ibuprofen has been researched along with Teeth, Impacted in 67 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to conduct a randomized prospective study about the efficacy of etodolac and ibuprofen on trismus, pain and edema regarding gender of patients submitted to impacted lower third molar teeth extraction." | 9.41 | The efficacy of etodolac and ibuprofen, regarding gender, on pain, edema and trismus after impacted lower third molar surgery: A randomized prospective clinical split-mouth study. ( Farnezi Bassi, AP; Faverani, LP; Reis, EN; Silva, LD, 2021) |
| "To compare the efficacy of ibuprofen (IBU) and etodolac (ETO) for controlling pain, edema, and trismus after extraction of lower third molars." | 9.22 | Comparative Assessment of the Effect of Ibuprofen and Etodolac on Edema, Trismus, and Pain in Lower Third Molar Surgery: A Randomized Clinical Trial. ( Bassi, AP; Grossi de Oliveira, GA; Silva de Oliveira, JC, 2016) |
| " Moreover, night administration of ibuprofen might not provide any significant benefits in terms of pain management and control of inflammation, and two doses during the day only could be sufficient for pain management after surgical interventions." | 5.51 | NSAID chronotherapy after impacted third molar extraction: a randomized controlled trial. ( Abusamak, M; Al Habashneh, R; Al-Nusair, M; Al-Tamimi, M; Al-Waeli, H; Gao, Q; Ghanim, M; Nicolau, B; Tamimi, F; Tamimi, Z, 2022) |
| "This study aimed to conduct a randomized prospective study about the efficacy of etodolac and ibuprofen on trismus, pain and edema regarding gender of patients submitted to impacted lower third molar teeth extraction." | 5.41 | The efficacy of etodolac and ibuprofen, regarding gender, on pain, edema and trismus after impacted lower third molar surgery: A randomized prospective clinical split-mouth study. ( Farnezi Bassi, AP; Faverani, LP; Reis, EN; Silva, LD, 2021) |
| "This randomized controlled clinical trial aimed to evaluate the preemptive effects of acetaminophen, ibuprofen, ketoprofen, nimesulide or dexamethasone on postoperative pain and edema in the surgical removal of impacted third molars." | 5.41 | Postoperative pain and edema control following different protocols of preemptive analgesia in the surgical removal of impacted third molars: A triple-blind parallel randomized placebo-controlled clinical trial. ( Araújo, AVA; Costa, FO; Cota, LOM; Cyrino, RM; Pinto Júnior, AAC; Santos, BFE, 2021) |
| "To compare the efficacy of ibuprofen (IBU) and etodolac (ETO) for controlling pain, edema, and trismus after extraction of lower third molars." | 5.22 | Comparative Assessment of the Effect of Ibuprofen and Etodolac on Edema, Trismus, and Pain in Lower Third Molar Surgery: A Randomized Clinical Trial. ( Bassi, AP; Grossi de Oliveira, GA; Silva de Oliveira, JC, 2016) |
| "SCIO-469 is a selective p38α mitogen-activated protein kinase (MAPK) inhibitor for preclinical models of acute pain." | 5.16 | Novel p38α mitogen-activated protein kinase inhibitor shows analgesic efficacy in acute postsurgical dental pain. ( Black, P; Chang, S; Daniels, SE; Desjardins, PJ; Protter, A; Tong, SE, 2012) |
| "This double-blind, randomized controlled study evaluated etoricoxib (90 and 120 mg), ibuprofen (600 mg), and acetaminophen (600 mg/codeine) (60 mg, (A/C)) in patients aged ≥ 18 years with moderate or severe pain after surgical extraction of ≥ 2 third molars (≥ 1 impacted)." | 5.15 | Evaluation of the dose range of etoricoxib in an acute pain setting using the postoperative dental pain model. ( Bandy, DP; Boice, J; Christensen, SE; Daniels, SE; Liu, H; Losada, MC; Mehta, A; Peloso, PM, 2011) |
| "Trismus was significantly lower in the control group than in the experimental group at 72 h postoperatively (p = 0." | 3.30 | Effect of time-dependent ibuprofen administration on the post operatory after impacted third molar extraction: a cross-over randomized controlled trial. ( Abusamak, M; García-Denche, JT; Marino, FAT; Pérez-González, F; Sáez-Alcaide, LM, 2023) |
| "The primary outcome chosen was postoperative pain, which was evaluated using the visual analogue scale (VAS) score recorded by each patient." | 2.90 | Evaluation of the efficacy of celecoxib and ibuprofen on postoperative pain, swelling, and mouth opening after surgical removal of impacted third molars: a randomized, controlled clinical trial. ( Cicciù, M; Isola, G; Matarese, G; Matarese, M; Ramaglia, L, 2019) |
| "Acute pain is a significant burden to the individual and to society." | 2.87 | Analgesic Efficacy of an Acetaminophen/Ibuprofen Fixed-dose Combination in Moderate to Severe Postoperative Dental Pain: A Randomized, Double-blind, Parallel-group, Placebo-controlled Trial. ( Atkinson, HC; Daniels, SE; Frampton, C; Stanescu, I, 2018) |
