ibuprofen has been researched along with Shock, Septic in 66 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ibuprofen administration during endotoxin shock seems to decrease the elevated ET concentrations, and increase the blood pressure." | 7.71 | Effects of ibuprofen on plasma endothelin levels and some vital parameters during endotoxin shock in rabbits. ( Akbulut, A; Canbaz, M; Celik, I; Vural, P, 2002) |
| "The arachidonic acid derivative thromboxane A2, a very potent platelet aggregator, is increased in endotoxin shock." | 7.67 | Treatment of experimental canine endotoxin shock with ibuprofen, a cyclooxygenase inhibitor. ( Almqvist, PM; Kuenzig, M; Schwartz, SI, 1984) |
| "We have concluded that Ibuprofen, a cyclooxygenase inhibitor with high specificity for the preferential blockage of thromboxane synthetase, significantly improves arterial blood pressure, cardiac index, and arterial pH during endotoxin shock in dogs (J." | 7.67 | Protection of myocardial function during endotoxin shock by ibuprofen. ( Bone, RC; Jacobs, ER; Perlmutter, BH; Soulsby, ME, 1984) |
| " We have previously shown that ibuprofen, a nonsteroidal anti-inflammatory drug, can improve the hemodynamic alterations of canine endotoxin shock." | 7.67 | Effects of ibuprofen on neutrophil function and acute lung injury in canine endotoxin shock. ( Balk, RA; Bone, RC; Jacobs, RF; Townsend, JW; Tryka, AF; Walls, RC, 1988) |
| "The dose response of the nonsteroidal anti-inflammatory drug, ibuprofen, was evaluated in order to determine the most efficacious dose in the treatment of canine endotoxin shock." | 7.67 | Low dose ibuprofen reverses the hemodynamic alterations of canine endotoxin shock. ( Balk, RA; Bone, RC; Jacobs, RF; Tryka, AF; Walls, RC, 1988) |
| "Ibuprofen was able to correct the pressure and flow changes caused by endotoxin, but did not prevent the hypoglycemia or accumulation of lactate and glycerol in plasma." | 5.27 | Effect of ibuprofen on the course of canine endotoxin shock. ( Abel, FL; Beck, RR, 1987) |
| "Ibuprofen administration during endotoxin shock seems to decrease the elevated ET concentrations, and increase the blood pressure." | 3.71 | Effects of ibuprofen on plasma endothelin levels and some vital parameters during endotoxin shock in rabbits. ( Akbulut, A; Canbaz, M; Celik, I; Vural, P, 2002) |
| "To evaluate the effects of ibuprofen on gram-negative septic shock, immature piglets were subjected to fecal-Escherichia coli peritonitis." | 3.68 | Ibuprofen therapy in experimental porcine gram-negative septic shock. ( Flynn, JF; Gore, DC; Griffin, MP; Herndon, DN; Lobe, TE; Traber, DL, 1991) |
| "In the present study, we observed the effects of indomethacin, ibuprofen, naloxone and morphine on plasma CGRP concentration 3 h after endotoxin shock in conscious rats." | 3.68 | [Antiinflammatory drugs inhibit the elevation of plasma CGRP concentration in endotoxin shock in rats]. ( Chen, MZ; Han, QD; Wang, XA; Yang, LH, 1991) |
| " The effects of ibuprofen, methylprednisolone-sodium succinate, and gentamicin alone, or in combination on survival time and, TxA2 and PGI2 production in rats in a LD100 fecal peritonitis shock model were assessed." | 3.67 | Ibuprofen, methylprednisolone, and gentamicin as conjoint therapy in septic shock. ( Cook, JA; Halushka, PV; Knapp, RG; Wise, WC, 1985) |
| "The arachidonic acid derivative thromboxane A2, a very potent platelet aggregator, is increased in endotoxin shock." | 3.67 | Treatment of experimental canine endotoxin shock with ibuprofen, a cyclooxygenase inhibitor. ( Almqvist, PM; Kuenzig, M; Schwartz, SI, 1984) |
