Page last updated: 2024-10-28

ibuprofen and Thromboembolism, Venous

ibuprofen has been researched along with Thromboembolism, Venous in 2 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Research Excerpts

Excerpt	Relevance	Reference
"Dalteparin is superior to the NSAID ibuprofen in preventing extension of superficial thrombophlebitis during the 14-day treatment period with similar relief of pain and no increase in bleeding."	9.16	A randomized trial of dalteparin compared with ibuprofen for the treatment of superficial thrombophlebitis. ( Aston, CE; Rathbun, SW; Whitsett, TL, 2012)
"Dalteparin is superior to the NSAID ibuprofen in preventing extension of superficial thrombophlebitis during the 14-day treatment period with similar relief of pain and no increase in bleeding."	5.16	A randomized trial of dalteparin compared with ibuprofen for the treatment of superficial thrombophlebitis. ( Aston, CE; Rathbun, SW; Whitsett, TL, 2012)

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Lee, T	1
Lu, N	1
Felson, DT	1
Choi, HK	1
Dalal, DS	1
Zhang, Y	1
Dubreuil, M	1
Rathbun, SW	1
Aston, CE	1
Whitsett, TL	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Management of Superficial Thrombophlebitis[NCT00264381]			Phase 4	72 participants (Actual)	Interventional	2002-10-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change From Baseline to Day 14 in Pain Assessment

Change in pain at day 14 as measured by 11-point Box Pain Scale, 0 being the least amount of pain, and 10 the most amount of pain (NCT00264381)
Timeframe: Day 1, Day 14

Intervention	units on a scale (Mean)
Ibuprofen 800 mg Tid	-2.28
Dalteparin 200 U/kg Then 10,000 U Daily	-2.23

Major and Minor Bleeding Secondary to Dalteparin and Ibuprofen Treatment During the 3 Month Follow up.

Number of participants with bleeding events related to treatment (NCT00264381)
Timeframe: 3 months

Intervention	participants (Number)
Ibuprofen 800 mg Tid	0
Dalteparin 200 U/kg Then 10,000 U Daily	0

Thrombosis Progression and Venous Thromboembolism (VTE)

Thrombosis progression and deep vein thrombosis at day 14 by ultrasound testing (NCT00264381)
Timeframe: Day 14

Intervention	participants (Number)
	Thrombosis progression	VTE
Dalteparin 200 U/kg Then 10,000 U Daily	0	0
Ibuprofen 800 mg Tid	4	0

Thrombosis Progression or Venous Thromboembolism (VTE) at 3 Months

Symptomatic thrombosis extension (DVT) or pulmonary embolism at 3 months documented by radiologic testing. (NCT00264381)
Timeframe: 3 months

Intervention	participants (Number)
	Thrombosis progression	VTE
Dalteparin 200 U/kg Then 10,000 U Daily	4	1
Ibuprofen 800 mg Tid	6	0

Trials

1 trial available for ibuprofen and Thromboembolism, Venous

Article	Year
A randomized trial of dalteparin compared with ibuprofen for the treatment of superficial thrombophlebitis. Journal of thrombosis and haemostasis : JTH, 2012, Volume: 10, Issue:5 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Dalte	2012

Other Studies

1 other study available for ibuprofen and Thromboembolism, Venous

Article	Year
Use of non-steroidal anti-inflammatory drugs correlates with the risk of venous thromboembolism in knee osteoarthritis patients: a UK population-based case-control study. Rheumatology (Oxford, England), 2016, Volume: 55, Issue:6 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Cyclooxygenase 2 Inhibitors; Di	2016