| "The mean VAS at each point of postoperative pain assessment was compared using one way analysis of variance (ANOVA) among the three groups." | 2.87 | Comparative Analgesic Effects of Ibuprofen, Celecoxib and Tramadol after third Molar Surgery: A Randomized Double Blind Controlled Trial. ( Akinbade, AO; Ndukwe, KC; Owotade, FJ, 2018) |
| "Postoperative pain was assessed using the visual analog scale (VAS) every 3 hours (while awake) for the first 48 hours after surgery." | 2.84 | Efficacy of Codeine When Added to Paracetamol (Acetaminophen) and Ibuprofen for Relief of Postoperative Pain After Surgical Removal of Impacted Third Molars: A Double-Blinded Randomized Control Trial. ( Best, AD; Cameron, CM; De Silva, HL; De Silva, RK; Thomson, WM; Tong, DC, 2017) |
| "The facial swelling and trismus were evaluated by measuring facial reference distances and maximum mouth opening." | 2.77 | Effect of preoperative ibuprofen on pain and swelling after lower third molar removal: a randomized controlled trial. ( Aznar-Arasa, L; Figueiredo, R; Gay-Escoda, C; Harutunian, K; Valmaseda-Castellón, E, 2012) |
| "Pain, swelling, infection, trismus and temperature were recorded on days 3, 7 and 14 after surgery." | 2.75 | Antibiotic prophylaxis in third molar surgery: A randomized double-blind placebo-controlled clinical trial using split-mouth technique. ( Morkel, JA; Siddiqi, A; Zafar, S, 2010) |
| " AEs were assessed at 8 hours after dosing in stage 1, at 72 hours after dosing in stage 2, and at the follow-up visit (7-10 days after surgery); in addition, patients were instructed to report any AE that occurred between scheduled assessments." | 2.75 | A single-tablet fixed-dose combination of racemic ibuprofen/paracetamol in the management of moderate to severe postoperative dental pain in adult and adolescent patients: a multicenter, two-stage, randomized, double-blind, parallel-group, placebo-control ( Aspley, S; Christensen, KS; Daniels, SE; Mehlisch, DR; Southerden, KA, 2010) |
| " Mild-to-moderate adverse effects were reported." | 2.74 | A randomized, double-blind, placebo-controlled study comparing the efficacy and safety of paracetamol, serratiopeptidase, ibuprofen and betamethasone using the dental impaction pain model. ( Chopra, D; Kakkar, AK; Mehra, P; Rehan, HS, 2009) |
| "Levobupivacaine is a valid alternative to traditional local anesthetics for surgical removal of lower third molars." | 2.74 | Postoperative pain relief after surgical removal of impacted third molars: a single-blind, randomized, controlled study to compare levobupivacaine and mepivacaine. ( Brienza, N; Crincoli, V; Di Bisceglie, MB; Favia, G; Giuliani, R; Massaro, M, 2009) |
| "Ibuprofen liquigel is a solubilized potassium ibuprofen 200-mg gelatin capsule formulation that was approved for over-the-counter use in 1995." | 2.69 | Ibuprofen liquigel for oral surgery pain. ( Cooper, SA; Doyle, G; Hersh, EV; Hong, D; Levin, LM; Secreto, SA; Waksman, J; Wedell, D, 2000) |
| "Ibuprofen was significantly better than codeine only through hour 3." | 2.67 | Ibuprofen controlled-release formulation. A clinical trial in dental impaction pain. ( Cooper, SA; Hersh, EV; Lamp, C; MacAfee, K; Quinn, PD; Sullivan, D, 1993) |
| " The slope of the dose-response curve of bromfenac was significant." | 2.67 | Analgesic efficacy of bromfenac, ibuprofen, and aspirin in postoperative oral surgery pain. ( Beaver, WT; Edquist, IA; Forbes, JA; Gongloff, CM; Jones, KF; Schwartz, MK; Smith, FG; Smith, WK, 1992) |
| "Seventy-four outpatients with postoperative pain after oral surgery were randomly assigned, on a double-blind basis, to receive a single oral dose of a controlled-release tablet (CRT) containing 600 mg ibuprofen, two 600-mg ibuprofen CRTs, or placebo." | 2.67 | Evaluation of an ibuprofen controlled-release tablet and placebo in postoperative oral surgery pain. ( Allen, HW; Beaver, WT; Forbes, JA; Moore, EM, 1991) |
| " All active treatments were significantly superior to placebo, and the slope of the dose-response curve for bromfenac was significant." | 2.67 | Evaluation of bromfenac, aspirin, and ibuprofen in postoperative oral surgery pain. ( Beaver, WT; Edquist, IA; Forbes, JA; Schwartz, MK; Smith, FG, 1991) |
| "Two-hundred six outpatients with postoperative pain after the surgical removal of impacted third molars were randomly assigned on a double-blind basis to receive oral doses of ketorolac tromethamine 10 and 20 mg, ibuprofen 400 mg, acetaminophen 600 mg, a combination of acetaminophen 600 mg plus codeine 60 mg, or placebo." | 2.67 | Evaluation of ketorolac, ibuprofen, acetaminophen, and an acetaminophen-codeine combination in postoperative oral surgery pain. ( Beaver, WT; Forbes, JA; Grodin, CD; Kehm, CJ, 1990) |