| "We have concluded that Ibuprofen, a cyclooxygenase inhibitor with high specificity for the preferential blockage of thromboxane synthetase, significantly improves arterial blood pressure, cardiac index, and arterial pH during endotoxin shock in dogs (J." | 3.67 | Protection of myocardial function during endotoxin shock by ibuprofen. ( Bone, RC; Jacobs, ER; Perlmutter, BH; Soulsby, ME, 1984) |
| " We recently reported that combined treatment with methylprednisolone, ibuprofen and naloxone significantly increased lasting survival in an LD100 canine endotoxin shock model." | 3.67 | Pulmonary platelet trapping in Escherichia coli endotoxin-injected dogs treated with methylprednisolone, ibuprofen and naloxone. ( Ekström, BF; Kuenzig, M; Schwartz, SI, 1986) |
| " We have previously shown that ibuprofen, a nonsteroidal anti-inflammatory drug, can improve the hemodynamic alterations of canine endotoxin shock." | 3.67 | Effects of ibuprofen on neutrophil function and acute lung injury in canine endotoxin shock. ( Balk, RA; Bone, RC; Jacobs, RF; Townsend, JW; Tryka, AF; Walls, RC, 1988) |
| "The dose response of the nonsteroidal anti-inflammatory drug, ibuprofen, was evaluated in order to determine the most efficacious dose in the treatment of canine endotoxin shock." | 3.67 | Low dose ibuprofen reverses the hemodynamic alterations of canine endotoxin shock. ( Balk, RA; Bone, RC; Jacobs, RF; Tryka, AF; Walls, RC, 1988) |
| " In a recent study the effects of short term treatment with methylprednisolone, naloxone and ibuprofen were studied in endotoxin shock." | 3.67 | Effect of high dose corticosteroids alone or combined with other drugs on survival in septic shock. ( Almqvist, PM; Ekström, B; Haglund, U; Kuenzig, M; Schwartz, SI, 1985) |
| "We investigated the effects of the thromboxane synthetase inhibitor 7-(1-imidazolyl)heptanoic acid (7-IHA) and the fatty acid cyclooxygenase inhibitors indomethacin or ibuprofen in the treatment of fecal peritonitis in the rat." | 3.66 | Gentamicin and indomethacin in the treatment of septic shock: effects on prostacyclin and thromboxane A2 production. ( Butler, RR; Cook, JA; Halushka, PV; Wise, WC, 1983) |
| "Ibuprofen was well tolerated when administered iv and rectally to patients with severe sepsis, although drug absorption was poor with the rectal route." | 2.67 | Effect of ibuprofen in patients with severe sepsis: a randomized, double-blind, multicenter study. The Ibuprofen Study Group. ( Clemmer, TP; Goris, GB; Haupt, MT; Jastremski, MS; Metz, CA, 1991) |
| "Ibuprofen is a potent cyclooxygenase inhibitor known to reduce the production of arachidonic acid metabolites." | 2.38 | Ibuprofen in acute-care therapy. ( Ehrlich, HP; Rockwell, WB, 1990) |
| "Treatment with ibuprofen, either before or after ETX, partly restored the elevated levels of nitrite/nitrate." | 1.33 | Ibuprofen reduces plasma nitrite/nitrate levels in a rabbit model of endotoxin-induced shock. ( Akbulut, H; Ayar, A; Canbaz, M; Celik, I; Vural, P, 2005) |
| "In ibuprofen-treated animals, Prostaglandin E2 levels stayed low for at least 90 minutes, but started to rise thereafter." | 1.31 | Effects of ibuprofen on the physiology and outcome of rabbit endotoxic shock. ( Akbulut, A; Canbaz, M; Celik, I; Felek, S; Kilic, SS; Rahman, A; Vural, P, 2002) |
| "Ibuprofen use was associated with NF in the setting of primary varicella." | 1.30 | A case-control study of necrotizing fasciitis during primary varicella. ( Alexander, ER; Duchin, JS; Koutsky, LA; Rubens, CE; Zerr, DM, 1999) |
