ibuprofen and Ulcer
ibuprofen has been researched along with Ulcer in 17 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
Ulcer: A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "This report demonstrates that gastrointestinal tract anatomical abnormalities or dysmotility may be contraindications for therapy with high-dose ibuprofen in patients with cystic fibrosis." | 8.82 | High-dose ibuprofen therapy associated with esophageal ulceration after pneumonectomy in a patient with cystic fibrosis: a case report. ( Anbar, RD; Mackey, JE, 2004) |
| " Published data indicate that diclofenac 75 to 150mg daily (25 to 50mg 3 times daily) is comparable in efficacy with ordinary aspirin 3 to 5g daily and indomethacin 75 to 150mg daily in rheumatoid arthritis and with indomethacin in osteoarthritis." | 8.76 | Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin. ( Avery, GS; Brogden, RN; Heel, RC; Pakes, GE; Speight, TM, 1980) |
| " Our pharmacokinetic studies of 7e demonstrated this prodrug is a potential candidate for a slower and sustained release form of rhein." | 5.38 | Bone-targeting glycol and NSAIDS ester prodrugs of rhein: synthesis, hydroxyapatite affinity, stability, anti-inflammatory, ulcerogenicity index and pharmacokinetics studies. ( Cai, J; Chao, M; Chen, J; Duan, Y; Ji, M; Yu, J, 2012) |
| "Ibuprofen rarely causes lower gastrointestinal adverse reactions but has been implicated in systemic and local side effects in patients with lupus." | 5.28 | Ulcerative proctitis in juvenile systemic lupus erythematosus after ibuprofen treatment. ( Khoury, MI, 1989) |
| "This report demonstrates that gastrointestinal tract anatomical abnormalities or dysmotility may be contraindications for therapy with high-dose ibuprofen in patients with cystic fibrosis." | 4.82 | High-dose ibuprofen therapy associated with esophageal ulceration after pneumonectomy in a patient with cystic fibrosis: a case report. ( Anbar, RD; Mackey, JE, 2004) |
| " Published data indicate that diclofenac 75 to 150mg daily (25 to 50mg 3 times daily) is comparable in efficacy with ordinary aspirin 3 to 5g daily and indomethacin 75 to 150mg daily in rheumatoid arthritis and with indomethacin in osteoarthritis." | 4.76 | Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin. ( Avery, GS; Brogden, RN; Heel, RC; Pakes, GE; Speight, TM, 1980) |
| "Ibuprofen caused mild ulceration of the small intestine in 50% of rats." | 3.70 | The effects of high-dose ibuprofen and pancreatic enzymes on the intestine of the rat. ( Beno, DW; Dy, SA; Jiyamapa, VA; Kimura, RE; Lloyd-Still, JD; Uhing, MR, 1999) |
| " Our pharmacokinetic studies of 7e demonstrated this prodrug is a potential candidate for a slower and sustained release form of rhein." | 1.38 | Bone-targeting glycol and NSAIDS ester prodrugs of rhein: synthesis, hydroxyapatite affinity, stability, anti-inflammatory, ulcerogenicity index and pharmacokinetics studies. ( Cai, J; Chao, M; Chen, J; Duan, Y; Ji, M; Yu, J, 2012) |
| "Hypertension was induced by DOCA-salt." | 1.35 | Synthesis and pharmacological investigation of 3-(substituted 1-phenylethanone)-4-(substituted phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates. ( Bhole, RP; Bhusari, KP; Chikhale, RV; Khedekar, PB, 2009) |
| "Ursodiol, the drug of choice for the treatment of cystic fibrosis liver disease, may offer a safe method of using high-dose IBU in these patients by ameliorating the enteropathy." | 1.31 | Ursodeoxycholic acid ameliorates ibuprofen-induced enteropathy in the rat. ( Beno, DW; Jiyamapa-Serna, VA; Kimura, RE; Lloyd-Still, JD; Uhing, MR, 2001) |
| "Ibuprofen rarely causes lower gastrointestinal adverse reactions but has been implicated in systemic and local side effects in patients with lupus." | 1.28 | Ulcerative proctitis in juvenile systemic lupus erythematosus after ibuprofen treatment. ( Khoury, MI, 1989) |
Research
Studies (17)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (23.53) | 18.7374 |
| 1990's | 3 (17.65) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 3 (17.65) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Amir, M | 1 |
| Kumar, H | 1 |
| Javed, SA | 1 |
| Chikhale, RV | 1 |
| Bhole, RP | 1 |
| Khedekar, PB | 1 |
| Bhusari, KP | 1 |
| Cai, J | 1 |
| Duan, Y | 1 |
| Yu, J | 1 |
| Chen, J | 1 |
| Chao, M | 1 |
| Ji, M | 1 |
| Abdellatif, KRA | 1 |
| Abdelall, EKA | 1 |
| Fadaly, WAA | 1 |
| Kamel, GM | 1 |
| Panda, SS | 1 |
| Girgis, AS | 1 |
| Thomas, SJ | 1 |
| Capito, JE | 1 |
| George, RF | 1 |
| Salman, A | 1 |
| El-Manawaty, MA | 1 |
| Samir, A | 1 |