| "Trismus was significantly reduced in the He-Ne laser and ibuprofen treatment groups." | 2.67 | A randomized double-blind clinical trial on the effectiveness of helium-neon laser in the prevention of pain, swelling and trismus after removal of impacted third molars. ( Barberia, E; Calatayud, J; Carrillo, JS; Donado, M; Manso, FJ; Martinez, JM, 1990) |
| "Ibuprofen is an appropriate analgesic for treating post-operative dental pain." | 2.66 | A comparison of ibuprofen and dihydrocodeine in relieving pain following wisdom teeth removal. ( Evans, CR; Flaum, GR; Frame, JW; Langford, R; Rout, PG, 1989) |
| " Time-effect and dose-response curves were generated from the relief and change in pain-intensity scores." | 2.64 | Comparative analgesic potency of aspirin and ibuprofen. ( Cooper, SA; Kruger, GO; Needle, SE, 1977) |
| "Pain, swelling and trismus were the commonest complaints." | 1.31 | Postoperative complaints following impacted mandibular third molar surgery in Ile-Ife, Nigeria. ( Assam, E; Oginni, FO; Ogunbodede, EO; Ugboko, VI, 2002) |
| "Ketoprofen is a nonsteroidal anti-inflammatory drug with both anti-inflammatory and analgesic properties." | 1.28 | The efficacy and safety of ketoprofen in postsurgical dental pain. ( Hersh, EV, 1991) |
| "Ibuprofen 400 mg was consistently more effective than aspirin 650 mg, acetaminophen 600 mg, and both aspirin and acetaminophen when combined with codeine 60 mg." | 1.27 | Five studies on ibuprofen for postsurgical dental pain. ( Cooper, SA, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (14.93) | 18.7374 |
| 1990's | 19 (28.36) | 18.2507 |
| 2000's | 13 (19.40) | 29.6817 |
| 2010's | 18 (26.87) | 24.3611 |
| 2020's | 7 (10.45) | 2.80 |
| Authors | Studies |
|---|---|
| Tamimi, Z | 1 |
| Abusamak, M | 2 |
| Al-Waeli, H | 1 |
| Al-Tamimi, M | 1 |
| Al Habashneh, R | 1 |
| Ghanim, M | 1 |
| Al-Nusair, M | 1 |
| Gao, Q | 1 |
| Nicolau, B | 1 |
| Tamimi, F | 1 |
| Pérez-González, F | 1 |
| Sáez-Alcaide, LM | 1 |
| García-Denche, JT | 1 |
| Marino, FAT | 1 |
| Brignardello-Petersen, R | 2 |
| Förderreuther, S | 1 |
| Lampert, A | 1 |
| Hitier, S | 1 |
| Lange, R | 1 |
| Weiser, T | 1 |
| Silva, LD | 1 |
| Reis, EN | 1 |
| Faverani, LP | 1 |
| Farnezi Bassi, AP | 1 |
| Kp, K | 1 |
| R, B | 1 |
| Santos, BFE | 1 |
| Costa, FO | 1 |
| Pinto Júnior, AAC | 1 |
| Araújo, AVA | 1 |
| Cyrino, RM | 1 |
| Cota, LOM | 1 |
| Best, AD | 1 |
| De Silva, RK | 1 |
| Thomson, WM | 1 |
| Tong, DC | 1 |
| Cameron, CM | 1 |
| De Silva, HL | 1 |
| Christensen, SE | 2 |
| Cooper, SA | 6 |
| Mack, RJ | 1 |
| McCallum, SW | 1 |
| Du, W | 1 |
| Freyer, A | 1 |
| Daniels, SE | 5 |
| Atkinson, HC | 1 |
| Stanescu, I | 1 |
| Frampton, C | 1 |
| Akinbade, AO | 1 |
| Ndukwe, KC | 1 |
| Owotade, FJ | 1 |
| Isola, G | 1 |
| Matarese, M | 1 |
| Ramaglia, L | 1 |
| Cicciù, M | 1 |
| Matarese, G | 1 |
| Mehra, P | 2 |
| Reebye, U | 1 |
| Nadershah, M | 1 |
| Cottrell, D | 1 |
| Catherine, B | 1 |
| Rood, JP | 2 |
| Silva de Oliveira, JC | 1 |
| Grossi de Oliveira, GA | 1 |
| Bassi, AP | 1 |
| Chopra, D | 1 |
| Rehan, HS | 1 |
| Kakkar, AK | 1 |
| Daniels, S | 1 |
| Reader, S | 1 |
| Berry, P | 1 |
| Goulder, M | 1 |
| Akural, EI | 1 |
| Järvimäki, V | 1 |
| Länsineva, A | 1 |
| Niinimaa, A | 1 |
| Alahuhta, S | 1 |
| Crincoli, V | 1 |
| Di Bisceglie, MB | 1 |
| Massaro, M | 1 |
| Giuliani, R | 1 |
| Favia, G | 1 |
| Brienza, N | 1 |
| Hill, CM | 2 |
| Mostafa, P | 1 |
| Stuart, AG | 1 |
| Thomas, DW | 2 |
| Walker, RV | 1 |
| Brkovic, BM | 1 |
| Zlatkovic, M | 1 |
| Jovanovic, D | 1 |
| Stojic, D | 1 |
| Siddiqi, A | 1 |
| Morkel, JA | 1 |
| Zafar, S | 1 |
| Mehlisch, DR | 2 |
| Aspley, S | 2 |
| Southerden, KA | 1 |
| Christensen, KS | 1 |
| Bandy, DP | 2 |
| Lustenberger, FD | 1 |
| Grätz, KW | 1 |
| Mutzbauer, TS | 1 |
| Boice, J | 1 |
| Losada, MC | 1 |
| Liu, H | 1 |
| Mehta, A | 1 |
| Peloso, PM | 1 |
| Tong, SE | 1 |
| Black, P | 1 |
| Chang, S | 1 |
| Protter, A | 1 |
| Desjardins, PJ | 2 |
| Nørholt, SE | 1 |
| Hallmer, F | 1 |
| Hartlev, J | 1 |
| Pallesen, L | 1 |
| Blomlöf, J | 1 |
| Hansen, EJ | 1 |
| Fernandes, N | 1 |
| Eriksson, L | 1 |
| Pinholt, EM | 1 |
| Aznar-Arasa, L | 1 |
| Harutunian, K | 1 |
| Figueiredo, R | 1 |
| Valmaseda-Castellón, E | 1 |
| Gay-Escoda, C | 1 |
| Macleod, AG | 1 |
| Ashford, B | 1 |
| Voltz, M | 1 |
| Williams, B | 1 |
| Cramond, T | 1 |
| Gorta, L | 1 |
| Simpson, JM | 1 |
| Oginni, FO | 1 |
| Ugboko, VI | 1 |
| Assam, E | 1 |
| Ogunbodede, EO | 1 |