| "Ibuprofen pretreatment alone or dual blockade (ibuprofen plus LY203647) protected blood pressure and renal blood flow at 1 and 3 hr after endotoxin infusion." | 1.29 | Effectiveness of dual cyclooxygense and leukotriene blockade with ibuprofen and LY203647 during canine endotoxic shock. ( Jimenez, AE; Passmore, JC, 1993) |
| "Ibuprofen abolished the increase in EVC." | 1.29 | Effect of the platelet-activating factor antagonist, TCV-309, and the cyclo-oxygenase inhibitor, ibuprofen, on the haemodynamic changes in canine experimental endotoxic shock. ( Iwao, H; Kim, S; Miura, K; Yamanaka, S; Yukimura, T, 1993) |
| "Ibuprofen pretreatment increases arterial pressure and reduces mortality in endotoxic dogs." | 1.28 | Cardiovascular response in canine endotoxic shock: effect of ibuprofen pretreatment. ( Pinsky, MR, 1992) |
| "Treatment with ibuprofen increased arterial pressure but did not improve blood flow; however, it effectively reversed the changes in compliance." | 1.28 | Portal venous compliance in canine endotoxin shock. ( Abel, FL; Beck, RR, 1991) |
| "coli septic shock without depressing the endogenous production of TNF or IL-6." | 1.28 | Ibuprofen intervention in canine septic shock: reduction of pathophysiology without decreased cytokines. ( Coran, AG; Drongowski, RA; Paik, JJ; Remick, DG, 1992) |
| "Ibuprofen-treated dogs required less NaHCO3 for acid-base maintenance than did dual-blocked animals." | 1.28 | Hemodynamic and renal advantages of dual cyclooxygenase and leukotriene blockade during canine endotoxic shock. ( Passmore, JC; Young, JS, 1990) |
| "Treatment with ibuprofen transiently blocked LPS-induced mesenteric hypoperfusion." | 1.28 | Ibuprofen improves survival but does not ameliorate increased gut mucosal permeability in endotoxic pigs. ( Fink, MP; Kaups, KL; Rothschild, HR; Wang, H, 1992) |
| "Ibuprofen, 10 mg/kg, was administered at 120 min or earlier, depending on the state of the animal; rapid recovery of arterial pressure and ventricular function occurred without a significant change in venous compliance." | 1.27 | Canine peripheral vascular response to endotoxin shock at a constant cardiac output. ( Abel, FL; Beck, RR, 1988) |
| "Ibuprofen was administered i." | 1.27 | Increased microvascular permeability in canine endotoxic shock: protective effects of ibuprofen. ( Hubbard, JD; Janssen, HF, 1988) |
| "Ibuprofen was able to correct the pressure and flow changes caused by endotoxin, but did not prevent the hypoglycemia or accumulation of lactate and glycerol in plasma." | 1.27 | Effect of ibuprofen on the course of canine endotoxin shock. ( Abel, FL; Beck, RR, 1987) |
| "In a canine endotoxic shock model (LD100), we studied the effects of opiate and prostaglandin inhibition 60 min after endotoxin administration." | 1.27 | The effects of vasoactive mediator antagonists on endotoxic shock in dogs. I. ( Hamburger, SA; Judy, WV; Toth, PD, 1984) |
| "Early endotoxic shock in the rat is associated with marked elevations of plasma TxB2 (the stable metabolite of TxA2) and lesser increases in plasma 6-keto-PGF1 alpha (the stable metabolite of PGI2)." | 1.27 | The potential role of thromboxane and prostacyclin in endotoxic and septic shock. ( Butler, RR; Cook, JA; Halushka, PV; Rambo, W; Reines, HD; Wise, WC, 1984) |
