ibuprofen and Sepsis studies

Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.

Research Excerpts

Excerpt	Relevance	Reference
" Most importantly, we wanted to report the effect of ibuprofen treatment on vital signs, organ failure, and mortality in hypothermic sepsis."	9.09	Effects of ibuprofen on the physiology and survival of hypothermic sepsis. Ibuprofen in Sepsis Study Group. ( Arons, MM; Bernard, GR; Christman, BW; Dupont, WD; Fulkerson, W; Russell, JA; Schein, R; Steinberg, KP; Summer, WR; Swindell, BB; Wheeler, AP; Wright, P, 1999)
"In the ibuprofen group, but not the placebo group, there were significant declines in urinary levels of prostacyclin and thromboxane, temperature, heart rate, oxygen consumption, and lactic acidosis."	9.08	The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. ( Bernard, GR; Christman, BW; Dupont, WD; Fulkerson, WJ; Higgins, SB; Russell, JA; Schein, R; Steinberg, KP; Summer, WR; Swindell, BB; Wheeler, AP; Wright, PE, 1997)
"Sepsis is still a major cause of death and many efforts have been made to improve the physical condition of sepsis patients and to reduce the high mortality rate associated with this disease."	5.42	Therapeutical Administration of Peptide Pep19-2.5 and Ibuprofen Reduces Inflammation and Prevents Lethal Sepsis. ( Barcena Varela, S; Brandenburg, K; Drömann, D; Ferrer-Espada, R; Goldmann, T; Gutsmann, T; Heinbockel, L; Martinez de Tejada, G; Marwitz, S; Mier, W; Reiling, N; Schürholz, T, 2015)
"Course of sepsis was evaluated by CRP and IL-6 levels."	5.38	The effects of ibuprofen on sepsis parameters in preterm neonates. ( Canpolat, FE; Celik, IH; Demirel, G; Dilmen, U; Erdeve, O; Oguz, SS, 2012)
" Most importantly, we wanted to report the effect of ibuprofen treatment on vital signs, organ failure, and mortality in hypothermic sepsis."	5.09	Effects of ibuprofen on the physiology and survival of hypothermic sepsis. Ibuprofen in Sepsis Study Group. ( Arons, MM; Bernard, GR; Christman, BW; Dupont, WD; Fulkerson, W; Russell, JA; Schein, R; Steinberg, KP; Summer, WR; Swindell, BB; Wheeler, AP; Wright, P, 1999)
"To evaluate the effects of endotoxemia on respiratory controller function, 12 subjects were randomized to receive endotoxin or saline; six also received ibuprofen, a cyclooxygenase inhibitor, and six received placebo."	5.09	Effect of endotoxin on ventilation and breath variability: role of cyclooxygenase pathway. ( Banks, SM; Godin, PJ; Jubran, A; Preas, HL; Reda, D; Suffredini, AF; Tobin, MJ; Vandivier, RW, 2001)
"In the ibuprofen group, but not the placebo group, there were significant declines in urinary levels of prostacyclin and thromboxane, temperature, heart rate, oxygen consumption, and lactic acidosis."	5.08	The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. ( Bernard, GR; Christman, BW; Dupont, WD; Fulkerson, WJ; Higgins, SB; Russell, JA; Schein, R; Steinberg, KP; Summer, WR; Swindell, BB; Wheeler, AP; Wright, PE, 1997)
"Male gender, chorioamnionitis, early sepsis, asphyxia, hemodynamic PDA, persistent hypotension, ibuprofen and paracetamol usage, and orogastric catheter administration were the main risk factors for gastric perforations in VLBW infants."	3.88	Neonatal gastric perforations in very low birth weight infants: a single center experience and review of the literature. ( Babayigit, A; Cetinkaya, M; Ozaydın, S; Sander, S, 2018)
" To assess the role of MIP-1alpha and MIP-1beta in human inflammation, healthy subjects were studied during experimental endotoxemia with prior administration of ibuprofen, a cyclooxygenase inhibitor, or dimeric p75 tumor necrosis factor (TNF)-alpha receptor, a TNF antagonist; septic patients were also studied."	3.70	Detection of macrophage inflammatory protein (MIP)-1alpha and MIP-1beta during experimental endotoxemia and human sepsis. ( Banks, SM; O'Grady, NP; Preas, HL; Reda, D; Suffredini, AF; Tropea, M; Vandivier, RW, 1999)