| Bjørnsson, GA | 1 |
| Haanaes, HR | 1 |
| Skoglund, LA | 1 |
| Joshi, A | 1 |
| Parara, E | 1 |
| Macfarlane, TV | 1 |
| Garwood, AJ | 1 |
| Lownie, JF | 2 |
| Cleaton-Jones, PE | 1 |
| Butz, SJ | 1 |
| Rondeau, PL | 1 |
| Yeung, E | 1 |
| Nelson, P | 1 |
| Schultze-Mosgau, S | 1 |
| Schmelzeisen, R | 1 |
| Frölich, JC | 1 |
| Schmele, H | 1 |
| Bakshi, R | 2 |
| Frenkel, G | 1 |
| Dietlein, G | 1 |
| Meurer-Witt, B | 1 |
| Schneider, B | 1 |
| Sinterhauf, U | 1 |
| Ahlström, U | 2 |
| Nilsson, P | 1 |
| Wåhlander, L | 1 |
| Quinn, PD | 1 |
| MacAfee, K | 1 |
| Hersh, EV | 3 |
| Sullivan, D | 1 |
| Lamp, C | 1 |
| Seymour, RA | 1 |
| Ward-Booth, P | 1 |
| Kelly, PJ | 1 |
| Troullos, E | 1 |
| Hargreaves, KM | 2 |
| Dionne, RA | 4 |
| Lownie, MA | 1 |
| Reinach, SG | 1 |
| Ziccardi, VB | 1 |
| Daly-DeJoy, E | 1 |
| Seng, GF | 1 |
| Ladov, MJ | 1 |
| Precheur, HV | 1 |
| Rauch, DM | 1 |
| Engel, PS | 1 |
| Stern, RK | 1 |
| Levin, LM | 1 |
| Doyle, G | 1 |
| Waksman, J | 1 |
| Wedell, D | 1 |
| Hong, D | 1 |
| Secreto, SA | 1 |
| Balkenohl, M | 1 |
| Walker, R | 1 |
| Mathé, H | 1 |
| Murray, G | 1 |
| Needle, SE | 1 |
| Kruger, GO | 1 |
| Lökken, P | 1 |
| Olsen, I | 1 |
| Bruaset, I | 1 |
| Norman-Pedersen, K | 1 |
| Hellman, M | 1 |
| Andersson, L | 1 |
| Strid, S | 1 |
| Forbes, JA | 4 |
| Beaver, WT | 4 |
| Jones, KF | 1 |
| Edquist, IA | 2 |
| Gongloff, CM | 1 |
| Smith, WK | 1 |
| Smith, FG | 2 |
| Schwartz, MK | 2 |
| Khan, AA | 1 |
| Malik, S | 1 |
| Zuberi, NI | 1 |
| Moore, EM | 1 |
| Allen, HW | 1 |
| Kehm, CJ | 1 |
| Grodin, CD | 1 |
| Habib, S | 1 |
| Matthews, RW | 1 |
| Scully, C | 1 |
| Levers, BG | 1 |
| Shepherd, JP | 1 |
| Walton, GM | 1 |
| Troullos, ES | 1 |
| Butler, DP | 1 |
| Carrillo, JS | 1 |
| Calatayud, J | 1 |
| Manso, FJ | 1 |
| Barberia, E | 1 |
| Martinez, JM | 1 |
| Donado, M | 1 |
| Frame, JW | 2 |
| Evans, CR | 1 |
| Flaum, GR | 1 |
| Langford, R | 1 |
| Rout, PG | 1 |
| Fisher, SE | 1 |
| Pickvance, NJ | 1 |
| Skene, AM | 1 |
| Hay, KD | 1 |
| Rivett, LJ | 1 |
| Bennett, KR | 1 |
| Reade, PC | 1 |
| Castro González, F | 1 |
| Martínez Garza, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Single-centre, Double-blind, Randomised, Two-stage, Parallel-group Study to Assess the Efficacy and Safety of the Fixed Dose Combination of Ibuprofen 400 mg and Caffeine 100 mg Versus Ibuprofen 400 mg, Caffeine 100 mg and Placebo in Patients With Postop[NCT01929031] | Phase 3 | 562 participants (Actual) | Interventional | 2013-08-31 | Completed | ||
| A Randomized, Double-Blind, Double-Dummy, Placebo-Controlled, Adaptive Design, Single-Dose Study of Intravenous N1539 in the Treatment of Pain Secondary to Dental Impaction Surgery[NCT00945763] | Phase 2 | 230 participants (Actual) | Interventional | 2009-07-31 | Completed | ||
| Maxigesic 325 Acute Dental Pain Study: A Double-blind, Placebo-controlled, Randomized, Parallel Group Comparison of the Effects of Maxigesic 325 Versus Acetaminophen, Ibuprofen and Placebo in Participants With Acute Dental Pain[NCT01420653] | Phase 3 | 408 participants (Actual) | Interventional | 2013-04-30 | Completed | ||
| Occurrence of Heart Arrhythmia During Restorative Dental Procedure Under Local Anesthesia , in Heart Failure Pacients. A Double-blind Study[NCT02228083] | 70 participants (Anticipated) | Interventional | 2014-09-30 | Recruiting | |||
| An Open-label, Single-dose, Pharmacokinetic Study of Acetaminophen/Naproxen Sodium Fixed Combination Tablets in Adolescents 12 to <17 Years of Age With Orthodontic Pain[NCT05844995] | Phase 1 | 30 participants (Anticipated) | Interventional | 2023-09-13 | Recruiting | ||
| Evaluation of Postoperative Edema and Pain Following Third Molar Extraction With Application of Pulsed Electromagnetic Field (PEMF) Therapy[NCT02376946] | 49 participants (Actual) | Interventional | 2014-01-31 | Terminated (stopped due to Sponsor decision) | |||
| Assessment of the Operative Course in Connection With Removal of Lower Third Molars With Particular Consideration to the Occurence of Pain and Swelling[NCT00805298] | 154 participants (Actual) | Interventional | 2008-08-31 | Completed | |||
| Towards Predicting the Analgesic Response to Ibuprofen Following Third-molar Extraction[NCT03893175] | Phase 1 | 86 participants (Actual) | Interventional | 2019-05-10 | Completed | ||
| Effect of Preoperative Pregabalin on Propofol Induction Dose[NCT01158859] | Phase 4 | 50 participants (Anticipated) | Interventional | 2010-04-30 | Completed | ||
