idazoxan has been researched along with Ache in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (18.52) | 18.7374 |
| 1990's | 15 (55.56) | 18.2507 |
| 2000's | 3 (11.11) | 29.6817 |
| 2010's | 4 (14.81) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Haubrich, DR; Hlasta, DJ; Luttinger, D; Perrone, MH; Silbernagel, MJ; Ward, SJ | 1 |
| Li, JX; Seaman, RW; Shang, L; Siemian, JN; Zhang, Y; Zhu, Q | 1 |
| Andurkar, SV; Bhalla, S; Gulati, A; Matwyshyn, G; Zhang, Z | 1 |
| de Castro Perez, A; de Francischi, JN; Gama Duarte, ID; Romero, TR | 1 |
| Li, JX; Winter, JC; Zhang, Y | 1 |
| Beitz, AJ; Kang, SY; Kim, CY; Lee, HJ; Lee, JH; Park, JH; Roh, DH; Yoon, SY | 1 |
| Andurkar, SV; Gulati, A | 1 |
| Cheng, JT; Chuang, YC; Lin, CR; Wang, CJ; Yang, LC | 1 |
| Desmeules, J; Guilbaud, G; Kayser, V | 1 |
| Doak, GJ; Reid, AR; Sawynok, J | 1 |
| Anton, F; Dubner, R; Kenshalo, DR; Thomas, DA; Williams, GM | 1 |
| D'Angelo, R; Detweiler, DJ; Eisenach, JC; Hood, DD; Tong, C | 1 |
| Fang, F; Proudfit, HK | 1 |
| Eisenach, JC; Pan, HL; Song, HK | 1 |
| Budai, D; Fields, HL; Harasawa, I | 1 |
| Clarke, RW; Ogilvie, J; Simpson, DA | 1 |
| Boronat, MA; García-Sevilla, JA; Olmos, G | 1 |
| Besson, JM; Guilbaud, G; Kayser, V | 2 |
| Proudfit, HK; Yeomans, DC | 1 |
| Alhaider, AA | 1 |
| Boublik, JH; Brown, MR; Hua, XY; Rivier, JE; Spicer, MA; Yaksh, TL | 1 |
| Danzebrink, RM; Gebhart, GF | 1 |
| Hayes, AG; Skingle, M; Tyers, MB | 1 |
| Simson, PE; Weiss, JM | 1 |
| Barasi, S; Clatworthy, A; Williams, JH | 1 |
| Duggan, AW; Zhao, ZQ | 1 |
27 other study(ies) available for idazoxan and Ache
| Article | Year |
|---|---|
Alpha 2-adrenergic agonists/antagonists: the synthesis and structure-activity relationships of a series of indolin-2-yl and tetrahydroquinolin-2-yl imidazolines.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brain; Clonidine; Imidazoles; Indoles; Male; Mice; Nociceptors; Pain; Prazosin; Quinolines; Rats; Structure-Activity Relationship; Vas Deferens | 1987 |
Effects of imidazoline I2 receptor agonists on reserpine-induced hyperalgesia and depressive-like behavior in rats.
Topics: Analgesics; Animals; Benzofurans; Depression; Disease Models, Animal; Fibromyalgia; Hyperalgesia; Idazoxan; Imidazoles; Imidazoline Receptors; Imidazolines; Male; Pain; Pain Measurement; Quinazolines; Rats; Rats, Sprague-Dawley; Reserpine | 2019 |
Determination of adrenergic and imidazoline receptor involvement in augmentation of morphine and oxycodone analgesia by clonidine and BMS182874.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Area Under Curve; Clonidine; Dansyl Compounds; Disease Models, Animal; Drug Synergism; Idazoxan; Imidazoline Receptors; Male; Morphine; Oxycodone; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Time Factors; Yohimbine | 2009 |
Probable involvement of alpha(2C)-adrenoceptor subtype and endogenous opioid peptides in the peripheral antinociceptive effect induced by xylazine.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Dinoprostone; Dose-Response Relationship, Drug; Hyperalgesia; Idazoxan; Imidazoles; Leucine; Male; Naloxone; Opioid Peptides; Pain; Pain Measurement; Rats; Rats, Wistar; Xylazine; Yohimbine | 2009 |
Morphine-induced antinociception in the rat: supra-additive interactions with imidazoline I₂ receptor ligands.
