Page last updated: 2024-10-28

ibuprofen and Thrombophlebitis

ibuprofen has been researched along with Thrombophlebitis in 4 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Thrombophlebitis: Inflammation of a vein associated with a blood clot (THROMBUS).

Research Excerpts

Excerpt	Relevance	Reference
"Dalteparin is superior to the NSAID ibuprofen in preventing extension of superficial thrombophlebitis during the 14-day treatment period with similar relief of pain and no increase in bleeding."	9.16	A randomized trial of dalteparin compared with ibuprofen for the treatment of superficial thrombophlebitis. ( Aston, CE; Rathbun, SW; Whitsett, TL, 2012)
"Dalteparin is superior to the NSAID ibuprofen in preventing extension of superficial thrombophlebitis during the 14-day treatment period with similar relief of pain and no increase in bleeding."	5.16	A randomized trial of dalteparin compared with ibuprofen for the treatment of superficial thrombophlebitis. ( Aston, CE; Rathbun, SW; Whitsett, TL, 2012)
"Fibrin deposition was reduced from 3."	1.27	Inferior vena cava replacement: the role of antiplatelet therapy. ( Dewanjee, MK; Gloviczki, P; Hollier, LH; Kaye, MP; Lovaas, ME, 1983)

Research

Studies (4)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (50.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Di Nisio, M	1
Peinemann, F	1
Porreca, E	1
Rutjes, AW	1
Rathbun, SW	1
Aston, CE	1
Whitsett, TL	1
Lovaas, ME	1
Gloviczki, P	1
Dewanjee, MK	1
Hollier, LH	1
Kaye, MP	1
Bagliani, A	1
Borri, P	1
Montalbetti, L	1
Parravicini, R	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Management of Superficial Thrombophlebitis[NCT00264381]			Phase 4	72 participants (Actual)	Interventional	2002-10-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change From Baseline to Day 14 in Pain Assessment

Change in pain at day 14 as measured by 11-point Box Pain Scale, 0 being the least amount of pain, and 10 the most amount of pain (NCT00264381)
Timeframe: Day 1, Day 14

Intervention	units on a scale (Mean)
Ibuprofen 800 mg Tid	-2.28
Dalteparin 200 U/kg Then 10,000 U Daily	-2.23

Major and Minor Bleeding Secondary to Dalteparin and Ibuprofen Treatment During the 3 Month Follow up.

Number of participants with bleeding events related to treatment (NCT00264381)
Timeframe: 3 months

Intervention	participants (Number)
Ibuprofen 800 mg Tid	0
Dalteparin 200 U/kg Then 10,000 U Daily	0

Thrombosis Progression and Venous Thromboembolism (VTE)

Thrombosis progression and deep vein thrombosis at day 14 by ultrasound testing (NCT00264381)
Timeframe: Day 14

Intervention	participants (Number)
	Thrombosis progression	VTE
Dalteparin 200 U/kg Then 10,000 U Daily	0	0
Ibuprofen 800 mg Tid	4	0

Thrombosis Progression or Venous Thromboembolism (VTE) at 3 Months

Symptomatic thrombosis extension (DVT) or pulmonary embolism at 3 months documented by radiologic testing. (NCT00264381)
Timeframe: 3 months

Intervention	participants (Number)
	Thrombosis progression	VTE
Dalteparin 200 U/kg Then 10,000 U Daily	4	1
Ibuprofen 800 mg Tid	6	0

Reviews

1 review available for ibuprofen and Thrombophlebitis

Article	Year
Treatment for superficial infusion thrombophlebitis of the upper extremity. The Cochrane database of systematic reviews, 2015, Nov-20, Issue:11 Topics: Anti-Inflammatory Agents; Anticoagulants; Catheterization, Peripheral; Dalteparin; Diclofenac; Drug	2015

Trials

1 trial available for ibuprofen and Thrombophlebitis

Article	Year
A randomized trial of dalteparin compared with ibuprofen for the treatment of superficial thrombophlebitis. Journal of thrombosis and haemostasis : JTH, 2012, Volume: 10, Issue:5 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Dalte	2012

Other Studies

2 other studies available for ibuprofen and Thrombophlebitis

Article	Year
Inferior vena cava replacement: the role of antiplatelet therapy. The Journal of surgical research, 1983, Volume: 35, Issue:3 Topics: Animals; Blood Platelets; Blood Vessel Prosthesis; Dogs; Erythrocytes; Fibrin; Ibuprofen; Platelet A	1983
[Therapy of thrombophlebitis of the lower extremities with 2-(4-isobutylphenyl) propionic acid]. Minerva cardioangiologica, 1975, Volume: 23, Issue:12 Topics: Adult; Aged; Drug Evaluation; Female; Humans; Ibuprofen; Leg; Male; Middle Aged; Phenylpropionates;	1975