Page last updated: 2024-10-28

ibuprofen and Respiratory Distress Syndrome, Newborn

ibuprofen has been researched along with Respiratory Distress Syndrome, Newborn in 19 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Respiratory Distress Syndrome, Newborn: A condition of the newborn marked by DYSPNEA with CYANOSIS, heralded by such prodromal signs as dilatation of the alae nasi, expiratory grunt, and retraction of the suprasternal notch or costal margins, mostly frequently occurring in premature infants, children of diabetic mothers, and infants delivered by cesarean section, and sometimes with no apparent predisposing cause.

Research Excerpts

ExcerptRelevanceReference
"Ibuprofen therapy on the third day of life is as efficacious as indomethacin for the treatment of patent ductus arteriosus in preterm infants with the respiratory distress syndrome and is significantly less likely to induce oliguria."5.09A comparison of ibuprofen and indomethacin for closure of patent ductus arteriosus. ( Degroote, K; Langhendries, JP; Lecoutere, D; Smets, K; Van de Broek, H; Van Overmeire, B; Weyler, J, 2000)
"Ibuprofen was administered on days 3, 4, and 5 by a 15-minute intravenous infusion of 10, 5, and 5 mg/kg, respectively, with the aim of closing the ductus arteriosus."2.70Ibuprofen pharmacokinetics in preterm infants with patent ductus arteriosus. ( Kearns, GL; Schepens, PJ; Touw, D; van den Anker, JN; Van Overmeire, B, 2001)
"Ibuprofen was not associated with adverse effects."2.69Prophylaxis of patent ductus arteriosus with ibuprofen in preterm infants. ( Bertini, G; Dani, C; Fabris, C; Murru, P; Reali, MF; Rubaltelli, FF; Vangi, V, 2000)
"Ibuprofen treatment seems to be as efficient as indomethacin in closing PDA on the third day of life in preterm infants with respiratory distress syndrome and seems to have fewer renal side effects."2.68Treatment of patent ductus arteriosus with ibuprofen. ( Creten, WL; Follens, I; Hartmann, S; Van Acker, KJ; Van Overmeire, B, 1997)
"Lower GA (P<0."1.35Factors affecting postnatal changes in serum creatinine in preterm infants with gestational age <32 weeks. ( Bonsante, F; Ferdinus, C; Gouyon, JB; Iacobelli, S; Labenne, M, 2009)
"Ibuprofen is a nonsteroidal anti-inflammatory agent that induces closure of the patent ductus arteriosus in neonates."1.35An optimized ibuprofen dosing scheme for preterm neonates with patent ductus arteriosus, based on a population pharmacokinetic and pharmacodynamic study. ( Eisinger, MJ; Hirt, D; Langhendries, JP; Marguglio, A; Schepens, P; Treluyer, JM; Urien, S; Van Overmeire, B, 2008)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (5.26)18.2507
2000's11 (57.89)29.6817
2010's7 (36.84)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lee, HC1
Durand, DJ1
Danielsen, B1
DueƱas, GV1
Powers, RJ1
Lu, D1
Liu, Y1
Tong, X1
Haw, MP1
Dani, C3
Bertini, G2
Corsini, I1
Elia, S1
Vangi, V2
Pratesi, S1
Rubaltelli, FF2
Iacobelli, S1
Bonsante, F1
Ferdinus, C1
Labenne, M1
Gouyon, JB1
Yokoi, T2
Hiraoka, M1
Miyamoto, M1
Kobayashi, Y1
Nishina, S1
Azuma, N1
Benitz, WE1
Sarici, SU1
Dabak, O1
Erdinc, K1
Okutan, V1
Lenk, MK1
Poggi, C1
Fontanelli, G1
Heo, MJ1
Lee, OS1
Lim, SC1
Bray, M1
Stucchi, I1
Fumagalli, M1
Pugni, L1
Ramenghi, L1
Agosti, M1
Mosca, F1
Heyman, E1
Morag, I1
Batash, D1
Keidar, R1
Baram, S1
Berkovitch, M1
Su, PH1
Chen, JY1
Su, CM1
Huang, TC1
Lee, HS1
Distefano, G1
Hirt, D1
Van Overmeire, B4
Treluyer, JM1
Langhendries, JP2
Marguglio, A1
Eisinger, MJ1
Schepens, P1
Urien, S1
Follens, I1
Hartmann, S1
Creten, WL1
Van Acker, KJ1
Smets, K1
Lecoutere, D1
Van de Broek, H1
Weyler, J1
Degroote, K1
Reali, MF1
Murru, P1
Fabris, C1
Touw, D1
Schepens, PJ1
Kearns, GL1
van den Anker, JN1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Combination of Acetaminophen and Ibuprofen in the Management of Patent Ductus Arteriosus in Premature Infants: A Pilot Study[NCT03103022]Phase 120 participants (Actual)Interventional2017-06-12Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for ibuprofen and Respiratory Distress Syndrome, Newborn

ArticleYear
Surgical Intervention in Preterm Neonates with Patent Ductus Arteriosus.
    Current pediatric reviews, 2016, Volume: 12, Issue:2