Topics: Adrenergic alpha-2 Receptor Antagonists; Agmatine; Analgesics; Analgesics, Opioid; Animals; Benzofurans; Disease Models, Animal; Drug Synergism; Idazoxan; Imidazoles; Imidazoline Receptors; Ligands; Male; Morphine; Pain; Rats; Rats, Sprague-Dawley; Saline Solution, Hypertonic; Yohimbine | 2011 |
Chemical stimulation of the ST36 acupoint reduces both formalin-induced nociceptive behaviors and spinal astrocyte activation via spinal alpha-2 adrenoceptors.
Topics: Acupuncture Points; Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Astrocytes; Bee Venoms; Citrates; Formaldehyde; Glial Fibrillary Acidic Protein; Idazoxan; Imidazoles; Injections, Spinal; Isoindoles; Male; Mice; Mice, Inbred ICR; Pain; Pain Management; Pain Measurement; Receptors, Adrenergic, alpha-2; Spinal Cord; Stimulation, Chemical | 2011 |
Assessment of the analgesic effect of centhaquin in mouse tail flick and hot-plate tests.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics; Analgesics, Opioid; Animals; Antihypertensive Agents; Body Temperature; Drug Interactions; Endothelin A Receptor Antagonists; Hot Temperature; Idazoxan; Imidazoline Receptors; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; Pain; Piperazines; Receptor, Endothelin A; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Yohimbine | 2011 |
Intrathecal clonidine decreases spinal nitric oxide release in a rat model of complete Freund's adjuvant induced inflammatory pain.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Enzyme Inhibitors; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Idazoxan; Injections, Spinal; Male; Myelitis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord | 2002 |
Systemic clonidine differentially modulates the abnormal reactions to mechanical and thermal stimuli in rats with peripheral mononeuropathy.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Clonidine; Cold Temperature; Dioxanes; Disease Models, Animal; Hot Temperature; Idazoxan; Injections, Intravenous; Male; Pain; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Reaction Time; Stress, Mechanical | 1995 |
Caffeine antinociception in the rat hot-plate and formalin tests and locomotor stimulation: involvement of noradrenergic mechanisms.
Topics: Adrenergic alpha-Antagonists; Animals; Caffeine; Dioxanes; Drug Synergism; Formaldehyde; Hot Temperature; Idazoxan; Male; Motor Activity; Norepinephrine; Pain; Pain Measurement; Phentolamine; Prazosin; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1995 |
Noradrenergic and opioid systems interact to alter the detection of noxious thermal stimuli and facial scratching in monkeys.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Antagonists; Animals; Behavior, Animal; Clonidine; Dioxanes; Electrophysiology; Hot Temperature; Idazoxan; Macaca fascicularis; Macaca mulatta; Male; Medulla Oblongata; Microinjections; Naloxone; Norepinephrine; Pain; Physical Stimulation; Receptors, Opioid | 1993 |
Cerebrospinal fluid norepinephrine and acetylcholine concentrations during acute pain.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Animals; Dioxanes; Electric Stimulation; Female; Femoral Nerve; Humans; Idazoxan; Imidazoles; Injections, Spinal; Labor, Obstetric; Norepinephrine; Pain; Pregnancy; Receptors, Adrenergic, alpha-2; Sheep; Spinal Cord; Sympathomimetics | 1996 |
Antinociception produced by microinjection of morphine in the rat periaqueductal gray is enhanced in the foot, but not the tail, by intrathecal injection of alpha1-adrenoceptor antagonists.
Topics: Adrenergic alpha-Antagonists; Afferent Pathways; Animals; Behavior, Animal; Dioxanes; Female; Foot; Idazoxan; Injections, Spinal; Microinjections; Morphine; Narcotics; Nociceptors; Pain; Periaqueductal Gray; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Spinal Cord; Tail | 1998 |
Spinal nitric oxide mediates antinociception from intravenous morphine.
Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Atropine; Drug Interactions; Enzyme Inhibitors; Idazoxan; Injections, Intravenous; Male; Morphine; Muscarinic Antagonists; Nitric Oxide; Nitric Oxide Synthase; Pain; Rats; Rats, Sprague-Dawley | 1998 |
Midbrain periaqueductal gray (PAG) inhibits nociceptive inputs to sacral dorsal horn nociceptive neurons through alpha2-adrenergic receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Bicuculline; Clonidine; Excitatory Amino Acids; Hot Temperature; Idazoxan; Iontophoresis; Male; Methoxamine; Neural Inhibition; Neurons; Norepinephrine; Pain; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Spinal Cord; Synapses | 1998 |
Tonic adrenergic and serotonergic inhibition of a withdrawal reflex in rabbits subjected to different levels of surgical preparation.
