 29.6817 |
| 2010's | 17 (38.64) | 24.3611 |
| 2020's | 1 (2.27) | 2.80 |
| Authors | Studies |
|---|---|
| Bellahsene, T; Dive, G; Godfroid, JJ; Guardiola-Lemaitre, B; Ktorza, A; Lamouri, A; Le Bihan, G; Manechez, D; Penicaud, L; Pfeiffer, B; Renard, P; Rondu, F; Touboul, E; Wang, X | 1 |
| Braisted, J; Dranchak, P; Earnest, TW; Gu, X; Hoon, MA; Inglese, J; Oliphant, E; Solinski, HJ | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Li, JX; Seaman, RW; Shang, L; Siemian, JN; Zhang, Y; Zhu, Q | 1 |
| Huang, C; Liu, J; Wang, HS; Wang, T; Wang, Y | 1 |
| Doudet, DJ; Fontain, J; Iversen, P; Landau, AM; Lillethorup, TP; Wegener, G | 1 |
| Doudet, DJ; Iversen, P; Landau, AM; Lillethorup, TP; Wegener, G | 1 |
| Hackett, D; Heal, DJ; Hutson, PH; Murray, F; Vickers, SP | 1 |
| Donahue, R; Jamal, AB; Kaushal, R; Ma, F; Taylor, BK; Westlund, KN; Zhang, L | 1 |
| Harvey, BH; Sallinen, J; Shahid, M; Uys, MM | 1 |
| Authier, N; Bertrand, M; Chapuy, E; Chenaf, C; Courteix, C; Eschalier, A; Gabriel, C; Libert, F; Marchand, F; Mocaër, E | 1 |
| Hashimoto, M; Ono, H; Tanabe, M | 1 |
| Andurkar, SV; Bhalla, S; Gulati, A; Matwyshyn, G; Zhang, Z | 1 |
| Chen, GQ; Chen, JF; Chen, YY; Han, Z; Shang, XF; Shao, B; Wang, XS; Xu, HQ; Yang, HM; Zheng, RY; Zhu, ZG | 1 |
| Han, Z; Jin, K; Shao, B; Xiao, MJ; Yang, GY; Zheng, RY | 1 |
| Alam, M; Danysz, W; Dekundy, A; Schmidt, WJ | 1 |
| Buck, K; Ferger, B | 1 |
| Buck, K; Ferger, B; Voehringer, P | 1 |
| Li, JX; Winter, JC; Zhang, Y | 1 |
| Barnum, CJ; Bhide, N; Bishop, C; Goldenberg, AA; Klioueva, A; Lindenbach, D; Surrena, MA; Tignor, S; Walters, H | 1 |
| Alba-Delgado, C; Berrocoso, E; Borges, G; Horrillo, I; Meana, JJ; Mico, JA; Neto, F; Ortega, JE; Sánchez-Blázquez, P | 1 |
| Beitz, AJ; Kang, SY; Kim, HW; Lee, HJ; Lee, JH; Moon, JY; Roh, DH; Yoon, SY | 1 |
| Gerlach, M; Halley, P; Riederer, P; van den Buuse, M | 1 |
| Benazzouz, A; Cardoit, L; Delaville, C; Zapata, J | 1 |
| Dominiak, P; Häuser, W; Jungbluth, B; Raasch, W; Schäfer, U | 1 |
| Colpaert, F; Domino, EF; Marien, M; Ni, L | 1 |
| Schmidt, WJ; Srinivasan, J | 2 |
| Conklin, D; Eisenach, JC; Obata, H | 1 |
| Hertel, P; Jardemark, KE; Langlois, X; Marcus, MM; Svensson, TH; Wadenberg, ML | 1 |
| Curry, R; DeGoes, S; Eisenach, JC; Hayashida, K | 1 |
| Desmeules, J; Guilbaud, G; Kayser, V | 1 |
| Jane, F; Menargues, A; Obach, R; Pruñonosa, J; Valles, J | 1 |
| Beleslin, DB; Jovanović-Mićić, D; Samardzić, R | 1 |
| Li, P; Smyth, DD | 1 |
| Nozaki-Taguchi, N; Yamamoto, T | 1 |
| Chopin, P; Colpaert, F; Marien, M; Martel, J | 1 |
| Brotchie, JM; Crossman, AR; Fox, SH; Henry, B; Peggs, D | 1 |
| Bezard, E; Brefel, C; Gross, CE; Ladure, P; Peyro-Saint-Paul, H; Rascol, O; Tison, F | 1 |
| Hébert, C; Lalonde, R; Reader, TA; Strazielle, C | 1 |
| Covey, WC; Ignatowski, TA; Knight, PR; Spengler, RN | 1 |
| Allie, S; Russell, V; Wiggins, T | 1 |
| Harvey, C; Kitzen, JM; McCallum, JD; Morin, ME | 1 |
| Simson, PE; Weiss, JM | 1 |
1 trial(s) available for idazoxan and Disease Models, Animal
| Article | Year |
|---|---|
Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery.