| Efficacy of Steroids on Functional Outcomes After Musculoskeletal Injuries of the Hand[NCT05003596] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2021-09-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Duration of pain relief was defined as the time between the administration of first dose of trial medication and first dose of rescue medication or second dose of trial medication, whichever was first. Duration of pain relief was censored at 8 hours. (NCT01929031)
Timeframe: 8 hours
| Intervention | hours (Median) |
|---|---|
| Placebo | 1.63 |
| Caffeine | 2.08 |
| Ibuprofen | 7.11 |
| Ibuprofen/Caffeine | 7.33 |
Time to meaningful pain relief was captured by a stopwatch, which was started by the study staff immediately after the administration of the first dose of trial medication and which was to be stopped by the patient as soon as he/she felt meaningful pain relief. Time to meaningful pain relief was censored at 8 hours. (NCT01929031)
Timeframe: 8 hours
| Intervention | hours (Median) |
|---|---|
| Placebo | NA |
| Caffeine | NA |
| Ibuprofen | 1.78 |
| Ibuprofen/Caffeine | 1.13 |
SPRID0-2h: Time-weighted sum of PAR and PID from 0 to 2 hours, score range: -10 (worst) to 28 (best). PI was assessed on a 0-10 numerical pain rating scale (NPRS), where 0=no pain and 10=worst possible pain, pre-dose and at 0.25,0.5,0.75,1,1.5 and 2 hours; PAR was assessed on a 5-point verbal rating scale (VRS) (0=none to 4=complete) at the same post-dose time points. Time-weights were equal to the elapsed time (hour) between the time point of interest and the preceding time point. All PAR and pain intensity (PI) assessments completed after the patient had taken rescue medication or the second dose of study medication, whichever was first, until hour 2 was considered missing. Last observation carried forward (LOCF) was used with the last completed PI/PAR assessments prior to first rescue/second study medication, whichever was first, to impute missing values up to 2 hours. (NCT01929031)
Timeframe: 0 to 2 hours
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Placebo | 2.059 |
| Caffeine | 2.612 |
| Ibuprofen | 6.990 |
| Ibuprofen/Caffeine | 10.584 |
SPRID0-8h: Time-weighted sum of PAR and PID from 0 to 8 hours, score range: -40 (worst) to 112 (best). PI was assessed on a 0-10 numerical pain rating scale (NPRS), where 0=no pain and 10=worst possible pain, pre-dose and at 0.25,0.5,0.75,1,1.5,2,3,4,5, 6,7 and 8 hours; PAR was assessed on a 5-point verbal rating scale (VRS) (0=none to 4=complete) at the same post-dose time points. Time-weights were equal to the elapsed time (hour) between the time point of interest and the preceding time point. All PAR and pain intensity (PI) assessments completed after the patient had taken rescue medication or the second dose of study medication, whichever was first, until hour 8 were considered missing. Last observation carried forward (LOCF) was used with the last completed PI/PAR assessments prior to first rescue/second study medication, whichever was first, to impute missing values up to 8 hours. (NCT01929031)
Timeframe: 0 to 8 hours
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Placebo | 10.554 |
| Caffeine | 15.824 |
| Ibuprofen | 40.165 |
| Ibuprofen/Caffeine | 52.291 |
"The time-adjusted Summed Pain Intensity Differences (SPIDs) of the VAS pain intensity scores up to 48 hours after the first dose of study medication.~This was calculated from the visual analogue scale (VAS) pain intensity scores recorded during the 48 hours double blind treatment period, with the last measure taken just prior to the final dose of blinded study medication. The visual analogue scale is 100mm long with 0= no pain and 100=worst pain imaginable. The Visual Analogue Scale It is expected that treatments which can provide superior analgesic effect will demonstrate a greater Summed Pain Intensity Difference." (NCT01420653)
Timeframe: 48 hours afte the first dose
| Intervention | score on a scale (Mean) |
|---|---|
| Maxigesic 325 | 31.56 |
| Acetaminophen | 17.71 |
| Ibuprofen | 23.18 |
| Placebo | 14.86 |
56 trials available for ibuprofen and Teeth, Impacted
| Article | Year |
|---|---|
NSAID chronotherapy after impacted third molar extraction: a randomized controlled trial.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chronotherapy; Double-Blind Method; Humans; Ibuprofen; Infl | 2022 |
Effect of time-dependent ibuprofen administration on the post operatory after impacted third molar extraction: a cross-over randomized controlled trial.
Topics: Cross-Over Studies; Double-Blind Method; Edema; Humans; Ibuprofen; Molar, Third; Pain, Postoperative | 2023 |
The Impact of Baseline Pain Intensity on the Analgesic Efficacy of Ibuprofen/Caffeine in Patients with Acute Postoperative Dental Pain: Post Hoc Subgroup Analysis of a Randomised Controlled Trial.