"Cyclo-oxygenase inhibition (with ibuprofen) combined with histamine (H1, H2) receptor antagonism (with diphenhydramine and cimetidine) attenuates microvascular leak injury in sepsis syndromes."	3.69	Multi-agent therapy in the treatment of sepsis-induced microvascular injury. ( Carey, PD; Fowler, AA; Sugerman, HJ; Walsh, CJ; Windsor, AC, 1994)
"Hypochlorous acid (HOCl), a neutrophil-generated oxidant, has been implicated in tissue destruction in sepsis-induced acute lung injury (ALI)."	3.68	Ibuprofen attenuates hypochlorous acid production from neutrophils in porcine acute lung injury. ( Byrne, K; Carey, PD; Fowler, AA; Jenkins, JK; Sielaff, TD; Sugerman, HJ; Walsh, CJ, 1990)
"Sepsis is still a major cause of death and many efforts have been made to improve the physical condition of sepsis patients and to reduce the high mortality rate associated with this disease."	1.42	Therapeutical Administration of Peptide Pep19-2.5 and Ibuprofen Reduces Inflammation and Prevents Lethal Sepsis. ( Barcena Varela, S; Brandenburg, K; Drömann, D; Ferrer-Espada, R; Goldmann, T; Gutsmann, T; Heinbockel, L; Martinez de Tejada, G; Marwitz, S; Mier, W; Reiling, N; Schürholz, T, 2015)
"Course of sepsis was evaluated by CRP and IL-6 levels."	1.38	The effects of ibuprofen on sepsis parameters in preterm neonates. ( Canpolat, FE; Celik, IH; Demirel, G; Dilmen, U; Erdeve, O; Oguz, SS, 2012)
"Lower GA (P<0."	1.35	Factors affecting postnatal changes in serum creatinine in preterm infants with gestational age <32 weeks. ( Bonsante, F; Ferdinus, C; Gouyon, JB; Iacobelli, S; Labenne, M, 2009)
"Ibuprofen pretreatment prevented the sepsis associated increase in both Kf and lung lavage protein concentration."	1.29	Cecal ligation and puncture is associated with pulmonary injury in the rat: role of cyclooxygenase pathway products. ( Carlson, RW; Schneidkraut, MJ, 1993)
"Treatment with ibuprofen given intravenously (12."	1.28	Splenectomy attenuates the inappropriate diuresis associated with tumor necrosis factor administration. ( Evans, DA; Jacobs, DO; Mealy, K; van Lanschot, JJ; Wilmore, DW, 1991)
"Ibuprofen is a cyclo-oxygenase inhibitor that is alleged to have additional direct effects on leukocyte function."	1.27	Effects of ibuprofen on endotoxin-induced alveolitis: biphasic dose response and dissociation between inflammation and hypoxemia. ( Pennock, B; Rinaldo, JE, 1986)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (17.86)	18.7374
1990's	15 (53.57)	18.2507
2000's	3 (10.71)	29.6817
2010's	4 (14.29)	24.3611
2020's	1 (3.57)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Liberal Versus Restrictive Platelet Transfusion for Treatment of Hemodynamically Significant Patent Ductus Arteriosus in Thrombocytopenic Preterm Neonates- A Randomized Open Label, Controlled Trial[NCT03022253]	Phase 3	44 participants (Anticipated)	Interventional	2016-03-31	Completed
[NCT00000574]	Phase 3	0 participants	Interventional	1990-09-30	Completed
A Phase II Double Blind Randomized Controlled Trial of High Dose Vitamin B12 in Septic Shock[NCT03783091]	Phase 2	20 participants (Anticipated)	Interventional	2019-08-05	Recruiting
Control of Fever in Septic Patients[NCT04227652]		140 participants (Actual)	Interventional	2013-09-03	Completed
Comparison of the Efficacy of Paracetamol and Ibuprofen in the Management of Fever in Sepsis Patients: A Randomized Double-Blind Controlled Study[NCT06061575]	Phase 4	84 participants (Anticipated)	Interventional	2023-10-31	Not yet recruiting
Phase 2 Single Center, Randomized, Placebo-controlled, Double-blind, Parallel Group Study to Evaluate Efficacy of Para-Tyrosine Supplementation on the Survival and Clinical Outcome in Patients With Sepsis[NCT03278730]	Phase 2	296 participants (Anticipated)	Interventional	2025-02-28	Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
The effects of ibuprofen on eicosanoid synthesis in sepsis. Critical care medicine, 1999, Volume: 27, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Cytokines; Disease Models, Anima	1999
[Multiple organ failure]. Vestnik khirurgii imeni I. I. Grekova, 2001, Volume: 160, Issue:3 Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Controlled Clinical Trials	2001