| "Endotoxic shock was induced by injecting Escherichia coli (0111:B4) endotoxin (1 mg/kg IV)." | 1.27 | Benoxaprofen attenuation of lethal canine endotoxic shock. ( Hamburger, SA; Hastings, GH; Judy, WV; Toth, PD, 1985) |
| "Pretreatment with ibuprofen (1-3." | 1.26 | Ibuprofen improves survival from endotoxic shock in the rat. ( Cook, JA; Eller, T; Halushka, PV; Wise, WC, 1980) |
| "Anisodamine hydrochloride is a vasoactive drug produced in the People's Republic of China that appears efficacious in clinical and experimental bacteremic shock, and about whose mode of action little is known." | 1.26 | Anisodamine inhibits thromboxane synthesis, granulocyte aggregation, and platelet aggregation. A possible mechanism for its efficacy in bacteremic shock. ( Coppo, PA; Hammerschmidt, DE; Jacob, HS; Xiu, RJ, 1982) |
| "Ibuprofen (14 mg/kg) was given 15 min before and 1 h 45 min after the administration of endotoxin." | 1.26 | The effects of a prostaglandin synthetase inhibitor, ibuprofen, on the cardiopulmonary response to endotoxin in sheep. ( Adams, T; Traber, DL, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 39 (59.09) | 18.7374 |
| 1990's | 23 (34.85) | 18.2507 |
| 2000's | 3 (4.55) | 29.6817 |
| 2010's | 1 (1.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Reymond, B | 1 |
| Huette, P | 1 |
| Roger, PA | 1 |
| Tredez, E | 1 |
| Gagneur, O | 1 |
| Sanguin, S | 1 |
| Guihéneuf, R | 1 |
| Dupont, H | 1 |
| Mahjoub, Y | 1 |
| Abou Arab, O | 1 |
| Celik, I | 3 |
| Akbulut, A | 2 |
| Kilic, SS | 1 |
| Rahman, A | 1 |
| Vural, P | 3 |
| Canbaz, M | 3 |
| Felek, S | 1 |
| Akbulut, H | 1 |
| Ayar, A | 1 |
| Hagmann, W | 1 |
| Denzlinger, C | 1 |
| Keppler, D | 1 |
| Butler, RR | 2 |
| Wise, WC | 5 |
| Halushka, PV | 5 |
| Cook, JA | 5 |
| Fink, MP | 4 |
| MacVittie, TJ | 1 |
| Casey, LC | 1 |
| Bone, RC | 6 |
| Jacobs, ER | 4 |
| Reines, HD | 1 |
| Rambo, W | 1 |
| Almqvist, PM | 3 |
| Kuenzig, M | 4 |
| Schwartz, SI | 4 |
| Ekström, B | 2 |
| Haglund, U | 2 |
| Elinger, JH | 1 |
| Seyde, WC | 1 |
| Longnecker, DE | 1 |
| Soulsby, ME | 2 |
| Perlmutter, BH | 1 |
| Toth, PD | 2 |
| Hamburger, SA | 2 |
| Judy, WV | 2 |
| Adams, T | 1 |
| Traber, DL | 2 |
| Peterson, PK | 1 |
| Schlievert, PM | 1 |
| Conroy, W | 1 |
| Kelly, JA | 1 |
| Spika, J | 1 |
| Quie, PG | 1 |
| Xiu, RJ | 1 |
| Hammerschmidt, DE | 1 |
| Coppo, PA | 1 |
| Jacob, HS | 1 |
| Wilson, FJ | 2 |
| Hiller, FC | 1 |
| Eller, T | 1 |
| Pettipher, ER | 1 |
| Wimberly, DJ | 1 |
| Wang, X | 2 |
| Han, C | 2 |
| Jones, SB | 1 |
| Yang, L | 2 |
| Fiscus, RR | 2 |
| Yamanaka, S | 1 |
| Iwao, H | 2 |
| Yukimura, T | 1 |
| Kim, S | 2 |
| Miura, K | 2 |
| Passmore, JC | 2 |
| Jimenez, AE | 1 |
| Herbertson, MJ | 1 |
| Werner, HA | 1 |
| Studer, W | 1 |
| Russell, JA | 1 |
| Walley, KR | 1 |
| Ebara, T | 1 |
| Matsuura, T | 1 |
| Imanishi, M | 1 |
| Yamano, Y | 1 |
| Mansilla-Roselló, A | 1 |
| Ferrón-Orihuela, JA | 1 |
| Ruiz-Cabello, F | 1 |
| Garrote-Lara, D | 1 |
| Fernández-Mondéjar, E | 1 |
| Delgado-Carrasco, ML | 1 |
| Ladny, JR | 1 |
| Dzienis, H | 1 |
| Dadan, J | 1 |
| Polaków, J | 1 |
| Venskutonis, D | 1 |
| Puchalski, Z | 1 |
| Zerr, DM | 1 |
| Alexander, ER | 1 |
| Duchin, JS | 1 |
| Koutsky, LA | 1 |
| Rubens, CE | 1 |
| Coran, AG | 2 |
| Drongowski, RA | 2 |
| Paik, JJ | 1 |
| Remick, DG | 1 |
| Martich, GD | 1 |
| Parker, MM | 1 |
| Cunnion, RE | 1 |
| Suffredini, AF | 1 |
| Pinsky, MR | 1 |
| Bond, RF | 1 |
| Krech, LH | 1 |
| Hershey, JC | 1 |
| Chen, M | 1 |
| Griffin, MP | 1 |
| Gore, DC | 1 |
| Lobe, TE | 1 |
| Flynn, JF | 1 |
| Herndon, DN | 1 |
| Kaups, KL | 1 |
| Wang, H | 1 |