Topics: Acute Pain; Adolescent; Adult; Analgesics; Caffeine; Dose-Response Relationship, Drug; Double-Blind | 2020 |
The efficacy of etodolac and ibuprofen, regarding gender, on pain, edema and trismus after impacted lower third molar surgery: A randomized prospective clinical split-mouth study.
Topics: Adolescent; Adult; Edema; Etodolac; Female; Humans; Ibuprofen; Male; Molar, Third; Mouth; Pain, Post | 2021 |
Postoperative pain and edema control following different protocols of preemptive analgesia in the surgical removal of impacted third molars: A triple-blind parallel randomized placebo-controlled clinical trial.
Topics: Analgesia; Double-Blind Method; Edema; Humans; Ibuprofen; Molar, Third; Pain, Postoperative; Tooth E | 2021 |
Efficacy of Codeine When Added to Paracetamol (Acetaminophen) and Ibuprofen for Relief of Postoperative Pain After Surgical Removal of Impacted Third Molars: A Double-Blinded Randomized Control Trial.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Codeine; Double-Blind Method; Drug Ther | 2017 |
A Randomized Double-Blind Controlled Trial of Intravenous Meloxicam in the Treatment of Pain Following Dental Impaction Surgery.
Topics: Administration, Intravenous; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dose-Respon | 2018 |
Analgesic Efficacy of an Acetaminophen/Ibuprofen Fixed-dose Combination in Moderate to Severe Postoperative Dental Pain: A Randomized, Double-blind, Parallel-group, Placebo-controlled Trial.
Topics: Acetaminophen; Acute Pain; Adolescent; Adult; Analgesics; Double-Blind Method; Drug Combinations; Fe | 2018 |
Comparative Analgesic Effects of Ibuprofen, Celecoxib and Tramadol after third Molar Surgery: A Randomized Double Blind Controlled Trial.
Topics: Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Double-Blind Meth | 2018 |
Evaluation of the efficacy of celecoxib and ibuprofen on postoperative pain, swelling, and mouth opening after surgical removal of impacted third molars: a randomized, controlled clinical trial.
Topics: Celecoxib; Double-Blind Method; Humans; Ibuprofen; Molar, Third; Pain, Postoperative; Tooth Extracti | 2019 |
Efficacy of anti-inflammatory drugs in third molar surgery: a randomized clinical trial.
Topics: Adolescent; Adult; Analysis of Variance; Anti-Inflammatory Agents; Dexamethasone; Dinoprostone; Doub | 2013 |
Comparative Assessment of the Effect of Ibuprofen and Etodolac on Edema, Trismus, and Pain in Lower Third Molar Surgery: A Randomized Clinical Trial.
Topics: Adolescent; Cyclooxygenase 2 Inhibitors; Edema; Etodolac; Female; Humans; Ibuprofen; Male; Mandible; | 2016 |
A randomized, double-blind, placebo-controlled study comparing the efficacy and safety of paracetamol, serratiopeptidase, ibuprofen and betamethasone using the dental impaction pain model.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory | 2009 |
Onset of analgesia with sodium ibuprofen, ibuprofen acid incorporating poloxamer and acetaminophen--a single-dose, double-blind, placebo-controlled study in patients with post-operative dental pain.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen | 2009 |
Effects of combination treatment with ketoprofen 100 mg + acetaminophen 1000 mg on postoperative dental pain: a single-dose, 10-hour, randomized, double-blind, active- and placebo-controlled clinical trial.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non- | 2009 |
Postoperative pain relief after surgical removal of impacted third molars: a single-blind, randomized, controlled study to compare levobupivacaine and mepivacaine.
Topics: Adult; Analgesics, Non-Narcotic; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Bupiva | 2009 |
ECG variations in patients pre- and post-local anaesthesia and analgesia.
Topics: Adult; Analgesics; Analgesics, Non-Narcotic; Anesthesia, Dental; Anesthetics, Local; Arrhythmia, Sin | 2009 |
Maxillary infiltration anaesthesia by ropivacaine for upper third molar surgery.
Topics: Adult; Amides; Analgesics, Non-Narcotic; Anesthesia, Dental; Anesthetics, Local; Arteries; Blood Pre | 2010 |
Antibiotic prophylaxis in third molar surgery: A randomized double-blind placebo-controlled clinical trial using split-mouth technique.
Topics: Acetaminophen; Adult; Amoxicillin; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Bacterial Agen | 2010 |
A single-tablet fixed-dose combination of racemic ibuprofen/paracetamol in the management of moderate to severe postoperative dental pain in adult and adolescent patients: a multicenter, two-stage, randomized, double-blind, parallel-group, placebo-control
Topics: Acetaminophen; Adolescent; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; | 2010 |
Comparison of the analgesic efficacy of concurrent ibuprofen and paracetamol with ibuprofen or paracetamol alone in the management of moderate to severe acute postoperative dental pain in adolescents and adults: a randomized, double-blind, placebo-control
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, | 2010 |
Efficacy of ibuprofen versus lornoxicam after third molar surgery: a randomized, double-blind, crossover pilot study.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Double-Blind Method; | 2011 |
Evaluation of the dose range of etoricoxib in an acute pain setting using the postoperative dental pain model.
Topics: Acetaminophen; Adolescent; Adult; Anesthesia, Dental; Anti-Inflammatory Agents, Non-Steroidal; Codei | 2011 |
Novel p38α mitogen-activated protein kinase inhibitor shows analgesic efficacy in acute postsurgical dental pain.
