Page last updated: 2024-10-28

ibuprofen and Ulcer

ibuprofen has been researched along with Ulcer in 17 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Ulcer: A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.

Research Excerpts

ExcerptRelevanceReference
"This report demonstrates that gastrointestinal tract anatomical abnormalities or dysmotility may be contraindications for therapy with high-dose ibuprofen in patients with cystic fibrosis."8.82High-dose ibuprofen therapy associated with esophageal ulceration after pneumonectomy in a patient with cystic fibrosis: a case report. ( Anbar, RD; Mackey, JE, 2004)
" Published data indicate that diclofenac 75 to 150mg daily (25 to 50mg 3 times daily) is comparable in efficacy with ordinary aspirin 3 to 5g daily and indomethacin 75 to 150mg daily in rheumatoid arthritis and with indomethacin in osteoarthritis."8.76Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin. ( Avery, GS; Brogden, RN; Heel, RC; Pakes, GE; Speight, TM, 1980)
" Our pharmacokinetic studies of 7e demonstrated this prodrug is a potential candidate for a slower and sustained release form of rhein."5.38Bone-targeting glycol and NSAIDS ester prodrugs of rhein: synthesis, hydroxyapatite affinity, stability, anti-inflammatory, ulcerogenicity index and pharmacokinetics studies. ( Cai, J; Chao, M; Chen, J; Duan, Y; Ji, M; Yu, J, 2012)
"Ibuprofen rarely causes lower gastrointestinal adverse reactions but has been implicated in systemic and local side effects in patients with lupus."5.28Ulcerative proctitis in juvenile systemic lupus erythematosus after ibuprofen treatment. ( Khoury, MI, 1989)
"This report demonstrates that gastrointestinal tract anatomical abnormalities or dysmotility may be contraindications for therapy with high-dose ibuprofen in patients with cystic fibrosis."4.82High-dose ibuprofen therapy associated with esophageal ulceration after pneumonectomy in a patient with cystic fibrosis: a case report. ( Anbar, RD; Mackey, JE, 2004)
" Published data indicate that diclofenac 75 to 150mg daily (25 to 50mg 3 times daily) is comparable in efficacy with ordinary aspirin 3 to 5g daily and indomethacin 75 to 150mg daily in rheumatoid arthritis and with indomethacin in osteoarthritis."4.76Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin. ( Avery, GS; Brogden, RN; Heel, RC; Pakes, GE; Speight, TM, 1980)
"Ibuprofen caused mild ulceration of the small intestine in 50% of rats."3.70The effects of high-dose ibuprofen and pancreatic enzymes on the intestine of the rat. ( Beno, DW; Dy, SA; Jiyamapa, VA; Kimura, RE; Lloyd-Still, JD; Uhing, MR, 1999)
" Our pharmacokinetic studies of 7e demonstrated this prodrug is a potential candidate for a slower and sustained release form of rhein."1.38Bone-targeting glycol and NSAIDS ester prodrugs of rhein: synthesis, hydroxyapatite affinity, stability, anti-inflammatory, ulcerogenicity index and pharmacokinetics studies. ( Cai, J; Chao, M; Chen, J; Duan, Y; Ji, M; Yu, J, 2012)
"Hypertension was induced by DOCA-salt."1.35Synthesis and pharmacological investigation of 3-(substituted 1-phenylethanone)-4-(substituted phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates. ( Bhole, RP; Bhusari, KP; Chikhale, RV; Khedekar, PB, 2009)
"Ursodiol, the drug of choice for the treatment of cystic fibrosis liver disease, may offer a safe method of using high-dose IBU in these patients by ameliorating the enteropathy."1.31Ursodeoxycholic acid ameliorates ibuprofen-induced enteropathy in the rat. ( Beno, DW; Jiyamapa-Serna, VA; Kimura, RE; Lloyd-Still, JD; Uhing, MR, 2001)
"Ibuprofen rarely causes lower gastrointestinal adverse reactions but has been implicated in systemic and local side effects in patients with lupus."1.28Ulcerative proctitis in juvenile systemic lupus erythematosus after ibuprofen treatment. ( Khoury, MI, 1989)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19904 (23.53)18.7374
1990's3 (17.65)18.2507
2000's5 (29.41)29.6817
2010's3 (17.65)24.3611
2020's2 (11.76)2.80

Authors

AuthorsStudies
Amir, M1
Kumar, H1
Javed, SA1
Chikhale, RV1
Bhole, RP1
Khedekar, PB1
Bhusari, KP1
Cai, J1
Duan, Y1
Yu, J1
Chen, J1
Chao, M1
Ji, M1
Abdellatif, KRA1
Abdelall, EKA1
Fadaly, WAA1
Kamel, GM1
Panda, SS1
Girgis, AS1
Thomas, SJ1
Capito, JE1
George, RF1
Salman, A1
El-Manawaty, MA1
Samir, A1
Meijuan, Z1
Yu, P1
Yuan, J1
Yu, T1
Sun, D1
Beà-Ardébol, S1
Gómez-Zubiaur, A1
Cabrera-Hernández, A1
Trasobares-Marugán, L1
Mackey, JE1
Anbar, RD1
Khan, MS1
Akhter, M1
Brogden, RN1
Heel, RC1
Pakes, GE1
Speight, TM1
Avery, GS1
Crosby, JC1
Ross, GJ1
Auchenbach, RC1
McCafferty, MH1
Kimura, RE2
Dy, SA1
Uhing, MR2
Beno, DW2
Jiyamapa, VA1
Lloyd-Still, JD2
Jiyamapa-Serna, VA1
Melarange, R1
Moore, G1
Blower, PR1
Coates, ME1
Ward, FW1
Ronaasen, V1
Khoury, MI1
Agha, FP1
Wilson, JA1
Nostrand, TT1
Charuzi, I1
Ovnat, A1
Zirkin, H1
Peiser, J1
Sukenik, S1