| Rothschild, HR | 2 |
| Wang, XA | 1 |
| Han, QD | 1 |
| Yang, LH | 1 |
| Chen, MZ | 1 |
| Abel, FL | 4 |
| Beck, RR | 4 |
| Haupt, MT | 1 |
| Jastremski, MS | 1 |
| Clemmer, TP | 1 |
| Metz, CA | 1 |
| Goris, GB | 1 |
| Young, JS | 1 |
| Byrne, K | 2 |
| Sielaff, TD | 2 |
| Michna, B | 1 |
| Carey, PD | 2 |
| Blocher, CR | 2 |
| Vasquez, A | 2 |
| Sugerman, HJ | 2 |
| Tatum, JL | 1 |
| Hirsh, JI | 1 |
| Rockwell, WB | 1 |
| Ehrlich, HP | 1 |
| Dinarello, CA | 1 |
| Okusawa, S | 1 |
| Gelfand, JA | 1 |
| Commins, LM | 1 |
| Loegering, DJ | 1 |
| Minnear, FL | 1 |
| Deniz, YF | 1 |
| Wang, HL | 1 |
| Lee, PC | 1 |
| Cohn, SM | 1 |
| Schmeling, DJ | 1 |
| Papadakis, E | 1 |
| Balk, RA | 2 |
| Jacobs, RF | 2 |
| Tryka, AF | 2 |
| Walls, RC | 2 |
| Townsend, JW | 1 |
| Hubbard, JD | 1 |
| Janssen, HF | 1 |
| Bertini, R | 1 |
| Bianchi, M | 1 |
| Ghezzi, P | 1 |
| Peevy, KJ | 1 |
| Ronnlund, RD | 1 |
| Chartrand, SA | 1 |
| Boerth, RC | 1 |
| Longenecker, GL | 1 |
| Nishijima, MK | 1 |
| Breslow, MJ | 1 |
| Miller, CF | 1 |
| Traystman, RJ | 1 |
| Ekström, BF | 1 |
| Jesmok, GJ | 1 |
| Aono, F | 1 |
| Simpson, J | 1 |
| Borgia, J | 1 |
| Butterfield, JH | 1 |
| Schwenk, NM | 1 |
| Colville, DS | 1 |
| Kuipers, BJ | 1 |
| Nelson, R | 1 |
| Roethel, R | 1 |
| Knapp, RG | 1 |
| O'Brien, WF | 1 |
| Golden, SM | 1 |
| Bibro, MC | 1 |
| Charkobardi, PK | 1 |
| Davis, SE | 1 |
| Hemming, VG | 1 |
| Hastings, GH | 1 |
| Rinaldo, JE | 1 |
| Dauber, JH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of the Efficacy of Paracetamol and Ibuprofen in the Management of Fever in Sepsis Patients: A Randomized Double-Blind Controlled Study[NCT06061575] | Phase 4 | 84 participants (Anticipated) | Interventional | 2023-10-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for ibuprofen and Shock, Septic
| Article | Year |
|---|---|
Ibuprofen in acute-care therapy.
Topics: Acute Disease; Animals; Cardiomyopathies; Humans; Ibuprofen; Immunity; Lung; Shock; Shock, Septic; W | 1990 |
2 trials available for ibuprofen and Shock, Septic
| Article | Year |
|---|---|
Effects of ibuprofen and pentoxifylline on the cardiovascular response of normal humans to endotoxin.
Topics: Adult; Cardiovascular Physiological Phenomena; Cardiovascular System; Endotoxins; Female; Hemodynami | 1992 |
Effect of ibuprofen in patients with severe sepsis: a randomized, double-blind, multicenter study. The Ibuprofen Study Group.
Topics: Administration, Rectal; Adolescent; Adult; Aged; Analysis of Variance; Chi-Square Distribution; Doub | 1991 |
63 other studies available for ibuprofen and Shock, Septic
| Article | Year |
|---|---|
Fatal Fusobacterium necrophorum infection with gynecological Lemierre's syndrome.
Topics: Analgesics, Non-Narcotic; Diagnosis, Differential; Fatal Outcome; Female; Fusobacterium Infections; | 2019 |
Effects of ibuprofen on the physiology and outcome of rabbit endotoxic shock.
Topics: Animals; Blood Pressure; Body Temperature; Cyclooxygenase Inhibitors; Dinoprostone; Heart Rate; Hema | 2002 |
Ibuprofen reduces plasma nitrite/nitrate levels in a rabbit model of endotoxin-induced shock.
Topics: Animals; Blood Pressure; Cyclooxygenase Inhibitors; Disease Models, Animal; Hypotension; Ibuprofen; | 2005 |
Role of peptide leukotrienes and their hepatobiliary elimination in endotoxin action.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Bile; Chromones; Dexamethason | 1984 |
Gentamicin and indomethacin in the treatment of septic shock: effects on prostacyclin and thromboxane A2 production.