Topics: Acute Pain; Administration, Oral; Adolescent; Adult; Analgesics; Double-Blind Method; Drug Administr | 2012 |
Analgesic efficacy with rapidly absorbed ibuprofen sodium dihydrate in postsurgical dental pain: results from the randomized QUIKK trial.
Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Cross-Over Studies; Double-Blind Method; Female; Humans | 2011 |
Effect of preoperative ibuprofen on pain and swelling after lower third molar removal: a randomized controlled trial.
Topics: Adult; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Edema; Female; | 2012 |
Paracetamol versus paracetamol-codeine in the treatment of post-operative dental pain: a randomized, double-blind, prospective trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-St | 2002 |
A randomized, double-blind crossover trial of paracetamol 1000 mg four times daily vs ibuprofen 600 mg: effect on swelling and other postoperative events after third molar surgery.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies | 2003 |
A double-blind randomised controlled clinical trial of the effect of preoperative ibuprofen, diclofenac, paracetamol with codeine and placebo tablets for relief of postoperative pain after removal of impacted third molars.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Ascorbic Acid; Codeine; Diclofenac; Double-Blind | 2004 |
Use of ibuprofen and methylprednisolone for the prevention of pain and swelling after removal of impacted third molars.
Topics: Adolescent; Adult; Cheek; Double-Blind Method; Drug Combinations; Edema; Female; Humans; Ibuprofen; | 1995 |
Use of ibuprofen and methylprednisolone for the prevention of pain and swelling after removal of impacted third molars.
Topics: Adolescent; Adult; Cheek; Double-Blind Method; Drug Combinations; Edema; Female; Humans; Ibuprofen; | 1995 |
Use of ibuprofen and methylprednisolone for the prevention of pain and swelling after removal of impacted third molars.
Topics: Adolescent; Adult; Cheek; Double-Blind Method; Drug Combinations; Edema; Female; Humans; Ibuprofen; | 1995 |
Use of ibuprofen and methylprednisolone for the prevention of pain and swelling after removal of impacted third molars.
Topics: Adolescent; Adult; Cheek; Double-Blind Method; Drug Combinations; Edema; Female; Humans; Ibuprofen; | 1995 |
A placebo-controlled comparative evaluation of diclofenac dispersible versus ibuprofen in postoperative pain after third molar surgery.
Topics: Administration, Oral; Adult; Aged; Diclofenac; Double-Blind Method; Female; Humans; Ibuprofen; Male; | 1994 |
The analgesic efficacy of diclofenac dispersible and ibuprofen in postoperative pain after dental extraction.
Topics: Administration, Oral; Adolescent; Adult; Analgesia; Diclofenac; Double-Blind Method; Female; Humans; | 1993 |
Ibuprofen controlled-release formulation. A clinical trial in dental impaction pain.
Topics: Adult; Analysis of Variance; Chi-Square Distribution; Codeine; Delayed-Action Preparations; Double-B | 1993 |
Evaluation of different doses of soluble ibuprofen and ibuprofen tablets in postoperative dental pain.
Topics: Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Chi-Square Distribution; Dose- | 1996 |
Ibuprofen elevates immunoreactive beta-endorphin levels in humans during surgical stress.
Topics: Adult; Analysis of Variance; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroi | 1997 |
Comparison of the safety and efficacy of a combination analgesic Myprodol and Ponstan in the treatment of dental pain.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-St | 1992 |
Single-dose vicoprofen compared with acetaminophen with codeine and placebo in patients with acute postoperative pain after third molar extractions.
Topics: Acetaminophen; Adolescent; Adult; Analgesics; Analysis of Variance; Chi-Square Distribution; Codeine | 2000 |
An open-label evaluation of the efficacy and safety of Stadol NS with ibuprofen in the treatment of pain after removal of impacted wisdom teeth.
Topics: Administration, Inhalation; Adolescent; Adult; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opio | 2000 |
Ibuprofen liquigel for oral surgery pain.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Dose-Response Relationshi | 2000 |
Pregabalin in patients with postoperative dental pain.
Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Anesthesia, Local; Anticonvulsants; Double-Blind Method | 2001 |
Comparative analgesic potency of aspirin and ibuprofen.
Topics: Analgesics; Aspirin; Drug Evaluation; Humans; Ibuprofen; Pain, Postoperative; Placebos; Tooth, Impac | 1977 |
Evaluation of preoperative ibuprofen for postoperative pain after removal of third molars.
Topics: Adolescent; Adult; Aspirin; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Drug Int | 1978 |
Bilateral surgical removal of impacted lower third molar teeth as a model for drug evaluation: a test with ibuprofen.
Topics: Adolescent; Adult; Clinical Trials as Topic; Drug Evaluation; Edema; Female; Hemostasis; Humans; Ibu | 1975 |
Analgesic efficacy of an ibuprofen-codeine combination in patients with pain after removal of lower third molars.
Topics: Adolescent; Adult; Analgesia; Aspirin; Codeine; Double-Blind Method; Drug Combinations; Female; Huma | 1992 |
Analgesic efficacy of bromfenac, ibuprofen, and aspirin in postoperative oral surgery pain.
Topics: Aspirin; Benzophenones; Bromobenzenes; Dose-Response Relationship, Drug; Double-Blind Method; Humans | 1992 |
Double blind study on emorfazone and ibuprofen in dental pain and inflammation.
Topics: Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Humans; Ibu | 1992 |
Evaluation of an ibuprofen controlled-release tablet and placebo in postoperative oral surgery pain.
Topics: Administration, Oral; Adolescent; Adult; Ambulatory Surgical Procedures; Analgesics; Delayed-Action | 1991 |
Evaluation of bromfenac, aspirin, and ibuprofen in postoperative oral surgery pain.