Article	Year
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. The New England journal of medicine, 1997, Mar-27, Volume: 336, Issue:13 Topics: Acidosis, Lactic; Double-Blind Method; Epoprostenol; Female; Fever; Hemodynamics; Humans; Ibuprofen;	1997
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. The New England journal of medicine, 1997, Mar-27, Volume: 336, Issue:13 Topics: Acidosis, Lactic; Double-Blind Method; Epoprostenol; Female; Fever; Hemodynamics; Humans; Ibuprofen;	1997
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. The New England journal of medicine, 1997, Mar-27, Volume: 336, Issue:13 Topics: Acidosis, Lactic; Double-Blind Method; Epoprostenol; Female; Fever; Hemodynamics; Humans; Ibuprofen;	1997
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. The New England journal of medicine, 1997, Mar-27, Volume: 336, Issue:13 Topics: Acidosis, Lactic; Double-Blind Method; Epoprostenol; Female; Fever; Hemodynamics; Humans; Ibuprofen;	1997
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. The New England journal of medicine, 1997, Mar-27, Volume: 336, Issue:13 Topics: Acidosis, Lactic; Double-Blind Method; Epoprostenol; Female; Fever; Hemodynamics; Humans; Ibuprofen;	1997
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. The New England journal of medicine, 1997, Mar-27, Volume: 336, Issue:13 Topics: Acidosis, Lactic; Double-Blind Method; Epoprostenol; Female; Fever; Hemodynamics; Humans; Ibuprofen;	1997
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. The New England journal of medicine, 1997, Mar-27, Volume: 336, Issue:13 Topics: Acidosis, Lactic; Double-Blind Method; Epoprostenol; Female; Fever; Hemodynamics; Humans; Ibuprofen;	1997
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. The New England journal of medicine, 1997, Mar-27, Volume: 336, Issue:13 Topics: Acidosis, Lactic; Double-Blind Method; Epoprostenol; Female; Fever; Hemodynamics; Humans; Ibuprofen;	1997
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. The New England journal of medicine, 1997, Mar-27, Volume: 336, Issue:13 Topics: Acidosis, Lactic; Double-Blind Method; Epoprostenol; Female; Fever; Hemodynamics; Humans; Ibuprofen;	1997
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. The New England journal of medicine, 1997, Mar-27, Volume: 336, Issue:13 Topics: Acidosis, Lactic; Double-Blind Method; Epoprostenol; Female; Fever; Hemodynamics; Humans; Ibuprofen;	1997
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. The New England journal of medicine, 1997, Mar-27, Volume: 336, Issue:13 Topics: Acidosis, Lactic; Double-Blind Method; Epoprostenol; Female; Fever; Hemodynamics; Humans; Ibuprofen;	1997
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. The New England journal of medicine, 1997, Mar-27, Volume: 336, Issue:13 Topics: Acidosis, Lactic; Double-Blind Method; Epoprostenol; Female; Fever; Hemodynamics; Humans; Ibuprofen;	1997
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. The New England journal of medicine, 1997, Mar-27, Volume: 336, Issue:13 Topics: Acidosis, Lactic; Double-Blind Method; Epoprostenol; Female; Fever; Hemodynamics; Humans; Ibuprofen;	1997
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. The New England journal of medicine, 1997, Mar-27, Volume: 336, Issue:13 Topics: Acidosis, Lactic; Double-Blind Method; Epoprostenol; Female; Fever; Hemodynamics; Humans; Ibuprofen;	1997