Topics: Adrenergic alpha-Antagonists; Amines; Analgesics; Analgesics, Opioid; Animals; Bee Venoms; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Gabapentin; gamma-Aminobutyric Acid; Humans; Hyperalgesia; Idazoxan; Male; Morphine; Norepinephrine; Pain, Postoperative; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Nerve Roots; Time Factors | 2007 |
43 other study(ies) available for idazoxan and Disease Models, Animal
| Article | Year |
|---|---|
Design and synthesis of imidazoline derivatives active on glucose homeostasis in a rat model of type II diabetes. 1. Synthesis and biological activities of N-benzyl-N'-(arylalkyl)-2-(4',5'-dihydro-1'H-imidazol-2'-yl)piperazines .
Topics: Animals; Blood Glucose; Cattle; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug Design; Glucose Tolerance Test; Homeostasis; Imidazoles; Male; Models, Molecular; Piperazines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2 | 1997 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Effects of imidazoline I2 receptor agonists on reserpine-induced hyperalgesia and depressive-like behavior in rats.
Topics: Analgesics; Animals; Benzofurans; Depression; Disease Models, Animal; Fibromyalgia; Hyperalgesia; Idazoxan; Imidazoles; Imidazoline Receptors; Imidazolines; Male; Pain; Pain Measurement; Quinazolines; Rats; Rats, Sprague-Dawley; Reserpine | 2019 |
L-DOPA-induced dyskinesia in a rat model of Parkinson's disease is associated with the fluctuational release of norepinephrine in the sensorimotor striatum.
Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Benzylamines; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Dyskinesia, Drug-Induced; Idazoxan; Levodopa; Male; Microdialysis; Neurotransmitter Agents; Norepinephrine; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine 3-Monooxygenase | 2014 |
Electroconvulsive shocks decrease α2-adrenoceptor binding in the Flinders rat model of depression.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Autoradiography; Biophysics; Brain; Depression; Disease Models, Animal; Electroshock; Female; Idazoxan; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Tritium | 2015 |
α2-adrenoceptor binding in Flinders-sensitive line compared with Flinders-resistant line and Sprague-Dawley rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic Neurons; Animals; Autoradiography; Brain; Depression; Disease Models, Animal; Female; Idazoxan; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 2015 |
Effects of lisdexamfetamine in a rat model of binge-eating.
Topics: Animals; Baclofen; Behavior, Animal; Benzazepines; Benzodiazepines; Body Weight; Bulimia; Disease Models, Animal; Eating; Feeding Behavior; Female; Idazoxan; Lisdexamfetamine Dimesylate; Naltrexone; Olanzapine; Prazosin; Prodrugs; Raclopride; Rats; Rats, Wistar; Rolipram | 2015 |
GABA-A receptor activity in the noradrenergic locus coeruleus drives trigeminal neuropathic pain in the rat; contribution of NAα1 receptors in the medial prefrontal cortex.