Topics: Administration, Oral; Adolescent; Adult; Analgesics; Aspirin; Benzophenones; Bromobenzenes; Dose-Res | 1991 |
Evaluation of ketorolac, ibuprofen, acetaminophen, and an acetaminophen-codeine combination in postoperative oral surgery pain.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Analgesia; Anti-Inflammatory Agents, Non-Ste | 1990 |
A study of the comparative efficacy of four common analgesics in the control of postsurgical dental pain.
Topics: Acetaminophen; Adult; Analgesics; Analysis of Variance; Aspirin; Caffeine; Codeine; Drug Combination | 1990 |
A comparison of ibuprofen and ibuprofen-codeine combination in the relief of post-operative oral surgery pain.
Topics: Adolescent; Adult; Aged; Codeine; Double-Blind Method; Drug Combinations; Drug Interactions; Humans; | 1990 |
Comparison of nonsteroidal anti-inflammatory drugs, ibuprofen and flurbiprofen, with methylprednisolone and placebo for acute pain, swelling, and trismus.
Topics: Adult; Double-Blind Method; Evaluation Studies as Topic; Female; Fever; Flurbiprofen; Humans; Ibupro | 1990 |
Comparison of nonsteroidal anti-inflammatory drugs, ibuprofen and flurbiprofen, with methylprednisolone and placebo for acute pain, swelling, and trismus.
Topics: Adult; Double-Blind Method; Evaluation Studies as Topic; Female; Fever; Flurbiprofen; Humans; Ibupro | 1990 |
Comparison of nonsteroidal anti-inflammatory drugs, ibuprofen and flurbiprofen, with methylprednisolone and placebo for acute pain, swelling, and trismus.
Topics: Adult; Double-Blind Method; Evaluation Studies as Topic; Female; Fever; Flurbiprofen; Humans; Ibupro | 1990 |
Comparison of nonsteroidal anti-inflammatory drugs, ibuprofen and flurbiprofen, with methylprednisolone and placebo for acute pain, swelling, and trismus.
Topics: Adult; Double-Blind Method; Evaluation Studies as Topic; Female; Fever; Flurbiprofen; Humans; Ibupro | 1990 |
A randomized double-blind clinical trial on the effectiveness of helium-neon laser in the prevention of pain, swelling and trismus after removal of impacted third molars.
Topics: Adult; Double-Blind Method; Edema; Female; Humans; Ibuprofen; Laser Therapy; Male; Molar, Third; Pai | 1990 |
A comparison of ibuprofen and dihydrocodeine in relieving pain following wisdom teeth removal.
Topics: Adolescent; Adult; Aged; Codeine; Female; Humans; Ibuprofen; Male; Middle Aged; Molar, Third; Pain M | 1989 |
A double-blind placebo-controlled comparison of three ibuprofen/codeine combinations and aspirin.
Topics: Aspirin; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug Combinations; Humans; Ibuprofe | 1986 |
Photogrammetry used to assess post-operative facial swelling in a drug trial.
Topics: Adolescent; Adult; Clinical Trials as Topic; Double-Blind Method; Face; Female; Humans; Ibuprofen; I | 1985 |
11 other studies available for ibuprofen and Teeth, Impacted
| Article | Year |
|---|---|
There are probably no added benefits of intravenous ketamine for postoperative pain in patients undergoing third-molar extraction who receive perioperative antibiotics, ibuprofen, and dexamethasone.
Topics: Anti-Bacterial Agents; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketamine; Molar; Molar | 2020 |
Evaluation and comparison of anti-inflammatory properties of ibuprofen using two drug delivery systems after third molar surgery: using chitosan microspheres as a carrier for local drug delivery in to the third molar socket and through the oral route.
Topics: Anti-Inflammatory Agents; Chitosan; Drug Delivery Systems; Edema; Humans; Ibuprofen; Mandible; Micro | 2021 |
Similar pain, swelling, and trismus after third-molar surgical extraction when receiving a phytotherapeutic drug, ibuprofen, or a placebo.
Topics: Edema; Humans; Ibuprofen; Molar; Molar, Third; Pain; Plant Extracts; Tooth Extraction; Tooth, Impact | 2019 |
The application of clinical audit to improve pain control following third molar surgery.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; | 2013 |
Postoperative complaints following impacted mandibular third molar surgery in Ile-Ife, Nigeria.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Edema; Female; Humans; Ibuprofen; Male; | 2002 |
Five studies on ibuprofen for postsurgical dental pain.
Topics: Acetaminophen; Adolescent; Adult; Analgesics; Aspirin; Codeine; Drug Combinations; Female; Humans; I | 1984 |
The effect of Ibuprofen (Brufen) following the removal of impacted third molar teeth.
Topics: Adolescent; Adult; Aged; Double-Blind Method; Female; Humans; Ibuprofen; Male; Middle Aged; Molar, T | 1983 |
Dental surgery pain analgesic.
Topics: Adolescent; Adult; Codeine; Double-Blind Method; Drug Evaluation; Female; Humans; Ibuprofen; Male; P | 1980 |
Additive analgesic effects of oxycodone and ibuprofen in the oral surgery model.
Topics: Adult; Analgesics, Opioid; Anesthesia Recovery Period; Anesthesia, Dental; Anti-Inflammatory Agents, | 1999 |
The efficacy and safety of ketoprofen in postsurgical dental pain.
Topics: Double-Blind Method; Humans; Ibuprofen; Ketoprofen; Molar, Third; Pain Measurement; Pain, Postoperat | 1991 |
[Comparative study of analgesics].
Topics: Dextropropoxyphene; Humans; Ibuprofen; Mouth; Pain, Postoperative; Pyrazoles; Tooth, Impacted | 1986 |