ici 204,219 has been researched along with Inflammation in 15 studies
zafirlukast: a leukotriene D4 receptor antagonist
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the effects of an orally administered corticosteroid (prednisone), an inhaled corticosteroid (flunisolide), a leukotriene-receptor antagonist (zafirlukast), an antiserotonergic drug (cyproheptadine), and a control substance on the asthmatic phenotype in cats with experimentally induced asthma." | 5.11 | Effects of drug treatment on inflammation and hyperreactivity of airways and on immune variables in cats with experimentally induced asthma. ( Berghaus, LJ; Berghaus, RD; Byerly, JR; Decile, KC; Gershwin, LJ; Hyde, DM; Reinero, CR; Schelegle, ES; Walby, WE, 2005) |
| "The results indicate that both Zafirlukast and Zileuton reduced the reported DCS symptoms, pulmonary edema, pleural and bronchoalveolar lavage protein levels, white blood cell counts in the pleural and bronchoalveolar lavage, and leukotriene levels in the bronchoalveolar lavage vs." | 3.74 | Pharmacological intervention to the inflammatory response from decompression sickness in rats. ( Butler, BD; Little, T, 2008) |
| " The choice of drug and dosage must be individualized to the patient." | 2.40 | Anti-inflammatory drugs for controlling asthma. ( O'Connell, EJ; Volcheck, GW, 1998) |
| "In this study, we report that in experimental autoimmune encephalomyelitis animals, CysLT1 is upregulated in immune tissue and the spinal cord, and CysLT levels in the blood and cerebrospinal fluid are also higher than in normal mice." | 1.37 | Antiasthmatic drugs targeting the cysteinyl leukotriene receptor 1 alleviate central nervous system inflammatory cell infiltration and pathogenesis of experimental autoimmune encephalomyelitis. ( Cui, Y; Du, C; Lv, J; Wang, L; Wei, W; Xie, X, 2011) |
| "Pain is commonly associated with inflammation." | 1.33 | Differential effect of zileuton, a 5-lipoxygenase inhibitor, against nociceptive paradigms in mice and rats. ( Kulkarni, SK; Patil, CS; Singh, VP, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (33.33) | 18.2507 |
| 2000's | 6 (40.00) | 29.6817 |
| 2010's | 4 (26.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Proschak, E | 1 |
| Heitel, P | 1 |
| Kalinowsky, L | 1 |
| Merk, D | 1 |
| Yan, L | 1 |
| Sun, A | 1 |
| Xu, X | 1 |
| Zhou, X | 1 |
| Cai, J | 1 |
| Liu, W | 1 |
| Wu, X | 1 |
| Gao, C | 1 |
| Wang, L | 1 |
| Du, C | 1 |
| Lv, J | 1 |
| Wei, W | 1 |
| Cui, Y | 1 |
| Xie, X | 1 |
| Neves, JS | 1 |
| Lima, LM | 1 |
| Fraga, CA | 1 |
| Barreiro, EJ | 1 |
| Miranda, AL | 1 |
| Diaz, BL | 1 |
| Balduino, A | 1 |
| Siqueira, Rde A | 1 |
| e Silva, PM | 1 |
| Martins, MA | 1 |
| Singh, VP | 1 |
| Patil, CS | 1 |
| Kulkarni, SK | 2 |
| Reinero, CR | 1 |
| Decile, KC | 1 |
| Byerly, JR | 1 |
| Berghaus, RD | 1 |
| Walby, WE | 1 |
| Berghaus, LJ | 1 |
| Hyde, DM | 1 |
| Schelegle, ES | 1 |
| Gershwin, LJ | 1 |
| Little, T | 1 |
| Butler, BD | 1 |
| Smith, LJ | 1 |
| Larkin, M | 1 |
| Drazen, JM | 1 |
| Dykewicz, MS | 1 |
| Ledford, DK | 1 |
| Volcheck, GW | 1 |
| O'Connell, EJ | 1 |
| Jain, NK | 1 |
| Singh, A | 1 |
| Corren, J | 1 |
| Spector, S | 1 |
| Fuller, L | 1 |
| Minkwitz, M | 1 |
| Mezzanotte, W | 1 |
5 reviews available for ici 204,219 and Inflammation
| Article | Year |
|---|---|
Opportunities and Challenges for Fatty Acid Mimetics in Drug Discovery.
Topics: Animals; Cyclooxygenase Inhibitors; Drug Discovery; Fatty Acids; Humans; Inflammation; Models, Molec | 2017 |
Leukotrienes in asthma. The potential therapeutic role of antileukotriene agents.
Topics: Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Humans; Hydroxyurea | 1996 |
New directions in asthma drug therapy.
Topics: Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Chromones; Humans; Hydroxyur | 1998 |
Recent findings in asthma likely to impact patient care.
Topics: Adrenergic beta-Agonists; Albuterol; Anti-Asthmatic Agents; Asthma; Gastroesophageal Reflux; Humans; | 1998 |
Anti-inflammatory drugs for controlling asthma.
Topics: Adult; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Child; Cromolyn Sodium; Glucocortico | 1998 |
2 trials available for ici 204,219 and Inflammation
| Article | Year |
|---|---|
Effects of drug treatment on inflammation and hyperreactivity of airways and on immune variables in cats with experimentally induced asthma.
Topics: Airway Resistance; Animals; Anti-Asthmatic Agents; Asthma; Bronchial Spasm; Bronchoalveolar Lavage F | 2005 |
Effects of zafirlukast upon clinical, physiologic, and inflammatory responses to natural cat allergen exposure.
Topics: Administration, Oral; Adolescent; Adult; Aged; Allergens; Animals; Anti-Asthmatic Agents; Cats; Chil | 2001 |
8 other studies available for ici 204,219 and Inflammation
| Article | Year |
|---|---|
Zafirlukast, a Cysteinyl Leukotriene Receptor 1 Antagonist, Reduces the Effect of Advanced Glycation End-Products in Rat Renal Mesangial Cells In Vitro.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glutathione Peroxidase; Glycation | 2019 |
Cysteinyl leukotriene receptor type 1 (CysLT1R) antagonist zafirlukast protects against TNF-α-induced endothelial inflammation.
Topics: Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Indoles | 2019 |
Antiasthmatic drugs targeting the cysteinyl leukotriene receptor 1 alleviate central nervous system inflammatory cell infiltration and pathogenesis of experimental autoimmune encephalomyelitis.
Topics: Acetates; Animals; Anti-Asthmatic Agents; Blood-Brain Barrier; Blotting, Western; Cell Separation; C | 2011 |
Evaluating the prophylactic potential of the phtalimide derivative LASSBio 552 on allergen-evoked inflammation in rats.
Topics: Allergens; Animals; Anti-Asthmatic Agents; Calcium; CD4-Positive T-Lymphocytes; Cell Movement; Chemo | 2005 |
Differential effect of zileuton, a 5-lipoxygenase inhibitor, against nociceptive paradigms in mice and rats.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Capillary Permeability; Carrageenan; Cyclopropanes; Dose | 2005 |
Pharmacological intervention to the inflammatory response from decompression sickness in rats.
Topics: Animals; Cyclooxygenase Inhibitors; Decompression Sickness; Hydroxyurea; Indoles; Indomethacin; Infl | 2008 |
New asthma drugs target inflammatory cascade.
Topics: Anti-Asthmatic Agents; Asthma; Humans; Indoles; Inflammation; Leukotriene Antagonists; Phenylcarbama | 1997 |
Role of cysteinyl leukotrienes in nociceptive and inflammatory conditions in experimental animals.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cell Migration Inhib | 2001 |