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. The New England journal of medicine, 1997, Mar-27, Volume: 336, Issue:13 Topics: Acidosis, Lactic; Double-Blind Method; Epoprostenol; Female; Fever; Hemodynamics; Humans; Ibuprofen;	1997
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. The New England journal of medicine, 1997, Mar-27, Volume: 336, Issue:13 Topics: Acidosis, Lactic; Double-Blind Method; Epoprostenol; Female; Fever; Hemodynamics; Humans; Ibuprofen;	1997
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. The New England journal of medicine, 1997, Mar-27, Volume: 336, Issue:13 Topics: Acidosis, Lactic; Double-Blind Method; Epoprostenol; Female; Fever; Hemodynamics; Humans; Ibuprofen;	1997
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. The New England journal of medicine, 1997, Mar-27, Volume: 336, Issue:13 Topics: Acidosis, Lactic; Double-Blind Method; Epoprostenol; Female; Fever; Hemodynamics; Humans; Ibuprofen;	1997
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. The New England journal of medicine, 1997, Mar-27, Volume: 336, Issue:13 Topics: Acidosis, Lactic; Double-Blind Method; Epoprostenol; Female; Fever; Hemodynamics; Humans; Ibuprofen;	1997
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. The New England journal of medicine, 1997, Mar-27, Volume: 336, Issue:13 Topics: Acidosis, Lactic; Double-Blind Method; Epoprostenol; Female; Fever; Hemodynamics; Humans; Ibuprofen;	1997
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. The New England journal of medicine, 1997, Mar-27, Volume: 336, Issue:13 Topics: Acidosis, Lactic; Double-Blind Method; Epoprostenol; Female; Fever; Hemodynamics; Humans; Ibuprofen;	1997
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. The New England journal of medicine, 1997, Mar-27, Volume: 336, Issue:13 Topics: Acidosis, Lactic; Double-Blind Method; Epoprostenol; Female; Fever; Hemodynamics; Humans; Ibuprofen;	1997
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. The New England journal of medicine, 1997, Mar-27, Volume: 336, Issue:13 Topics: Acidosis, Lactic; Double-Blind Method; Epoprostenol; Female; Fever; Hemodynamics; Humans; Ibuprofen;	1997
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. The New England journal of medicine, 1997, Mar-27, Volume: 336, Issue:13 Topics: Acidosis, Lactic; Double-Blind Method; Epoprostenol; Female; Fever; Hemodynamics; Humans; Ibuprofen;	1997
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. The New England journal of medicine, 1997, Mar-27, Volume: 336, Issue:13 Topics: Acidosis, Lactic; Double-Blind Method; Epoprostenol; Female; Fever; Hemodynamics; Humans; Ibuprofen;	1997
Effects of ibuprofen on the physiology and survival of hypothermic sepsis. Ibuprofen in Sepsis Study Group. Critical care medicine, 1999, Volume: 27, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Epoprostenol; Female; Fever; Humans; Hypothermia; Ibuprofen	1999
Effect of endotoxin on ventilation and breath variability: role of cyclooxygenase pathway. American journal of respiratory and critical care medicine, 2001, Aug-15, Volume: 164, Issue:4 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Blood Gas Analysis; Carbon Dioxide; Dyspnea; Endotox	2001
Prostacyclin and thromboxane A2 formation is increased in human sepsis syndrome. Effects of cyclooxygenase inhibition. The American review of respiratory disease, 1991, Volume: 144, Issue:5 Topics: Cyclooxygenase Inhibitors; Double-Blind Method; Epoprostenol; Humans; Ibuprofen; Multiple Organ Fail	1991