Reviews

2 reviews available for ibuprofen and Ulcer

ArticleYear
High-dose ibuprofen therapy associated with esophageal ulceration after pneumonectomy in a patient with cystic fibrosis: a case report.
    BMC pediatrics, 2004, Sep-13, Volume: 4

    Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Barrett Esophagus; Combined Modality Therapy; C

2004
Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin.
    Drugs, 1980, Volume: 20, Issue:1

    Topics: Adult; Animals; Arthritis, Rheumatoid; Aspirin; Cyclooxygenase Inhibitors; Diclofenac; Drug Interact

1980

Other Studies

15 other studies available for ibuprofen and Ulcer

ArticleYear
Condensed bridgehead nitrogen heterocyclic system: synthesis and pharmacological activities of 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole derivatives of ibuprofen and biphenyl-4-yloxy acetic acid.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:10

    Topics: Acute Disease; Analgesics; Animals; Bacteria; Diphenylacetic Acids; Female; Fungi; Hepatocytes; Ibup

2008
Synthesis and pharmacological investigation of 3-(substituted 1-phenylethanone)-4-(substituted phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:9

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Blood Pressure; Edema; Hyper

2009
Bone-targeting glycol and NSAIDS ester prodrugs of rhein: synthesis, hydroxyapatite affinity, stability, anti-inflammatory, ulcerogenicity index and pharmacokinetics studies.
    European journal of medicinal chemistry, 2012, Volume: 55

    Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Bone and Bones; Chemistry Techniqu

2012
Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1,3,5-triarylpyrazoline and 1,5-diarylpyrazole derivatives as selective COX-2 inhibitors.
    Bioorganic & medicinal chemistry letters, 2016, Jan-15, Volume: 26, Issue:2

    Topics: Anti-Inflammatory Agents; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; P

2016
Synthesis, pharmacological profile and 2D-QSAR studies of curcumin-amino acid conjugates as potential drug candidates.
    European journal of medicinal chemistry, 2020, Jun-15, Volume: 196

    Topics: Amino Acids; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; An

2020
Stomach ulcer caused by mistakenly oral medication of 14,400 mg ibuprofen: A case report.
    Medicine, 2023, May-19, Volume: 102, Issue:20

    Topics: Adult; Duodenal Ulcer; Female; Gastric Mucosa; Gastritis; Helicobacter Infections; Helicobacter pylo

2023
Non-infectious genital ulcer: The relevance of anamnesis.
    Medicina clinica, 2017, 09-08, Volume: 149, Issue:5

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Drug Eruptions; Humans; Ibuprofen; Male; Medical His

2017
Synthesis, pharmacological activity and hydrolytic behavior of glyceride prodrugs of ibuprofen.
    European journal of medicinal chemistry, 2005, Volume: 40, Issue:4

    Topics: Acetic Acid; Analgesics; Animals; Glycerides; Hydrogen-Ion Concentration; Hydrolysis; Ibuprofen; Mic

2005
Nonsteroidal anti-inflammatory drug-induced ulceration diagnosed on barium enema.
    Journal of clinical gastroenterology, 1998, Volume: 27, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Barium Sulfate; Cecal Diseases; Contrast Media; Enema; Huma

1998
The effects of high-dose ibuprofen and pancreatic enzymes on the intestine of the rat.
    Journal of pediatric gastroenterology and nutrition, 1999, Volume: 29, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Ibuprofen; Intestinal Diseases; Intestine

1999
Ursodeoxycholic acid ameliorates ibuprofen-induced enteropathy in the rat.
    Journal of pediatric gastroenterology and nutrition, 2001, Volume: 32, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Catheterization; Cholagogues and Choleretics; Cyst

2001
A comparison of indomethacin with ibuprofen on gastrointestinal mucosal integrity in conventional and germ-free rats.
    Alimentary pharmacology & therapeutics, 1992, Volume: 6, Issue:1

    Topics: Animals; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Germ-Free Life; Ibuprofen; Indomethaci

1992
Ulcerative proctitis in juvenile systemic lupus erythematosus after ibuprofen treatment.
    The Journal of rheumatology, 1989, Volume: 16, Issue:2

    Topics: Adolescent; Female; Humans; Ibuprofen; Lupus Erythematosus, Systemic; Proctitis; Ulcer

1989
Medication-induced esophagitis.
    Gastrointestinal radiology, 1986, Volume: 11, Issue:1

    Topics: Adult; Doxycycline; Esophagitis; Esophagus; Female; Humans; Ibuprofen; Male; Middle Aged; Radiograph

1986
Ibuprofen and benign cecal ulcer.
    The Journal of rheumatology, 1985, Volume: 12, Issue:1

    Topics: Cecal Diseases; Female; Humans; Ibuprofen; Middle Aged; Ulcer

1985