ici 204,219 has been researched along with Chemical and Drug Induced Liver Injury in 21 studies
zafirlukast: a leukotriene D4 receptor antagonist
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tamoxifen was given orally to all groups, except for 1st group, in the dose of 45 mg/kg for 10 days to induce liver injury." | 1.48 | Zafirlukast and vincamine ameliorate tamoxifen-induced oxidative stress and inflammation: Role of the JNK/ERK pathway. ( Awad, AS; El Fattah, MA; El-Dessouki, AM; Zaki, HF, 2018) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| " Although this new product has been well accepted because of its convenient dosing and relatively few side effects, several cases of Churg-Strauss syndrome have been reported to be associated with its use." | 1.31 | Vasculitis induced by zafirlukast therapy. ( Canataroglu, A; Erken, E; Gumurdulu, D; Ozer, H; Soy, M, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (52.38) | 29.6817 |
| 2010's | 10 (47.62) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Aleo, MD | 1 |
| Luo, Y | 1 |
| Swiss, R | 1 |
| Bonin, PD | 1 |
| Potter, DM | 1 |
| Will, Y | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| El-Dessouki, AM | 1 |
| El Fattah, MA | 1 |
| Awad, AS | 1 |
| Zaki, HF | 1 |
| Soy, M | 1 |
| Ozer, H | 1 |
| Canataroglu, A | 1 |
| Gumurdulu, D | 1 |
| Erken, E | 1 |
| Su, CW | 1 |
| Wu, JC | 1 |
| Huang, YH | 1 |
| Huang, YS | 1 |
| Chang, FY | 1 |
| Lee, SD | 1 |
| Davern, TJ | 2 |
| Bass, NM | 2 |
| Wooltorton, E | 1 |
| Chohnabayashi, N | 1 |
| Sugiura, R | 1 |
| Nishimura, N | 1 |
| Grieco, AJ | 1 |
| Burstein-Stein, J | 1 |
| Reinus, JF | 1 |
| Persky, S | 1 |
| Burkiewicz, JS | 1 |
| Quan, D | 1 |
| Actis, GC | 1 |
| Morgando, A | 1 |
| Lagget, M | 1 |
| David, E | 1 |
| Rizzetto, M | 1 |
| Molés, JR | 1 |
| Primo, J | 1 |
| Fernández, JM | 1 |
| Hinojosa, JE | 1 |
| Danese, S | 1 |
| De Vitis, I | 1 |
| Gasbarrini, A | 1 |
3 reviews available for ici 204,219 and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Leukotriene antagonists.
Topics: Adult; Aged; Anti-Asthmatic Agents; Asthma; Chemical and Drug Induced Liver Injury; Female; Humans; | 2003 |
[Adverse effects of leukotriene-antagonists].
Topics: Acetates; Anaphylaxis; Chemical and Drug Induced Liver Injury; Chromones; Cyclopropanes; Drug Intera | 2007 |
18 other studies available for ici 204,219 and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2014 |
Zafirlukast and vincamine ameliorate tamoxifen-induced oxidative stress and inflammation: Role of the JNK/ERK pathway.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Caspase 3; Chemical and Drug Induced Liver Injury; | 2018 |
Vasculitis induced by zafirlukast therapy.
Topics: Anti-Asthmatic Agents; Chemical and Drug Induced Liver Injury; Churg-Strauss Syndrome; Eosinophilia; | 2002 |
Zafirlukast-induced acute hepatitis.
Topics: Acute Disease; Aged; Anti-Asthmatic Agents; Chemical and Drug Induced Liver Injury; Female; Humans; | 2002 |
Asthma drug zafirlukast (Accolate): serious hepatic events.
Topics: Anti-Asthmatic Agents; Asthma; Chemical and Drug Induced Liver Injury; Drug Interactions; Humans; In | 2004 |
Correction: Liver injury and rosiglitazone.
Topics: Chemical and Drug Induced Liver Injury; Humans; Hypoglycemic Agents; Indoles; Phenylcarbamates; Rosi | 2000 |
Oral montelukast versus inhaled salmeterol to prevent exercise-induced bronchoconstriction.
Topics: Acetates; Aged; Albuterol; Anti-Asthmatic Agents; Asthma, Exercise-Induced; Bronchodilator Agents; C | 2000 |
Severe liver injury after treatment with the leukotriene receptor antagonist zafirlukast.
Topics: Adrenal Cortex Hormones; Adult; Alanine Transaminase; Anti-Asthmatic Agents; Aspartate Aminotransfer | 2000 |
Zafirlukast-related hepatitis: report of a further case.
Topics: Anti-Asthmatic Agents; Chemical and Drug Induced Liver Injury; Humans; Indoles; Male; Middle Aged; P | 2001 |
Acute hepatocellular injury associated with zafirlukast.
Topics: Acute Disease; Anti-Asthmatic Agents; Chemical and Drug Induced Liver Injury; Female; Humans; Indole | 2001 |
Severe liver injury associated with zafirlukast.
Topics: Chemical and Drug Induced Liver Injury; Female; Humans; Indoles; Leukotriene Antagonists; Liver Func | 2001 |