Topics: Activating Transcription Factor 3; Adrenergic alpha-Antagonists; Adrenergic Neurons; Animals; Bicuculline; Chronic Pain; Disease Models, Animal; Facial Pain; GABA-A Receptor Antagonists; Hyperalgesia; Idazoxan; Locus Coeruleus; Male; Neuralgia; Oxathiins; Prefrontal Cortex; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, GABA-A; Trigeminal Nerve Injuries | 2016 |
The α2C-adrenoceptor antagonist, ORM-10921, exerts antidepressant-like effects in the Flinders Sensitive Line rat.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Antidepressive Agents; Behavior, Animal; Benzofurans; Cognitive Dysfunction; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Idazoxan; Imipramine; Male; Motor Activity; Quinolizidines; Rats; Swimming | 2017 |
Agomelatine: a new opportunity to reduce neuropathic pain-preclinical evidence.
Topics: Acetamides; Adrenergic alpha-2 Receptor Antagonists; Amines; Animals; Antineoplastic Agents; Constriction, Pathologic; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Experimental; Disease Models, Animal; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Hypnotics and Sedatives; Idazoxan; Male; Motor Activity; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiophenes | 2017 |
Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Benzazepines; Benzofurans; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Electromyography; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intraperitoneal; Ligands; Male; Mice; Muscle Rigidity; Muscle, Skeletal; Parkinsonian Disorders; Reserpine; Time Factors; Yohimbine | 2008 |
Determination of adrenergic and imidazoline receptor involvement in augmentation of morphine and oxycodone analgesia by clonidine and BMS182874.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Area Under Curve; Clonidine; Dansyl Compounds; Disease Models, Animal; Drug Synergism; Idazoxan; Imidazoline Receptors; Male; Morphine; Oxycodone; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Time Factors; Yohimbine | 2009 |
Idazoxan attenuates spinal cord injury by enhanced astrocytic activation and reduced microglial activation in rat experimental autoimmune encephalomyelitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Cerebral Cortex; Cytokines; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Gene Expression Regulation; Idazoxan; Imidazoline Receptors; Microglia; Multiple Sclerosis; Neuroprotective Agents; Rats; Rats, Wistar; RNA, Messenger; Spinal Cord | 2009 |
Attenuation of ischemia-induced rat brain injury by 2-(-2-benzofuranyl)-2-imidazoline, a high selectivity ligand for imidazoline I(2) receptors.
Topics: Animals; Benzofurans; Brain Injuries; Brain Ischemia; Caspase 3; Disease Models, Animal; Idazoxan; Imidazoles; Imidazoline Receptors; In Situ Nick-End Labeling; Male; Neurologic Examination; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Tetrazolium Salts | 2009 |
Effects of glutamate and alpha2-noradrenergic receptor antagonists on the development of neurotoxicity produced by chronic rotenone in rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Basal Ganglia; Behavior, Animal; Catalepsy; Cyclopentanes; Disease Models, Animal; Dopamine; Excitatory Amino Acid Antagonists; Hypokinesia; Idazoxan; Male; Motor Activity; Muscle Rigidity; Neuroprotective Agents; Neurotoxicity Syndromes; Parkinsonian Disorders; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Adrenergic, alpha-2; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Rotenone; Serotonin; Substantia Nigra; Time Factors | 2009 |
The selective alpha1 adrenoceptor antagonist HEAT reduces L-DOPA-induced dyskinesia in a rat model of Parkinson's disease.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Antiparkinson Agents; Brain; Cerebrospinal Fluid; Disease Models, Animal; Dyskinesia, Drug-Induced; Idazoxan; Levodopa; Male; Motor Activity; Oxidopamine; Parkinsonian Disorders; Plasma; Propranolol; Random Allocation; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Tetralones | 2010 |
The alpha(2) adrenoceptor antagonist idazoxan alleviates L-DOPA-induced dyskinesia by reduction of striatal dopamine levels: an in vivo microdialysis study in 6-hydroxydopamine-lesioned rats.
