icg-001 has been researched along with Endometriosis* in 1 studies
1 other study(ies) available for icg-001 and Endometriosis
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β-catenin signaling inhibitors ICG-001 and C-82 improve fibrosis in preclinical models of endometriosis.
Endometriosis exhibits unique characteristics, such as fibrosis, resistance to apoptosis, and promotion of cell proliferation; however, its pathophysiology is not fully understood. Recurrence rates after treatment are high, and the progression risk continues until menopause; hence, more effective therapy for endometriosis is needed. CREB-binding protein (CBP)/β-catenin signaling inhibitors have demonstrated antifibrogenetic effects in liver, lung, and skin diseases. The present study evaluated the effects of two CBP/β-catenin signaling inhibitors, ICG-001 and C-82, on the progression of endometriosis using endometriotic cyst stromal cells from the ovary and normal endometrial stromal cells from the uterus. ICG-001 was also evaluated in a mouse model. ICG-001 and C-82 inhibited cell proliferation, fibrogenesis, and cell migration, and promoted apoptosis in vitro. ICG-001 inhibited the growth of endometriotic lesions in the mouse model. CBP/β-catenin signaling plays an important role in the pathophysiology of endometriosis. Inhibiting the CBP/β-catenin signal can be a therapeutic target for endometriosis. Topics: Animals; beta Catenin; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Endometriosis; Female; Heterocyclic Compounds, 2-Ring; Humans; Mice; Piperazines; Pyrimidinones; Signal Transduction | 2019 |