Page last updated: 2024-10-28

ibuprofen and Stevens-Johnson Syndrome

ibuprofen has been researched along with Stevens-Johnson Syndrome in 22 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.

Research Excerpts

ExcerptRelevanceReference
"We report the case of a 10 year-old girl who had Stevens-Johnson syndrome and cholestasis after ibuprofen therapy."8.82Acute vanishing bile duct syndrome after ibuprofen therapy in a child. ( Bresson-Hadni, S; Felix, S; Jacquemin, E; Menget, A; Taghian, M; Tran, TA, 2004)
" Her constellation of symptoms and presentation were most consistent with a diagnosis of Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome secondary to ibuprofen exposure."7.91Stevens-Johnson syndrome/toxic epidermal necrolysis: treatment with low-dose corticosteroids, vitamin C and thiamine. ( Babakhani, A; Busaileh, AZ; Marik, PE; Middendorf, MM, 2019)
"We present a case report of a 7-year-old patient who developed toxic epidermal necrolysis (TEN) and vanishing bile duct syndrome (VBDS) after oral ibuprofen intake."7.83Acute vanishing bile duct syndrome after the use of ibuprofen. ( Artan, R; Basturk, A; Duman, O; Gelen, MT; Yılmaz, A, 2016)
" The objective of the current report was to analyze the reliability and correlation between the clinical symptoms observed in a patient that presented an ibuprofen-induced Stevens-Johnson Syndrome (SJS), her lymphocyte toxicity assay to the incriminated drug, and the cytokine secretion in the patient's sera."7.74Apoptosis in ibuprofen-induced Stevens-Johnson syndrome. ( Neuman, M; Nicar, M, 2007)
"We report the case of a 10 year-old girl who had Stevens-Johnson syndrome and cholestasis after ibuprofen therapy."4.82Acute vanishing bile duct syndrome after ibuprofen therapy in a child. ( Bresson-Hadni, S; Felix, S; Jacquemin, E; Menget, A; Taghian, M; Tran, TA, 2004)
" Her constellation of symptoms and presentation were most consistent with a diagnosis of Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome secondary to ibuprofen exposure."3.91Stevens-Johnson syndrome/toxic epidermal necrolysis: treatment with low-dose corticosteroids, vitamin C and thiamine. ( Babakhani, A; Busaileh, AZ; Marik, PE; Middendorf, MM, 2019)
"We present a case report of a 7-year-old patient who developed toxic epidermal necrolysis (TEN) and vanishing bile duct syndrome (VBDS) after oral ibuprofen intake."3.83Acute vanishing bile duct syndrome after the use of ibuprofen. ( Artan, R; Basturk, A; Duman, O; Gelen, MT; Yılmaz, A, 2016)
" The objective of the current report was to analyze the reliability and correlation between the clinical symptoms observed in a patient that presented an ibuprofen-induced Stevens-Johnson Syndrome (SJS), her lymphocyte toxicity assay to the incriminated drug, and the cytokine secretion in the patient's sera."3.74Apoptosis in ibuprofen-induced Stevens-Johnson syndrome. ( Neuman, M; Nicar, M, 2007)
"Stevens-Johnson syndrome and toxic epidermal necrolysis are two serious immune diseases within the context of bullous mucocutaneous syndrome."1.46Stevens-Johnson syndrome in childhood. ( Blanco, N; Gutiérrez, B; Hernández, Á; Martín, C; Puertas, D; Rivera, M; Torrelo, A; Valls, I, 2017)
"Fixed drug eruptions (FDE) are peculiar drug rashes that tend to be violaceous, hyperpigmented, and round to oval-shaped plaques with dusky gray centers."1.42Bullous fixed drug eruption masquerading as recurrent Stevens Johnson syndrome. ( Dharamsi, FM; Dharamsi, JW; Michener, MD, 2015)
"Toxic epidermal necrolysis is a serious dermatologic condition and a potentially life threatening disease, which is drug or infection induced."1.40Ibuprofen associated acute vanishing bile duct syndrome and toxic epidermal necrolysis in an infant. ( Kim, HY; Kim, SH; Park, JH; Yang, HK, 2014)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19902 (9.09)18.7374
1990's2 (9.09)18.2507
2000's6 (27.27)29.6817
2010's11 (50.00)24.3611
2020's1 (4.55)2.80