Topics: Adrenergic alpha-Antagonists; Animals; Decerebrate State; Electric Stimulation; Electromyography; Escape Reaction; Female; Forelimb; Hindlimb Suspension; Idazoxan; Male; Muscle, Skeletal; Pain; Physical Stimulation; Piperazines; Pyridines; Rabbits; Reflex; Serotonin Antagonists; Skin | 1999 |
Attenuation of tolerance to opioid-induced antinociception by idazoxan and other I2-ligands.
Topics: Animals; Drug Tolerance; Idazoxan; Imidazoles; Imidazoline Receptors; Ligands; Male; Morphine; Pain; Pentazocine; Rats; Rats, Sprague-Dawley; Receptors, Drug | 1999 |
Evidence for a noradrenergic component in the antinociceptive effect of the analgesic agent tramadol in an animal model of clinical pain, the arthritic rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arthritis; Dioxanes; Drug Interactions; Idazoxan; Injections, Intravenous; Norepinephrine; Pain; Pain Measurement; Rats; Receptors, Opioid; Tramadol; Yohimbine | 1992 |
Potent antinociceptive effects of clonidine systemically administered in an experimental model of clinical pain, the arthritic rat.
Topics: Adrenergic beta-Antagonists; Analgesics; Analysis of Variance; Animals; Arthritis, Experimental; Clonidine; Dioxanes; Idazoxan; Injections, Intravenous; Male; Pain; Rats; Rats, Sprague-Dawley; Sensory Thresholds; Vocalization, Animal; Yohimbine | 1992 |
Antinociception induced by microinjection of substance P into the A7 catecholamine cell group in the rat.
Topics: Afferent Pathways; Analgesics; Animals; Blood Pressure; Catecholamines; Dioxanes; Female; Hot Temperature; Idazoxan; Injections, Spinal; Microinjections; Models, Neurological; Neurons; Norepinephrine; Pain; Pons; Rats; Rats, Inbred Strains; Reflex; Serotonin; Skin Temperature; Stereotaxic Techniques; Substance P; Tyrosine 3-Monooxygenase; Yohimbine | 1992 |
Antinociceptive effect of ketanserin in mice: involvement of supraspinal 5-HT2 receptors in nociceptive transmission.
Topics: Acetates; Acetic Acid; Adrenergic alpha-Antagonists; Analgesics; Animals; Brain Chemistry; Dioxanes; Dopamine; Idazoxan; Ketanserin; Male; Methysergide; Mice; Norepinephrine; Pain; Reaction Time; Receptors, Serotonin; Serotonin; Synaptic Transmission | 1991 |
The antinociceptive effects of spinally administered neuropeptide Y in the rat: systematic studies on structure-activity relationship.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Idazoxan; Injections, Spinal; Male; Motor Activity; Naloxone; Neuropeptide Y; Pain; Parasympathomimetics; Peptide Fragments; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1991 |
Antinociceptive effects of intrathecal adrenoceptor agonists in a rat model of visceral nociception.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Dioxanes; Idazoxan; Male; Pain; Prazosin; Rats; Rats, Inbred Strains; Yohimbine | 1990 |
Antagonism of alpha-adrenoceptor agonist-induced antinociception in the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Dioxanes; Dioxins; Female; Hypnotics and Sedatives; Idazoxan; Injections, Subcutaneous; Male; Pain; Psychomotor Performance; Rats | 1986 |
Alpha-2 receptor blockade increases responsiveness of locus coeruleus neurons to excitatory stimulation.
Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Idazoxan; Injections, Intravenous; Locus Coeruleus; Male; Neurons; Nicotine; Pain; Physical Stimulation; Rats; Rats, Inbred Strains; Yohimbine | 1987 |
Intrathecal 5-hydroxytryptamine and electrical stimulation of the nucleus raphe magnus in rats both reduce the antinociceptive potency of intrathecally administered noradrenaline.
Topics: Analgesics; Animals; Dioxanes; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Idazoxan; Injections, Spinal; Male; Norepinephrine; Pain; Raphe Nuclei; Rats; Rats, Inbred Strains; Sensory Thresholds; Serotonin; Spinal Cord | 1988 |
Idazoxan blocks the action of noradrenaline but not spinal inhibition from electrical stimulation of the locus coeruleus and nucleus Kolliker-Fuse of the cat.
Topics: Action Potentials; Animals; Cats; Clonidine; Dioxanes; Dioxins; Electric Stimulation; Idazoxan; Locus Coeruleus; Neural Inhibition; Neurons, Afferent; Norepinephrine; Pain; Physical Stimulation; Spinal Cord | 1988 |