ibuprofen-arginine and Epistaxis

Ibuprofen arginate is a salt formulation of ibuprofen designed to reach target concentrations rapidly. The primary objective of this study was to compare the 12-h pharmacokinetic profile of S(+)-ibuprofen following administration of single doses of ibuprofen arginate (600 mg) and dexibuprofen (400 mg) in healthy volunteers.. Twenty-four volunteers were recruited into an open-label, randomised, two-period, single-centre study with crossover design.. Both treatments were well tolerated. Ibuprofen arginate and dexibuprofen showed similar bioavailability for S(+)-ibuprofen. Compared with dexibuprofen, ibuprofen arginate demonstrated a 45% higher maximum concentration (C(max)), and a time to peak concentration (T(max)) 2 h sooner.. Ibuprofen arginate approaches maximum concentrations of S(+)-ibuprofen faster and higher than dexibuprofen.

Topics: Administration, Oral; Adolescent; Adult; Algorithms; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Arginine; Biological Availability; Chromatography, High Pressure Liquid; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Combinations; Epistaxis; Female; Half-Life; Headache; Humans; Ibuprofen; Male; Metabolic Clearance Rate; Stereoisomerism; Therapeutic Equivalency; Time Factors