Topics: Animals; Epoprostenol; Fatty Acids, Essential; Female; Fibrin Fibrinogen Degradation Products; Genta | 1983 |
Inhibition of prostaglandin synthesis restores normal hemodynamics in canine hyperdynamic sepsis.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Disease Models, Animal; Dogs; Escherichia coli Infections; Fe | 1984 |
Research on ibuprofen for sepsis and respiratory failure.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Cardiac Output; Dogs; Hydrogen-Ion Con | 1984 |
The potential role of thromboxane and prostacyclin in endotoxic and septic shock.
Topics: Animals; Arachidonic Acids; Aspirin; Cyclooxygenase Inhibitors; Epoprostenol; Fatty Acids; Gentamici | 1984 |
Treatment of experimental canine endotoxin shock with ibuprofen, a cyclooxygenase inhibitor.
Topics: Animals; Blood Pressure; Dogs; Female; Hematocrit; Hypotension; Ibuprofen; Leukocyte Count; Lung; Ma | 1984 |
Increased survival of endotoxin-injected dogs treated with methylprednisolone, naloxone, and ibuprofen.
Topics: Animals; Blood Cell Count; Blood Pressure; Dogs; Drug Therapy, Combination; Endotoxins; Female; Ibup | 1984 |
Methylprednisolone plus ibuprofen increases mortality in septic rats.
Topics: Animals; Drug Therapy, Combination; Ibuprofen; Methylprednisolone; Neutrophils; Rats; Rats, Inbred S | 1984 |
Protection of myocardial function during endotoxin shock by ibuprofen.
Topics: Animals; Biological Transport, Active; Calcium; Dogs; Female; Heart; Hemodynamics; Ibuprofen; Male; | 1984 |
The effects of vasoactive mediator antagonists on endotoxic shock in dogs. I.
Topics: Animals; Blood Pressure; Disease Models, Animal; Dogs; Endorphins; Hemodynamics; Ibuprofen; Male; Na | 1984 |
The effects of a prostaglandin synthetase inhibitor, ibuprofen, on the cardiopulmonary response to endotoxin in sheep.
Topics: Animals; Blood Pressure; Blood Proteins; Blood Volume; Cardiac Output; Endotoxins; Escherichia coli; | 1982 |
Protection against staphylococcal pyrogenic exotoxin type C-enhanced endotoxin lethality with methylprednisolone and IgG.
Topics: Animals; Endotoxins; Ibuprofen; Immunoglobulin G; Methylprednisolone; Rabbits; Shock, Septic; Staphy | 1983 |
Implications for thromboxane A2 in the pathogenesis of endotoxic shock.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Dinoprost; Disseminated Intravascular Coagulation; Fibrin Fib | 1981 |
Anisodamine inhibits thromboxane synthesis, granulocyte aggregation, and platelet aggregation. A possible mechanism for its efficacy in bacteremic shock.
Topics: Animals; Cell Aggregation; Cricetinae; Depression, Chemical; Granulocytes; Humans; Ibuprofen; Platel | 1982 |
Ibuprofen in canine endotoxin shock.
Topics: Animals; Blood Pressure; Cardiac Output; Disease Models, Animal; Dogs; Hydrogen-Ion Concentration; I | 1982 |
Ibuprofen improves survival from endotoxic shock in the rat.
Topics: Acid Phosphatase; Animals; Fibrin Fibrinogen Degradation Products; Glucuronidase; Ibuprofen; Lysosom | 1980 |
Cyclooxygenase inhibitors enhance tumour necrosis factor production and mortality in murine endotoxic shock.
Topics: Animals; Cyclooxygenase Inhibitors; Death; Enzyme-Linked Immunosorbent Assay; Escherichia coli; Ibup | 1994 |
Calcitonin gene-related peptide release in endotoxicosis may be mediated by prostaglandins.
Topics: Animals; Aspirin; Blood Glucose; Blood Pressure; Calcitonin Gene-Related Peptide; Cyclooxygenase Inh | 1995 |
Effect of the platelet-activating factor antagonist, TCV-309, and the cyclo-oxygenase inhibitor, ibuprofen, on the haemodynamic changes in canine experimental endotoxic shock.
Topics: Animals; Dogs; Endotoxins; Female; Hemodynamics; Ibuprofen; Isoquinolines; Male; Nitric Oxide; Plate | 1993 |
Effectiveness of dual cyclooxygense and leukotriene blockade with ibuprofen and LY203647 during canine endotoxic shock.
Topics: Acetophenones; Acid-Base Equilibrium; Animals; Aspartate Aminotransferases; Blood Glucose; Blood Pre | 1993 |
Decreased left ventricular contractility during porcine endotoxemia is not prevented by ibuprofen.