Authors

AuthorsStudies
Middendorf, MM1
Busaileh, AZ1
Babakhani, A1
Marik, PE1
Liccioli, G1
Filippeschi, C1
Giovannini, M1
Capone, M1
Oranges, T1
Barni, S1
Sarti, L1
Parronchi, P1
Mori, F1
Barry, RJ1
Zanetto, U1
Kolli, S1
Morjaria, R1
Atanasković-Marković, M1
Medjo, B1
Gavrović-Jankulović, M1
Ćirković Veličković, T1
Nikolić, D1
Nestorović, B1
Kim, HY1
Yang, HK1
Kim, SH1
Park, JH1
Balint, B1
Stepic, N1
Todorovic, M1
Zolotarevski, L1
Ostojic, G1
Vucetic, D1
Pavlovic, M1
Novakovic, M1
Dharamsi, FM1
Michener, MD1
Dharamsi, JW1
Basturk, A1
Artan, R1
Yılmaz, A1
Gelen, MT1
Duman, O1
Blanco, N1
Gutiérrez, B1
Valls, I1
Puertas, D1
Martín, C1
Rivera, M1
Hernández, Á1
Torrelo, A1
Mao Martín, L1
Hernández Blanco, C1
Antolín Arias, J1
Cabello Carro, J1
Gatson, NT1
Travers, JB2
Al-Hassani, M1
Warren, SJ1
Hyatt, AM1
Chen, JF1
Chiang, CP1
Selbst, SM1
Osterhoudt, K1
Taghian, M1
Tran, TA1
Bresson-Hadni, S1
Menget, A1
Felix, S1
Jacquemin, E1
Paquet, P1
Jacob, E1
Piérard, GE1
Neuman, M1
Nicar, M1
Elkrief, L1
Chryssostalis, A1
Moachon, L1
Franck, N1
Terris, B1
Chaussade, S1
Sogni, P1
Srivastava, M1
Perez-Atayde, A1
Jonas, MM1
Sanclemente, G1
De la Roche, CA1
Escobar, CE1
Falabella, R1
Morelli, MS1
O'Brien, FX1
Sternlieb, P1
Robinson, RM1
Bigby, M1
Stern, R1

Reviews

3 reviews available for ibuprofen and Stevens-Johnson Syndrome

ArticleYear
Acute vanishing bile duct syndrome after ibuprofen therapy in a child.
    The Journal of pediatrics, 2004, Volume: 145, Issue:2

    Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Bile Duct Diseases; Bile Ducts, Intrahepatic

2004
Stevens-Johnson Syndrome and cholestatic hepatitis.
    Digestive diseases and sciences, 2001, Volume: 46, Issue:11

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cholestasis;

2001
Cutaneous reactions to nonsteroidal anti-inflammatory drugs. A review.
    Journal of the American Academy of Dermatology, 1985, Volume: 12, Issue:5 Pt 1

    Topics: Acetates; Anti-Inflammatory Agents; Aspirin; Drug Eruptions; Humans; Ibuprofen; Indomethacin; ortho-

1985

Other Studies

19 other studies available for ibuprofen and Stevens-Johnson Syndrome

ArticleYear
Stevens-Johnson syndrome/toxic epidermal necrolysis: treatment with low-dose corticosteroids, vitamin C and thiamine.
    BMJ case reports, 2019, Nov-02, Volume: 12, Issue:11

    Topics: Administration, Intravenous; Adrenal Cortex Hormones; Adult; Antioxidants; Ascorbic Acid; Drug Thera

2019
Mycoplasma pneumoniae-associated mucocutaneous disease in children: A case series with allergy workup in a tertiary care paediatric hospital.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2021, Volume: 51, Issue:5

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Child; Child, Preschool;

2021
Toxic epidermal necrolysis: the red eye and red herrings in casualty.
    BMJ case reports, 2018, Oct-12, Volume: 2018

    Topics: Adrenal Cortex Hormones; Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Conj

2018
Stevens-Johnson syndrome and toxic epidermal necrolysis in children.
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2013, Volume: 24, Issue:7