    Topics: Bronchopulmonary Dysplasia; Combined Modality Therapy; Cyclooxygenase Inhibitors; Ductus Arteriosus,

2016
Treatment of persistent patent ductus arteriosus in preterm infants: time to accept the null hypothesis?
    Journal of perinatology : official journal of the California Perinatal Association, 2010, Volume: 30, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cardiac Surgical Procedures; Confidence Intervals; Ductus A

2010
[The pharmacological manipulation of Botallo's duct in the duct-dependent congenital cardiopathies and in the preterm infants with respiratory distress. A review and personal findings].
    Minerva pediatrica, 2005, Volume: 57, Issue:1

    Topics: Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Agents; Cerebral Angiography; C

2005

Trials

5 trials available for ibuprofen and Respiratory Distress Syndrome, Newborn

ArticleYear
Comparison of ibuprofen and indomethacin therapy for patent ductus arteriosus in preterm infants.
    Pediatrics international : official journal of the Japan Pediatric Society, 2003, Volume: 45, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Femal

2003
Treatment of patent ductus arteriosus with ibuprofen.
    Archives of disease in childhood. Fetal and neonatal edition, 1997, Volume: 76, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Administration Schedule; Ductus Arteriosus, Patent; Ec

1997
A comparison of ibuprofen and indomethacin for closure of patent ductus arteriosus.
    The New England journal of medicine, 2000, Sep-07, Volume: 343, Issue:10

    Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin; Infant, Newbo

2000
Prophylaxis of patent ductus arteriosus with ibuprofen in preterm infants.
    Acta paediatrica (Oslo, Norway : 1992), 2000, Volume: 89, Issue:11

    Topics: Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Apgar Score; Birth Weight; Cyclooxygenase Inhi

2000
Ibuprofen pharmacokinetics in preterm infants with patent ductus arteriosus.
    Clinical pharmacology and therapeutics, 2001, Volume: 70, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Ductus Arteriosus; Gestational Age; Human

2001

Other Studies

11 other studies available for ibuprofen and Respiratory Distress Syndrome, Newborn

ArticleYear
Hospital variation in medical and surgical treatment of patent ductus arteriosus.
    American journal of perinatology, 2015, Volume: 32, Issue:4

    Topics: Birth Weight; California; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Female; Gestational

2015
[Clinical characteristics and cardiac hemodynamic changes of patent ductus ateriosus in preterm infants].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2015, Volume: 53, Issue:3

    Topics: Birth Weight; Bronchopulmonary Dysplasia; Cardiac Output; Cyclooxygenase Inhibitors; Ductus Arterios

2015
The fate of ductus arteriosus in infants at 23-27 weeks of gestation: from spontaneous closure to ibuprofen resistance.
    Acta paediatrica (Oslo, Norway : 1992), 2008, Volume: 97, Issue:9

    Topics: Blood Coagulation; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Resistance; Duc

2008
Factors affecting postnatal changes in serum creatinine in preterm infants with gestational age <32 weeks.
    Journal of perinatology : official journal of the California Perinatal Association, 2009, Volume: 29, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Creatinine; Ductus Arteriosus, Patent; Female; Gestational

2009
Vascular abnormalities in aggressive posterior retinopathy of prematurity detected by fluorescein angiography.
    Ophthalmology, 2009, Volume: 116, Issue:7

    Topics: Capillary Permeability; Ductus Arteriosus, Patent; Female; Fluorescein Angiography; Gestational Age;

2009
An unreported complication of intravenously administered ibuprofen: gastrointestinal bleeding.
    European review for medical and pharmacological sciences, 2012, Volume: 16, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Gastrointestinal Hemorrhage; Hum

2012
Relationship between platelet count and volume and spontaneous and pharmacological closure of ductus arteriosus in preterm infants.
    American journal of perinatology, 2013, Volume: 30, Issue:5

    Topics: Blood Platelets; Cell Size; Cohort Studies; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Fe

2013
Comparative evaluation for the use of oral ibuprofen and intravenous indomethacin in Korean infants with patent ductus.
    Archives of pharmacal research, 2012, Volume: 35, Issue:9

    Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Comorbidity; Ductus Arteriosus, Paten

2012
Blood withdrawal and infusion via umbilical catheters: effect on cerebral perfusion and influence of ibuprofen.
    Biology of the neonate, 2003, Volume: 84, Issue:3

    Topics: Arteries; Blood Pressure; Blood Specimen Collection; Blood Transfusion; Blood Volume; Catheterizatio

2003
Closure of patent ductus arteriosus with oral ibuprofen suspension in premature newborns: a pilot study.
    Pediatrics, 2003, Volume: 112, Issue:5

    Topics: Administration, Oral; Cerebral Hemorrhage; Drug Evaluation; Ductus Arteriosus, Patent; Gestational A

2003
An optimized ibuprofen dosing scheme for preterm neonates with patent ductus arteriosus, based on a population pharmacokinetic and pharmacodynamic study.
    British journal of clinical pharmacology, 2008, Volume: 65, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Ductus Arteriosus, Patent; Humans; Ibupro

2008