Topics: Analysis of Variance; Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Evaluation, P | 1996 |
Role of platelet-activating factor and prostanoids in hemodynamic changes in rat experimental endotoxic shock.
Topics: Animals; Bridged Bicyclo Compounds; Fatty Acids, Monounsaturated; Hemodynamics; Ibuprofen; Isoquinol | 1996 |
Differential effects of IL-1 beta and ibuprofen after endotoxic challenge in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Drug Interactions; Female; Ibuprofen | 1997 |
[The effect of some drugs on the levels of selected cytokines in experimental septic shock].
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Dexamethasone; Disease Models, Animal; Ibuprofen; Live | 1997 |
A case-control study of necrotizing fasciitis during primary varicella.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Chickenpox; Child; Child, Preschool; | 1999 |
Effects of ibuprofen on plasma endothelin levels and some vital parameters during endotoxin shock in rabbits.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Cyclooxygenase Inhibitors; Disease | 2002 |
Ibuprofen intervention in canine septic shock: reduction of pathophysiology without decreased cytokines.
Topics: Animals; Blood Pressure; Cardiac Output; Cytokines; Dinoprostone; Dogs; Endotoxins; Escherichia coli | 1992 |
Cardiovascular response in canine endotoxic shock: effect of ibuprofen pretreatment.
Topics: Acidosis; Animals; Disease Models, Animal; Dogs; Hemodynamics; Ibuprofen; Lactates; Lactic Acid; Oxy | 1992 |
Effect of ibuprofen upon denervated skeletal muscle resistance and compliance vessels during endotoxemia.
Topics: Animals; Arteries; Denervation; Disease Models, Animal; Dogs; Endotoxins; Ibuprofen; Microcirculatio | 1992 |
Ibuprofen, indomethacin, and high-dose aspirin, but not low-dose aspirin or imidazole, inhibit CGRP elevations in plasma during endotoxicosis.
Topics: Animals; Aspirin; Calcitonin Gene-Related Peptide; Dose-Response Relationship, Drug; Endotoxins; Ibu | 1992 |
Ibuprofen therapy in experimental porcine gram-negative septic shock.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Escherichia coli Infections; Ibuprofen; Leukocyte Count; Peri | 1991 |
Ibuprofen improves survival but does not ameliorate increased gut mucosal permeability in endotoxic pigs.
Topics: Animals; Hemodynamics; Hydrogen-Ion Concentration; Ibuprofen; Ileum; Intestinal Mucosa; Lipopolysacc | 1992 |
[Antiinflammatory drugs inhibit the elevation of plasma CGRP concentration in endotoxin shock in rats].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcitonin Gene-Related Peptide; Ibuprofen; Indome | 1991 |
Portal venous compliance in canine endotoxin shock.
Topics: Animals; Blood Pressure; Dogs; Endotoxins; Ibuprofen; Kinetics; Male; Portal Vein; Shock, Septic; Sp | 1991 |
Hemodynamic and renal advantages of dual cyclooxygenase and leukotriene blockade during canine endotoxic shock.
Topics: Acetophenones; Animals; Bicarbonates; Blood Pressure; Cardiac Output; Cyclooxygenase Inhibitors; Diu | 1990 |
Increased survival time after delayed histamine and prostaglandin blockade in a porcine model of severe sepsis-induced lung injury.
Topics: Animals; Cimetidine; Diphenhydramine; Drug Therapy, Combination; Extravascular Lung Water; Hemodynam | 1990 |
Ranitidine compared to cimetidine in multiagent pharmacological treatment of porcine Pseudomonas ARDS.
Topics: Animals; Cimetidine; Diphenhydramine; Drug Therapy, Combination; Hemodynamics; Ibuprofen; Pseudomona | 1990 |
Interleukin-1 induces a shock-like state in rabbits: synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition.
Topics: Animals; Blood Pressure; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Synergism; Hemodyna | 1989 |
Effect of ibuprofen and dexamethasone on Kupffer cell complement receptor function after endotoxemia and the phagocytosis of erythrocytes.
Topics: Animals; Dexamethasone; Erythrocytes; Ibuprofen; Immunoglobulin gamma-Chains; Kupffer Cells; Male; P | 1989 |
Systemic and mesenteric O2 metabolism in endotoxic pigs: effect of ibuprofen and meclofenamate.
Topics: 6-Ketoprostaglandin F1 alpha; Analysis of Variance; Animals; Cyclooxygenase Inhibitors; Endotoxins; | 1989 |
The beneficial effects of ibuprofen on a lethal live E. coli septic shock model and the relationship of these effects to superoxide radical production.