Article	Year
Prim-O-glucosycimifugin attenuates liver injury in septic mice by inhibiting NLRP3 inflammasome/caspase-1 signaling cascades in macrophages. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Volume: 106 Topics: Adenosine Triphosphate; Animals; Caspase 1; Chromones; Ibuprofen; Inflammasomes; Interleukin-18; Lip	2022
Neonatal gastric perforations in very low birth weight infants: a single center experience and review of the literature. Pediatric surgery international, 2018, Volume: 34, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Asphyxia Neonatorum; Chorioamnionitis; Ductus Arteriosus, P	2018
Therapeutical Administration of Peptide Pep19-2.5 and Ibuprofen Reduces Inflammation and Prevents Lethal Sepsis. PloS one, 2015, Volume: 10, Issue:7 Topics: Amino Acid Sequence; Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Dinopr	2015
Factors affecting postnatal changes in serum creatinine in preterm infants with gestational age <32 weeks. Journal of perinatology : official journal of the California Perinatal Association, 2009, Volume: 29, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Creatinine; Ductus Arteriosus, Patent; Female; Gestational	2009
The effects of ibuprofen on sepsis parameters in preterm neonates. Early human development, 2012, Volume: 88, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; C-Reactive Protein; Case-Control Studies; Ductus Arteriosus	2012
Thrombocytopenia in the first 24 hours after birth and incidence of patent ductus arteriosus. Pediatrics, 2012, Volume: 130, Issue:3 Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Echocardiography, Doppler; Female; Humans; Ibu	2012
Comparison of thromboxane inhibitors to cyclooxygenase inhibitors on survival in a newborn rat model for group B streptococcal sepsis. Advances in prostaglandin, thromboxane, and leukotriene research, 1983, Volume: 12 Topics: Animals; Animals, Newborn; Ibuprofen; Indomethacin; Rats; Rats, Inbred Strains; Sepsis; Streptococca	1983
Inhibition of prostaglandin synthesis restores normal hemodynamics in canine hyperdynamic sepsis. Annals of surgery, 1984, Volume: 200, Issue:5 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Disease Models, Animal; Dogs; Escherichia coli Infections; Fe	1984
Multi-agent therapy in the treatment of sepsis-induced microvascular injury. The British journal of surgery, 1994, Volume: 81, Issue:12 Topics: Animals; Cell Membrane Permeability; Cimetidine; Diphenhydramine; Hemodynamics; Hypochlorous Acid; I	1994
Efficacy of tumor necrosis factor alpha and eicosanoid inhibitors in experimental models of neonatal sepsis. FEMS immunology and medical microbiology, 1994, Volume: 9, Issue:1 Topics: Acetophenones; Animals; Animals, Newborn; Bacterial Toxins; Chromonar; Eicosanoids; Endotoxins; Ibup	1994
Regional blood flow distribution in endotoxin-treated dogs: modification by ibuprofen. Journal of critical care, 1994, Volume: 9, Issue:3 Topics: Animals; Blood Gas Analysis; Dogs; Endotoxins; Escherichia coli; Fluid Therapy; Hemodynamics; Ibupro	1994
Cecal ligation and puncture is associated with pulmonary injury in the rat: role of cyclooxygenase pathway products. Prostaglandins, 1993, Volume: 45, Issue:4 Topics: Animals; Bronchoalveolar Lavage Fluid; Capillaries; Capillary Permeability; Cecum; Ibuprofen; Ligati	1993
Strategies for the treatment of sepsis. The New England journal of medicine, 1997, Mar-27, Volume: 336, Issue:13 Topics: Humans; Ibuprofen; Sepsis	1997
Ibuprofen in patients with sepsis. The New England journal of medicine, 1997, Sep-04, Volume: 337, Issue:10 Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Ibuprofen; Interleukin-6; Prostaglandin Antagonists	1997
Detection of macrophage inflammatory protein (MIP)-1alpha and MIP-1beta during experimental endotoxemia and human sepsis. The Journal of infectious diseases, 1999, Volume: 179, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antigens, CD; Chemokine CCL3; Chemokine CCL4; Child; Cyc	1999
The neutrophil respiratory burst and tissue injury in septic acute lung injury: the effect of cyclooxygenase inhibition in swine. Surgery, 1992, Volume: 112, Issue:1 Topics: Acute Disease; Animals; Bronchoalveolar Lavage Fluid; Capillaries; Ibuprofen; Kinetics; Leukocyte Co	1992
Ibuprofen restores cellular immunity and decreases susceptibility to sepsis following hemorrhage. The Journal of surgical research, 1992, Volume: 53, Issue:1 Topics: Animals; Blood Pressure; Cells, Cultured; Concanavalin A; Cytokines; Disease Susceptibility; DNA Rep	1992
Splenectomy attenuates the inappropriate diuresis associated with tumor necrosis factor administration. Surgery, gynecology & obstetrics, 1991, Volume: 172, Issue:4 Topics: Analysis of Variance; Animals; Dogs; Female; Ibuprofen; Male; Natriuresis; Polyuria; Prostaglandin-E	1991
Ibuprofen attenuates hypochlorous acid production from neutrophils in porcine acute lung injury. The Journal of surgical research, 1990, Volume: 49, Issue:3 Topics: Animals; Bronchoalveolar Lavage Fluid; Capillary Permeability; Cyclooxygenase Inhibitors; Extravascu	1990
The beneficial effects of ibuprofen on a lethal live E. coli septic shock model and the relationship of these effects to superoxide radical production. Progress in clinical and biological research, 1989, Volume: 299 Topics: Animals; Dogs; Dopamine; Escherichia coli Infections; Fluid Therapy; Free Radicals; Hemodynamics; Ib	1989
Effects of ibuprofen on endotoxin-induced alveolitis: biphasic dose response and dissociation between inflammation and hypoxemia. The American journal of the medical sciences, 1986, Volume: 291, Issue:1 Topics: Animals; Dose-Response Relationship, Drug; Endotoxins; Escherichia coli; Ibuprofen; Neutrophils; Pre	1986
Limited effects of prostaglandin inhibitors in Escherichia coli sepsis. Surgery, 1985, Volume: 98, Issue:2 Topics: Acute Disease; Animals; Body Temperature; Disease Models, Animal; Dogs; Escherichia coli Infections;	1985

