ici-154129 and Cerebrovascular-Disorders

A highly predictive spinal "stroke" model in the unanesthetized rabbit was utilized to compare the effects of naloxone and the delta-selective opiate antagonist M154,129 on neurological recovery following ischemic injury to the central nervous system. Naloxone treatment protected against both moderate (20 min aortic occlusion) and severe (25 min aortic occlusion) degrees of ischemic spinal injury, whereas treatment with M154,129 failed to improve recovery in either model. These findings confirm that naloxone therapy can alter the pathophysiological sequelae caused by a critical reduction in blood flow to the central nervous system and suggests that its beneficial effects do not relate to actions at the delta-opiate receptor.

Topics: Animals; Cerebrovascular Disorders; Disease Models, Animal; Enkephalin, Leucine; Male; Motor Activity; Naloxone; Rabbits; Spinal Cord