Topics: Adrenergic Agents; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Antiparkinson Agents; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Dopamine; Dyskinesia, Drug-Induced; Idazoxan; Levodopa; Male; Microdialysis; Neurotoxicity Syndromes; Oxidopamine; Rats; Rats, Wistar; Tandem Mass Spectrometry | 2010 |
Morphine-induced antinociception in the rat: supra-additive interactions with imidazoline I₂ receptor ligands.
Topics: Adrenergic alpha-2 Receptor Antagonists; Agmatine; Analgesics; Analgesics, Opioid; Animals; Benzofurans; Disease Models, Animal; Drug Synergism; Idazoxan; Imidazoles; Imidazoline Receptors; Ligands; Male; Morphine; Pain; Rats; Rats, Sprague-Dawley; Saline Solution, Hypertonic; Yohimbine | 2011 |
Effects of noradrenergic denervation on L-DOPA-induced dyskinesia and its treatment by α- and β-adrenergic receptor antagonists in hemiparkinsonian rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adrenergic Neurons; Animals; Behavior, Animal; Corpus Striatum; Desipramine; Disease Models, Animal; Dyskinesia, Drug-Induced; Hippocampus; Idazoxan; Levodopa; Male; Molecular Targeted Therapy; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Propranolol; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Sympathectomy, Chemical | 2012 |
The function of alpha-2-adrenoceptors in the rat locus coeruleus is preserved in the chronic constriction injury model of neuropathic pain.
Topics: Action Potentials; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Brimonidine Tartrate; Clonidine; Desipramine; Disease Models, Animal; Idazoxan; Locus Coeruleus; Male; MAP Kinase Signaling System; Medulla Oblongata; Neuralgia; Norepinephrine; Prefrontal Cortex; Quinoxalines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Signal Transduction; Spinal Cord | 2012 |
Repetitive treatment with diluted bee venom reduces neuropathic pain via potentiation of locus coeruleus noradrenergic neuronal activity and modulation of spinal NR1 phosphorylation in rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic Neurons; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Bee Venoms; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Gene Expression Regulation; Idazoxan; Locus Coeruleus; Male; Microscopy, Immunoelectron; Motor Activity; Oncogene Proteins v-fos; Pain Measurement; Phosphorylation; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Rotarod Performance Test; Sciatica; Time Factors; Tyrosine 3-Monooxygenase | 2012 |
The effect of piribedil on L-DOPA-induced dyskinesias in a rat model of Parkinson's disease: differential role of α(2) adrenergic mechanisms.
Topics: Adrenergic Agents; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Antiparkinson Agents; Benserazide; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Dyskinesia, Drug-Induced; Dystonia; Facial Asymmetry; Idazoxan; Levodopa; Locomotion; Oxidopamine; Parkinson Disease; Piribedil; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Statistics, Nonparametric; Upper Extremity | 2013 |
Activation of subthalamic alpha 2 noradrenergic receptors induces motor deficits as a consequence of neuronal burst firing.
Topics: Action Potentials; Adrenergic Agents; Adrenergic alpha-2 Receptor Agonists; Adrenergic Neurons; Animals; Disease Models, Animal; Exploratory Behavior; Idazoxan; Male; Motor Activity; Movement Disorders; Oxidopamine; Rats; Receptors, Adrenergic, alpha-2; Subthalamic Nucleus; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2012 |
Modification of noradrenaline release in pithed spontaneously hypertensive rats by I1-binding sites in addition to alpha2-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Agmatine; Animals; Antihypertensive Agents; Benzofurans; Binding Sites; Blood Pressure; Disease Models, Animal; Heart Rate; Idazoxan; Imidazoles; Male; Norepinephrine; Phenoxybenzamine; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2 | 2003 |
Effects of (+/-)-idazoxan alone and in combination with L-DOPA methyl ester in MPTP-induced hemiparkinsonian monkeys.