ibuprofen and Sepsis

Research Excerpts

Research

Studies (28)

Authors

Clinical Trials (6)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Liu, LL	1
Yan, X	1
Xue, KY	1
Wang, XM	1
Li, LY	1
Chen, HY	1
Li, RL	1
Li, H	1
Lan, J	1
Xin, JJ	1
Li, X	1
Zhuo, CL	1
Wu, Z	1
Zhang, D	1
Huang, WJ	1
Wang, YL	1
Li, XY	1
Jiang, W	1
Zhang, HY	1
Babayigit, A	1
Ozaydın, S	1
Cetinkaya, M	1
Sander, S	1
Heinbockel, L	1
Marwitz, S	1
Barcena Varela, S	1
Ferrer-Espada, R	1
Reiling, N	1
Goldmann, T	1
Gutsmann, T	1
Mier, W	1
Schürholz, T	1
Drömann, D	1
Brandenburg, K	1
Martinez de Tejada, G	1
Iacobelli, S	1
Bonsante, F	1
Ferdinus, C	1
Labenne, M	1
Gouyon, JB	1
Demirel, G	1
Celik, IH	1
Canpolat, FE	1
Erdeve, O	1
Oguz, SS	1
Dilmen, U	1
Sallmon, H	1
Weber, SC	1
Hüning, B	1
Stein, A	1
Horn, PA	1
Metze, BC	1
Dame, C	1
Bührer, C	1
Felderhoff-Müser, U	1
Hansmann, G	1
Koehne, P	1
Short, BL	1
Miller, MK	1
Stroud, CY	1
Fletcher, JR	2
Fink, MP	1
MacVittie, TJ	1
Casey, LC	1
Carey, PD	3
Windsor, AC	1
Walsh, CJ	3
Fowler, AA	3
Sugerman, HJ	3
Mancuso, G	1
Cusumano, V	1
Cook, JA	1
Smith, E	1
Squadrito, F	1
Blandino, G	1
Teti, G	1
Winslow, C	1
Dorinsky, PM	1
Schneidkraut, MJ	1
Carlson, RW	1
Bernard, GR	3
Wheeler, AP	2
Russell, JA	2
Schein, R	2
Summer, WR	2
Steinberg, KP	2
Fulkerson, WJ	1
Wright, PE	2
Christman, BW	2
Dupont, WD	2
Higgins, SB	2
Swindell, BB	3
Warren, HS	1
Zimmerli, W	1
Widmer, AF	1
O'Grady, NP	1
Tropea, M	1
Preas, HL	2
Reda, D	2
Vandivier, RW	2
Banks, SM	2
Suffredini, AF	2
Arons, MM	1
Fulkerson, W	1
Wright, P	1
Grinëv, MV	1
Golubeva, AV	1
Jubran, A	1
Godin, PJ	1
Tobin, MJ	1
Jenkins, JK	2
Byrne, K	2
Ertel, W	1
Morrison, MH	1
Meldrum, DR	1
Ayala, A	1
Chaudry, IH	1
van Lanschot, JJ	1
Mealy, K	1
Jacobs, DO	1
Evans, DA	1
Wilmore, DW	2
Reines, HD	1
Halushka, PV	1
Metz, CA	1
Watts, FL	1
Vrbanac, JJ	1
Sielaff, TD	1
Schmeling, DJ	1
Drongowski, RA	1
Coran, AG	1
Rinaldo, JE	1
Pennock, B	1
Hulton, NR	1
Johnson, DJ	1