Topics: Animals; Dogs; Dopamine; Escherichia coli Infections; Fluid Therapy; Free Radicals; Hemodynamics; Ib | 1989 |
Influence of ibuprofen on renal function in acutely endotoxemic dogs.
Topics: Animals; Blood Glucose; Dogs; Endotoxins; Ibuprofen; Kidney Diseases; Kidney Function Tests; Male; S | 1989 |
Canine peripheral vascular response to endotoxin shock at a constant cardiac output.
Topics: Animals; Blood Pressure; Cardiac Output; Compliance; Dogs; Endotoxins; Escherichia coli; Hemodynamic | 1988 |
Low dose ibuprofen reverses the hemodynamic alterations of canine endotoxin shock.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Escherichia coli; Hemodynamics; Hypotension; Ibupro | 1988 |
Effects of ibuprofen on neutrophil function and acute lung injury in canine endotoxin shock.
Topics: Acute Disease; Animals; Bronchoalveolar Lavage Fluid; Cell Adhesion; Dogs; Dose-Response Relationshi | 1988 |
Increased microvascular permeability in canine endotoxic shock: protective effects of ibuprofen.
Topics: Animals; Blood Proteins; Capillary Permeability; Dogs; Female; Ibuprofen; Lymph; Male; Molecular Wei | 1988 |
Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor.
Topics: Adrenal Cortex; Adrenalectomy; Animals; Dexamethasone; Ibuprofen; Interleukin-1; Lipopolysaccharides | 1988 |
Ibuprofen in experimental group B streptococcal shock.
Topics: Animals; Blood Cell Count; Blood Gas Analysis; Hemodynamics; Ibuprofen; Rabbits; Shock, Septic; Stre | 1988 |
Increased hemodynamic and survival with endotoxin and septic shock with ibuprofen treatment.
Topics: Animals; Anti-Bacterial Agents; Escherichia coli Infections; Hemodynamics; Ibuprofen; Indomethacin; | 1987 |
Effect of naloxone and ibuprofen on organ blood flow during endotoxic shock in pig.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Hemodynamics; Ibuprofen; Microspheres; Naloxone; Regional Blo | 1988 |
Pulmonary platelet trapping in Escherichia coli endotoxin-injected dogs treated with methylprednisolone, ibuprofen and naloxone.
Topics: Animals; Blood Platelets; Blood Pressure; Diarrhea; Dogs; Endotoxins; Escherichia coli; Female; Hema | 1986 |
Effect of ibuprofen on components of an acute systemic inflammatory response evoked by intravenous endotoxin administration in the conscious sheep.
Topics: Animals; Body Temperature; Capillary Permeability; Dose-Response Relationship, Drug; Endotoxins; Hem | 1987 |
Effect of ibuprofen on the course of canine endotoxin shock.
Topics: Animals; Blood Glucose; Dogs; Glycerol; Hemodynamics; Ibuprofen; Lactates; Liver Circulation; Male; | 1987 |
Severe generalized reactions to ibuprofen: report of a case.
Topics: Diagnosis, Differential; Disseminated Intravascular Coagulation; Female; Fever; Humans; Hypotension; | 1986 |
Low-dose dopamine preserves renal blood flow in endotoxin shocked dogs treated with ibuprofen.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Diuresis; Dogs; Dopamine; Female; Hemodynamics; Ibuprofen; In | 1985 |
Ibuprofen, methylprednisolone, and gentamicin as conjoint therapy in septic shock.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Disease Models, Animal; Drug Therapy, Combination; Female; Ge | 1985 |
Effect of high dose corticosteroids alone or combined with other drugs on survival in septic shock.
Topics: Animals; Dogs; Drug Therapy, Combination; Endotoxins; Humans; Ibuprofen; Methylprednisolone; Naloxon | 1985 |
Short-term responses in neonatal lambs after infusion of group B streptococcal extract.
Topics: Animals; Animals, Newborn; Cell Extracts; Dinoprost; Female; Hypertension; Ibuprofen; Infusions, Par | 1985 |
Benoxaprofen attenuation of lethal canine endotoxic shock.
Topics: Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Dogs; Hemodynamics; Ibuprofen; Lipoxygen | 1985 |
Effect of methylprednisolone and of ibuprofen, a nonsteroidal antiinflammatory agent, on bronchoalveolar inflammation following endotoxemia.
Topics: Animals; Bronchitis; Gram-Negative Bacteria; Ibuprofen; Leukocyte Count; Methylprednisolone; Neutrop | 1985 |