Topics: Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Idazoxan; Levodopa; Macaca nemestrina; Parkinson Disease, Secondary; Time Factors | 2003 |
The effect of the alpha2-adrenoreceptor antagonist idazoxan against 6-hydroxydopamine-induced Parkinsonism in rats: multiple facets of action?
Topics: Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Brain; Catalepsy; Disease Models, Animal; Dopamine; Exploratory Behavior; Hydroxyindoleacetic Acid; Idazoxan; Male; Motor Activity; Oxidopamine; Parkinsonian Disorders; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Serotonin; Time Factors | 2004 |
Treatment with alpha2-adrenoceptor antagonist, 2-methoxy idazoxan, protects 6-hydroxydopamine-induced Parkinsonian symptoms in rats: neurochemical and behavioral evidence.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Brain Chemistry; Catalepsy; Disease Models, Animal; Dopamine; Drug Interactions; Hydroxyindoleacetic Acid; Idazoxan; Male; Motor Activity; Norepinephrine; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Reaction Time; Serotonin; Statistics, Nonparametric | 2004 |
Spinal noradrenaline transporter inhibition by reboxetine and Xen2174 reduces tactile hypersensitivity after surgery in rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Atropine; Behavior, Animal; Disease Models, Animal; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drosophila Proteins; Drug Interactions; Hyperalgesia; Idazoxan; Male; Morpholines; Muscarinic Antagonists; Pain Threshold; Pain, Postoperative; Peptides; Rats; Rats, Sprague-Dawley; Reboxetine; Snail Family Transcription Factors; Spinal Cord; Time Factors; Transcription Factors | 2005 |
Combined alpha2 and D2/3 receptor blockade enhances cortical glutamatergic transmission and reverses cognitive impairment in the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Cerebral Cortex; Clozapine; Cognition Disorders; Disease Models, Animal; Dizocilpine Maleate; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Idazoxan; In Vitro Techniques; Male; Maze Learning; Raclopride; Radioligand Assay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Synaptic Transmission | 2005 |
Systemic clonidine differentially modulates the abnormal reactions to mechanical and thermal stimuli in rats with peripheral mononeuropathy.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Clonidine; Cold Temperature; Dioxanes; Disease Models, Animal; Hot Temperature; Idazoxan; Injections, Intravenous; Male; Pain; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Reaction Time; Stress, Mechanical | 1995 |
A pharmacokinetic-pharmacodynamic linking model for the alpha 2-adrenergic antagonism of idazoxan on clonidine-induced mydriasis in the rat.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Animals; Chromatography, High Pressure Liquid; Clonidine; Computer Simulation; Dioxanes; Disease Models, Animal; Dose-Response Relationship, Drug; Half-Life; Idazoxan; Injections, Intravenous; Male; Models, Chemical; Mydriasis; Pupil; Rats; Rats, Sprague-Dawley; Tissue Distribution | 1995 |
The role of alpha-adrenergic mechanisms within the area postrema in dopamine-induced emesis.
Topics: Adrenergic alpha-Antagonists; alpha-Methyltyrosine; Animals; Atropine; Cats; Cerebral Ventricles; Dioxanes; Disease Models, Animal; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Hemicholinium 3; Idazoxan; Injections, Intraventricular; Male; Mecamylamine; Methyltyrosines; Methysergide; Naloxone; Oxidopamine; Prazosin; Reserpine; Tolazoline; Tyrosine 3-Monooxygenase; Vomiting; Yohimbine | 1995 |
Suppressed renal response to 2,6-dimethyl clonidine but not clonidine in one kidney-one clip hypertensive rats.