    Topics: Adrenal Cortex Hormones; Allergens; Carbamazepine; Ceftriaxone; Child; Child, Preschool; Drug Erupti

2013
Ibuprofen associated acute vanishing bile duct syndrome and toxic epidermal necrolysis in an infant.
    Yonsei medical journal, 2014, Volume: 55, Issue:3

    Topics: Female; Humans; Ibuprofen; Infant; Stevens-Johnson Syndrome

2014
Ibuprofen-induced extensive toxic epidermal necrolysis - a multidisciplinary therapeutic approach in a single case.
    Blood transfusion = Trasfusione del sangue, 2014, Volume: 12, Issue:3

    Topics: Adult; Analgesics, Non-Narcotic; Female; Humans; Ibuprofen; Leukapheresis; Plasma Exchange; Stevens-

2014
Bullous fixed drug eruption masquerading as recurrent Stevens Johnson syndrome.
    The Journal of emergency medicine, 2015, Volume: 48, Issue:5

    Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Blister; Diagnosis, Different

2015
Acute vanishing bile duct syndrome after the use of ibuprofen.
    Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology, 2016, Volume: 17, Issue:3

    Topics: Antipyretics; Child; Cholestasis, Intrahepatic; Humans; Ibuprofen; Male; Stevens-Johnson Syndrome; S

2016
Stevens-Johnson syndrome in childhood.
    Archivos de la Sociedad Espanola de Oftalmologia, 2017, Volume: 92, Issue:5

    Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Biological Dressings; Child; Combined Modality Thera

2017
[Toxic epidermal necrolysis].
    Medicina clinica, 2008, Sep-13, Volume: 131, Issue:8

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Female; Humans; Ibuprofen; Skin; Stevens-Joh

2008
Progression of toxic epidermal necrolysis after tanning bed exposure.
    Archives of dermatology, 2011, Volume: 147, Issue:6

    Topics: Cell Line; Disease Progression; Erythema; Female; Humans; Ibuprofen; Immunoglobulins, Intravenous; K

2011
Dermacase. Can you identify this condition? Generalized fixed drug eruption.
    Canadian family physician Medecin de famille canadien, 2012, Volume: 58, Issue:6

    Topics: Aged; Diagnosis, Differential; Drug Eruptions; Erythema Multiforme; Humans; Ibuprofen; Male; Pemphig

2012
Pediatric emergency medicine: legal briefs.
    Pediatric emergency care, 2012, Volume: 28, Issue:12

    Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aortic Aneurysm; Aortic Dissection; Appendicitis;

2012
Cystic lesion of the parotid following drug-induced toxic epidermal necrolysis (Lyell's syndrome).
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2005, Volume: 34, Issue:6

    Topics: Adult; Amylases; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cysts; Epitheliu

2005
Apoptosis in ibuprofen-induced Stevens-Johnson syndrome.
    Translational research : the journal of laboratory and clinical medicine, 2007, Volume: 149, Issue:5

    Topics: Adolescent; Apoptosis; Caspases; Cytokines; Cytotoxicity Tests, Immunologic; Female; Humans; Ibuprof

2007
[Severe cholestatic hepatitis associated with Stevens-Johnson syndrome after taking ibuprofen].
    Gastroenterologie clinique et biologique, 2007, Volume: 31, Issue:11

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cholestasis,

2007
Drug-associated acute-onset vanishing bile duct and Stevens-Johnson syndromes in a child.
    Gastroenterology, 1998, Volume: 115, Issue:3

    Topics: Acute Disease; Adult; Bile Duct Diseases; Biopsy; Child; Cholestasis; Female; Humans; Ibuprofen; Liv

1998
Pentoxyfylline in toxic epidermal necrolysis and Stevens-Johnson syndrome.
    International journal of dermatology, 1999, Volume: 38, Issue:11

    Topics: Child, Preschool; Drug Eruptions; Female; Humans; Ibuprofen; Male; Pentoxifylline; Stevens-Johnson S

1999
Stevens-Johnson syndrome plus toxic hepatitis due to ibuprofen.
    New York state journal of medicine, 1978, Volume: 78, Issue:8

    Topics: Adult; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Humans; Ibuprofen; M

1978