| Meijuan, Z | 1 |
| Yu, P | 1 |
| Yuan, J | 1 |
| Yu, T | 1 |
| Sun, D | 1 |
| Beà-Ardébol, S | 1 |
| Gómez-Zubiaur, A | 1 |
| Cabrera-Hernández, A | 1 |
| Trasobares-Marugán, L | 1 |
| Mackey, JE | 1 |
| Anbar, RD | 1 |
| Khan, MS | 1 |
| Akhter, M | 1 |
| Brogden, RN | 1 |
| Heel, RC | 1 |
| Pakes, GE | 1 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| Crosby, JC | 1 |
| Ross, GJ | 1 |
| Auchenbach, RC | 1 |
| McCafferty, MH | 1 |
| Kimura, RE | 2 |
| Dy, SA | 1 |
| Uhing, MR | 2 |
| Beno, DW | 2 |
| Jiyamapa, VA | 1 |
| Lloyd-Still, JD | 2 |
| Jiyamapa-Serna, VA | 1 |
| Melarange, R | 1 |
| Moore, G | 1 |
| Blower, PR | 1 |
| Coates, ME | 1 |
| Ward, FW | 1 |
| Ronaasen, V | 1 |
| Khoury, MI | 1 |
| Agha, FP | 1 |
| Wilson, JA | 1 |
| Nostrand, TT | 1 |
| Charuzi, I | 1 |
| Ovnat, A | 1 |
| Zirkin, H | 1 |
| Peiser, J | 1 |
| Sukenik, S | 1 |
Reviews
2 reviews available for ibuprofen and Ulcer
| Article | Year |
|---|---|
High-dose ibuprofen therapy associated with esophageal ulceration after pneumonectomy in a patient with cystic fibrosis: a case report.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Barrett Esophagus; Combined Modality Therapy; C | 2004 |
Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin.
Topics: Adult; Animals; Arthritis, Rheumatoid; Aspirin; Cyclooxygenase Inhibitors; Diclofenac; Drug Interact | 1980 |
Other Studies
15 other studies available for ibuprofen and Ulcer
| Article | Year |
|---|---|
Condensed bridgehead nitrogen heterocyclic system: synthesis and pharmacological activities of 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole derivatives of ibuprofen and biphenyl-4-yloxy acetic acid.
Topics: Acute Disease; Analgesics; Animals; Bacteria; Diphenylacetic Acids; Female; Fungi; Hepatocytes; Ibup | 2008 |
Synthesis and pharmacological investigation of 3-(substituted 1-phenylethanone)-4-(substituted phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Blood Pressure; Edema; Hyper | 2009 |
Bone-targeting glycol and NSAIDS ester prodrugs of rhein: synthesis, hydroxyapatite affinity, stability, anti-inflammatory, ulcerogenicity index and pharmacokinetics studies.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Bone and Bones; Chemistry Techniqu | 2012 |
Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1,3,5-triarylpyrazoline and 1,5-diarylpyrazole derivatives as selective COX-2 inhibitors.
Topics: Anti-Inflammatory Agents; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; P | 2016 |
Synthesis, pharmacological profile and 2D-QSAR studies of curcumin-amino acid conjugates as potential drug candidates.
Topics: Amino Acids; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; An | 2020 |
Stomach ulcer caused by mistakenly oral medication of 14,400 mg ibuprofen: A case report.
Topics: Adult; Duodenal Ulcer; Female; Gastric Mucosa; Gastritis; Helicobacter Infections; Helicobacter pylo | 2023 |
Non-infectious genital ulcer: The relevance of anamnesis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Drug Eruptions; Humans; Ibuprofen; Male; Medical His | 2017 |
Synthesis, pharmacological activity and hydrolytic behavior of glyceride prodrugs of ibuprofen.
Topics: Acetic Acid; Analgesics; Animals; Glycerides; Hydrogen-Ion Concentration; Hydrolysis; Ibuprofen; Mic | 2005 |
Nonsteroidal anti-inflammatory drug-induced ulceration diagnosed on barium enema.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Barium Sulfate; Cecal Diseases; Contrast Media; Enema; Huma | 1998 |
The effects of high-dose ibuprofen and pancreatic enzymes on the intestine of the rat.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Ibuprofen; Intestinal Diseases; Intestine | 1999 |
Ursodeoxycholic acid ameliorates ibuprofen-induced enteropathy in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Catheterization; Cholagogues and Choleretics; Cyst | 2001 |
A comparison of indomethacin with ibuprofen on gastrointestinal mucosal integrity in conventional and germ-free rats.
Topics: Animals; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Germ-Free Life; Ibuprofen; Indomethaci | 1992 |
Ulcerative proctitis in juvenile systemic lupus erythematosus after ibuprofen treatment.
Topics: Adolescent; Female; Humans; Ibuprofen; Lupus Erythematosus, Systemic; Proctitis; Ulcer | 1989 |
Medication-induced esophagitis.
Topics: Adult; Doxycycline; Esophagitis; Esophagus; Female; Humans; Ibuprofen; Male; Middle Aged; Radiograph | 1986 |
Ibuprofen and benign cecal ulcer.
Topics: Cecal Diseases; Female; Humans; Ibuprofen; Middle Aged; Ulcer | 1985 |