Topics: Adrenergic alpha-Agonists; Animals; Binding Sites; Clonidine; Dioxanes; Disease Models, Animal; Hypertension, Renovascular; Idazoxan; Kidney; Male; Natriuresis; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Receptors, Drug; Tritium; Yohimbine | 1993 |
Clonidine, but not morphine, delays the development of thermal hyperesthesia induced by sciatic nerve constriction injury in the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Disease Models, Animal; Hyperesthesia; Idazoxan; Ligation; Male; Morphine; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Sciatic Nerve; Spinal Cord; Sympathetic Nervous System; Temperature; Time Factors | 1996 |
Neuroprotective effects of the alpha2-adrenoceptor antagonists, (+)-efaroxan and (+/-)-idazoxan, against quinolinic acid-induced lesions of the rat striatum.
Topics: Adrenergic alpha-Antagonists; Animals; Apomorphine; Behavior, Animal; Benzofurans; Choline O-Acetyltransferase; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Enzyme Activation; Huntington Disease; Idazoxan; Imidazoles; Male; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 1998 |
The alpha2-adrenergic receptor antagonist idazoxan reduces dyskinesia and enhances anti-parkinsonian actions of L-dopa in the MPTP-lesioned primate model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenergic Antagonists; Animals; Antiparkinson Agents; Brain; Callithrix; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Drug Synergism; Dyskinesias; Female; Idazoxan; Levodopa; Male; Receptors, Adrenergic, alpha-2; Time Factors; Yohimbine | 1999 |
Effect of the alpha 2 adrenoreceptor antagonist, idazoxan, on motor disabilities in MPTP-treated monkey.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenergic alpha-Antagonists; Animals; Disease Models, Animal; Dopamine Agents; Dose-Response Relationship, Drug; Female; Idazoxan; Macaca fascicularis; Motor Skills Disorders; Parkinson Disease | 1999 |
Regional brain distribution of noradrenaline uptake sites, and of alpha1-alpha2- and beta-adrenergic receptors in PCD mutant mice: a quantitative autoradiographic study.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Autoradiography; Basal Ganglia; Brain Stem; Cerebral Cortex; Disease Models, Animal; Female; Fluoxetine; Hypothalamus; Idazoxan; Limbic System; Mice; Mice, Neurologic Mutants; Norepinephrine; Prazosin; Propanolamines; Purkinje Cells; Radioligand Assay; Receptors, Adrenergic; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta; Spinocerebellar Degenerations; Thalamus; Tritium | 1999 |
Brain-derived TNFalpha: involvement in neuroplastic changes implicated in the conscious perception of persistent pain.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brain; Chronic Disease; Clonidine; Consciousness; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Hippocampus; Hyperalgesia; Idazoxan; Male; Neuronal Plasticity; Pain, Intractable; Perceptual Disorders; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Spinal Cord; Tumor Necrosis Factor-alpha | 2000 |
Increased noradrenergic activity in prefrontal cortex slices of an animal model for attention-deficit hyperactivity disorder--the spontaneously hypertensive rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Attention Deficit Disorder with Hyperactivity; Brimonidine Tartrate; Disease Models, Animal; Dopamine; Down-Regulation; Hypertension; Idazoxan; In Vitro Techniques; Male; Models, Neurological; Norepinephrine; Prefrontal Cortex; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Long-Evans; Receptors, Adrenergic, alpha-2 | 2000 |
Antithrombotic activity of the phosphodiesterase III inhibitor pelrinone in a canine model of coronary artery thrombosis: enhancement of efficacy with concurrent alpha 2-adrenergic antagonism.
Topics: Adenosine Diphosphate; Adrenergic alpha-Antagonists; Animals; Blood Coagulation; Coronary Thrombosis; Dioxanes; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fibrinolytic Agents; Hemodynamics; Idazoxan; Male; Phosphodiesterase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrimidines | 1991 |
Altered activity of the locus coeruleus in an animal model of depression.
Topics: Adrenergic alpha-Antagonists; Animals; Depression; Dioxanes; Disease Models, Animal; Electrophysiology; Electroshock; Idazoxan; Locus Coeruleus; Male; Motor Activity; Neurons; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Reference Values; Stress, Psychological | 1988 |